The Experts below are selected from a list of 279 Experts worldwide ranked by ideXlab platform
Scott A. Guelcher - One of the best experts on this subject based on the ideXlab platform.
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biocompatibility and Chemical Reaction Kinetics of injectable settable polyurethane allograft bone biocomposites
Acta Biomaterialia, 2012Co-Authors: Jonathan Page, Edna M. Prieto, Jerald E. Dumas, Katarzyna J. Zienkiewicz, Joseph C. Wenke, Pamela B Brownbaer, Scott A. GuelcherAbstract:Abstract Injectable and settable bone grafts offer significant advantages over pre-formed implants due to their ability to be administered using minimally invasive techniques and to conform to the shape of the defect. However, injectable biomaterials present biocompatibility challenges due to the potential toxicity and ultimate fate of reactive components that are not incorporated in the final cured product. In this study the effects of stoichiometry and triethylenediamine (TEDA) catalyst concentration on the reactivity, injectability, and biocompatibility of two component lysine-derived polyurethane (PUR) biocomposites were investigated. Rate constants were measured for the Reactions of water (a blowing agent resulting in the generation of pores), polyester triol, dipropylene glycol (DPG), and allograft bone particles with the isocyanate-terminated prepolymer using an in situ attenuated total reflection Fourier transform infrared spectroscopy technique. Based on the measured rate constants, a kinetic model predicting the conversion of each component with time was developed. Despite the fact that TEDA is a well-known urethane gelling catalyst, it was found to preferentially catalyze the blowing Reaction with water relative to the gelling Reactions by a ratio >17:1. Thus the kinetic model predicted that the prepolymer and water proceeded to full conversion, while the conversions of polyester triol and DPG were
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Biocompatibility and Chemical Reaction Kinetics of injectable, settable polyurethane/allograft bone biocomposites.
Acta biomaterialia, 2012Co-Authors: Jonathan M. Page, Edna M. Prieto, Jerald E. Dumas, Katarzyna J. Zienkiewicz, Joseph C. Wenke, Pamela B Brownbaer, Scott A. GuelcherAbstract:Abstract Injectable and settable bone grafts offer significant advantages over pre-formed implants due to their ability to be administered using minimally invasive techniques and to conform to the shape of the defect. However, injectable biomaterials present biocompatibility challenges due to the potential toxicity and ultimate fate of reactive components that are not incorporated in the final cured product. In this study the effects of stoichiometry and triethylenediamine (TEDA) catalyst concentration on the reactivity, injectability, and biocompatibility of two component lysine-derived polyurethane (PUR) biocomposites were investigated. Rate constants were measured for the Reactions of water (a blowing agent resulting in the generation of pores), polyester triol, dipropylene glycol (DPG), and allograft bone particles with the isocyanate-terminated prepolymer using an in situ attenuated total reflection Fourier transform infrared spectroscopy technique. Based on the measured rate constants, a kinetic model predicting the conversion of each component with time was developed. Despite the fact that TEDA is a well-known urethane gelling catalyst, it was found to preferentially catalyze the blowing Reaction with water relative to the gelling Reactions by a ratio >17:1. Thus the kinetic model predicted that the prepolymer and water proceeded to full conversion, while the conversions of polyester triol and DPG were
Suzanne A Blum - One of the best experts on this subject based on the ideXlab platform.
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deconvoluting subensemble Chemical Reaction Kinetics of platinum sulfur ligand exchange detected with single molecule fluorescence microscopy
Inorganic Chemistry, 2011Co-Authors: Melody N Esfandiari, Yong Wang, Jonathan Y Bass, Suzanne A BlumAbstract:The subensemble Kinetics of a platinum–sulfur covalent Chemical Reaction at the solution/surface interface of a model industrial catalyst support was examined using single-molecule fluorescence microscopy (SMFM) and was found to exhibit biexponential first-order kinetic behavior. The observed Kinetics was a convolution of the observation probability and Chemical Reaction rate. These results suggest that deconvolution strategies may be broadly important for obtaining accurate Chemical Reaction Kinetics with SMFM.
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Deconvoluting Subensemble Chemical Reaction Kinetics of Platinum–Sulfur Ligand Exchange Detected with Single-Molecule Fluorescence Microscopy
Inorganic chemistry, 2011Co-Authors: N. Melody Esfandiari, Yong Wang, Jonathan Y Bass, Suzanne A BlumAbstract:The subensemble Kinetics of a platinum–sulfur covalent Chemical Reaction at the solution/surface interface of a model industrial catalyst support was examined using single-molecule fluorescence microscopy (SMFM) and was found to exhibit biexponential first-order kinetic behavior. The observed Kinetics was a convolution of the observation probability and Chemical Reaction rate. These results suggest that deconvolution strategies may be broadly important for obtaining accurate Chemical Reaction Kinetics with SMFM.
Edna M. Prieto - One of the best experts on this subject based on the ideXlab platform.
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biocompatibility and Chemical Reaction Kinetics of injectable settable polyurethane allograft bone biocomposites
Acta Biomaterialia, 2012Co-Authors: Jonathan Page, Edna M. Prieto, Jerald E. Dumas, Katarzyna J. Zienkiewicz, Joseph C. Wenke, Pamela B Brownbaer, Scott A. GuelcherAbstract:Abstract Injectable and settable bone grafts offer significant advantages over pre-formed implants due to their ability to be administered using minimally invasive techniques and to conform to the shape of the defect. However, injectable biomaterials present biocompatibility challenges due to the potential toxicity and ultimate fate of reactive components that are not incorporated in the final cured product. In this study the effects of stoichiometry and triethylenediamine (TEDA) catalyst concentration on the reactivity, injectability, and biocompatibility of two component lysine-derived polyurethane (PUR) biocomposites were investigated. Rate constants were measured for the Reactions of water (a blowing agent resulting in the generation of pores), polyester triol, dipropylene glycol (DPG), and allograft bone particles with the isocyanate-terminated prepolymer using an in situ attenuated total reflection Fourier transform infrared spectroscopy technique. Based on the measured rate constants, a kinetic model predicting the conversion of each component with time was developed. Despite the fact that TEDA is a well-known urethane gelling catalyst, it was found to preferentially catalyze the blowing Reaction with water relative to the gelling Reactions by a ratio >17:1. Thus the kinetic model predicted that the prepolymer and water proceeded to full conversion, while the conversions of polyester triol and DPG were
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Biocompatibility and Chemical Reaction Kinetics of injectable, settable polyurethane/allograft bone biocomposites.
Acta biomaterialia, 2012Co-Authors: Jonathan M. Page, Edna M. Prieto, Jerald E. Dumas, Katarzyna J. Zienkiewicz, Joseph C. Wenke, Pamela B Brownbaer, Scott A. GuelcherAbstract:Abstract Injectable and settable bone grafts offer significant advantages over pre-formed implants due to their ability to be administered using minimally invasive techniques and to conform to the shape of the defect. However, injectable biomaterials present biocompatibility challenges due to the potential toxicity and ultimate fate of reactive components that are not incorporated in the final cured product. In this study the effects of stoichiometry and triethylenediamine (TEDA) catalyst concentration on the reactivity, injectability, and biocompatibility of two component lysine-derived polyurethane (PUR) biocomposites were investigated. Rate constants were measured for the Reactions of water (a blowing agent resulting in the generation of pores), polyester triol, dipropylene glycol (DPG), and allograft bone particles with the isocyanate-terminated prepolymer using an in situ attenuated total reflection Fourier transform infrared spectroscopy technique. Based on the measured rate constants, a kinetic model predicting the conversion of each component with time was developed. Despite the fact that TEDA is a well-known urethane gelling catalyst, it was found to preferentially catalyze the blowing Reaction with water relative to the gelling Reactions by a ratio >17:1. Thus the kinetic model predicted that the prepolymer and water proceeded to full conversion, while the conversions of polyester triol and DPG were
Jerald E. Dumas - One of the best experts on this subject based on the ideXlab platform.
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biocompatibility and Chemical Reaction Kinetics of injectable settable polyurethane allograft bone biocomposites
Acta Biomaterialia, 2012Co-Authors: Jonathan Page, Edna M. Prieto, Jerald E. Dumas, Katarzyna J. Zienkiewicz, Joseph C. Wenke, Pamela B Brownbaer, Scott A. GuelcherAbstract:Abstract Injectable and settable bone grafts offer significant advantages over pre-formed implants due to their ability to be administered using minimally invasive techniques and to conform to the shape of the defect. However, injectable biomaterials present biocompatibility challenges due to the potential toxicity and ultimate fate of reactive components that are not incorporated in the final cured product. In this study the effects of stoichiometry and triethylenediamine (TEDA) catalyst concentration on the reactivity, injectability, and biocompatibility of two component lysine-derived polyurethane (PUR) biocomposites were investigated. Rate constants were measured for the Reactions of water (a blowing agent resulting in the generation of pores), polyester triol, dipropylene glycol (DPG), and allograft bone particles with the isocyanate-terminated prepolymer using an in situ attenuated total reflection Fourier transform infrared spectroscopy technique. Based on the measured rate constants, a kinetic model predicting the conversion of each component with time was developed. Despite the fact that TEDA is a well-known urethane gelling catalyst, it was found to preferentially catalyze the blowing Reaction with water relative to the gelling Reactions by a ratio >17:1. Thus the kinetic model predicted that the prepolymer and water proceeded to full conversion, while the conversions of polyester triol and DPG were
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Biocompatibility and Chemical Reaction Kinetics of injectable, settable polyurethane/allograft bone biocomposites.
Acta biomaterialia, 2012Co-Authors: Jonathan M. Page, Edna M. Prieto, Jerald E. Dumas, Katarzyna J. Zienkiewicz, Joseph C. Wenke, Pamela B Brownbaer, Scott A. GuelcherAbstract:Abstract Injectable and settable bone grafts offer significant advantages over pre-formed implants due to their ability to be administered using minimally invasive techniques and to conform to the shape of the defect. However, injectable biomaterials present biocompatibility challenges due to the potential toxicity and ultimate fate of reactive components that are not incorporated in the final cured product. In this study the effects of stoichiometry and triethylenediamine (TEDA) catalyst concentration on the reactivity, injectability, and biocompatibility of two component lysine-derived polyurethane (PUR) biocomposites were investigated. Rate constants were measured for the Reactions of water (a blowing agent resulting in the generation of pores), polyester triol, dipropylene glycol (DPG), and allograft bone particles with the isocyanate-terminated prepolymer using an in situ attenuated total reflection Fourier transform infrared spectroscopy technique. Based on the measured rate constants, a kinetic model predicting the conversion of each component with time was developed. Despite the fact that TEDA is a well-known urethane gelling catalyst, it was found to preferentially catalyze the blowing Reaction with water relative to the gelling Reactions by a ratio >17:1. Thus the kinetic model predicted that the prepolymer and water proceeded to full conversion, while the conversions of polyester triol and DPG were
Yong Wang - One of the best experts on this subject based on the ideXlab platform.
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deconvoluting subensemble Chemical Reaction Kinetics of platinum sulfur ligand exchange detected with single molecule fluorescence microscopy
Inorganic Chemistry, 2011Co-Authors: Melody N Esfandiari, Yong Wang, Jonathan Y Bass, Suzanne A BlumAbstract:The subensemble Kinetics of a platinum–sulfur covalent Chemical Reaction at the solution/surface interface of a model industrial catalyst support was examined using single-molecule fluorescence microscopy (SMFM) and was found to exhibit biexponential first-order kinetic behavior. The observed Kinetics was a convolution of the observation probability and Chemical Reaction rate. These results suggest that deconvolution strategies may be broadly important for obtaining accurate Chemical Reaction Kinetics with SMFM.
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Deconvoluting Subensemble Chemical Reaction Kinetics of Platinum–Sulfur Ligand Exchange Detected with Single-Molecule Fluorescence Microscopy
Inorganic chemistry, 2011Co-Authors: N. Melody Esfandiari, Yong Wang, Jonathan Y Bass, Suzanne A BlumAbstract:The subensemble Kinetics of a platinum–sulfur covalent Chemical Reaction at the solution/surface interface of a model industrial catalyst support was examined using single-molecule fluorescence microscopy (SMFM) and was found to exhibit biexponential first-order kinetic behavior. The observed Kinetics was a convolution of the observation probability and Chemical Reaction rate. These results suggest that deconvolution strategies may be broadly important for obtaining accurate Chemical Reaction Kinetics with SMFM.