The Experts below are selected from a list of 215760 Experts worldwide ranked by ideXlab platform
Hidemichi Fujii - One of the best experts on this subject based on the ideXlab platform.
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Decomposition analysis of green Chemical Technology inventions from 1971 to 2010 in Japan
Journal of Cleaner Production, 2016Co-Authors: Hidemichi FujiiAbstract:Green chemistry plays an important role in achieving sustainable development through pollution prevention in manufacturing sectors. This study examines the determining factors leading to green Chemical patent applications in Japan from 1971 to 2010. The novel contribution of the present research is to clarify companies' research and development strategies using log mean Divisia index with a focus on two factors: corporate priority given to green Chemical patent inventions and the scale effect of research and development activities. I focus on five green Chemical technologies: (1) aqueous solvents, (2) selected white bioTechnology, (3) totally chlorine-free bleaching, (4) biodegradable packaging, and (5) bioChemical fuel cells. The first three technologies are mainly applied in production processes in manufacturing sectors. I describe two main findings. First, green Chemical technologies applied in production processes have increased due to both the scale-up effect and increased research prioritization. This result implies that policies that encourage overall research activity promote the invention of green Chemical technologies that can be utilized in production. Second, biodegradable packaging and bioChemical fuel cells related to product design and renewable energy increased mainly as a result of increased research prioritization. Therefore, a specific research policy is more important than a policy intended to stimulate overall research activities in encouraging the invention of biodegradable packaging and bioChemical fuel cell technologies.
Şükrü Beydemir - One of the best experts on this subject based on the ideXlab platform.
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discovery of potent carbonic anhydrase acetylcholinesterase and butyrylcholinesterase enzymes inhibitors the new amides and thiazolidine 4 ones synthesized on an acetophenone base
Journal of Biochemical and Molecular Toxicology, 2017Co-Authors: Parham Taslimi, İlhami Gulçin, Afsun Sujayev, Vagif Farzaliyev, Sabiya Osmanova, Sabira Sardarova, Ruya Kaya, Fatma Koc, Şükrü BeydemirAbstract:Compounds containing nitrogen and sulfur atoms can be widely used in various fields, including industry, medicine, bioTechnology, and Chemical Technology. Among them, amides of acids and heterocyclic compounds have an important place. These amides and thiazolidine-4-ones showed good inhibitory action against butyrylcholinesterase (BChE), acetylcholinesterase (AChE), and human carbonic anhydrase isoforms. AChE exists at high concentrations in the brain and red blood cells. BChE is an important enzyme that is plentiful in the liver, and it is released into the blood in a soluble form. They were demonstrated to have effective inhibition profiles with Ki values of 23.76-102.75 nM against hCA I, 58.92-136.64 nM against hCA II, 1.40-12.86 nM against AChE, and 9.82-52.77 nM against BChE. On the other hand, acetazolamide showed Ki value of 482.63 ± 56.20 nM against hCA I, and 1019.60 ± 163.70 nM against hCA II. Additionally, Tacrine inhibited AChE and BChE, showing Ki values of 397.03 ± 31.66 and 210.21 ± 15.98 nM, respectively.
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Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors
Taylor & Francis Group, 2017Co-Authors: İlhami Gulçin, Malahat Abbasova, Parham Taslimi, Zübeyir Huyut, Leyla Safarova, Afsun Sujayev, Vagif Farzaliyev, Şükrü Beydemir, Saleh H. Alwasel, Claudiu T. SupuranAbstract:Compounds containing nitrogen and sulfur atoms can be widely used in various fields such as industry, medicine, bioTechnology and Chemical Technology. Therefore, the reactions of aminomethylation and alkoxymethylation of mercaptobenzothiazole, mercaptobenzoxazole and 2-aminothiazole were developed. Additionally, the alkoxymethyl derivatives of mercaptobenzoxazole and 2-aminothiazole were synthesized by a reaction with hemiformals, which are prepared by the reaction of alcohols and formaldehyde. In this study, the inhibitory effects of these molecules were investigated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) enzymes and carbonic anhydrase I, and II isoenzymes (hCA I and II). Both hCA isoenzymes were significantly inhibited by the recently synthesized molecules, with Ki values in the range of 58–157 nM for hCA I, and 81–215 nM for hCA II. Additionally, the Ki parameters of these molecules for BChE and AChE were calculated in the ranges 23–88 and 18–78 nM, respectively
İlhami Gulçin - One of the best experts on this subject based on the ideXlab platform.
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discovery of potent carbonic anhydrase acetylcholinesterase and butyrylcholinesterase enzymes inhibitors the new amides and thiazolidine 4 ones synthesized on an acetophenone base
Journal of Biochemical and Molecular Toxicology, 2017Co-Authors: Parham Taslimi, İlhami Gulçin, Afsun Sujayev, Vagif Farzaliyev, Sabiya Osmanova, Sabira Sardarova, Ruya Kaya, Fatma Koc, Şükrü BeydemirAbstract:Compounds containing nitrogen and sulfur atoms can be widely used in various fields, including industry, medicine, bioTechnology, and Chemical Technology. Among them, amides of acids and heterocyclic compounds have an important place. These amides and thiazolidine-4-ones showed good inhibitory action against butyrylcholinesterase (BChE), acetylcholinesterase (AChE), and human carbonic anhydrase isoforms. AChE exists at high concentrations in the brain and red blood cells. BChE is an important enzyme that is plentiful in the liver, and it is released into the blood in a soluble form. They were demonstrated to have effective inhibition profiles with Ki values of 23.76-102.75 nM against hCA I, 58.92-136.64 nM against hCA II, 1.40-12.86 nM against AChE, and 9.82-52.77 nM against BChE. On the other hand, acetazolamide showed Ki value of 482.63 ± 56.20 nM against hCA I, and 1019.60 ± 163.70 nM against hCA II. Additionally, Tacrine inhibited AChE and BChE, showing Ki values of 397.03 ± 31.66 and 210.21 ± 15.98 nM, respectively.
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Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors
Taylor & Francis Group, 2017Co-Authors: İlhami Gulçin, Malahat Abbasova, Parham Taslimi, Zübeyir Huyut, Leyla Safarova, Afsun Sujayev, Vagif Farzaliyev, Şükrü Beydemir, Saleh H. Alwasel, Claudiu T. SupuranAbstract:Compounds containing nitrogen and sulfur atoms can be widely used in various fields such as industry, medicine, bioTechnology and Chemical Technology. Therefore, the reactions of aminomethylation and alkoxymethylation of mercaptobenzothiazole, mercaptobenzoxazole and 2-aminothiazole were developed. Additionally, the alkoxymethyl derivatives of mercaptobenzoxazole and 2-aminothiazole were synthesized by a reaction with hemiformals, which are prepared by the reaction of alcohols and formaldehyde. In this study, the inhibitory effects of these molecules were investigated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) enzymes and carbonic anhydrase I, and II isoenzymes (hCA I and II). Both hCA isoenzymes were significantly inhibited by the recently synthesized molecules, with Ki values in the range of 58–157 nM for hCA I, and 81–215 nM for hCA II. Additionally, the Ki parameters of these molecules for BChE and AChE were calculated in the ranges 23–88 and 18–78 nM, respectively
Fengqi You - One of the best experts on this subject based on the ideXlab platform.
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how to assess the potential of emerging green technologies towards a prospective environmental and techno economic assessment framework
Green Chemistry, 2019Co-Authors: Gwenny Thomassen, Miet Van Dael, Steven Van Passel, Fengqi YouAbstract:For sustainable production and consumption, emerging green technologies need to be optimized towards a minimal environmental impact and a maximal economic impact. In an early stage of Technology development, more flexibility is available to adapt the Technology. Therefore, a prospective environmental and techno-economic assessment is required. The prospective assessment differs at the different stages of Technology development, as also the data availability and accuracy evolves. This paper reviews the different prospective technological, economic and environmental assessment methods which have been used to assess the potential of new green Chemical technologies. Based on the current best practices, an overarching framework is introduced to assess the technological, economic and environmental potential of an emerging green Chemical Technology at the different stages of Technology development.
Steven Van Passel - One of the best experts on this subject based on the ideXlab platform.
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how to assess the potential of emerging green technologies towards a prospective environmental and techno economic assessment framework
Green Chemistry, 2019Co-Authors: Gwenny Thomassen, Miet Van Dael, Steven Van Passel, Fengqi YouAbstract:For sustainable production and consumption, emerging green technologies need to be optimized towards a minimal environmental impact and a maximal economic impact. In an early stage of Technology development, more flexibility is available to adapt the Technology. Therefore, a prospective environmental and techno-economic assessment is required. The prospective assessment differs at the different stages of Technology development, as also the data availability and accuracy evolves. This paper reviews the different prospective technological, economic and environmental assessment methods which have been used to assess the potential of new green Chemical technologies. Based on the current best practices, an overarching framework is introduced to assess the technological, economic and environmental potential of an emerging green Chemical Technology at the different stages of Technology development.