The Experts below are selected from a list of 807 Experts worldwide ranked by ideXlab platform

Giuliana Lo Cascio - One of the best experts on this subject based on the ideXlab platform.

  • assessment of immune response to sars cov 2 with fully automated maglumi 2019 ncov igg and igm Chemiluminescence Immunoassays
    Clinical Chemistry and Laboratory Medicine, 2020
    Co-Authors: Giuseppe Lippi, Gian Luca Salvagno, Manuela Pegoraro, Valentina Militello, Cecilia Caloi, Angelo Peretti, Stefania Gaino, Antonella Bassi, Chiara Bovo, Giuliana Lo Cascio
    Abstract:

    The aim of this study was to analyze the immunological response to SARS-CoV-2 using novel fully automated Chemiluminescence Immunoassays (CLIAs) The direct comparison by receiver operating characteristic (ROC) curve analysis of MAGLUMI 2019-nCoV IgG positive/negative vs Euroimmun Anti-SARS-CoV-2 IgG positive/negative results yielded an overall concordance of 88% (kappa statistics, 0 47;95% CI, 0 26-0 68;p=1 30 AU/mL Despite being different immunoglobulin classes, an analogous analysis between MAGLUMI 2019-nCoV IgM positive/negative vs Euroimmun Anti-SARS-CoV-2 IgA positive/negative results yielded an overall concordance of 90% (kappa statistics, 0 39;95% CI, 0 14-0 65;p=0 001), AUC of 0 64 (95% CI, 0 53-0 75;p=0 001) and Spearman correlation (absorbance) of 0 26 (95% CI, 0 09-0 41;p=0 003) The ROC curve, recalculated using MAGLUMI 2019-nCoV IgM absorbance data vs Euroimmun Anti-SARS-CoV-2 positive/negative IgA results, yielded a substantial increase in the AUC (0 87;95% CI, 0 77-0 97;p<0 001) The results of this study complement those previous published by Padoan et al [5], demonstrating that results of MAGLUMI 2019-nCoV IgM and IgG are well aligned with those of Euroimmun Anti-SARS-CoV-2 IgA and IgG, especially concerning the IgG and the cumulative immunoglobulin profile

Giuseppe Lippi - One of the best experts on this subject based on the ideXlab platform.

  • assessment of immune response to sars cov 2 with fully automated maglumi 2019 ncov igg and igm Chemiluminescence Immunoassays
    Clinical Chemistry and Laboratory Medicine, 2020
    Co-Authors: Giuseppe Lippi, Gian Luca Salvagno, Manuela Pegoraro, Valentina Militello, Cecilia Caloi, Angelo Peretti, Stefania Gaino, Antonella Bassi, Chiara Bovo, Giuliana Lo Cascio
    Abstract:

    The aim of this study was to analyze the immunological response to SARS-CoV-2 using novel fully automated Chemiluminescence Immunoassays (CLIAs) The direct comparison by receiver operating characteristic (ROC) curve analysis of MAGLUMI 2019-nCoV IgG positive/negative vs Euroimmun Anti-SARS-CoV-2 IgG positive/negative results yielded an overall concordance of 88% (kappa statistics, 0 47;95% CI, 0 26-0 68;p=1 30 AU/mL Despite being different immunoglobulin classes, an analogous analysis between MAGLUMI 2019-nCoV IgM positive/negative vs Euroimmun Anti-SARS-CoV-2 IgA positive/negative results yielded an overall concordance of 90% (kappa statistics, 0 39;95% CI, 0 14-0 65;p=0 001), AUC of 0 64 (95% CI, 0 53-0 75;p=0 001) and Spearman correlation (absorbance) of 0 26 (95% CI, 0 09-0 41;p=0 003) The ROC curve, recalculated using MAGLUMI 2019-nCoV IgM absorbance data vs Euroimmun Anti-SARS-CoV-2 positive/negative IgA results, yielded a substantial increase in the AUC (0 87;95% CI, 0 77-0 97;p<0 001) The results of this study complement those previous published by Padoan et al [5], demonstrating that results of MAGLUMI 2019-nCoV IgM and IgG are well aligned with those of Euroimmun Anti-SARS-CoV-2 IgA and IgG, especially concerning the IgG and the cumulative immunoglobulin profile

Ina U Park - One of the best experts on this subject based on the ideXlab platform.

  • screening for syphilis with the treponemal immunoassay analysis of discordant serology results and implications for clinical management
    The Journal of Infectious Diseases, 2011
    Co-Authors: Ina U Park, Joan M Chow, Jennifer Shieh, Gail Bolan, Mark Stanley, Jonathan M. Schapiro
    Abstract:

    Background. Screening for syphilis with treponemal Chemiluminescence Immunoassays (CIA) identifies patients with discordant serology who are not identified with traditional screening methods (eg, CIA-positive, rapid plasma regain (RPR)-negative). We sought to describe the clinical characteristics and management of patients with discordant syphilis serology. Methods. From August 2007‐October 2007, patients with CIA-positive, RPR-negative serology were tested with the Treponema pallidum particle agglutination assay (TP-PA) at Kaiser Permanente Northern California. Clinical and demographic characteristics, prior syphilis history and CIA index values were compared for CIApositive, RPR-negative patients according to TP-PA status. Results. Of 21623 assays, 439 (2%) were CIA-positive and 255/439 (58%) were RPR-negative; subsequently, 184 (72%) were TP-PA-positive and 71 (28%) were TP-PA‐negative. TP-PA‐positive patients were more likely to be male, HIV-positive, homosexual, previously treated for syphilis (57% versus 9%), with higher median CIA index values (9.8 versus 1.6) (all P , .0001). After repeat testing, 7/31 (23%) CIA-positive, RPR-negative, TP-PA‐negative patients seroreverted to CIA-negative. Conclusions. TP-PA results in conjunction with clinical/behavioral assessment helped guide the management of patients with CIA-positive, RPR-negative serology. TP-PA-positive patients were both highly likely to have prior syphilis and major epidemiologic risk factors for syphilis. CIA-positive, RPR-negative, TP-PA-negative serology may represent a false-positive CIA in low-prevalence populations.

Angelo Peretti - One of the best experts on this subject based on the ideXlab platform.

  • assessment of immune response to sars cov 2 with fully automated maglumi 2019 ncov igg and igm Chemiluminescence Immunoassays
    Clinical Chemistry and Laboratory Medicine, 2020
    Co-Authors: Giuseppe Lippi, Gian Luca Salvagno, Manuela Pegoraro, Valentina Militello, Cecilia Caloi, Angelo Peretti, Stefania Gaino, Antonella Bassi, Chiara Bovo, Giuliana Lo Cascio
    Abstract:

    The aim of this study was to analyze the immunological response to SARS-CoV-2 using novel fully automated Chemiluminescence Immunoassays (CLIAs) The direct comparison by receiver operating characteristic (ROC) curve analysis of MAGLUMI 2019-nCoV IgG positive/negative vs Euroimmun Anti-SARS-CoV-2 IgG positive/negative results yielded an overall concordance of 88% (kappa statistics, 0 47;95% CI, 0 26-0 68;p=1 30 AU/mL Despite being different immunoglobulin classes, an analogous analysis between MAGLUMI 2019-nCoV IgM positive/negative vs Euroimmun Anti-SARS-CoV-2 IgA positive/negative results yielded an overall concordance of 90% (kappa statistics, 0 39;95% CI, 0 14-0 65;p=0 001), AUC of 0 64 (95% CI, 0 53-0 75;p=0 001) and Spearman correlation (absorbance) of 0 26 (95% CI, 0 09-0 41;p=0 003) The ROC curve, recalculated using MAGLUMI 2019-nCoV IgM absorbance data vs Euroimmun Anti-SARS-CoV-2 positive/negative IgA results, yielded a substantial increase in the AUC (0 87;95% CI, 0 77-0 97;p<0 001) The results of this study complement those previous published by Padoan et al [5], demonstrating that results of MAGLUMI 2019-nCoV IgM and IgG are well aligned with those of Euroimmun Anti-SARS-CoV-2 IgA and IgG, especially concerning the IgG and the cumulative immunoglobulin profile

Gian Luca Salvagno - One of the best experts on this subject based on the ideXlab platform.

  • assessment of immune response to sars cov 2 with fully automated maglumi 2019 ncov igg and igm Chemiluminescence Immunoassays
    Clinical Chemistry and Laboratory Medicine, 2020
    Co-Authors: Giuseppe Lippi, Gian Luca Salvagno, Manuela Pegoraro, Valentina Militello, Cecilia Caloi, Angelo Peretti, Stefania Gaino, Antonella Bassi, Chiara Bovo, Giuliana Lo Cascio
    Abstract:

    The aim of this study was to analyze the immunological response to SARS-CoV-2 using novel fully automated Chemiluminescence Immunoassays (CLIAs) The direct comparison by receiver operating characteristic (ROC) curve analysis of MAGLUMI 2019-nCoV IgG positive/negative vs Euroimmun Anti-SARS-CoV-2 IgG positive/negative results yielded an overall concordance of 88% (kappa statistics, 0 47;95% CI, 0 26-0 68;p=1 30 AU/mL Despite being different immunoglobulin classes, an analogous analysis between MAGLUMI 2019-nCoV IgM positive/negative vs Euroimmun Anti-SARS-CoV-2 IgA positive/negative results yielded an overall concordance of 90% (kappa statistics, 0 39;95% CI, 0 14-0 65;p=0 001), AUC of 0 64 (95% CI, 0 53-0 75;p=0 001) and Spearman correlation (absorbance) of 0 26 (95% CI, 0 09-0 41;p=0 003) The ROC curve, recalculated using MAGLUMI 2019-nCoV IgM absorbance data vs Euroimmun Anti-SARS-CoV-2 positive/negative IgA results, yielded a substantial increase in the AUC (0 87;95% CI, 0 77-0 97;p<0 001) The results of this study complement those previous published by Padoan et al [5], demonstrating that results of MAGLUMI 2019-nCoV IgM and IgG are well aligned with those of Euroimmun Anti-SARS-CoV-2 IgA and IgG, especially concerning the IgG and the cumulative immunoglobulin profile