The Experts below are selected from a list of 6777 Experts worldwide ranked by ideXlab platform

Peter Langer - One of the best experts on this subject based on the ideXlab platform.

Omer A Akrawi - One of the best experts on this subject based on the ideXlab platform.

Aws M Hamdy - One of the best experts on this subject based on the ideXlab platform.

David J Michaelis - One of the best experts on this subject based on the ideXlab platform.

  • dual optimization approach to bimetallic nanoparticle catalysis impact of m1 m2 ratio and supporting polymer structure on reactivity
    ACS Catalysis, 2015
    Co-Authors: Venkatareddy Udumula, Jefferson H Tyler, Paul S Minson, Donald A. Davis, Matthew R. Linford, Hao Wang, David J Michaelis
    Abstract:

    A dual optimization approach to nanoparticle catalysis is reported in which both the composition of a bimetallic nanoparticle and the electronic properties of the supporting polystyrene-based polymer can be varied to optimize reactivity and Chemoselectivity in nitroarene reductions. Ruthenium–cobalt nanoparticles supported on polystyrene are shown to catalyze nitroarene reductions at room temperature with exceptional activity, as compared with monometallic ruthenium catalysts. Both the identity of the second metal and the M1/M2 ratio show a profound effect on the Chemoselectivity of nitroarene reductions. These polymer-supported bimetallic catalysts are shown to react with nearly complete Chemoselectivity for nitro group reduction over a variety of easily reducible functional groups. The electronic properties of the supporting polymer also have a significant impact on catalysis, in which electron-deficient polystyrenes enable 100% conversion to the aniline product in just 20 min at room temperature. Polym...

  • Dual Optimization Approach to Bimetallic Nanoparticle Catalysis: Impact of M1/M2 Ratio and Supporting Polymer Structure on Reactivity
    2015
    Co-Authors: Venkatareddy Udumula, Jefferson H Tyler, Paul S Minson, Donald A. Davis, Matthew R. Linford, Hao Wang, David J Michaelis
    Abstract:

    A dual optimization approach to nanoparticle catalysis is reported in which both the composition of a bimetallic nanoparticle and the electronic properties of the supporting polystyrene-based polymer can be varied to optimize reactivity and Chemoselectivity in nitroarene reductions. Ruthenium–cobalt nanoparticles supported on polystyrene are shown to catalyze nitroarene reductions at room temperature with exceptional activity, as compared with monometallic ruthenium catalysts. Both the identity of the second metal and the M1/M2 ratio show a profound effect on the Chemoselectivity of nitroarene reductions. These polymer-supported bimetallic catalysts are shown to react with nearly complete Chemoselectivity for nitro group reduction over a variety of easily reducible functional groups. The electronic properties of the supporting polymer also have a significant impact on catalysis, in which electron-deficient polystyrenes enable 100% conversion to the aniline product in just 20 min at room temperature. Polymer effects are also shown to influence the mechanism of the reduction reaction, in addition to accelerating the rate, confirming the impact of the polymer structure on catalytic efficiency. These catalysts are easily prepared in a single step from commercial materials and can be readily recycled without loss of activity

Douglas D Young - One of the best experts on this subject based on the ideXlab platform.

  • application of the solid supported glaser hay reaction to natural product synthesis
    Journal of Organic Chemistry, 2016
    Co-Authors: Jessica S Lampkowski, Diya M Uthappa, John F Halonski, Johnathan C Maza, Douglas D Young
    Abstract:

    The Glaser–Hay coupling of terminal alkynes is a useful synthetic reaction for the preparation of polyynes; however, Chemoselectivity issues have precluded its widespread utilization. Conducting the reaction on a solid-support provides a mechanism to alleviate the Chemoselectivity issues and provide products in high purities and yields. Moreover, the polyyne core is a key component to several natural products. Herein, we describe the application of a solid-supported Glaser–Hay reaction in the preparation of several natural products. These compounds were then screened for antibacterial activity, illustrating the utility of the methodology.

  • Application of the Solid-Supported Glaser–Hay Reaction to Natural Product Synthesis
    2016
    Co-Authors: Jessica S Lampkowski, Diya M Uthappa, John F Halonski, Johnathan C Maza, Douglas D Young
    Abstract:

    The Glaser–Hay coupling of terminal alkynes is a useful synthetic reaction for the preparation of polyynes; however, Chemoselectivity issues have precluded its widespread utilization. Conducting the reaction on a solid-support provides a mechanism to alleviate the Chemoselectivity issues and provide products in high purities and yields. Moreover, the polyyne core is a key component to several natural products. Herein, we describe the application of a solid-supported Glaser–Hay reaction in the preparation of several natural products. These compounds were then screened for antibacterial activity, illustrating the utility of the methodology