The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Ying-hao Wang - One of the best experts on this subject based on the ideXlab platform.
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High frequency of GNA14, GNAQ, and GNA11 mutations in Cherry Hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms
Modern Pathology, 2019Co-Authors: Jau-yu Liau, Chih-chi Chen, Yung-chuan Chung, Jia-huei Tsai, Ying-hao WangAbstract:Cherry Hemangioma is the most common Hemangioma in adult life. Neoplastic and non-neoplastic theories had both been proposed for its pathogenesis, but its nature is still poorly understood. We noted a significant subset of anastomosing Hemangiomas and congenital Hemangiomas harbored a population of small capillaries surrounded by a perivascular hyaline layer, reminiscent of the vessels seen in Cherry Hemangioma. Both anastomosing Hemangioma and congenital Hemangioma harbor recurrent mutations in exon 5 of GNAQ and its paralogues. In this study, we analyzed 68 Cherry Hemangiomas and 17 Cherry Hemangioma-like Hemangiomas exhibiting additional non-classical features including markedly dilated, cavernous vessels, and/or a deep component extending to the deep dermis. By Sanger sequencing, GNAQ , GNA11 , and GNA14 exon 5 mutations were identified in 12, 4, and 32 Cherry Hemangiomas, respectively, and 5, 3, and 3 Cherry Hemangioma-like Hemangiomas, respectively. MassARRAY analysis detected mutations (including exon 2 GNAQ ^G48V mutations) in additional 8 Cherry Hemangiomas and 3 Cherry Hemangioma-like Hemangiomas. Overall, the Cherry Hemangiomas and Cherry Hemangioma-like Hemangiomas had equal GNA mutation rates (82%), and GNA14 and GNAQ mutations were present in approximately half of Cherry Hemangiomas and Cherry Hemangioma-like Hemangiomas, respectively. All mutations were mutually exclusive. KRAS ^G12V mutation was also detected in one Cherry Hemangioma-like Hemangioma without GNA mutations. In summary, our study demonstrated recurrent GNA14 / GNAQ / GNA11 mutations were present in the majority of this very common Hemangioma and established its neoplastic nature. Our results also expanded the morphological spectrum of GNA -mutated Hemangiomas to include tumors composed of cavernous-like vessels and indicated GNA14 was the most commonly mutated gene in vascular tumors.
Jau-yu Liau - One of the best experts on this subject based on the ideXlab platform.
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High frequency of GNA14, GNAQ, and GNA11 mutations in Cherry Hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms
Modern Pathology, 2019Co-Authors: Jau-yu Liau, Chih-chi Chen, Yung-chuan Chung, Jia-huei Tsai, Ying-hao WangAbstract:Cherry Hemangioma is the most common Hemangioma in adult life. Neoplastic and non-neoplastic theories had both been proposed for its pathogenesis, but its nature is still poorly understood. We noted a significant subset of anastomosing Hemangiomas and congenital Hemangiomas harbored a population of small capillaries surrounded by a perivascular hyaline layer, reminiscent of the vessels seen in Cherry Hemangioma. Both anastomosing Hemangioma and congenital Hemangioma harbor recurrent mutations in exon 5 of GNAQ and its paralogues. In this study, we analyzed 68 Cherry Hemangiomas and 17 Cherry Hemangioma-like Hemangiomas exhibiting additional non-classical features including markedly dilated, cavernous vessels, and/or a deep component extending to the deep dermis. By Sanger sequencing, GNAQ , GNA11 , and GNA14 exon 5 mutations were identified in 12, 4, and 32 Cherry Hemangiomas, respectively, and 5, 3, and 3 Cherry Hemangioma-like Hemangiomas, respectively. MassARRAY analysis detected mutations (including exon 2 GNAQ ^G48V mutations) in additional 8 Cherry Hemangiomas and 3 Cherry Hemangioma-like Hemangiomas. Overall, the Cherry Hemangiomas and Cherry Hemangioma-like Hemangiomas had equal GNA mutation rates (82%), and GNA14 and GNAQ mutations were present in approximately half of Cherry Hemangiomas and Cherry Hemangioma-like Hemangiomas, respectively. All mutations were mutually exclusive. KRAS ^G12V mutation was also detected in one Cherry Hemangioma-like Hemangioma without GNA mutations. In summary, our study demonstrated recurrent GNA14 / GNAQ / GNA11 mutations were present in the majority of this very common Hemangioma and established its neoplastic nature. Our results also expanded the morphological spectrum of GNA -mutated Hemangiomas to include tumors composed of cavernous-like vessels and indicated GNA14 was the most commonly mutated gene in vascular tumors.
Chih-chi Chen - One of the best experts on this subject based on the ideXlab platform.
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High frequency of GNA14, GNAQ, and GNA11 mutations in Cherry Hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms
Modern Pathology, 2019Co-Authors: Jau-yu Liau, Chih-chi Chen, Yung-chuan Chung, Jia-huei Tsai, Ying-hao WangAbstract:Cherry Hemangioma is the most common Hemangioma in adult life. Neoplastic and non-neoplastic theories had both been proposed for its pathogenesis, but its nature is still poorly understood. We noted a significant subset of anastomosing Hemangiomas and congenital Hemangiomas harbored a population of small capillaries surrounded by a perivascular hyaline layer, reminiscent of the vessels seen in Cherry Hemangioma. Both anastomosing Hemangioma and congenital Hemangioma harbor recurrent mutations in exon 5 of GNAQ and its paralogues. In this study, we analyzed 68 Cherry Hemangiomas and 17 Cherry Hemangioma-like Hemangiomas exhibiting additional non-classical features including markedly dilated, cavernous vessels, and/or a deep component extending to the deep dermis. By Sanger sequencing, GNAQ , GNA11 , and GNA14 exon 5 mutations were identified in 12, 4, and 32 Cherry Hemangiomas, respectively, and 5, 3, and 3 Cherry Hemangioma-like Hemangiomas, respectively. MassARRAY analysis detected mutations (including exon 2 GNAQ ^G48V mutations) in additional 8 Cherry Hemangiomas and 3 Cherry Hemangioma-like Hemangiomas. Overall, the Cherry Hemangiomas and Cherry Hemangioma-like Hemangiomas had equal GNA mutation rates (82%), and GNA14 and GNAQ mutations were present in approximately half of Cherry Hemangiomas and Cherry Hemangioma-like Hemangiomas, respectively. All mutations were mutually exclusive. KRAS ^G12V mutation was also detected in one Cherry Hemangioma-like Hemangioma without GNA mutations. In summary, our study demonstrated recurrent GNA14 / GNAQ / GNA11 mutations were present in the majority of this very common Hemangioma and established its neoplastic nature. Our results also expanded the morphological spectrum of GNA -mutated Hemangiomas to include tumors composed of cavernous-like vessels and indicated GNA14 was the most commonly mutated gene in vascular tumors.
Yung-chuan Chung - One of the best experts on this subject based on the ideXlab platform.
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High frequency of GNA14, GNAQ, and GNA11 mutations in Cherry Hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms
Modern Pathology, 2019Co-Authors: Jau-yu Liau, Chih-chi Chen, Yung-chuan Chung, Jia-huei Tsai, Ying-hao WangAbstract:Cherry Hemangioma is the most common Hemangioma in adult life. Neoplastic and non-neoplastic theories had both been proposed for its pathogenesis, but its nature is still poorly understood. We noted a significant subset of anastomosing Hemangiomas and congenital Hemangiomas harbored a population of small capillaries surrounded by a perivascular hyaline layer, reminiscent of the vessels seen in Cherry Hemangioma. Both anastomosing Hemangioma and congenital Hemangioma harbor recurrent mutations in exon 5 of GNAQ and its paralogues. In this study, we analyzed 68 Cherry Hemangiomas and 17 Cherry Hemangioma-like Hemangiomas exhibiting additional non-classical features including markedly dilated, cavernous vessels, and/or a deep component extending to the deep dermis. By Sanger sequencing, GNAQ , GNA11 , and GNA14 exon 5 mutations were identified in 12, 4, and 32 Cherry Hemangiomas, respectively, and 5, 3, and 3 Cherry Hemangioma-like Hemangiomas, respectively. MassARRAY analysis detected mutations (including exon 2 GNAQ ^G48V mutations) in additional 8 Cherry Hemangiomas and 3 Cherry Hemangioma-like Hemangiomas. Overall, the Cherry Hemangiomas and Cherry Hemangioma-like Hemangiomas had equal GNA mutation rates (82%), and GNA14 and GNAQ mutations were present in approximately half of Cherry Hemangiomas and Cherry Hemangioma-like Hemangiomas, respectively. All mutations were mutually exclusive. KRAS ^G12V mutation was also detected in one Cherry Hemangioma-like Hemangioma without GNA mutations. In summary, our study demonstrated recurrent GNA14 / GNAQ / GNA11 mutations were present in the majority of this very common Hemangioma and established its neoplastic nature. Our results also expanded the morphological spectrum of GNA -mutated Hemangiomas to include tumors composed of cavernous-like vessels and indicated GNA14 was the most commonly mutated gene in vascular tumors.
Jia-huei Tsai - One of the best experts on this subject based on the ideXlab platform.
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High frequency of GNA14, GNAQ, and GNA11 mutations in Cherry Hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms
Modern Pathology, 2019Co-Authors: Jau-yu Liau, Chih-chi Chen, Yung-chuan Chung, Jia-huei Tsai, Ying-hao WangAbstract:Cherry Hemangioma is the most common Hemangioma in adult life. Neoplastic and non-neoplastic theories had both been proposed for its pathogenesis, but its nature is still poorly understood. We noted a significant subset of anastomosing Hemangiomas and congenital Hemangiomas harbored a population of small capillaries surrounded by a perivascular hyaline layer, reminiscent of the vessels seen in Cherry Hemangioma. Both anastomosing Hemangioma and congenital Hemangioma harbor recurrent mutations in exon 5 of GNAQ and its paralogues. In this study, we analyzed 68 Cherry Hemangiomas and 17 Cherry Hemangioma-like Hemangiomas exhibiting additional non-classical features including markedly dilated, cavernous vessels, and/or a deep component extending to the deep dermis. By Sanger sequencing, GNAQ , GNA11 , and GNA14 exon 5 mutations were identified in 12, 4, and 32 Cherry Hemangiomas, respectively, and 5, 3, and 3 Cherry Hemangioma-like Hemangiomas, respectively. MassARRAY analysis detected mutations (including exon 2 GNAQ ^G48V mutations) in additional 8 Cherry Hemangiomas and 3 Cherry Hemangioma-like Hemangiomas. Overall, the Cherry Hemangiomas and Cherry Hemangioma-like Hemangiomas had equal GNA mutation rates (82%), and GNA14 and GNAQ mutations were present in approximately half of Cherry Hemangiomas and Cherry Hemangioma-like Hemangiomas, respectively. All mutations were mutually exclusive. KRAS ^G12V mutation was also detected in one Cherry Hemangioma-like Hemangioma without GNA mutations. In summary, our study demonstrated recurrent GNA14 / GNAQ / GNA11 mutations were present in the majority of this very common Hemangioma and established its neoplastic nature. Our results also expanded the morphological spectrum of GNA -mutated Hemangiomas to include tumors composed of cavernous-like vessels and indicated GNA14 was the most commonly mutated gene in vascular tumors.