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Michael T. Davies-coleman - One of the best experts on this subject based on the ideXlab platform.

  • Makaluvic Acids from the South African Latrunculid Sponge Strongylodesma aliwaliensis
    Journal of natural products, 2005
    Co-Authors: Robert A. Keyzers, Toufiek Samaai, Catherine E. Arendse, Denver T. Hendricks, Michael T. Davies-coleman
    Abstract:

    Two new metabolites, makaluvic acid C (1) and N-1-beta-d-ribofuranosylmakaluvic acid C (2), were isolated from the recently described sponge Strongylodesma aliwaliensis collected off the east coast of South Africa. Standard spectroscopic techniques provided the structures of both compounds. Chiral GC analysis of the peracetylated aldononitrile derivative of the acid hydrolysate of 2 confirmed the d-configuration of the ribose moiety in this compound. Compound 2 and four related pyrroloquinoline metabolites, isolated previously from S. aliwaliensis, exhibited in vitro cytotoxicity against esophageal cancer cells.

  • Novel pyrroloquinoline ribosides from the South African latrunculid sponge Strongylodesma aliwaliensis
    Tetrahedron Letters, 2004
    Co-Authors: Robert A. Keyzers, Toufiek Samaai, Michael T. Davies-coleman
    Abstract:

    Two novel pyrroloquinoline ribosides, N-1-β-D-ribofuranosyldamirone C (1), and N-1-β-D-ribofuranosylmakaluvamine I (2) were isolated from a new species of South African latrunculid sponge, Strongylodesma aliwaliensis. Standard spectroscopic techniques were used to determine the structures of 1 and 2. Molecular modeling studies and NOESY data of 1 and 2, in combination with Chiral GC analysis of their derivatized acid hydrolysis products, established the β-D-configuration of the ribofuranose moieties.

Robert A. Keyzers - One of the best experts on this subject based on the ideXlab platform.

  • Makaluvic Acids from the South African Latrunculid Sponge Strongylodesma aliwaliensis
    Journal of natural products, 2005
    Co-Authors: Robert A. Keyzers, Toufiek Samaai, Catherine E. Arendse, Denver T. Hendricks, Michael T. Davies-coleman
    Abstract:

    Two new metabolites, makaluvic acid C (1) and N-1-beta-d-ribofuranosylmakaluvic acid C (2), were isolated from the recently described sponge Strongylodesma aliwaliensis collected off the east coast of South Africa. Standard spectroscopic techniques provided the structures of both compounds. Chiral GC analysis of the peracetylated aldononitrile derivative of the acid hydrolysate of 2 confirmed the d-configuration of the ribose moiety in this compound. Compound 2 and four related pyrroloquinoline metabolites, isolated previously from S. aliwaliensis, exhibited in vitro cytotoxicity against esophageal cancer cells.

  • Novel pyrroloquinoline ribosides from the South African latrunculid sponge Strongylodesma aliwaliensis
    Tetrahedron Letters, 2004
    Co-Authors: Robert A. Keyzers, Toufiek Samaai, Michael T. Davies-coleman
    Abstract:

    Two novel pyrroloquinoline ribosides, N-1-β-D-ribofuranosyldamirone C (1), and N-1-β-D-ribofuranosylmakaluvamine I (2) were isolated from a new species of South African latrunculid sponge, Strongylodesma aliwaliensis. Standard spectroscopic techniques were used to determine the structures of 1 and 2. Molecular modeling studies and NOESY data of 1 and 2, in combination with Chiral GC analysis of their derivatized acid hydrolysis products, established the β-D-configuration of the ribofuranose moieties.

Samson Abah Abagale - One of the best experts on this subject based on the ideXlab platform.

Toufiek Samaai - One of the best experts on this subject based on the ideXlab platform.

  • Makaluvic Acids from the South African Latrunculid Sponge Strongylodesma aliwaliensis
    Journal of natural products, 2005
    Co-Authors: Robert A. Keyzers, Toufiek Samaai, Catherine E. Arendse, Denver T. Hendricks, Michael T. Davies-coleman
    Abstract:

    Two new metabolites, makaluvic acid C (1) and N-1-beta-d-ribofuranosylmakaluvic acid C (2), were isolated from the recently described sponge Strongylodesma aliwaliensis collected off the east coast of South Africa. Standard spectroscopic techniques provided the structures of both compounds. Chiral GC analysis of the peracetylated aldononitrile derivative of the acid hydrolysate of 2 confirmed the d-configuration of the ribose moiety in this compound. Compound 2 and four related pyrroloquinoline metabolites, isolated previously from S. aliwaliensis, exhibited in vitro cytotoxicity against esophageal cancer cells.

  • Novel pyrroloquinoline ribosides from the South African latrunculid sponge Strongylodesma aliwaliensis
    Tetrahedron Letters, 2004
    Co-Authors: Robert A. Keyzers, Toufiek Samaai, Michael T. Davies-coleman
    Abstract:

    Two novel pyrroloquinoline ribosides, N-1-β-D-ribofuranosyldamirone C (1), and N-1-β-D-ribofuranosylmakaluvamine I (2) were isolated from a new species of South African latrunculid sponge, Strongylodesma aliwaliensis. Standard spectroscopic techniques were used to determine the structures of 1 and 2. Molecular modeling studies and NOESY data of 1 and 2, in combination with Chiral GC analysis of their derivatized acid hydrolysis products, established the β-D-configuration of the ribofuranose moieties.

Haruna Braimah - One of the best experts on this subject based on the ideXlab platform.