The Experts below are selected from a list of 58647 Experts worldwide ranked by ideXlab platform
Lihua Qiu - One of the best experts on this subject based on the ideXlab platform.
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transient axial Chirality controlled asymmetric rhodium carbene c sp2 h functionalization for the synthesis of chiral fluorenes
Nature Communications, 2020Co-Authors: Kuiyong Dong, Xing Fan, Chao Pei, Yang Zheng, Sailan Chang, Ju Cai, Lihua QiuAbstract:In catalytic asymmetric reactions, the formation of chiral molecules generally relies on a direct Chirality transfer (point or axial Chirality) from a chiral catalyst to products in the stereo-determining step. Herein, we disclose a transient-axial-Chirality transfer strategy to achieve asymmetric reaction. This method relies on transferring point Chirality from the catalyst to a dirhodium carbene intermediate with axial Chirality, namely a transient-axial-Chirality since this species is an intermediate of the reaction. The transient Chirality is then transferred to the final product by C(sp2)-H functionalization reaction with exceptionally high enantioselectivity. We also generalize this strategy for the asymmetric cascade reaction involving dual carbene/alkyne metathesis (CAM), a transition-metal-catalyzed method to access chiral 9-aryl fluorene frameworks in high yields with up to 99% ee. Detailed DFT calculations shed light on the mode of the transient-axial-Chirality transfer and the detailed mechanism of the CAM reaction. The formation of chiral molecules generally relies on direct Chirality transfer from catalyst to products. Here, the authors report a strategy based on point Chirality transfer from the catalyst to a dirhodium carbene intermediate with axial Chirality, which is then transferred to products via C(sp2)-H functionalization.
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transient axial Chirality controlled asymmetric rhodium carbene c sp 2 h functionalization for the synthesis of chiral fluorenes
Nature Communications, 2020Co-Authors: Kuiyong Dong, Xing Fan, Chao Pei, Yang Zheng, Sailan Chang, Ju Cai, Lihua QiuAbstract:In catalytic asymmetric reactions, the formation of chiral molecules generally relies on a direct Chirality transfer (point or axial Chirality) from a chiral catalyst to products in the stereo-determining step. Herein, we disclose a transient-axial-Chirality transfer strategy to achieve asymmetric reaction. This method relies on transferring point Chirality from the catalyst to a dirhodium carbene intermediate with axial Chirality, namely a transient-axial-Chirality since this species is an intermediate of the reaction. The transient Chirality is then transferred to the final product by C(sp2)-H functionalization reaction with exceptionally high enantioselectivity. We also generalize this strategy for the asymmetric cascade reaction involving dual carbene/alkyne metathesis (CAM), a transition-metal-catalyzed method to access chiral 9-aryl fluorene frameworks in high yields with up to 99% ee. Detailed DFT calculations shed light on the mode of the transient-axial-Chirality transfer and the detailed mechanism of the CAM reaction.
Kuiyong Dong - One of the best experts on this subject based on the ideXlab platform.
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transient axial Chirality controlled asymmetric rhodium carbene c sp2 h functionalization for the synthesis of chiral fluorenes
Nature Communications, 2020Co-Authors: Kuiyong Dong, Xing Fan, Chao Pei, Yang Zheng, Sailan Chang, Ju Cai, Lihua QiuAbstract:In catalytic asymmetric reactions, the formation of chiral molecules generally relies on a direct Chirality transfer (point or axial Chirality) from a chiral catalyst to products in the stereo-determining step. Herein, we disclose a transient-axial-Chirality transfer strategy to achieve asymmetric reaction. This method relies on transferring point Chirality from the catalyst to a dirhodium carbene intermediate with axial Chirality, namely a transient-axial-Chirality since this species is an intermediate of the reaction. The transient Chirality is then transferred to the final product by C(sp2)-H functionalization reaction with exceptionally high enantioselectivity. We also generalize this strategy for the asymmetric cascade reaction involving dual carbene/alkyne metathesis (CAM), a transition-metal-catalyzed method to access chiral 9-aryl fluorene frameworks in high yields with up to 99% ee. Detailed DFT calculations shed light on the mode of the transient-axial-Chirality transfer and the detailed mechanism of the CAM reaction. The formation of chiral molecules generally relies on direct Chirality transfer from catalyst to products. Here, the authors report a strategy based on point Chirality transfer from the catalyst to a dirhodium carbene intermediate with axial Chirality, which is then transferred to products via C(sp2)-H functionalization.
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transient axial Chirality controlled asymmetric rhodium carbene c sp 2 h functionalization for the synthesis of chiral fluorenes
Nature Communications, 2020Co-Authors: Kuiyong Dong, Xing Fan, Chao Pei, Yang Zheng, Sailan Chang, Ju Cai, Lihua QiuAbstract:In catalytic asymmetric reactions, the formation of chiral molecules generally relies on a direct Chirality transfer (point or axial Chirality) from a chiral catalyst to products in the stereo-determining step. Herein, we disclose a transient-axial-Chirality transfer strategy to achieve asymmetric reaction. This method relies on transferring point Chirality from the catalyst to a dirhodium carbene intermediate with axial Chirality, namely a transient-axial-Chirality since this species is an intermediate of the reaction. The transient Chirality is then transferred to the final product by C(sp2)-H functionalization reaction with exceptionally high enantioselectivity. We also generalize this strategy for the asymmetric cascade reaction involving dual carbene/alkyne metathesis (CAM), a transition-metal-catalyzed method to access chiral 9-aryl fluorene frameworks in high yields with up to 99% ee. Detailed DFT calculations shed light on the mode of the transient-axial-Chirality transfer and the detailed mechanism of the CAM reaction.
Inbal Tuvi-arad - One of the best experts on this subject based on the ideXlab platform.
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Chiral Ramachandran Plots II: General Trends and Protein Chirality Spectra
Biochemistry, 2018Co-Authors: Huan Wang, David Avnir, Inbal Tuvi-aradAbstract:The degree of Chirality of protein backbone residues is used to enrich the Ramachandran plot (RP) and create three-dimensional chiral RPs with much more structural information. Detailed comparative analysis of the four classical RPs (general, glycine, proline, and pre-proline) is provided, including statistical analysis of quantitative Chirality distributions in the maps and in the secondary structures. Our results show that points with outlier Chirality levels represent special transitional points in the folded protein such as α-helix kinks, twists of β-strands, and transition points between secondary structures. A protein Chirality spectrum in which the degree of Chirality of each residue is plotted against the sequence number explores these special points. More than 65000 residues extracted from 200 high-quality proteins are used for this study, which shows that quantitative Chirality is a general and useful structural parameter for protein conformational studies.
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Chiral Ramachandran Plots II: General Trends and Protein Chirality Spectra
2018Co-Authors: Huan Wang, David Avnir, Inbal Tuvi-aradAbstract:The degree of Chirality of protein backbone residues is used to enrich the Ramachandran plot (RP) and create three-dimensional chiral RPs with much more structural information. Detailed comparative analysis of the four classical RPs (general, glycine, proline, and pre-proline) is provided, including statistical analysis of quantitative Chirality distributions in the maps and in the secondary structures. Our results show that points with outlier Chirality levels represent special transitional points in the folded protein such as α-helix kinks, twists of β-strands, and transition points between secondary structures. A protein Chirality spectrum in which the degree of Chirality of each residue is plotted against the sequence number explores these special points. More than 65000 residues extracted from 200 high-quality proteins are used for this study, which shows that quantitative Chirality is a general and useful structural parameter for protein conformational studies
Huan Wang - One of the best experts on this subject based on the ideXlab platform.
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Chiral Ramachandran Plots II: General Trends and Protein Chirality Spectra
Biochemistry, 2018Co-Authors: Huan Wang, David Avnir, Inbal Tuvi-aradAbstract:The degree of Chirality of protein backbone residues is used to enrich the Ramachandran plot (RP) and create three-dimensional chiral RPs with much more structural information. Detailed comparative analysis of the four classical RPs (general, glycine, proline, and pre-proline) is provided, including statistical analysis of quantitative Chirality distributions in the maps and in the secondary structures. Our results show that points with outlier Chirality levels represent special transitional points in the folded protein such as α-helix kinks, twists of β-strands, and transition points between secondary structures. A protein Chirality spectrum in which the degree of Chirality of each residue is plotted against the sequence number explores these special points. More than 65000 residues extracted from 200 high-quality proteins are used for this study, which shows that quantitative Chirality is a general and useful structural parameter for protein conformational studies.
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Chiral Ramachandran Plots II: General Trends and Protein Chirality Spectra
2018Co-Authors: Huan Wang, David Avnir, Inbal Tuvi-aradAbstract:The degree of Chirality of protein backbone residues is used to enrich the Ramachandran plot (RP) and create three-dimensional chiral RPs with much more structural information. Detailed comparative analysis of the four classical RPs (general, glycine, proline, and pre-proline) is provided, including statistical analysis of quantitative Chirality distributions in the maps and in the secondary structures. Our results show that points with outlier Chirality levels represent special transitional points in the folded protein such as α-helix kinks, twists of β-strands, and transition points between secondary structures. A protein Chirality spectrum in which the degree of Chirality of each residue is plotted against the sequence number explores these special points. More than 65000 residues extracted from 200 high-quality proteins are used for this study, which shows that quantitative Chirality is a general and useful structural parameter for protein conformational studies
Chao Pei - One of the best experts on this subject based on the ideXlab platform.
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transient axial Chirality controlled asymmetric rhodium carbene c sp2 h functionalization for the synthesis of chiral fluorenes
Nature Communications, 2020Co-Authors: Kuiyong Dong, Xing Fan, Chao Pei, Yang Zheng, Sailan Chang, Ju Cai, Lihua QiuAbstract:In catalytic asymmetric reactions, the formation of chiral molecules generally relies on a direct Chirality transfer (point or axial Chirality) from a chiral catalyst to products in the stereo-determining step. Herein, we disclose a transient-axial-Chirality transfer strategy to achieve asymmetric reaction. This method relies on transferring point Chirality from the catalyst to a dirhodium carbene intermediate with axial Chirality, namely a transient-axial-Chirality since this species is an intermediate of the reaction. The transient Chirality is then transferred to the final product by C(sp2)-H functionalization reaction with exceptionally high enantioselectivity. We also generalize this strategy for the asymmetric cascade reaction involving dual carbene/alkyne metathesis (CAM), a transition-metal-catalyzed method to access chiral 9-aryl fluorene frameworks in high yields with up to 99% ee. Detailed DFT calculations shed light on the mode of the transient-axial-Chirality transfer and the detailed mechanism of the CAM reaction. The formation of chiral molecules generally relies on direct Chirality transfer from catalyst to products. Here, the authors report a strategy based on point Chirality transfer from the catalyst to a dirhodium carbene intermediate with axial Chirality, which is then transferred to products via C(sp2)-H functionalization.
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transient axial Chirality controlled asymmetric rhodium carbene c sp 2 h functionalization for the synthesis of chiral fluorenes
Nature Communications, 2020Co-Authors: Kuiyong Dong, Xing Fan, Chao Pei, Yang Zheng, Sailan Chang, Ju Cai, Lihua QiuAbstract:In catalytic asymmetric reactions, the formation of chiral molecules generally relies on a direct Chirality transfer (point or axial Chirality) from a chiral catalyst to products in the stereo-determining step. Herein, we disclose a transient-axial-Chirality transfer strategy to achieve asymmetric reaction. This method relies on transferring point Chirality from the catalyst to a dirhodium carbene intermediate with axial Chirality, namely a transient-axial-Chirality since this species is an intermediate of the reaction. The transient Chirality is then transferred to the final product by C(sp2)-H functionalization reaction with exceptionally high enantioselectivity. We also generalize this strategy for the asymmetric cascade reaction involving dual carbene/alkyne metathesis (CAM), a transition-metal-catalyzed method to access chiral 9-aryl fluorene frameworks in high yields with up to 99% ee. Detailed DFT calculations shed light on the mode of the transient-axial-Chirality transfer and the detailed mechanism of the CAM reaction.
