The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform

Hua Zuo - One of the best experts on this subject based on the ideXlab platform.

P.k. Dubey - One of the best experts on this subject based on the ideXlab platform.

  • A validated CE method for determining dimethylsulfate a carcinogen and Chloroacetyl Chloride a potential genotoxin at trace levels in drug substances.
    Journal of pharmaceutical and biomedical analysis, 2011
    Co-Authors: Muzaffar Khan, K. Jayasree, K.v.s.r. Krishna Reddy, P.k. Dubey
    Abstract:

    A simple and rapid capillary zone electrophoretic method was developed for determining dimethyl sulfate a possible human carcinogen and mutagen and Chloroacetyl Chloride a potential genotoxic agent at trace levels in pharmaceutical drug substances by indirect photometric detection. A systematic screening of various anionic probes was performed to obtain the best separation conditions and sensitivity. High sensitivities with low quantification and detection levels were achieved for dimethylsulfate and Chloroacetyl Chloride using a background electrolyte (BGE) containing 5 mM pyridine dicarboxylic acid as the probe ion. The method is specific, precise and accurate for the two genotoxins. The optimized method was validated for specificity, precision, linearity, accuracy and stability in solution. Calibration curves were linear (R>0.999) for both dimethylsulfate and Chloroacetyl Chloride in the range LOQ - 300% of nominal concentrations. The CE method was effectively implemented for estimating dimethylsulfate and Chloroacetyl Chloride in two different active pharmaceutical ingredients (APIs).

Hao Yang - One of the best experts on this subject based on the ideXlab platform.

Jerry Tso - One of the best experts on this subject based on the ideXlab platform.

  • Trace level determination of Chloroacetyl Chloride and degradation products by derivatization gas chromatography.
    Journal of pharmaceutical and biomedical analysis, 2017
    Co-Authors: Marie-france Morissette, Larry Wigman, Jerry Tso
    Abstract:

    A gas chromatographic procedure has been developed for the trace determination of Chloroacetyl Chloride (CAC) and two of its impurities: methyl chloroacetate (MCA) and chloroacetic acid (CAA). All three compounds are derivatized using piperidine in dichloroethane prior to their analysis via gas chromatography coupled with a flame ionization detection (GC-FID). Recoveries of each compound were assessed in two different pharmaceutical matrices (intermediate and final active pharmaceutical ingredient) and ranged from 75 to 125%. The limit of quantitation has been determined to be 0.10% wt/wt for CAA and 0.03% wt/wt for CAC and MCA. The linearity ranged from 0.03 to 5.00% wt/wt for CAC and MCA and from 0.10 to 5.00% wt/wt for CAA, with correlation coefficients from 0.9995 to 1.0000. Repeatability was evaluated at LOQ and at 5.00% wt/wt and was found to be between 1.4-3.0%.

Pragati Sharma - One of the best experts on this subject based on the ideXlab platform.

  • Solvent‐free cycloaddition reaction of 3‐indolylimines with Chloroacetyl Chloride under microwave irradiation
    Heteroatom Chemistry, 2003
    Co-Authors: Anshu Dandia, Ruby Singh, Pragati Sharma
    Abstract:

    Solvent-free approach is developed for the rapid synthesis of spiro[azetidine-indoles] 6a–g on basic alumina supported potassium carbonate (K2CO3–Al2O3) from the cycloaddition reaction of indolylimines 3 and Chloroacetyl Chloride 4 as synthons using microwaves. The procedure neither required toxic and hazardous base nor volatile solvents. 3 was synthesized in situ by the neat reaction of indole-2,3-diones 1 and fluorinated anilines 2 under microwave irradiation. Solvent-free aminoalkylation of spiro compounds 6a and 6b has been carried out under microwaves. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:468–473, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10180

  • solvent free cycloaddition reaction of 3 indolylimines with Chloroacetyl Chloride under microwave irradiation
    Heteroatom Chemistry, 2003
    Co-Authors: Anshu Dandia, Ruby Singh, Pragati Sharma
    Abstract:

    Solvent-free approach is developed for the rapid synthesis of spiro[azetidine-indoles] 6a–g on basic alumina supported potassium carbonate (K2CO3–Al2O3) from the cycloaddition reaction of indolylimines 3 and Chloroacetyl Chloride 4 as synthons using microwaves. The procedure neither required toxic and hazardous base nor volatile solvents. 3 was synthesized in situ by the neat reaction of indole-2,3-diones 1 and fluorinated anilines 2 under microwave irradiation. Solvent-free aminoalkylation of spiro compounds 6a and 6b has been carried out under microwaves. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:468–473, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10180