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Anny Setijo Rahaju - One of the best experts on this subject based on the ideXlab platform.

  • the effect of singawalang petiveria alliaceae leaves extract on the Blood Cholesterol Level profile of liver and Blood vessel in hypercolesterolemic rats
    Asian Journal of Medicine and Biomedicine, 2018
    Co-Authors: Arifa Mustika, Anny Setijo Rahaju
    Abstract:

    This study has been conducted to determine the effects of Singawalang ( Petiveria alliaceae ) leaves extract on Cholesterol Blood Level, profile of liver and Blood vessel in hyperCholesterolemic rats. The research is essential to attain a scientific evidence, for the use of Singawalang leaves extract, as treatment for hyperCholesterolemia. Twenty-five hyperCholesterolemic rats were randomly assigned into five different groups. Group 1 received the drug vehicle, group 2 were treated with simvastatin at a dose of 0.18mg / head / day/ orally. Whereas groups 3, 4, and 5 were treated with the Singawalang leaves extract at doses of 90 mg / kg bw; 180 mg / kg bw and 360 mg / kg bw respectively. The treatment was administered once-a-day, orally for 14 days. On the 15 th day, those rats were sacrificed for organs and Blood investigations. The results showed a decrease in Cholesterol Levels in all groups following the treatment. Differences in Cholesterol Levels before and after treatment were significant (p = 0.000; p<0.05). In addition, there were no improvement in the profile of liver and Blood vessel following the treatment. This research concluded that the extract of Singawalang leaves decreased total Cholesterol Level in hyperCholesterolemic rats. Keywords: Petiveria aliacea; hyperCholesterolemic; liver; Blood vessel

  • The effect of Singawalang (Petiveria alliaceae) leaves extract on the Blood Cholesterol Level, profile of liver and Blood vessel in Hypercolesterolemic rats
    2018
    Co-Authors: Arifa Mustika, Anny Setijo Rahaju
    Abstract:

    This study has been conducted to determine the effects of Singawalang ( Petiveria alliaceae ) leaves extract on Cholesterol Blood Level, profile of liver and Blood vessel in hyperCholesterolemic rats. The research is essential to attain a scientific evidence, for the use of Singawalang leaves extract, as treatment for hyperCholesterolemia. Twenty-five hyperCholesterolemic rats were randomly assigned into five different groups. Group 1 received the drug vehicle, group 2 were treated with simvastatin at a dose of 0.18mg / head / day/ orally. Whereas groups 3, 4, and 5 were treated with the Singawalang leaves extract at doses of 90 mg / kg bw; 180 mg / kg bw and 360 mg / kg bw respectively. The treatment was administered once-a-day, orally for 14 days. On the 15 th day, those rats were sacrificed for organs and Blood investigations. The results showed a decrease in Cholesterol Levels in all groups following the treatment. Differences in Cholesterol Levels before and after treatment were significant (p = 0.000; p

Arifa Mustika - One of the best experts on this subject based on the ideXlab platform.

  • the effect of singawalang petiveria alliaceae leaves extract on the Blood Cholesterol Level profile of liver and Blood vessel in hypercolesterolemic rats
    Asian Journal of Medicine and Biomedicine, 2018
    Co-Authors: Arifa Mustika, Anny Setijo Rahaju
    Abstract:

    This study has been conducted to determine the effects of Singawalang ( Petiveria alliaceae ) leaves extract on Cholesterol Blood Level, profile of liver and Blood vessel in hyperCholesterolemic rats. The research is essential to attain a scientific evidence, for the use of Singawalang leaves extract, as treatment for hyperCholesterolemia. Twenty-five hyperCholesterolemic rats were randomly assigned into five different groups. Group 1 received the drug vehicle, group 2 were treated with simvastatin at a dose of 0.18mg / head / day/ orally. Whereas groups 3, 4, and 5 were treated with the Singawalang leaves extract at doses of 90 mg / kg bw; 180 mg / kg bw and 360 mg / kg bw respectively. The treatment was administered once-a-day, orally for 14 days. On the 15 th day, those rats were sacrificed for organs and Blood investigations. The results showed a decrease in Cholesterol Levels in all groups following the treatment. Differences in Cholesterol Levels before and after treatment were significant (p = 0.000; p<0.05). In addition, there were no improvement in the profile of liver and Blood vessel following the treatment. This research concluded that the extract of Singawalang leaves decreased total Cholesterol Level in hyperCholesterolemic rats. Keywords: Petiveria aliacea; hyperCholesterolemic; liver; Blood vessel

  • The effect of Singawalang (Petiveria alliaceae) leaves extract on the Blood Cholesterol Level, profile of liver and Blood vessel in Hypercolesterolemic rats
    2018
    Co-Authors: Arifa Mustika, Anny Setijo Rahaju
    Abstract:

    This study has been conducted to determine the effects of Singawalang ( Petiveria alliaceae ) leaves extract on Cholesterol Blood Level, profile of liver and Blood vessel in hyperCholesterolemic rats. The research is essential to attain a scientific evidence, for the use of Singawalang leaves extract, as treatment for hyperCholesterolemia. Twenty-five hyperCholesterolemic rats were randomly assigned into five different groups. Group 1 received the drug vehicle, group 2 were treated with simvastatin at a dose of 0.18mg / head / day/ orally. Whereas groups 3, 4, and 5 were treated with the Singawalang leaves extract at doses of 90 mg / kg bw; 180 mg / kg bw and 360 mg / kg bw respectively. The treatment was administered once-a-day, orally for 14 days. On the 15 th day, those rats were sacrificed for organs and Blood investigations. The results showed a decrease in Cholesterol Levels in all groups following the treatment. Differences in Cholesterol Levels before and after treatment were significant (p = 0.000; p

F S Nadia - One of the best experts on this subject based on the ideXlab platform.

  • total Cholesterol Blood Level based on isoflavone and vitamin e intake in hyperCholesterolemia
    Journal of Nutrition and Food Sciences, 2017
    Co-Authors: S Bintanah, H S Kusuma, F Moeis, A P Purwanto, F S Nadia
    Abstract:

    HyperCholesterolemia is a condition whereby the Blood Cholesterol Level exceeds normal values. Cholesterol in food can increase Blood Cholesterol Level; fat, Cholesterol, and antioxidant intake are known to have major roles in the progress of coronary heart disease. This study seeks to determine the correlation of isoflavone and vitamin E intake from foodstuffs to total Blood Cholesterol Level in hyperCholesterolemia pationts. The research uses descriptive analytic methods. Isoflavone and vitamin E intake is recorded for 24 respondents through food recall and food frequency questionnaires. Total Blood Cholesterol Levels for these respondents are then obtained from the medical records of Roemani Muhammadiyah Hospital Semarang. This study uses the Rank-Spearman test. The results are that 66.7% of respondents are male, 37.5% are 45-50 years old, 70.8% have ≥ 80 mg intake of isoflavones, but all respondents have <15 mg intake of vitamin E. There is a significant correlation between isoflavone/vitamin E intake and total Blood Cholesterol Level (p-value=0.000, p-value=0.008). Thus, isoflavones and vitamin E intake may affect total Blood Cholesterol Levels.

Moeis F - One of the best experts on this subject based on the ideXlab platform.

  • Total Cholesterol Blood Level Based on Isoflavone and Vitamin E Intake in HyperCholesterolemia
    Journal of Nutrition & Food Sciences, 2017
    Co-Authors: Bintanah S, H S Kusuma, Moeis F
    Abstract:

    HyperCholesterolemia is a condition whereby the Blood Cholesterol Level exceeds normal values. Cholesterol in food can increase Blood Cholesterol Level; fat, Cholesterol, and antioxidant intake are known to have major roles in the progress of coronary heart disease. This study seeks to determine the correlation of isoflavone and vitamin E intake from foodstuffs to total Blood Cholesterol Level in hyperCholesterolemia pationts. The research uses descriptive analytic methods. Isoflavone and vitamin E intake is recorded for 24 respondents through food recall and food frequency questionnaires. Total Blood Cholesterol Levels for these respondents are then obtained from the medical records of Roemani Muhammadiyah Hospital Semarang. This study uses the Rank-Spearman test. The results are that 66.7% of respondents are male, 37.5% are 45-50 years old, 70.8% have ≥ 80 mg intake of isoflavones, but all respondents have

Nanang Wiyono - One of the best experts on this subject based on the ideXlab platform.

  • The Influence of Brotowali Extract (Tinospora crispa (L.) Miers.)onCholesterol Blood Level of Rattus norvegicus with High Cholesterol Intake
    2017
    Co-Authors: Dicky Maulana Lazuardi, Ida Nurwati, Nanang Wiyono
    Abstract:

    Introduction : Coronary Heart Disease is the disease that often suffered by Indonesian people which known with high Cholesterol rate.Brotowali’s stem contains saponin, flavonoid and polifenol, which potential to inhibit Blood  total Cholesterolincrease. The r esearch is for to know more the influence of the content of the brotowali’s stem extract against total Blood Cholesterol Levels. Method: This  research is as experimental laboratoric research with Randomized Controlled Trial design that post-test only control group design, have done in Histology Laboratorium of the Sebelas Maret University, Surakarta. The subject are 32 male white rats, Wistar strain, aged 2 months, weighing more or less than 200 grams. Brotowali’s stem extract made by using maceration method in Biological Pharmacy Laboratory, Pharmacy Faculty, Gadjah Mada University. The rat were divided randomly into 4 groups, each group consisting of 8 rats. In the negative control group was only given regular feed, propiltiourasil (PTU) and distilled water, the positive control group was given 5 gram duck egg yolk per 4,5 ml of aquadest , regular feed, PTU and distilled water. Whereas in the treatment group I and II was given 5 gram/4,5 ml of duck egg yolk suspense, regular feed, PTU, water and given 50 mg/200 gr and 100 mg/200gr extract of the brotowali’s stem. Rats were fasted during 12 hours and then their Blood Cholesterol Levels checked after the 21 days treatment period. The sample measured with TMS 24i Premium spectrophotometer with 600 nm wave. The data were analyzed by one-way ANOVA with SPSS for Windows version 22. Result : Total Cholesterol Levels of negative control group is 91,00±19,46 mg/dl,on the positive control group is 104,12±13,66 mg/dl,on treatment group I is 91,50±16,08 mg/dl and on treatment group 2 is 84,62±13,45 mg/dl.The result of  one-way ANOVA test showed there is no significant total Cholesterol Blood Level difference between 4 groups of rats with p=0,120. Conclusion : Brotowali’s stem extract has not give an effect on total Cholesterol Blood Levels of Rattus norvegicus with high Cholesterol intake . Keywords : Brotowali’s stem extract, total Cholesterol, Rattus norvergicus