The Experts below are selected from a list of 10677 Experts worldwide ranked by ideXlab platform
Christian J Gillin - One of the best experts on this subject based on the ideXlab platform.
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pilocarpine an orally active muscarinic Cholinergic Agonist induces rem sleep and reduces delta sleep in normal volunteers
Psychiatry Research-neuroimaging, 1990Co-Authors: Alan Berkowitz, Laura Sutton, David S Janowsky, Christian J GillinAbstract:The effect of oral pilocarpine, a direct-acting muscarinic, Cholinergic Agonist, on polygraphic sleep parameters was studied in 13 healthy male volunteers. Subjects received placebo and oral pilocarpine (25 mg) in a double-blind, counterbalanced, crossover design. Pilocarpine shortened the latency of rapid eye movement (REM) sleep and increased total REM time, REM%, and the duration of the first REM period. In addition, it reduced Stage 4 sleep and Delta sleep. Pulse rate was not significantly changed during the first hour of darkness after administration of pilocarpine. Subjective sleep experience and the subjects' condition in the morning were not altered. These results suggest that pilocarpine has central effects (i.e., induction of REM sleep) that are similar to those of other centrally acting muscarinic cholinomimetic agents.
Laura Sutton - One of the best experts on this subject based on the ideXlab platform.
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pilocarpine an orally active muscarinic Cholinergic Agonist induces rem sleep and reduces delta sleep in normal volunteers
Psychiatry Research-neuroimaging, 1990Co-Authors: Alan Berkowitz, Laura Sutton, David S Janowsky, Christian J GillinAbstract:The effect of oral pilocarpine, a direct-acting muscarinic, Cholinergic Agonist, on polygraphic sleep parameters was studied in 13 healthy male volunteers. Subjects received placebo and oral pilocarpine (25 mg) in a double-blind, counterbalanced, crossover design. Pilocarpine shortened the latency of rapid eye movement (REM) sleep and increased total REM time, REM%, and the duration of the first REM period. In addition, it reduced Stage 4 sleep and Delta sleep. Pulse rate was not significantly changed during the first hour of darkness after administration of pilocarpine. Subjective sleep experience and the subjects' condition in the morning were not altered. These results suggest that pilocarpine has central effects (i.e., induction of REM sleep) that are similar to those of other centrally acting muscarinic cholinomimetic agents.
David S Janowsky - One of the best experts on this subject based on the ideXlab platform.
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pilocarpine an orally active muscarinic Cholinergic Agonist induces rem sleep and reduces delta sleep in normal volunteers
Psychiatry Research-neuroimaging, 1990Co-Authors: Alan Berkowitz, Laura Sutton, David S Janowsky, Christian J GillinAbstract:The effect of oral pilocarpine, a direct-acting muscarinic, Cholinergic Agonist, on polygraphic sleep parameters was studied in 13 healthy male volunteers. Subjects received placebo and oral pilocarpine (25 mg) in a double-blind, counterbalanced, crossover design. Pilocarpine shortened the latency of rapid eye movement (REM) sleep and increased total REM time, REM%, and the duration of the first REM period. In addition, it reduced Stage 4 sleep and Delta sleep. Pulse rate was not significantly changed during the first hour of darkness after administration of pilocarpine. Subjective sleep experience and the subjects' condition in the morning were not altered. These results suggest that pilocarpine has central effects (i.e., induction of REM sleep) that are similar to those of other centrally acting muscarinic cholinomimetic agents.
Marisela Morales - One of the best experts on this subject based on the ideXlab platform.
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rewarding injections of the Cholinergic Agonist carbachol into the ventral tegmental area induce locomotion and c fos expression in the retrosplenial area and supramammillary nucleus
Brain Research, 2003Co-Authors: Satoshi Ikemoto, Brian M Witkin, Marisela MoralesAbstract:Previously we found that intra-ventral tegmental injections of the Cholinergic Agonist carbachol induce reward; such injections induce conditioned place preference and rats learn quickly to self-administer carbachol directly into the ventral tegmental area (VTA). To determine what brain regions are activated by such rewarding injections we studied the expression of the transcription factor c-Fos in local and distant brain regions following ventral tegmental injections of carbachol in rats. We also measured locomotion induced by such injections. Carbachol injections into the VTA induced vigorous locomotion while carbachol injections into the regions 1 mm dorsal or 1 mm lateral to the VTA induced delayed attenuated locomotion. Ventral tegmental injections of carbachol induced c-Fos expression throughout the brain. Significant correlations between locomotion c-Fos positive nuclei were found in the retrosplenial area the posterior hypothalamus including the supramammillary nucleus. These results suggest that the retrosplenial area supramammillary nucleus may be parts of the circuitry for the reward triggered by ventral tegmental Cholinergic stimulation.
Alan Berkowitz - One of the best experts on this subject based on the ideXlab platform.
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pilocarpine an orally active muscarinic Cholinergic Agonist induces rem sleep and reduces delta sleep in normal volunteers
Psychiatry Research-neuroimaging, 1990Co-Authors: Alan Berkowitz, Laura Sutton, David S Janowsky, Christian J GillinAbstract:The effect of oral pilocarpine, a direct-acting muscarinic, Cholinergic Agonist, on polygraphic sleep parameters was studied in 13 healthy male volunteers. Subjects received placebo and oral pilocarpine (25 mg) in a double-blind, counterbalanced, crossover design. Pilocarpine shortened the latency of rapid eye movement (REM) sleep and increased total REM time, REM%, and the duration of the first REM period. In addition, it reduced Stage 4 sleep and Delta sleep. Pulse rate was not significantly changed during the first hour of darkness after administration of pilocarpine. Subjective sleep experience and the subjects' condition in the morning were not altered. These results suggest that pilocarpine has central effects (i.e., induction of REM sleep) that are similar to those of other centrally acting muscarinic cholinomimetic agents.