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Elegast Monbaliu - One of the best experts on this subject based on the ideXlab platform.
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Dystonia and Choreoathetosis presence and severity in relation to powered wheelchair mobility performance in children and youth with dyskinetic cerebral palsy.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2020Co-Authors: Saranda Bekteshi, Marco J. Konings, Ioana Gabriela Nica, Sotirios Gakopoulos, Jean-marie Aerts, Hans Hallez, Elegast MonbaliuAbstract:Abstract Introduction Power wheelchairs (PW) with head/foot steering systems are used as an alternative to joysticks in children with severe dyskinetic cerebral palsy (DCP). Mobility training programs are unstandardized to date, and insight on dystonia, Choreoathetosis, and mobility performance may lead to greater independent mobility. Objective To map the presence and severity of dystonia and Choreoathetosis during PW mobility in DCP and their relation with mobility performance. Methods Ten participants with DCP performed four PW mobility tasks using a head/foot steering system. Dystonia and Choreoathetosis in the neck and arm regions were evaluated using the Dyskinesia Impairment Mobility Scale (DIMS). PW mobility performance was assessed using time-on-task and the number of errors during performance. The Wilcoxon-signed rank test and the Spearman's correlation coefficients were used to explore differences and correlations. Results Median levels of dystonia (83.6%) were significantly higher (p Conclusions Dystonia is more present and severe during PW mobility than Choreoathetosis. The hypertonic hallmark of dystonia may mask the hyperkinetic hallmark of Choreoathetosis, resulting in lower median levels. Results may suggest that with an increase in driving experience, children with DCP adopt deliberate strategies to minimize the negative impact of arm overflow movements on mobility performance, however, future research with bigger sample size and additional outcome measures is strongly encouraged.
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eye gaze gaming intervention in children with dyskinetic cerebral palsy a pilot study of task performance and its relation with dystonia and Choreoathetosis
Developmental Neurorehabilitation, 2020Co-Authors: Saranda Bekteshi, Inti Vanmechelen, Jan Deklerck, Els Ortibus, Bernard Dan, Marco J. Konings, Jean-marie Aerts, Hans Hallez, Petra Karlsson, Elegast MonbaliuAbstract:To investigate the operational competences screen navigation and dwell function underlying eye gaze performance, and the relation of dystonia and Choreoathetosis with eye gaze performance in childr...
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presence and severity of dystonia and Choreoathetosis overflow movements in participants with dyskinetic cerebral palsy and their relation with functional classification scales
Disability and Rehabilitation, 2020Co-Authors: Inti Vanmechelen, Saranda Bekteshi, Kyra Bossier, Hilde Feys, Jan Deklerck, Elegast MonbaliuAbstract:Background: This cross-sectional study aims to investigate the presence and severity of overflow movements of dystonia and Choreoathetosis in dyskinetic cerebral palsy (CP) and to assess the relati...
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Test-retest reliability of the Dyskinesia Impairment Scale: measuring dystonia and Choreoathetosis in dyskinetic cerebral palsy.
Developmental medicine and child neurology, 2019Co-Authors: Inti Vanmechelen, Hilde Feys, Bernard Dan, Elegast MonbaliuAbstract:Aim To assess test-retest reliability of the Dyskinesia Impairment Scale (DIS) in children and young adults with dyskinetic cerebral palsy (CP). Method Dystonia and Choreoathetosis were assessed in 15 participants with dyskinetic CP (13 males, 2 females; age range 5-22y, mean 14y, SD 4y) using the DIS in two separate sessions over 7 days. Exclusion criteria were changes in muscle relaxant medication within the previous 3 months, orthopaedic or neurosurgical interventions within the previous year, and spinal fusion. Intraclass correlation coefficient, confidence intervals (CI), standard error of measurement, and the minimal detectable difference (MDD) were determined for test-retest reliability. Result Intraclass correlation coefficients of the DIS, the dystonia subscale of the DIS, and the Choreoathetosis subscale of the DIS were 0.98 (95% CI 0.94-0.99), 0.97 (95% CI 0.92-0.99), and 0.96 (95% CI 0.90-0.99). The standard error of measurement and MDD were 2.6% and 7.2%. Interpretation The DIS is a reliable tool to assess dystonia and Choreoathetosis; it remains stable over time in children and young adults with dyskinetic CP. These results add to the current evidence for good clinimetric properties of the DIS. What this paper adds The Dyskinesia Impairment Scale (DIS) shows stability in scoring dystonia and Choreoathetosis. The total DIS score and dystonia and Choreoathetosis subscales are clinically useful.
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Presence and severity of dystonia and Choreoathetosis overflow movements in participants with dyskinetic cerebral palsy and their relation with functional classification scales
2019Co-Authors: Inti Vanmechelen, Saranda Bekteshi, Kyra Bossier, Hilde Feys, Jan Deklerck, Elegast MonbaliuAbstract:Background: This cross-sectional study aims to investigate the presence and severity of overflow movements of dystonia and Choreoathetosis in dyskinetic cerebral palsy (CP) and to assess the relationship of overflow movements with functional classification scales. Methods: Fifty-two subjects with dyskinetic CP were included. Presence and severity of dystonia and Choreoathetosis overflow movements were assessed with the Dyskinesia Impairment Scale. Functional abilities were classified with the Gross Motor Function Classification System, Manual Ability Classification System, Viking Speech Scale, Communication Function Classification System, and Eating and Drinking Ability Classification System. Results: Dystonia and Choreoathetosis overflow movements were simultaneously present. Median scores of dystonia overflow movements were significantly higher than Choreoathetosis overflow movements. Dystonia and Choreoathetosis overflow movements were significantly higher in extremities than in the central body. Correlations between dystonia and Choreoathetosis overflow movements were fair. Moderate to good correlations were found between dystonia overflow score and Gross Motor Function Classification System, Manual Ability Classification System, and Eating and Drinking Ability Classification System. Conclusions: This is the first study to assess overflow movements in dyskinetic CP. All participants presented with dystonia and Choreoathetosis overflow movements, with higher values for dystonia overflow movements. Dystonia overflow movements seem to have a larger impact on functional abilities.Implications for rehabilitationDystonia and Choreoathetosis overflow movements are both present in children with dyskinetic cerebral palsy, with dystonia overflow movements being more severe than Choreoathetosis overflow movements.Overflow movements impact heavily on daily functional ability and the execution of voluntary activities.Dystonia overflow movements show good correlations with functional classification scales.The measurable characteristics of overflow movements can be used as a guideline for targeted treatment with, e.g., botulinum-toxin-A injections. Dystonia and Choreoathetosis overflow movements are both present in children with dyskinetic cerebral palsy, with dystonia overflow movements being more severe than Choreoathetosis overflow movements. Overflow movements impact heavily on daily functional ability and the execution of voluntary activities. Dystonia overflow movements show good correlations with functional classification scales. The measurable characteristics of overflow movements can be used as a guideline for targeted treatment with, e.g., botulinum-toxin-A injections.
Monbaliu Elegast - One of the best experts on this subject based on the ideXlab platform.
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Dystonia and Choreoathetosis presence and severity in relation to powered wheelchair mobility performance in children and youth with dyskinetic cerebral palsy
'Elsevier BV', 2020Co-Authors: Bekteshi Saranda, Konings Marco, Nica, Ioana Gabriela, Gakopoulos Sotirios, Aerts Jean-marie, Hallez Hans, Monbaliu ElegastAbstract:Introduction: Power wheelchairs (PW) with head/foot steering systems are used as an alternative to joysticks in children with severe dyskinetic cerebral palsy (DCP). Mobility training programs are unstandardized to date, and insight on dystonia, Choreoathetosis, and mobility performance may lead to greater independent mobility. Objective: To map the presence and severity of dystonia and Choreoathetosis during PW mobility in DCP and their relation with mobility performance. Methods: Ten participants with DCP performed four PW mobility tasks using a head/foot steering system. Dystonia and Choreoathetosis in the neck and arm regions were evaluated using the Dyskinesia Impairment Mobility Scale (DIMS). PW mobility performance was assessed using time-on-task and the number of errors during performance. The Wilcoxon-signed rank test and the Spearman's correlation coefficients were used to explore differences and correlations. Results: Median levels of dystonia (83.6%) were significantly higher (p < 0.01) than median levels of Choreoathetosis (34.4%). Positive significant correlations were found between the Arm Proximal DIMS and the PW mobility experience (rs¼-0.92, p < 0.001), and between the Arm Distal DIMS and the number of errors (rs ¼ 0.66, p ¼ 0.039) during mobility performance. Conclusions: Dystonia is more present and severe during PW mobility than Choreoathetosis. The hypertonic hallmark of dystonia may mask the hyperkinetic hallmark of Choreoathetosis, resulting in lower median levels. Results may suggest that with an increase in driving experience, children with DCP adopt deliberate strategies to minimize the negative impact of arm overflow movements on mobility performance, however, future research with bigger sample size and additional outcome measures is strongly encouraged.status: accepte
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Reliability and Validity of the Dyskinesia Impairment Scale in Children and Young Adults with Inherited or Idiopathic Dystonia
'MDPI AG', 2020Co-Authors: Danielsson Annika, Vanmechelen Inti, Monbaliu Elegast, Lidbeck Cecilia, Krumlinde-sundholm Lena, Ortibus Els, Tedroff KristinaAbstract:Background: The Dyskinesia Impairment Scale (DIS) is a new assessment scale for dystonia and Choreoathetosis in children and youth with dyskinetic cerebral palsy. Today, the Burke–Fahn–Marsden Dystonia Rating Scale (BFM) is mostly used to assess dystonia in children with inherited dystonia. The aim of this study was to assess reliability and validity of the DIS in children and youth with inherited or idiopathic dystonia. Methods: Reliability was measured by (1) the intraclass correlation coefficients (ICCs) for inter-rater and test-retest reliability, as well as (2) standard error of measurement (SEM) and minimal detectable difference (MDD). For concurrent validity of the DIS-dystonia subscale, the BFM was administered. Results: In total, 11 males and 9 females (median age 16 years and 7 months, range 6 to 24 years) were included. For inter-rater reliability, the ICCs for the DIS total score and the dystonia and Choreoathetosis subscale scores were 0.83, 0.87, and 0.71, respectively. For test-retest reliability, the ICCs for the DIS total score and the dystonia and Choreoathetosis subscale scores were 0.95, 0.88, and 0.93, respectively. The SEM and MDD for the total DIS were 3.98% and 11.04%, respectively. The Spearman correlation coefficient between the dystonia subscale and the BFM was 0.88 (p < 0.01). Conclusions: Good to excellent inter-rater, test-retest reliability, and validity were found for the total DIS and the dystonia subscale. The Choreoathetosis subscale showed moderate inter-rater reliability and excellent test-retest reliability. The DIS may be a promising tool to assess dystonia and Choreoathetosis in children and young adults with inherited or idiopathic dystonia.status: Published onlin
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Presence and severity of dystonia and Choreoathetosis overflow movements in participants with dyskinetic cerebral palsy and their relation with functional classification scales
'Informa UK Limited', 2020Co-Authors: Vanmechelen Inti, Bekteshi Saranda, Bossier Kyra, Feys Hilde, Deklerck Jan, Monbaliu ElegastAbstract:Background: This cross-sectional study aims to investigate the presence and severity of overflow movements of dystonia and Choreoathetosis in dyskinetic cerebral palsy (CP) and to assess the relationship of overflow movements with functional classification scales. Methods: Fifty-two subjects with dyskinetic CP were included. Presence and severity of dystonia and Choreoathetosis overflow movements were assessed with the Dyskinesia Impairment Scale. Functional abilities were classified with the Gross Motor Function Classification System, Manual Ability Classification System, Viking Speech Scale, Communication Function Classification System, and Eating and Drinking Ability Classification System. Results: Dystonia and Choreoathetosis overflow movements were simultaneously present. Median scores of dystonia overflow movements were significantly higher than Choreoathetosis overflow movements. Dystonia and Choreoathetosis overflow movements were significantly higher in extremities than in the central body. Correlations between dystonia and Choreoathetosis overflow movements were fair. Moderate to good correlations were found between dystonia overflow score and Gross Motor Function Classification System, Manual Ability Classification System, and Eating and Drinking Ability Classification System. Conclusions: This is the first study to assess overflow movements in dyskinetic CP. All participants presented with dystonia and Choreoathetosis overflow movements, with higher values for dystonia overflow movements. Dystonia overflow movements seem to have a larger impact on functional abilities.status: Published onlin
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Dystonia and Choreoathetosis presence and severity in relation to powered wheelchair mobility performance in children and youth with dyskinetic cerebral palsy
'Elsevier BV', 2020Co-Authors: Bekteshi Saranda, Konings Marco, Nica, Ioana Gabriela, Gakopoulos Sotirios, Aerts Jean-marie, Hallez Hans, Monbaliu ElegastAbstract:Introduction: Power wheelchairs (PW) with head/foot steering systems are used as an alternative to joysticks in children with severe dyskinetic cerebral palsy (DCP). Mobility training programs are unstandardized to date, and insight on dystonia, Choreoathetosis, and mobility performance may lead to greater independent mobility. Objective: To map the presence and severity of dystonia and Choreoathetosis during PW mobility in DCP and their relation with mobility performance. Methods: Ten participants with DCP performed four PW mobility tasks using a head/foot steering system. Dystonia and Choreoathetosis in the neck and arm regions were evaluated using the Dyskinesia Impairment Mobility Scale (DIMS). PW mobility performance was assessed using time-on-task and the number of errors during performance. The Wilcoxon-signed rank test and the Spearman's correlation coefficients were used to explore differences and correlations. Results: Median levels of dystonia (83.6%) were significantly higher (p < 0.01) than median levels of Choreoathetosis (34.4%). Positive significant correlations were found between the Arm Proximal DIMS and the PW mobility experience (rs¼-0.92, p < 0.001), and between the Arm Distal DIMS and the number of errors (rs ¼ 0.66, p ¼ 0.039) during mobility performance. Conclusions: Dystonia is more present and severe during PW mobility than Choreoathetosis. The hypertonic hallmark of dystonia may mask the hyperkinetic hallmark of Choreoathetosis, resulting in lower median levels. Results may suggest that with an increase in driving experience, children with DCP adopt deliberate strategies to minimize the negative impact of arm overflow movements on mobility performance, however, future research with bigger sample size and additional outcome measures is strongly encouraged.status: publishe
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Test–retest reliability of the Dyskinesia Impairment Scale: dystonia and Choreoathetosis can be reliably measured over time in dyskinetic cerebral palsy
'Wiley', 2019Co-Authors: Vanmechelen Inti, Feys Hilde, Dan Bernard, Monbaliu ElegastAbstract:Aim The aim of this study was to assess test-retest reliability of the Dyskinesia Impairment Scale (DIS) in children and young adults with dyskinetic cerebral palsy. Method Dystonia and Choreoathetosis was assessed in 15 participants with dyskinetic cerebral palsy (13 males; 5-22y, mean 14y, SD 5y) using the Dyskinesia Impairment Scale in two separate sessions over seven days. Exclusion criteria were changes in muscle relaxant medication within the previous 3 months, orthopaedic or neurosurgical interventions within the previous year, and spinal fusion. Intra-class correlation coefficient (ICC), confidence intervals (CI), standard error of measurement, and the minimal detectable difference were determined for test-retest reliability. Result ICCs of the DIS, the dystonia subscale and the Choreoathetosis subscale of the DIS were 0.98 (95% CI=0.94-0.99), 0.97 (95% CI=0.92-0.99) and 0.96 (95% CI=0.90-0.99). The standard error of measurement and minimal detectable difference were 2.6% and 7.2%. Interpretation The DIS is a reliable tool to assess dystonia and Choreoathetosis; it remains stable over time in children and young adults with dyskinetic cerebral palsy. These results add to the current evidence for good clinimetric properties of the DIS.status: publishe
Georg Auburger - One of the best experts on this subject based on the ideXlab platform.
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Gene locus FPD1 of the dystonic Mount-Reback type of autosomal-dominant paroxysmal Choreoathetosis
Neurology, 1997Co-Authors: K. Hofele, R. Benecke, Georg AuburgerAbstract:Genes for paroxysmal Choreoathetosis have been localized to chromosomes 1p and 2q. We have reinvestigated one of the classic large autosomal-dominant pedigrees of the dystonic Mount-Reback type of paroxysmal Choreoathetosis 20 years after its first assessment. These patients prefer diazepam for both prevention and treatment of attacks and did not develop addiction on an intermittent regime. Migraine occurred in a third of the patients. Genetic data localized the underlying mutation to the FPD1 locus (familial paroxysmal dyskinesia type 1) on chromosome 2q and support locus homogeneity for the Mount-Reback syndrome. The data also refine the FPD1 candidate region to 3.6 cM between the markers D2S164 and D2S2359, which may facilitate the investigation of the role of the candidate ion channel gene SLC2C.
Hilde Feys - One of the best experts on this subject based on the ideXlab platform.
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presence and severity of dystonia and Choreoathetosis overflow movements in participants with dyskinetic cerebral palsy and their relation with functional classification scales
Disability and Rehabilitation, 2020Co-Authors: Inti Vanmechelen, Saranda Bekteshi, Kyra Bossier, Hilde Feys, Jan Deklerck, Elegast MonbaliuAbstract:Background: This cross-sectional study aims to investigate the presence and severity of overflow movements of dystonia and Choreoathetosis in dyskinetic cerebral palsy (CP) and to assess the relati...
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Test-retest reliability of the Dyskinesia Impairment Scale: measuring dystonia and Choreoathetosis in dyskinetic cerebral palsy.
Developmental medicine and child neurology, 2019Co-Authors: Inti Vanmechelen, Hilde Feys, Bernard Dan, Elegast MonbaliuAbstract:Aim To assess test-retest reliability of the Dyskinesia Impairment Scale (DIS) in children and young adults with dyskinetic cerebral palsy (CP). Method Dystonia and Choreoathetosis were assessed in 15 participants with dyskinetic CP (13 males, 2 females; age range 5-22y, mean 14y, SD 4y) using the DIS in two separate sessions over 7 days. Exclusion criteria were changes in muscle relaxant medication within the previous 3 months, orthopaedic or neurosurgical interventions within the previous year, and spinal fusion. Intraclass correlation coefficient, confidence intervals (CI), standard error of measurement, and the minimal detectable difference (MDD) were determined for test-retest reliability. Result Intraclass correlation coefficients of the DIS, the dystonia subscale of the DIS, and the Choreoathetosis subscale of the DIS were 0.98 (95% CI 0.94-0.99), 0.97 (95% CI 0.92-0.99), and 0.96 (95% CI 0.90-0.99). The standard error of measurement and MDD were 2.6% and 7.2%. Interpretation The DIS is a reliable tool to assess dystonia and Choreoathetosis; it remains stable over time in children and young adults with dyskinetic CP. These results add to the current evidence for good clinimetric properties of the DIS. What this paper adds The Dyskinesia Impairment Scale (DIS) shows stability in scoring dystonia and Choreoathetosis. The total DIS score and dystonia and Choreoathetosis subscales are clinically useful.
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Presence and severity of dystonia and Choreoathetosis overflow movements in participants with dyskinetic cerebral palsy and their relation with functional classification scales
2019Co-Authors: Inti Vanmechelen, Saranda Bekteshi, Kyra Bossier, Hilde Feys, Jan Deklerck, Elegast MonbaliuAbstract:Background: This cross-sectional study aims to investigate the presence and severity of overflow movements of dystonia and Choreoathetosis in dyskinetic cerebral palsy (CP) and to assess the relationship of overflow movements with functional classification scales. Methods: Fifty-two subjects with dyskinetic CP were included. Presence and severity of dystonia and Choreoathetosis overflow movements were assessed with the Dyskinesia Impairment Scale. Functional abilities were classified with the Gross Motor Function Classification System, Manual Ability Classification System, Viking Speech Scale, Communication Function Classification System, and Eating and Drinking Ability Classification System. Results: Dystonia and Choreoathetosis overflow movements were simultaneously present. Median scores of dystonia overflow movements were significantly higher than Choreoathetosis overflow movements. Dystonia and Choreoathetosis overflow movements were significantly higher in extremities than in the central body. Correlations between dystonia and Choreoathetosis overflow movements were fair. Moderate to good correlations were found between dystonia overflow score and Gross Motor Function Classification System, Manual Ability Classification System, and Eating and Drinking Ability Classification System. Conclusions: This is the first study to assess overflow movements in dyskinetic CP. All participants presented with dystonia and Choreoathetosis overflow movements, with higher values for dystonia overflow movements. Dystonia overflow movements seem to have a larger impact on functional abilities.Implications for rehabilitationDystonia and Choreoathetosis overflow movements are both present in children with dyskinetic cerebral palsy, with dystonia overflow movements being more severe than Choreoathetosis overflow movements.Overflow movements impact heavily on daily functional ability and the execution of voluntary activities.Dystonia overflow movements show good correlations with functional classification scales.The measurable characteristics of overflow movements can be used as a guideline for targeted treatment with, e.g., botulinum-toxin-A injections. Dystonia and Choreoathetosis overflow movements are both present in children with dyskinetic cerebral palsy, with dystonia overflow movements being more severe than Choreoathetosis overflow movements. Overflow movements impact heavily on daily functional ability and the execution of voluntary activities. Dystonia overflow movements show good correlations with functional classification scales. The measurable characteristics of overflow movements can be used as a guideline for targeted treatment with, e.g., botulinum-toxin-A injections.
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The relationship of dystonia and Choreoathetosis with activity, participation and quality of life in children and youth with dyskinetic cerebral palsy
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2016Co-Authors: Elegast Monbaliu, Paul De Cock, Lisa Mailleux, Bernard Dan, Hilde FeysAbstract:Abstract Aim To relate dystonia and Choreoathetosis with activity, participation and quality of life (QOL) in children and youth with dyskinetic Cerebral Palsy (CP). Methods Fifty-four participants with dyskinetic CP (mean age 14y6m, SD 4y2m, range 6–22y) were included. The Dyskinesia Impairment Scale (DIS) was used to evaluate dystonia and Choreoathetosis. Activity, participation and quality of life (QOL) were assessed with the Gross Motor Function Measure (GMFM), the Functional Mobility Scale (FMS), the Jebsen-Taylor Hand Function Test (JTT), the ABILHAND-Kids Questionnaire (ABIL-K), the Life Habits Kids (LIFE-H) and the Quality of Life Questionnaire for children with CP (CP-QOL). Spearman's rank correlation coefficient ( r s ) was used to assess the relationship between the movement disorders and activity, participation and QOL measures. Results Significant negative correlations were found between dystonia and the activity scales with Spearman's rank correlation coefficient ( r s ) varying between −0.65 (95% CI = −0.78 to −0.46) and −0.71 (95% CI = −0,82 to −0.55). Correlations were also found with the LIFE-H ( r s = −0.43; 95%CI = −0.64 to −0.17) and the CP-QOL ( r s = −0.32; 95%CI = −0.56 to −0.03). As far as Choreoathetosis is concerned, no or only weak relationships were found with the activity, participation and quality of life scales. Interpretation This cross-sectional study is the first to examine the relationship of dystonia and Choreoathetosis in dyskinetic CP with the level of activity, participation and QOL. The results revealed dystonia has a higher impact on activity, participation and quality of life than Choreoathetosis. These findings seem to suggest it is necessary to first focus on dystonia reducing intervention strategies and secondly on Choreoathetosis.
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clinical patterns of dystonia and Choreoathetosis in participants with dyskinetic cerebral palsy
Developmental Medicine & Child Neurology, 2016Co-Authors: Elegast Monbaliu, Paul De Cock, Els Ortibus, Lieve Heyrman, Katrijn Klingels, Hilde FeysAbstract:Aim The aim of the study was to map clinical patterns of dystonia and Choreoathetosis and to assess the relation between functional classifications and basal ganglia and thalamus lesions in participants with dyskinetic cerebral palsy (CP). Methods In this cross-sectional study, 55 participants with dyskinetic CP (mean age 14y 6mo, SD 4y 1mo; range 6–22y) were assessed with the Dyskinesia Impairment Scale and classified with the Gross Motor Function Classification System (GMFCS), Manual Ability Classification System (MACS), and Communication Function Classification System (CFCS). Results Dystonia and Choreoathetosis are simultaneously present. Median levels of dystonia (70.2%) were significantly higher than levels of Choreoathetosis (26.7%) and both were significantly higher during activity than at rest (both p<0.01). High correlations were found between dystonia levels and GMFCS level (Spearman's rank correlation coefficient, rS=0.70; 95% confidence interval [CI] 0.53–0.81; p<0.01) and MACS (rS=0.65; 95% CI 0.47–0.81; p<0.01), and fair correlation with CFCS (rs=0.36; 95% CI=0.11–0.57; p<0.05). No significant correlation was found between Choreoathetosis levels and motor classifications. Finally, higher Choreoathetosis levels were found in participants with pure thalamus and basal ganglia lesions (p=0.03) than mixed lesions, but not for dystonia (p=0.41). Interpretation Dystonia and Choreoathetosis increase during activity. However, dystonia predominates and seems to have a larger impact on functional abilities. Our findings further suggest that Choreoathetosis seems to be more linked to pure thalamus and basal ganglia lesions than dystonia.
Inti Vanmechelen - One of the best experts on this subject based on the ideXlab platform.
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eye gaze gaming intervention in children with dyskinetic cerebral palsy a pilot study of task performance and its relation with dystonia and Choreoathetosis
Developmental Neurorehabilitation, 2020Co-Authors: Saranda Bekteshi, Inti Vanmechelen, Jan Deklerck, Els Ortibus, Bernard Dan, Marco J. Konings, Jean-marie Aerts, Hans Hallez, Petra Karlsson, Elegast MonbaliuAbstract:To investigate the operational competences screen navigation and dwell function underlying eye gaze performance, and the relation of dystonia and Choreoathetosis with eye gaze performance in childr...
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presence and severity of dystonia and Choreoathetosis overflow movements in participants with dyskinetic cerebral palsy and their relation with functional classification scales
Disability and Rehabilitation, 2020Co-Authors: Inti Vanmechelen, Saranda Bekteshi, Kyra Bossier, Hilde Feys, Jan Deklerck, Elegast MonbaliuAbstract:Background: This cross-sectional study aims to investigate the presence and severity of overflow movements of dystonia and Choreoathetosis in dyskinetic cerebral palsy (CP) and to assess the relati...
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Test-retest reliability of the Dyskinesia Impairment Scale: measuring dystonia and Choreoathetosis in dyskinetic cerebral palsy.
Developmental medicine and child neurology, 2019Co-Authors: Inti Vanmechelen, Hilde Feys, Bernard Dan, Elegast MonbaliuAbstract:Aim To assess test-retest reliability of the Dyskinesia Impairment Scale (DIS) in children and young adults with dyskinetic cerebral palsy (CP). Method Dystonia and Choreoathetosis were assessed in 15 participants with dyskinetic CP (13 males, 2 females; age range 5-22y, mean 14y, SD 4y) using the DIS in two separate sessions over 7 days. Exclusion criteria were changes in muscle relaxant medication within the previous 3 months, orthopaedic or neurosurgical interventions within the previous year, and spinal fusion. Intraclass correlation coefficient, confidence intervals (CI), standard error of measurement, and the minimal detectable difference (MDD) were determined for test-retest reliability. Result Intraclass correlation coefficients of the DIS, the dystonia subscale of the DIS, and the Choreoathetosis subscale of the DIS were 0.98 (95% CI 0.94-0.99), 0.97 (95% CI 0.92-0.99), and 0.96 (95% CI 0.90-0.99). The standard error of measurement and MDD were 2.6% and 7.2%. Interpretation The DIS is a reliable tool to assess dystonia and Choreoathetosis; it remains stable over time in children and young adults with dyskinetic CP. These results add to the current evidence for good clinimetric properties of the DIS. What this paper adds The Dyskinesia Impairment Scale (DIS) shows stability in scoring dystonia and Choreoathetosis. The total DIS score and dystonia and Choreoathetosis subscales are clinically useful.
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Presence and severity of dystonia and Choreoathetosis overflow movements in participants with dyskinetic cerebral palsy and their relation with functional classification scales
2019Co-Authors: Inti Vanmechelen, Saranda Bekteshi, Kyra Bossier, Hilde Feys, Jan Deklerck, Elegast MonbaliuAbstract:Background: This cross-sectional study aims to investigate the presence and severity of overflow movements of dystonia and Choreoathetosis in dyskinetic cerebral palsy (CP) and to assess the relationship of overflow movements with functional classification scales. Methods: Fifty-two subjects with dyskinetic CP were included. Presence and severity of dystonia and Choreoathetosis overflow movements were assessed with the Dyskinesia Impairment Scale. Functional abilities were classified with the Gross Motor Function Classification System, Manual Ability Classification System, Viking Speech Scale, Communication Function Classification System, and Eating and Drinking Ability Classification System. Results: Dystonia and Choreoathetosis overflow movements were simultaneously present. Median scores of dystonia overflow movements were significantly higher than Choreoathetosis overflow movements. Dystonia and Choreoathetosis overflow movements were significantly higher in extremities than in the central body. Correlations between dystonia and Choreoathetosis overflow movements were fair. Moderate to good correlations were found between dystonia overflow score and Gross Motor Function Classification System, Manual Ability Classification System, and Eating and Drinking Ability Classification System. Conclusions: This is the first study to assess overflow movements in dyskinetic CP. All participants presented with dystonia and Choreoathetosis overflow movements, with higher values for dystonia overflow movements. Dystonia overflow movements seem to have a larger impact on functional abilities.Implications for rehabilitationDystonia and Choreoathetosis overflow movements are both present in children with dyskinetic cerebral palsy, with dystonia overflow movements being more severe than Choreoathetosis overflow movements.Overflow movements impact heavily on daily functional ability and the execution of voluntary activities.Dystonia overflow movements show good correlations with functional classification scales.The measurable characteristics of overflow movements can be used as a guideline for targeted treatment with, e.g., botulinum-toxin-A injections. Dystonia and Choreoathetosis overflow movements are both present in children with dyskinetic cerebral palsy, with dystonia overflow movements being more severe than Choreoathetosis overflow movements. Overflow movements impact heavily on daily functional ability and the execution of voluntary activities. Dystonia overflow movements show good correlations with functional classification scales. The measurable characteristics of overflow movements can be used as a guideline for targeted treatment with, e.g., botulinum-toxin-A injections.