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Garcia Garcia Olga - One of the best experts on this subject based on the ideXlab platform.

  • Tomografia de coherència òptica swept-source com a mètode de valoració de la coroide en les coroiditis estromals primàries
    'Edicions de la Universitat de Barcelona', 2017
    Co-Authors: Garcia Garcia Olga
    Abstract:

    ANTECEDENTS DEL TEMA: La valoració de la coroides s’ha fet fins el 2005 amb l’angiografia amb verd d’indocianina (AVI), mètode invasiu que requereix l’ injecció d’un contrast per vena antecubital. A partir del 2010, amb la tomografia de coherència òptica d’alta penetració, s’ha aconseguit valorar-la amb un mètode no invasiu. Però, l’ interpretació d’aquest mètode és lleugerament subjectiva i laboriosa, ja que requereix mesurar el gruix de la coroides de forma manual. Per tant, no és aplicable a la clínica diària. A partir del 2013 comença la tecnologia swept source. HIPÒTESI: Amb la utilització d’una tomografia de coherència òptica tipus swept source (SS-OCT), l’aparell es capaç de valorar automàticament el gruix coroïdal; la qual cosa pot permetre tenir una mesura objectiva de l’esmentat gruix i poder valorar l’evolució de les coroïditis estromals primàries (CEP) de forma més fiable, ràpida i no invasiva. OBJECTIUS: 1- Valorar les alteracions qualitatives de la coroides en les CEP en la fase aguda i crònica. 2- Valorar les alteracions quantitatives (variacions del gruix coroïdal) en la fase aguda per a valorar la resposta al tractament segons l’evolució del gruix coroïdal. 3- Valorar les alteracions quantitatives (variacions del gruix coroïdal) en la fase crònica/ convalescent per valorar la repercussió de la cicatrització i les recidives. 4- Valorar la diferencia entre el gruix coroïdal subfoveal i el promig del gruix de l’àrea corresponent a la reixeta de l’EDTRS en les CEP. METODOLOGIA UTILITZADA: Estudi prospectiu, longitudinal i cas-control dels pacients diagnosticats al Servei d’Oftalmologia de l’Hospital Universitari de Bellvitge des de finals del 2013 fins a finals del 2016. Realització d’una SS-OCT (prototipus Atlantis DRI-1 OCT, Topcon Corporation) en el diagnòstic i seguiment de les CEP [Síndrome de Vogt-Koyanagi-Harada (VKH) i malaltia de birdshot o corioretinopatia en perdigonada (BD)]. RESULTATS : 1- En la corioretinopatia en perdigonada, la SS-OCT ens confirma l’existència d’inflamació retiniana i coroïdal, gracies a les alteracions qualitatives observades; però, degut al poc engruiximent de la coroides i a la manca d’observació directa dels granulomes (pel seu petit tamany), no substitueix la informació obtinguda amb l’AVI. Tanmateix, son exploracions complementaries, ja que la SS-OCT ens permet discernir si les lesions hipofluorescents de l’angiografia son veritables zones inflamades o be zones atròfiques, i per tant, curades. Hi ha hagut una correlació positiva en el 60 % de les visites entre els resultats obtinguts amb la SS-OCT i la resta de les exploracions utilitzades fins ara pel seguiment de la malaltia ( camp visual, AVI i electroretinograma). 2- En la síndrome de VKH aguda, la SS-OCT ha demostrat ser molt útil pel diagnòstic (alteracions qualitatives: despreniments serosos multifocals bilaterals, septes,...i alteracions qualitatives: engruiximent coroïdal), i per a valorar la resposta al tractament (engruiximent coroïdal basal que es va aprimant). En la forma recidivant ha permès detectar l’augment del gruix coroïdal en les recidives; i en les formes curades, fer el seguiment de la malaltia (aprimament progressiu de la coroide) i diagnosticar recidives. La SS-OCT ha diagnosticat recidives coroïdals asimptomàtiques (sense pèrdua d’agudesa visual) que haurien passat desapercebudes. Del total de les recidives: 62.5 % en aguts, 42 % en recidivants i 25 % en curats, van ser diagnosticades amb SS-OCT). 3- En tots els casos s’ha confirmat la inflamació coroïdal detectada amb la SS-OCT mitjançant la realització d’una AVI. CONCLUSIONS: 1- La medició automàtica del gruix coroïdal amb la SS-OCT és una exploració ràpida, incruenta i objectiva que ha permès fer un millor seguiment de les CEP. 2- En la BD ens dona informació complementària a les exploracions que disposàvem fins ara. 3- En la VKH en fase aguda ha permès valorar la resposta al tractament i les recidives. En la fase convalescent/crònica ha permès valorar les recidives i la tendència a l’aprimament coroïdal. 4- La SS-OCT ha diagnosticat recidives coroïdals asimptomàtiques. 5- La SS-OCT podria estalviar l’AVI quan el diagnòstic de recaiguda és evident.Background: Since 2010, high-penetration optic-coherence tomography (OCT) has been used to measure Choroidal thickness manually. However, the choroid can be now be be measured automatically with swept-source OCT (SS-OCT). Hypothesis: Using the automatic measurement feature of SS-OCT to qualitatively and quantitatively assess changes in primary stromal choroiditis (PSC) may provide a rapid and accurate approach to monitoring these patients. Methods: Prospective, longitudinal case-control study of PSC [Vogt-Koyanagi-Harada syndrome (VKH) and birdshot disease (BD)] in a tertiary university hospital with a 3-year follow-up period (from 2013 to 2016). SS-OCT was performed at each visit and Choroidal thickness was measured automatically. The study sample consisted of the following: 12 BD patients and 35 VKH patients (9 acute and 26 convalescent/chronic) and 17 healthy controls. There were no statistically differences between the groups in terms of sex or age at baseline. Patients with more than 3 diopters of myopia or hypermetropia were excluded. Results: 1- BD: SS-OCT confirms retinal and Choroidal Inflammation. However, the small size of the Choroidal granulomas, together with the small increase in Choroidal thickness, suggest that SS-OCT is best used as a complement to other methods, including visual acuity assessment, indocyanine green angiography (ICGA), electroretinogram, and visual field testing (which was perfectly correlated with SS-OCT in nearly 60% of patients) . 2- VKH: SS-OCT was useful in the diagnosis of VKH, helping to detect both qualitative (multifocal bilateral serous retinal detachments, retinal pigmentary epithelial folds, and ondulations) and quantitative changes (Choroidal thickening). In addition, SS-OCT was valuable for follow-up, enabling detection of post-treatment decreases in Choroidal thickness and increases in patients with VKH relapse: 62% of acute VKH Choroidal relapses (42% of these relapses in the convalescent/chronic group) were diagnosed with SS-OCT based on increased Choroidal thickness without loss of visual acuity and no intraocular signs of Inflammation. 3- All the Choroidal relapses were confirmed with inflammatory signs evidenced on ICGA. Conclusions: SS-OCT is a non-invasive and rapid approach to assessing Choroidal and retinal changes in patients with primary stromal choroiditis (VKH and BD), providing a simple method of monitoring the course of these diseases. SS-OCT complements conventional tests in BD and decreases the need for ICGA in VKH

  • Tomografia de coherència òptica swept-source com a mètode de valoració de la coroide en les coroiditis estromals primàries
    'Edicions de la Universitat de Barcelona', 2017
    Co-Authors: Garcia Garcia Olga
    Abstract:

    [cat] ANTECEDENTS DEL TEMA: La valoració de la coroides s’ha fet fins el 2005 amb l’angiografia amb verd d’indocianina (AVI), mètode invasiu que requereix l’ injecció d’un contrast per vena antecubital. A partir del 2010, amb la tomografia de coherència òptica d’alta penetració, s’ha aconseguit valorar-la amb un mètode no invasiu. Però, l’ interpretació d’aquest mètode és lleugerament subjectiva i laboriosa, ja que requereix mesurar el gruix de la coroides de forma manual. Per tant, no és aplicable a la clínica diària. A partir del 2013 comença la tecnologia swept source. HIPÒTESI: Amb la utilització d’una tomografia de coherència òptica tipus swept source (SS-OCT), l’aparell es capaç de valorar automàticament el gruix coroïdal; la qual cosa pot permetre tenir una mesura objectiva de l’esmentat gruix i poder valorar l’evolució de les coroïditis estromals primàries (CEP) de forma més fiable, ràpida i no invasiva. OBJECTIUS: 1- Valorar les alteracions qualitatives de la coroides en les CEP en la fase aguda i crònica. 2- Valorar les alteracions quantitatives (variacions del gruix coroïdal) en la fase aguda per a valorar la resposta al tractament segons l’evolució del gruix coroïdal. 3- Valorar les alteracions quantitatives (variacions del gruix coroïdal) en la fase crònica/ convalescent per valorar la repercussió de la cicatrització i les recidives. 4- Valorar la diferencia entre el gruix coroïdal subfoveal i el promig del gruix de l’àrea corresponent a la reixeta de l’EDTRS en les CEP. METODOLOGIA UTILITZADA: Estudi prospectiu, longitudinal i cas-control dels pacients diagnosticats al Servei d’Oftalmologia de l’Hospital Universitari de Bellvitge des de finals del 2013 fins a finals del 2016. Realització d’una SS-OCT (prototipus Atlantis DRI-1 OCT, Topcon Corporation) en el diagnòstic i seguiment de les CEP [Síndrome de Vogt-Koyanagi-Harada (VKH) i malaltia de birdshot o corioretinopatia en perdigonada (BD)]. RESULTATS : 1- En la corioretinopatia en perdigonada, la SS-OCT ens confirma l’existència d’inflamació retiniana i coroïdal, gracies a les alteracions qualitatives observades; però, degut al poc engruiximent de la coroides i a la manca d’observació directa dels granulomes (pel seu petit tamany), no substitueix la informació obtinguda amb l’AVI. Tanmateix, son exploracions complementaries, ja que la SS-OCT ens permet discernir si les lesions hipofluorescents de l’angiografia son veritables zones inflamades o be zones atròfiques, i per tant, curades. Hi ha hagut una correlació positiva en el 60 % de les visites entre els resultats obtinguts amb la SS-OCT i la resta de les exploracions utilitzades fins ara pel seguiment de la malaltia ( camp visual, AVI i electroretinograma). 2- En la síndrome de VKH aguda, la SS-OCT ha demostrat ser molt útil pel diagnòstic (alteracions qualitatives: despreniments serosos multifocals bilaterals, septes,...i alteracions qualitatives: engruiximent coroïdal), i per a valorar la resposta al tractament (engruiximent coroïdal basal que es va aprimant). En la forma recidivant ha permès detectar l’augment del gruix coroïdal en les recidives; i en les formes curades, fer el seguiment de la malaltia (aprimament progressiu de la coroide) i diagnosticar recidives. La SS-OCT ha diagnosticat recidives coroïdals asimptomàtiques (sense pèrdua d’agudesa visual) que haurien passat desapercebudes. Del total de les recidives: 62.5 % en aguts, 42 % en recidivants i 25 % en curats, van ser diagnosticades amb SS-OCT). 3- En tots els casos s’ha confirmat la inflamació coroïdal detectada amb la SS-OCT mitjançant la realització d’una AVI. CONCLUSIONS: 1- La medició automàtica del gruix coroïdal amb la SS-OCT és una exploració ràpida, incruenta i objectiva que ha permès fer un millor seguiment de les CEP. 2- En la BD ens dona informació complementària a les exploracions que disposàvem fins ara. 3- En la VKH en fase aguda ha permès valorar la resposta al tractament i les recidives. En la fase convalescent/crònica ha permès valorar les recidives i la tendència a l’aprimament coroïdal. 4- La SS-OCT ha diagnosticat recidives coroïdals asimptomàtiques. 5- La SS-OCT podria estalviar l’AVI quan el diagnòstic de recaiguda és evident.[eng] Background: Since 2010, high-penetration optic-coherence tomography (OCT) has been used to measure Choroidal thickness manually. However, the choroid can be now be be measured automatically with swept-source OCT (SS-OCT). Hypothesis: Using the automatic measurement feature of SS-OCT to qualitatively and quantitatively assess changes in primary stromal choroiditis (PSC) may provide a rapid and accurate approach to monitoring these patients. Methods: Prospective, longitudinal case-control study of PSC [Vogt-Koyanagi-Harada syndrome (VKH) and birdshot disease (BD)] in a tertiary university hospital with a 3-year follow-up period (from 2013 to 2016). SS-OCT was performed at each visit and Choroidal thickness was measured automatically. The study sample consisted of the following: 12 BD patients and 35 VKH patients (9 acute and 26 convalescent/chronic) and 17 healthy controls. There were no statistically differences between the groups in terms of sex or age at baseline. Patients with more than 3 diopters of myopia or hypermetropia were excluded. Results: 1- BD: SS-OCT confirms retinal and Choroidal Inflammation. However, the small size of the Choroidal granulomas, together with the small increase in Choroidal thickness, suggest that SS-OCT is best used as a complement to other methods, including visual acuity assessment, indocyanine green angiography (ICGA), electroretinogram, and visual field testing (which was perfectly correlated with SS-OCT in nearly 60% of patients) . 2- VKH: SS-OCT was useful in the diagnosis of VKH, helping to detect both qualitative (multifocal bilateral serous retinal detachments, retinal pigmentary epithelial folds, and ondulations) and quantitative changes (Choroidal thickening). In addition, SS-OCT was valuable for follow-up, enabling detection of post-treatment decreases in Choroidal thickness and increases in patients with VKH relapse: 62% of acute VKH Choroidal relapses (42% of these relapses in the convalescent/chronic group) were diagnosed with SS-OCT based on increased Choroidal thickness without loss of visual acuity and no intraocular signs of Inflammation. 3- All the Choroidal relapses were confirmed with inflammatory signs evidenced on ICGA. Conclusions: SS-OCT is a non-invasive and rapid approach to assessing Choroidal and retinal changes in patients with primary stromal choroiditis (VKH and BD), providing a simple method of monitoring the course of these diseases. SS-OCT complements conventional tests in BD and decreases the need for ICGA in VKH

Ju Byung Chae - One of the best experts on this subject based on the ideXlab platform.

  • Choroidal Inflammation and choriocapillaris ischemia in focal Choroidal excavation in comparison to pachychoroid neovasculopathy
    Retina-the Journal of Retinal and Vitreous Diseases, 2020
    Co-Authors: Eoi Jong Seo, Tae Hwan Moon, Dong Yoon Kim, Ju Byung Chae
    Abstract:

    PURPOSE To investigate the choriocapillaris and Choroidal characteristics of focal Choroidal excavation (FCE) in order to establish pathomechanisms of the disease. METHODS 30 eyes with FCE, 27 eyes with pachychoroid neovasculopathy (PNV) and 25 participants without any conditions (control group) were analyzed retrospectively. The thickness of both choriocapillaris-equivalent and whole choroid was measured at three different points: under the lesion (excavation or neovascularization), in the normal retina, and in the fovea of fellow eye. Indocyanine green angiographs (ICGA) were collected to confirm choriocapillaris ischemia and Choroidal Inflammation presence. RESULTS In both FCE and PNV, choriocapillaris-equivalent attenuation was observed under the lesion compared to other region of the retina (28.1±11.3µm vs 69.4±20.0µm in FCE; 23.5±9.7µm vs 62.3±14.7µm in PNV; both p<0.001). We also observed focal thinning of the whole choroid under the lesion (149.7±88.7µm vs 296.6±83.2µm, p<0.001) in FCE, but not in PNV. Pachy-vessels distribution on OCT and numerous dark areas on ICGA implied that Choroidal Inflammation was related to the FCE occurrence. CONCLUSION Choriocapillaris ischemia was related to both FCE and PNV. The Choroidal thinning under the excavation and adjacent pachy-vessels observed in FCE suggested that focal Inflammation and scarring may contribute to choriocapillaris ischemia and eventual retinal pigment epithelium retraction with dysfunction in the pathomechanism.

Rachel R Caspi - One of the best experts on this subject based on the ideXlab platform.

  • comparative analysis of induced vs spontaneous models of autoimmune uveitis targeting the interphotoreceptor retinoid binding protein
    PLOS ONE, 2013
    Co-Authors: Jun Chen, Chi-chao Chan, Haohua Qian, Reiko Horai, Yishay Falick, Rachel R Caspi
    Abstract:

    Animal models of autoimmunity to the retina mimic specific features of human uveitis, but no model by itself reproduces the full spectrum of human disease. We compared three mouse models of uveitis that target the interphotoreceptor retinoid binding protein (IRBP): (i) the “classical” model of experimental autoimmune uveitis (EAU) induced by immunization with IRBP; (ii) spontaneous uveitis in IRBP T cell receptor transgenic mice (R161H) and (iii) spontaneous uveitis in Autoimmune Regulator (AIRE)−/− mice. Disease course and severity, pathology and changes in visual function were studied using fundus imaging and histological examinations, optical coherence tomography and electroretinography. All models were on the B10.RIII background. Unlike previously reported, IRBP-induced EAU in B10.RIII mice exhibited two distinct patterns of disease depending on clinical scores developed after onset: severe monophasic with extensive destruction of the retina and rapid loss of visual signal, or lower grade with a prolonged chronic phase culminating after several months in retinal degeneration and loss of vision. R161H and AIRE−/− mice spontaneously developed chronic progressive Inflammation; visual function declined gradually as retinal degeneration developed. Spontaneous uveitis in R161H mice was characterized by persistent cellular infiltrates and lymphoid aggregation, whereas AIRE−/− mice characteristically developed multi-focal infiltrates and severe Choroidal Inflammation. These data demonstrate variability and unique distinguishing features in the different models of uveitis, suggesting that each one can represent distinct aspects of uveitis in humans.

  • Histopathology of induced and spontaneous uveitis models.
    2013
    Co-Authors: Jun Chen, Chi-chao Chan, Haohua Qian, Reiko Horai, Yishay Falick, Rachel R Caspi
    Abstract:

    A–D, Mice were immunized with IRBP in adjuvant and eyes were collected at the indicated days after immunization. Note severe ocular Inflammation including vitritis, retinal swelling and destruction, retinal folds and infiltrates, subretinal hemorrhage, and Choroidal Inflammation at the peak of Inflammation on day 14 p.i. (A–B, low and high magnification). During the acute phase of EAU, 18–21 days after immunization, eye histology showed well developed retinal lesions and infiltrating cells in the choroid, vitreous, as well as subretinal hemorrhage (arrow) (B and C). Retinal folds were seen in mice that developed the chronic form of EAU (D). E–H, Histology of R161H mice at different ages. Note cellular infiltrates and exudates in the vitreous and in the retina (E–F, low and high magnification), lymphoid aggregation in the retina (G, asterisk), photoreceptor layer destruction (H) and Choroidal Inflammation (G–H). I–P, Histology of AIRE−/− mice at different ages. Note severe choroiditis (I–J, low magnification; N, high magnification), granuloma-like lesions in the retina (K, low magnification; M–N, high magnification), photoreceptor layer destruction and retinal degeneration (O–P, high magnification). Fourteen B10RIII mice with EAU (10 for monophasic form, 4 for chronic form), 12 R161H and 13 AIRE−/− mice were included in the histological examination. Eyes of 2–3 mice were harvested at each time point.

  • Comparison of OCT images with fundus and histological findings of the retina in EAU.
    2013
    Co-Authors: Jun Chen, Chi-chao Chan, Haohua Qian, Reiko Horai, Rachel R Caspi
    Abstract:

    EAU was induced in B10RIII mice by immunization with 8 ug IRBP in CFA. A, Normal retinal layers in a healthy eye assessed by cross-sectional OCT image in comparison with histological section of murine retina. Note ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer nuclear layer (ONL), IS/OS of photoreceptor layer (PRL), retinal pigment epithelium (RPE) and choroid (CH). B (a–f), Comparison of cross-sectional OCT images of retina with histological sections of the same eyes at different stages of EAU: a–b, early onset of EAU (13 days post immunization). Note largely normal retinal morphology on OCT and histology, but a moderate degree of cellular infiltrates is apparent in the vitreous near the optic nerve head (arrow); c, acute phase of EAU (14 days post immunization). Note retinal pathology including vitritis, retinal edema, retinal folds (arrow), subretinal hemorrhage (asterisk), retinal and Choroidal Inflammation. Heavy cellular infiltration in the anterior chamber (not shown) and vitreous limit OCT resolution of retinal layers. In correlation with the pathological findings, OCT shows cellular infiltrates in the vitreous, retinal vasculitis and edema, and retinal folds; d–f, resolution phase of EAU (21–28 days post immunization), partial clearing of ocular media facilitate OCT visualization of cellular infiltration in the vitreous (d), retinal folds (e, arrow), choroiditis (e, yellow arrow) as well as degenerating PRL (f). Eighteen mice were included for histological examination, and eyes of 2–3 mice were harvested at individual time point.

Deming Sun - One of the best experts on this subject based on the ideXlab platform.

  • characterization of il 17 interphotoreceptor retinoid binding protein specific t cells in experimental autoimmune uveitis
    Investigative Ophthalmology & Visual Science, 2007
    Co-Authors: Yong Peng, Gencheng Han, Hui Shao, Yali Wang, Henry J Kaplan, Deming Sun
    Abstract:

    Experimental autoimmune uveitis (EAU) is a T cell-mediated autoimmune disease that serves as a model for several posterior uveitides, such as Behcet disease, Vogt-Koyanagi-Harada syndrome, birdshot retinochoroidopathy, and sympathetic ophthalmia.1,2 The histopathology of EAU is characterized by posterior retinal and Choroidal Inflammation, granuloma formation, vasculitis, photoreceptor damage, vitreitis, and varying degrees of anterior uveitis.2 EAU is induced in animals by immunization with retinal antigens or by the adoptive transfer of retinal antigen-specific T lymphocytes.3,4 Among the ocular antigens known to induce EAU in rodent models are interphotoreceptor retinoid-binding protein (IRBP)5 and the soluble retinal antigen (S-antigen).6,7 Thus far, it is thought that the major subsets of pathogenic autoreactive T cells produce proinflammatory cytokines, including IFN-γ and IL-2, and belong to the Th1-type of CD4 T cells.8 Recent studies have shown that a specific autoreactive T-cell subset that produces IL-17, but not IFN-γ or IL-4, is crucially involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, experimental autoimmune encephalomyelitis (EAE),9–11 and other allergic diseases,12–14 especially during the chronic phase. IL-17–deficient mice are resistant to an arthritislike disease15,16 and have impaired host defense against microbial infection and an increased incidence of acquired delayed-type hypersensitivity.15 In addition, autoimmune-prone mice become disease resistant after they are treated with an IL-17R antagonist.17 To determine the role of IL-17+ T cells in the pathogenesis of EAU and the interrelationship between previously characterized uveitogenic T-cell subsets and IL-17+ T cells, we studied the induction and pathologic function of IL-17+ T cells. We were particularly interested in determining whether IL-17 was expressed only by CD4 autoreactive T cells or also by CD8 autoreactive T cells and in comparing the pathogenic effect of IL-17+ T cells specific for the uveitogenic antigen with that of nonspecific IL-17+ T cells. We showed that CD4 and CD8 autoreactive T cells in EAU were equally capable of expressing IL-17 and that IRBP-specific T cells preferentially expressed IL-17 when they were expanded by IL-23, whereas IFN-γ– expressing cells were dominant when the T cells were cultured with IL-2. We also showed that both sets of expanded T cells were uveitogenic. Comparison of IL-17+ T cells elicited by antigen-specific stimulation in vitro with those elicited by antigen-nonspecific activation (anti-CD3 antibody) demonstrated that only antigen-specific IL-17+ T cells were uveitogenic. Finally, we showed that the ligation of Toll-like receptor (TLR) greatly enhanced the activation of IL-17–producing T cells in vivo and in vitro. Our results provide direct evidence that IL-17+ autoreactive T cells elicited by uveitogenic antigen are pathogenic, that the number and activation of these T cells is regulated by available cytokines, that the activation of such T-cell subsets is regulated by factors other than autoantigen, such as mycobacterial components in complete Freund adjuvant (CFA), and that pertussis toxin (PTX), which is essential for the induction of EAU in animal models, promotes the activation of IL-17+ autoreactive T cells.

Eoi Jong Seo - One of the best experts on this subject based on the ideXlab platform.

  • Choroidal Inflammation and choriocapillaris ischemia in focal Choroidal excavation in comparison to pachychoroid neovasculopathy
    Retina-the Journal of Retinal and Vitreous Diseases, 2020
    Co-Authors: Eoi Jong Seo, Tae Hwan Moon, Dong Yoon Kim, Ju Byung Chae
    Abstract:

    PURPOSE To investigate the choriocapillaris and Choroidal characteristics of focal Choroidal excavation (FCE) in order to establish pathomechanisms of the disease. METHODS 30 eyes with FCE, 27 eyes with pachychoroid neovasculopathy (PNV) and 25 participants without any conditions (control group) were analyzed retrospectively. The thickness of both choriocapillaris-equivalent and whole choroid was measured at three different points: under the lesion (excavation or neovascularization), in the normal retina, and in the fovea of fellow eye. Indocyanine green angiographs (ICGA) were collected to confirm choriocapillaris ischemia and Choroidal Inflammation presence. RESULTS In both FCE and PNV, choriocapillaris-equivalent attenuation was observed under the lesion compared to other region of the retina (28.1±11.3µm vs 69.4±20.0µm in FCE; 23.5±9.7µm vs 62.3±14.7µm in PNV; both p<0.001). We also observed focal thinning of the whole choroid under the lesion (149.7±88.7µm vs 296.6±83.2µm, p<0.001) in FCE, but not in PNV. Pachy-vessels distribution on OCT and numerous dark areas on ICGA implied that Choroidal Inflammation was related to the FCE occurrence. CONCLUSION Choriocapillaris ischemia was related to both FCE and PNV. The Choroidal thinning under the excavation and adjacent pachy-vessels observed in FCE suggested that focal Inflammation and scarring may contribute to choriocapillaris ischemia and eventual retinal pigment epithelium retraction with dysfunction in the pathomechanism.