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J. Verhoef - One of the best experts on this subject based on the ideXlab platform.

  • Christiaan Eijkman first bacteriologist at utrecht university nobel laureate for his work on vitamins
    Fems Immunology and Medical Microbiology, 1999
    Co-Authors: J. Verhoef, H. Snippe, H.s.l.m. Nottet
    Abstract:

    One century ago, Christiaan Eijkman was appointed Professor of Bacteriology and Hygiene at the University of Utrecht, The Netherlands. Despite his appointment to teach bacteriology, Christiaan Eijkman made his main contribution to medical science not in bacteriology but in nutrition. He discovered that beri-beri was not an infection but a nutritional deficiency (later called vitamin deficiency) and received the Nobel Prize for Medicine in 1929 for these observations. These landmark studies were made in the former Dutch East Indies. As professor of bacteriology he established an important school of medical microbiology in The Netherlands.

  • Christiaan Eijkman
    Antonie van Leeuwenhoek, 1999
    Co-Authors: J. Verhoef, H. Snippe, H.s.l.m. Nottet
    Abstract:

    One century ago, Christiaan Eijkman was appointed Professor of Bacteriology at the Utrecht University, The Netherlands. Despite his appointment to teach bacteriology, Christiaan Eijkman made his main contribution to medical science not in bacteriology but in nutrition. He discovered that Beri-Beri was not an infection but a nutritient deficiency (later called vitamin-deficiency) and was awarded the Nobel Prize for Medicine in 1929 for these observations. These landmark studies were made in the former Dutch East Indies. Interestingly, the results of his studies were presented in the Dutch language, in the medical journal of the Dutch East Indies. As a professor of Bacteriology, his work was the beginning of an important school in biochemistry in The Netherlands.

  • Christiaan Eijkman first bacteriologist at utrecht university nobel laureate for his work on vitamins
    Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology, 1999
    Co-Authors: J. Verhoef, H. Snippe, H.s.l.m. Nottet
    Abstract:

    One century ago, Christiaan Eijkman was appointed Professor of Bacteriology at the Utrecht University, The Netherlands. Despite his appointment to teach bacteriology, Christiaan Eijkman made his main contribution to medical science not in bacteriology but in nutrition. He discovered that Beri-Beri was not an infection but a nutritient deficiency (later called vitamin-deficiency) and was awarded the Nobel Prize for Medicine in 1929 for these observations. These landmark studies were made in the former Dutch East Indies. Interestingly, the results of his studies were presented in the Dutch language, in the medical journal of the Dutch East Indies. As a professor of Bacteriology, his work was the beginning of an important school in biochemistry in The Netherlands.

  • Eijkman Centennial on Infections in the 21st Century ‘Successes from the past, challenges for the future’
    FEMS immunology and medical microbiology, 1999
    Co-Authors: J. Verhoef, A.j.w. Van Alphen, W. Alexander Scheffers
    Abstract:

    In 1898, Christiaan Eijkman was inaugurated as Professor of Hygiene and Bacteriology at Utrecht University, Utrecht, The Netherlands. In 1929, he received the Nobel Prize for his research on beri-beri, a disease that is caused by a vitamin deficiency. Eijkman conducted …

H.s.l.m. Nottet - One of the best experts on this subject based on the ideXlab platform.

  • Christiaan Eijkman first bacteriologist at utrecht university nobel laureate for his work on vitamins
    Fems Immunology and Medical Microbiology, 1999
    Co-Authors: J. Verhoef, H. Snippe, H.s.l.m. Nottet
    Abstract:

    One century ago, Christiaan Eijkman was appointed Professor of Bacteriology and Hygiene at the University of Utrecht, The Netherlands. Despite his appointment to teach bacteriology, Christiaan Eijkman made his main contribution to medical science not in bacteriology but in nutrition. He discovered that beri-beri was not an infection but a nutritional deficiency (later called vitamin deficiency) and received the Nobel Prize for Medicine in 1929 for these observations. These landmark studies were made in the former Dutch East Indies. As professor of bacteriology he established an important school of medical microbiology in The Netherlands.

  • Christiaan Eijkman
    Antonie van Leeuwenhoek, 1999
    Co-Authors: J. Verhoef, H. Snippe, H.s.l.m. Nottet
    Abstract:

    One century ago, Christiaan Eijkman was appointed Professor of Bacteriology at the Utrecht University, The Netherlands. Despite his appointment to teach bacteriology, Christiaan Eijkman made his main contribution to medical science not in bacteriology but in nutrition. He discovered that Beri-Beri was not an infection but a nutritient deficiency (later called vitamin-deficiency) and was awarded the Nobel Prize for Medicine in 1929 for these observations. These landmark studies were made in the former Dutch East Indies. Interestingly, the results of his studies were presented in the Dutch language, in the medical journal of the Dutch East Indies. As a professor of Bacteriology, his work was the beginning of an important school in biochemistry in The Netherlands.

  • Christiaan Eijkman first bacteriologist at utrecht university nobel laureate for his work on vitamins
    Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology, 1999
    Co-Authors: J. Verhoef, H. Snippe, H.s.l.m. Nottet
    Abstract:

    One century ago, Christiaan Eijkman was appointed Professor of Bacteriology at the Utrecht University, The Netherlands. Despite his appointment to teach bacteriology, Christiaan Eijkman made his main contribution to medical science not in bacteriology but in nutrition. He discovered that Beri-Beri was not an infection but a nutritient deficiency (later called vitamin-deficiency) and was awarded the Nobel Prize for Medicine in 1929 for these observations. These landmark studies were made in the former Dutch East Indies. Interestingly, the results of his studies were presented in the Dutch language, in the medical journal of the Dutch East Indies. As a professor of Bacteriology, his work was the beginning of an important school in biochemistry in The Netherlands.

H. Snippe - One of the best experts on this subject based on the ideXlab platform.

  • Christiaan Eijkman first bacteriologist at utrecht university nobel laureate for his work on vitamins
    Fems Immunology and Medical Microbiology, 1999
    Co-Authors: J. Verhoef, H. Snippe, H.s.l.m. Nottet
    Abstract:

    One century ago, Christiaan Eijkman was appointed Professor of Bacteriology and Hygiene at the University of Utrecht, The Netherlands. Despite his appointment to teach bacteriology, Christiaan Eijkman made his main contribution to medical science not in bacteriology but in nutrition. He discovered that beri-beri was not an infection but a nutritional deficiency (later called vitamin deficiency) and received the Nobel Prize for Medicine in 1929 for these observations. These landmark studies were made in the former Dutch East Indies. As professor of bacteriology he established an important school of medical microbiology in The Netherlands.

  • Christiaan Eijkman
    Antonie van Leeuwenhoek, 1999
    Co-Authors: J. Verhoef, H. Snippe, H.s.l.m. Nottet
    Abstract:

    One century ago, Christiaan Eijkman was appointed Professor of Bacteriology at the Utrecht University, The Netherlands. Despite his appointment to teach bacteriology, Christiaan Eijkman made his main contribution to medical science not in bacteriology but in nutrition. He discovered that Beri-Beri was not an infection but a nutritient deficiency (later called vitamin-deficiency) and was awarded the Nobel Prize for Medicine in 1929 for these observations. These landmark studies were made in the former Dutch East Indies. Interestingly, the results of his studies were presented in the Dutch language, in the medical journal of the Dutch East Indies. As a professor of Bacteriology, his work was the beginning of an important school in biochemistry in The Netherlands.

  • Christiaan Eijkman first bacteriologist at utrecht university nobel laureate for his work on vitamins
    Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology, 1999
    Co-Authors: J. Verhoef, H. Snippe, H.s.l.m. Nottet
    Abstract:

    One century ago, Christiaan Eijkman was appointed Professor of Bacteriology at the Utrecht University, The Netherlands. Despite his appointment to teach bacteriology, Christiaan Eijkman made his main contribution to medical science not in bacteriology but in nutrition. He discovered that Beri-Beri was not an infection but a nutritient deficiency (later called vitamin-deficiency) and was awarded the Nobel Prize for Medicine in 1929 for these observations. These landmark studies were made in the former Dutch East Indies. Interestingly, the results of his studies were presented in the Dutch language, in the medical journal of the Dutch East Indies. As a professor of Bacteriology, his work was the beginning of an important school in biochemistry in The Netherlands.

W. Alexander Scheffers - One of the best experts on this subject based on the ideXlab platform.

Kenneth J. Carpenter - One of the best experts on this subject based on the ideXlab platform.

  • The discovery of thiamin.
    Annals of nutrition & metabolism, 2012
    Co-Authors: Kenneth J. Carpenter
    Abstract:

    Thiamin deficiency was long known as 'beriberi' in English and 'kakke' in Japan and China. The cause of beriberi was attributed to miasmas rising from wet soil and later to an unknown infectious organism. Systematic studies of beriberi began in the Dutch East Indies in the 1880s. Cornelis Pekelharing and Cornelis Winkler investigated beriberi in the Dutch East Indies and thought that they had isolated a micrococcus that was responsible for the disease. Christiaan Eijkman observed that chickens fed white rice developed a leg paralysis or 'polyneuritis', whereas chickens fed brown (unpolished) rice did not. Gerrit Grijns succeeded Eijkman in the beriberi studies in Java and concluded correctly that there were unknown substances in foods that were needed for the peripheral nervous system. In 1926, Barend Jansen and Willem Donath isolated and crystallized a substance that cured polyneuritis in pigeons. Robert Williams synthesized thiamin in 1936.

  • Eijkman's contribution to the discovery of vitamins.
    The Journal of nutrition, 1995
    Co-Authors: Kenneth J. Carpenter, Barbara Sutherland
    Abstract:

    The work by Christiaan Eijkman in Batavia (now Djakarta, the capital of Indonesia) between 1890 and 1900, for which he received a Nobel Prize, is reviewed. While searching for a microorganism responsible for beriberi, he found that a condition of polyneuritis, with similarities to beriberi, could be produced consistently in chickens by feeding them polished rice, and that addition of the silverskin removed during polishing prevented this. He showed further that the silverskin did not act by physically preventing the entry of microorganisms into the endosperm, nor was its action explained by the protein and salts that it contributed. His tentative hypothesis was that this fraction contributed an antidote to a nerve poison produced by the fermentation of starch in the chickens' crop. However, his successor continued to use Eijkman's animal model and was able to show that silverskin supplied some unknown factor(s) that was required regardless of whether or not the diet contained starch. Fractionation eventually showed thiamin to be the active factor.