The Experts below are selected from a list of 627 Experts worldwide ranked by ideXlab platform
Chengjian Zhu - One of the best experts on this subject based on the ideXlab platform.
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Chiral Tertiary Amine Thiourea-Catalyzed Asymmetric Inverse-Electron-Demand Diels–Alder Reaction of Chromone Heterodienes Using 3‑Vinylindoles as Dienophiles
2016Co-Authors: Zhijie Mao, Aijun Lin, Yan Shi, Haibin Mao, Yixiang Cheng, Chengjian ZhuAbstract:A straightforward and efficient protocol for the construction of structurally and biologically interesting chiral flavanoids incorporating three privileged structures, i.e., Chromanone, dihydropyran, and indole, has been developed on the basis of chiral bifunctional tertiary amine thiourea-catalyzed asymmetric inverse-electron-demand Diels–Alder reaction of chromone heterodienes and 3-vinylindoles, which were used as dienophiles
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chiral tertiary amine thiourea catalyzed asymmetric inverse electron demand diels alder reaction of chromone heterodienes using 3 vinylindoles as dienophiles
Journal of Organic Chemistry, 2013Co-Authors: Zhijie Mao, Aijun Lin, Yan Shi, Haibin Mao, Yixiang Cheng, Chengjian ZhuAbstract:A straightforward and efficient protocol for the construction of structurally and biologically interesting chiral flavanoids incorporating three privileged structures, i.e., Chromanone, dihydropyran, and indole, has been developed on the basis of chiral bifunctional tertiary amine thiourea-catalyzed asymmetric inverse-electron-demand Diels–Alder reaction of chromone heterodienes and 3-vinylindoles, which were used as dienophiles.
Tsutomu Ishikawa - One of the best experts on this subject based on the ideXlab platform.
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concise synthesis of anti hiv 1 active inophyllum b and calanolide a by application of quinine catalyzed intramolecular oxo michael addition
Journal of Organic Chemistry, 2004Co-Authors: Etsuko Sekino, Tomohiro Tanaka, Takuya Kumamoto, Tomoko Ikeda, Tsutomu IshikawaAbstract:(-)-Quinine-catalyzed intramolecular oxo-Michael addition (IMA) of 7-hydroxy-5-methoxy-8-tigloylcoumarins was developed for the enantioselective construction of 2,3-dimethyl-4-Chromanone systems in the context of the asymmetric synthesis of anti-HIV-1 active Calophyllum coumarins. Combination of the IMA and MgI(2)-assisted demethylation of the 5-methoxy group along with isomerization of the formed Chromanone systems as key steps successfully led to the concise synthesis of (+)-inophyllum B and (+)-calanolide A, possible candidates for AIDS drugs. Further examination of the asymmetric IMA with cinchona alkaloids lacking a methoxy group on the quinoline skeleton suggested the influence of the methoxy substituent on stereoselectivity at the stereogenic centers of the Chromanone systems.
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solvent effects on stereoselectivity in 2 3 dimethyl 4 Chromanone cyclization by quinine catalyzed asymmetric intramolecular oxo michael addition
Tetrahedron-asymmetry, 2000Co-Authors: Tomohiro Tanaka, Takuya Kumamoto, Tsutomu IshikawaAbstract:Abstract Examination of the quinine-catalyzed asymmetric intramolecular oxo-Michael addition of o -tigloylphenol in various solvents led to high stereoselectivity in Chromanone cyclization when chlorobenzene was used as a solvent, giving cis -2,3-dimethyl-4-Chromanone with 60% de and 98% ee.
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An approach to anti-HIV-1 active Calophyllum coumarin synthesis: An enantioselective construction of 2,3-dimethyl-4-Chromanone ring by quinine-assisted intramolecular Michael-type addition
Tetrahedron Letters, 1999Co-Authors: Tsutomu Ishikawa, Tomohiro Tanaka, Takuya KumamotoAbstract:Abstract (−)-Quinine effectively catalyzes an intramolecular Michael-type addition of 7-hydroxy-8-tigloylcoumarin to give a diastereoisomeric mixture of the corresponding cyclized coumarin with a 2,3-dimethyl-4-Chromanone skeleton. Satisfactory enantioselectivity was observed in a cis -Chromanone construction, but not in a trans -one.
Zhijie Mao - One of the best experts on this subject based on the ideXlab platform.
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Chiral Tertiary Amine Thiourea-Catalyzed Asymmetric Inverse-Electron-Demand Diels–Alder Reaction of Chromone Heterodienes Using 3‑Vinylindoles as Dienophiles
2016Co-Authors: Zhijie Mao, Aijun Lin, Yan Shi, Haibin Mao, Yixiang Cheng, Chengjian ZhuAbstract:A straightforward and efficient protocol for the construction of structurally and biologically interesting chiral flavanoids incorporating three privileged structures, i.e., Chromanone, dihydropyran, and indole, has been developed on the basis of chiral bifunctional tertiary amine thiourea-catalyzed asymmetric inverse-electron-demand Diels–Alder reaction of chromone heterodienes and 3-vinylindoles, which were used as dienophiles
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chiral tertiary amine thiourea catalyzed asymmetric inverse electron demand diels alder reaction of chromone heterodienes using 3 vinylindoles as dienophiles
Journal of Organic Chemistry, 2013Co-Authors: Zhijie Mao, Aijun Lin, Yan Shi, Haibin Mao, Yixiang Cheng, Chengjian ZhuAbstract:A straightforward and efficient protocol for the construction of structurally and biologically interesting chiral flavanoids incorporating three privileged structures, i.e., Chromanone, dihydropyran, and indole, has been developed on the basis of chiral bifunctional tertiary amine thiourea-catalyzed asymmetric inverse-electron-demand Diels–Alder reaction of chromone heterodienes and 3-vinylindoles, which were used as dienophiles.
Takuya Kumamoto - One of the best experts on this subject based on the ideXlab platform.
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concise synthesis of anti hiv 1 active inophyllum b and calanolide a by application of quinine catalyzed intramolecular oxo michael addition
Journal of Organic Chemistry, 2004Co-Authors: Etsuko Sekino, Tomohiro Tanaka, Takuya Kumamoto, Tomoko Ikeda, Tsutomu IshikawaAbstract:(-)-Quinine-catalyzed intramolecular oxo-Michael addition (IMA) of 7-hydroxy-5-methoxy-8-tigloylcoumarins was developed for the enantioselective construction of 2,3-dimethyl-4-Chromanone systems in the context of the asymmetric synthesis of anti-HIV-1 active Calophyllum coumarins. Combination of the IMA and MgI(2)-assisted demethylation of the 5-methoxy group along with isomerization of the formed Chromanone systems as key steps successfully led to the concise synthesis of (+)-inophyllum B and (+)-calanolide A, possible candidates for AIDS drugs. Further examination of the asymmetric IMA with cinchona alkaloids lacking a methoxy group on the quinoline skeleton suggested the influence of the methoxy substituent on stereoselectivity at the stereogenic centers of the Chromanone systems.
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solvent effects on stereoselectivity in 2 3 dimethyl 4 Chromanone cyclization by quinine catalyzed asymmetric intramolecular oxo michael addition
Tetrahedron-asymmetry, 2000Co-Authors: Tomohiro Tanaka, Takuya Kumamoto, Tsutomu IshikawaAbstract:Abstract Examination of the quinine-catalyzed asymmetric intramolecular oxo-Michael addition of o -tigloylphenol in various solvents led to high stereoselectivity in Chromanone cyclization when chlorobenzene was used as a solvent, giving cis -2,3-dimethyl-4-Chromanone with 60% de and 98% ee.
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An approach to anti-HIV-1 active Calophyllum coumarin synthesis: An enantioselective construction of 2,3-dimethyl-4-Chromanone ring by quinine-assisted intramolecular Michael-type addition
Tetrahedron Letters, 1999Co-Authors: Tsutomu Ishikawa, Tomohiro Tanaka, Takuya KumamotoAbstract:Abstract (−)-Quinine effectively catalyzes an intramolecular Michael-type addition of 7-hydroxy-8-tigloylcoumarin to give a diastereoisomeric mixture of the corresponding cyclized coumarin with a 2,3-dimethyl-4-Chromanone skeleton. Satisfactory enantioselectivity was observed in a cis -Chromanone construction, but not in a trans -one.
Tomohiro Tanaka - One of the best experts on this subject based on the ideXlab platform.
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concise synthesis of anti hiv 1 active inophyllum b and calanolide a by application of quinine catalyzed intramolecular oxo michael addition
Journal of Organic Chemistry, 2004Co-Authors: Etsuko Sekino, Tomohiro Tanaka, Takuya Kumamoto, Tomoko Ikeda, Tsutomu IshikawaAbstract:(-)-Quinine-catalyzed intramolecular oxo-Michael addition (IMA) of 7-hydroxy-5-methoxy-8-tigloylcoumarins was developed for the enantioselective construction of 2,3-dimethyl-4-Chromanone systems in the context of the asymmetric synthesis of anti-HIV-1 active Calophyllum coumarins. Combination of the IMA and MgI(2)-assisted demethylation of the 5-methoxy group along with isomerization of the formed Chromanone systems as key steps successfully led to the concise synthesis of (+)-inophyllum B and (+)-calanolide A, possible candidates for AIDS drugs. Further examination of the asymmetric IMA with cinchona alkaloids lacking a methoxy group on the quinoline skeleton suggested the influence of the methoxy substituent on stereoselectivity at the stereogenic centers of the Chromanone systems.
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solvent effects on stereoselectivity in 2 3 dimethyl 4 Chromanone cyclization by quinine catalyzed asymmetric intramolecular oxo michael addition
Tetrahedron-asymmetry, 2000Co-Authors: Tomohiro Tanaka, Takuya Kumamoto, Tsutomu IshikawaAbstract:Abstract Examination of the quinine-catalyzed asymmetric intramolecular oxo-Michael addition of o -tigloylphenol in various solvents led to high stereoselectivity in Chromanone cyclization when chlorobenzene was used as a solvent, giving cis -2,3-dimethyl-4-Chromanone with 60% de and 98% ee.
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An approach to anti-HIV-1 active Calophyllum coumarin synthesis: An enantioselective construction of 2,3-dimethyl-4-Chromanone ring by quinine-assisted intramolecular Michael-type addition
Tetrahedron Letters, 1999Co-Authors: Tsutomu Ishikawa, Tomohiro Tanaka, Takuya KumamotoAbstract:Abstract (−)-Quinine effectively catalyzes an intramolecular Michael-type addition of 7-hydroxy-8-tigloylcoumarin to give a diastereoisomeric mixture of the corresponding cyclized coumarin with a 2,3-dimethyl-4-Chromanone skeleton. Satisfactory enantioselectivity was observed in a cis -Chromanone construction, but not in a trans -one.
