Chromatography - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Chromatography

The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform

Chromatography – Free Register to Access Experts & Abstracts

Ting Zhou – One of the best experts on this subject based on the ideXlab platform.

  • recent advances of online coupling of sample preparation techniques with ultra high performance liquid Chromatography and supercritical fluid Chromatography
    IEEE Journal of Solid-state Circuits, 2019
    Co-Authors: Yanshan Liang, Ting Zhou
    Abstract:

    : Ultra high performance liquid Chromatography and supercritical fluid Chromatography techniques are favored because of their high efficiency and fast analysis speed. Although many sample preparation techniques have been coupled with common liquid Chromatography online, the online coupling of sample preparation with the two popular Chromatography techniques have gained increasing attention owing to the increasing requirements of efficiency and sensitivity. In this review, we have discussed and summarized the recent advances of the online coupling of sample preparation with ultra high performance liquid Chromatography and supercritical fluid Chromatography techniques. The main sample preparation techniques that have been coupled with ultra high performance liquid Chromatography online are solid-phase extraction and in-tube solid-phase microextraction, while solid-phase extraction and supercritical fluid extraction are the main techniques that have been coupled with supercritical fluid Chromatography online. Especially, the strategies for online coupling of sample preparation with Chromatography techniques were summarized. Typical applications and growing trends of the online coupling techniques were also discussed in detail. With the increasing demands of improving the efficiency, throughput, and analytical capability toward complex samples of the analysis methods, online coupling of sample preparation with Chromatography techniques will acquire further development.

Caroline West – One of the best experts on this subject based on the ideXlab platform.

  • use and practice of achiral and chiral supercritical fluid Chromatography in pharmaceutical analysis and purification
    IEEE Journal of Solid-state Circuits, 2016
    Co-Authors: Elise Lemasson, Sophie Bertin, Caroline West
    Abstract:

    The interest of pharmaceutical companies for complementary high-performance chromatographic tools to assess a product’s purity or enhance this purity is on the rise. The high-throughput capability and economic benefits of supercritical fluid Chromatography, but also the “green” aspect of CO2 as the principal solvent, render supercritical fluid Chromatography very attractive for a wide range of pharmaceutical applications. The recent reintroduction of new robust instruments dedicated to supercritical fluid Chromatography and the progress in stationary phase technology have also greatly benefited supercritical fluid Chromatography. Additionally, it was shown several times that supercritical fluid Chromatography could be orthogonal to reversed-phase high-performance liquid Chromatography and could efficiently compete with it. Supercritical fluid Chromatography is an adequate tool for small molecules of pharmaceutical interest: synthetic intermediates, active pharmaceutical ingredients, impurities, or degradation products. In this review, we first discuss about general chromatographic conditions for supercritical fluid Chromatography analysis to better suit compounds of pharmaceutical interest. We also discuss about the use of achiral and chiral supercritical fluid Chromatography for analytical purposes and the recent applications in these areas. The use of preparative supercritical fluid Chromatography by pharmaceutical companies is also covered.

Yanshan Liang – One of the best experts on this subject based on the ideXlab platform.

  • recent advances of online coupling of sample preparation techniques with ultra high performance liquid Chromatography and supercritical fluid Chromatography
    IEEE Journal of Solid-state Circuits, 2019
    Co-Authors: Yanshan Liang, Ting Zhou
    Abstract:

    : Ultra high performance liquid Chromatography and supercritical fluid Chromatography techniques are favored because of their high efficiency and fast analysis speed. Although many sample preparation techniques have been coupled with common liquid Chromatography online, the online coupling of sample preparation with the two popular Chromatography techniques have gained increasing attention owing to the increasing requirements of efficiency and sensitivity. In this review, we have discussed and summarized the recent advances of the online coupling of sample preparation with ultra high performance liquid Chromatography and supercritical fluid Chromatography techniques. The main sample preparation techniques that have been coupled with ultra high performance liquid Chromatography online are solid-phase extraction and in-tube solid-phase microextraction, while solid-phase extraction and supercritical fluid extraction are the main techniques that have been coupled with supercritical fluid Chromatography online. Especially, the strategies for online coupling of sample preparation with Chromatography techniques were summarized. Typical applications and growing trends of the online coupling techniques were also discussed in detail. With the increasing demands of improving the efficiency, throughput, and analytical capability toward complex samples of the analysis methods, online coupling of sample preparation with Chromatography techniques will acquire further development.

Elise Lemasson – One of the best experts on this subject based on the ideXlab platform.

  • use and practice of achiral and chiral supercritical fluid Chromatography in pharmaceutical analysis and purification
    IEEE Journal of Solid-state Circuits, 2016
    Co-Authors: Elise Lemasson, Sophie Bertin, Caroline West
    Abstract:

    The interest of pharmaceutical companies for complementary high-performance chromatographic tools to assess a product’s purity or enhance this purity is on the rise. The high-throughput capability and economic benefits of supercritical fluid Chromatography, but also the “green” aspect of CO2 as the principal solvent, render supercritical fluid Chromatography very attractive for a wide range of pharmaceutical applications. The recent reintroduction of new robust instruments dedicated to supercritical fluid Chromatography and the progress in stationary phase technology have also greatly benefited supercritical fluid Chromatography. Additionally, it was shown several times that supercritical fluid Chromatography could be orthogonal to reversed-phase high-performance liquid Chromatography and could efficiently compete with it. Supercritical fluid Chromatography is an adequate tool for small molecules of pharmaceutical interest: synthetic intermediates, active pharmaceutical ingredients, impurities, or degradation products. In this review, we first discuss about general chromatographic conditions for supercritical fluid Chromatography analysis to better suit compounds of pharmaceutical interest. We also discuss about the use of achiral and chiral supercritical fluid Chromatography for analytical purposes and the recent applications in these areas. The use of preparative supercritical fluid Chromatography by pharmaceutical companies is also covered.

Haixia Zhou – One of the best experts on this subject based on the ideXlab platform.

  • development of automated online gel permeation Chromatography gas chromatograph mass spectrometry for measuring multiresidual pesticides in agricultural products
    Journal of Chromatography B, 2007
    Co-Authors: Yuki Hashi, Haixia Zhou
    Abstract:

    Abstract An automated online gel permeation Chromatographygas chromatograph mass spectrometer (GPC–GC/MS) was developed for the rapid determination of residual pesticides in agricultural products. Pesticides were extracted from homogenized food samples with acetonitrile and decontaminated via the matrix solid-phase dispersion (MSPD) technique, using a primary secondary amine as sorbent prior to GPC–GC/MS analysis. A slightly modified preparation method and automated GPC step proved useful in minimizing matrix interference. To evaluate the performance of the system, 97 target pesticides were spiked at a concentration of 0.1 mg/kg into a range of food types, including potato, cabbage, carrot, apple, orange, cucumber, and rice. A low flow rate of 0.1 mL/min in GPC resulted in a 40-fold reduction in solvent consumption compared with conventional GPC column applications. The combination of MSPD technique and GPC–GC/MS for the analysis of the 97 pesticides can be accomplished within 90 min. Most pesticides were recovered in the range of 70–120%, with relative standard deviation generally less than 10%. The results demonstrate that the method can be successfully applied with acceptable recoveries to a broad range of target pesticides within a diverse range of food types.