The Experts below are selected from a list of 123387 Experts worldwide ranked by ideXlab platform

Yuanfang Guan - One of the best experts on this subject based on the ideXlab platform.

  • functional networks of highest connected splice isoforms from the Chromosome 17 Human proteome project
    Journal of Proteome Research, 2015
    Co-Authors: Hongdong Li, Rajasree Menon, Brandon Govindarajoo, Bharat Panwar, Yang Zhang, Gilbert S Omenn, Yuanfang Guan
    Abstract:

    Alternative splicing allows a single gene to produce multiple transcript-level splice isoforms from which the translated proteins may show differences in their expression and function. Identifying the major functional or canonical isoform is important for understanding gene and protein functions. Identification and characterization of splice isoforms is a stated goal of the HUPO Human Proteome Project and of neXtProt. Multiple efforts have catalogued splice isoforms as “dominant”, “principal”, or “major” isoforms based on expression or evolutionary traits. In contrast, we recently proposed highest connected isoforms (HCIs) as a new class of canonical isoforms that have the strongest interactions in a functional network and revealed their significantly higher (differential) transcript-level expression compared to nonhighest connected isoforms (NCIs) regardless of tissues/cell lines in the mouse. HCIs and their expression behavior in the Human remain unexplored. Here we identified HCIs for 6157 multi-isofor...

Hongdong Li - One of the best experts on this subject based on the ideXlab platform.

  • functional networks of highest connected splice isoforms from the Chromosome 17 Human proteome project
    Journal of Proteome Research, 2015
    Co-Authors: Hongdong Li, Rajasree Menon, Brandon Govindarajoo, Bharat Panwar, Yang Zhang, Gilbert S Omenn, Yuanfang Guan
    Abstract:

    Alternative splicing allows a single gene to produce multiple transcript-level splice isoforms from which the translated proteins may show differences in their expression and function. Identifying the major functional or canonical isoform is important for understanding gene and protein functions. Identification and characterization of splice isoforms is a stated goal of the HUPO Human Proteome Project and of neXtProt. Multiple efforts have catalogued splice isoforms as “dominant”, “principal”, or “major” isoforms based on expression or evolutionary traits. In contrast, we recently proposed highest connected isoforms (HCIs) as a new class of canonical isoforms that have the strongest interactions in a functional network and revealed their significantly higher (differential) transcript-level expression compared to nonhighest connected isoforms (NCIs) regardless of tissues/cell lines in the mouse. HCIs and their expression behavior in the Human remain unexplored. Here we identified HCIs for 6157 multi-isofor...

Gilbert S Omenn - One of the best experts on this subject based on the ideXlab platform.

  • functional networks of highest connected splice isoforms from the Chromosome 17 Human proteome project
    Journal of Proteome Research, 2015
    Co-Authors: Hongdong Li, Rajasree Menon, Brandon Govindarajoo, Bharat Panwar, Yang Zhang, Gilbert S Omenn, Yuanfang Guan
    Abstract:

    Alternative splicing allows a single gene to produce multiple transcript-level splice isoforms from which the translated proteins may show differences in their expression and function. Identifying the major functional or canonical isoform is important for understanding gene and protein functions. Identification and characterization of splice isoforms is a stated goal of the HUPO Human Proteome Project and of neXtProt. Multiple efforts have catalogued splice isoforms as “dominant”, “principal”, or “major” isoforms based on expression or evolutionary traits. In contrast, we recently proposed highest connected isoforms (HCIs) as a new class of canonical isoforms that have the strongest interactions in a functional network and revealed their significantly higher (differential) transcript-level expression compared to nonhighest connected isoforms (NCIs) regardless of tissues/cell lines in the mouse. HCIs and their expression behavior in the Human remain unexplored. Here we identified HCIs for 6157 multi-isofor...

Yang Zhang - One of the best experts on this subject based on the ideXlab platform.

  • functional networks of highest connected splice isoforms from the Chromosome 17 Human proteome project
    Journal of Proteome Research, 2015
    Co-Authors: Hongdong Li, Rajasree Menon, Brandon Govindarajoo, Bharat Panwar, Yang Zhang, Gilbert S Omenn, Yuanfang Guan
    Abstract:

    Alternative splicing allows a single gene to produce multiple transcript-level splice isoforms from which the translated proteins may show differences in their expression and function. Identifying the major functional or canonical isoform is important for understanding gene and protein functions. Identification and characterization of splice isoforms is a stated goal of the HUPO Human Proteome Project and of neXtProt. Multiple efforts have catalogued splice isoforms as “dominant”, “principal”, or “major” isoforms based on expression or evolutionary traits. In contrast, we recently proposed highest connected isoforms (HCIs) as a new class of canonical isoforms that have the strongest interactions in a functional network and revealed their significantly higher (differential) transcript-level expression compared to nonhighest connected isoforms (NCIs) regardless of tissues/cell lines in the mouse. HCIs and their expression behavior in the Human remain unexplored. Here we identified HCIs for 6157 multi-isofor...

Bharat Panwar - One of the best experts on this subject based on the ideXlab platform.

  • functional networks of highest connected splice isoforms from the Chromosome 17 Human proteome project
    Journal of Proteome Research, 2015
    Co-Authors: Hongdong Li, Rajasree Menon, Brandon Govindarajoo, Bharat Panwar, Yang Zhang, Gilbert S Omenn, Yuanfang Guan
    Abstract:

    Alternative splicing allows a single gene to produce multiple transcript-level splice isoforms from which the translated proteins may show differences in their expression and function. Identifying the major functional or canonical isoform is important for understanding gene and protein functions. Identification and characterization of splice isoforms is a stated goal of the HUPO Human Proteome Project and of neXtProt. Multiple efforts have catalogued splice isoforms as “dominant”, “principal”, or “major” isoforms based on expression or evolutionary traits. In contrast, we recently proposed highest connected isoforms (HCIs) as a new class of canonical isoforms that have the strongest interactions in a functional network and revealed their significantly higher (differential) transcript-level expression compared to nonhighest connected isoforms (NCIs) regardless of tissues/cell lines in the mouse. HCIs and their expression behavior in the Human remain unexplored. Here we identified HCIs for 6157 multi-isofor...