The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform
Francesca Micci - One of the best experts on this subject based on the ideXlab platform.
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Chromosome 19 rearrangements in ovarian carcinomas: Zinc finger genes are particularly targeted
Genes chromosomes & cancer, 2014Co-Authors: Marianne Lislerud Smebye, Anita Sveen, Lisbeth Haugom, Ben Davidson, Claes G. Tropé, Ragnhild A. Lothe, Sverre Heim, Rolf Inge Skotheim, Francesca MicciAbstract:Chromosome 19 is frequently rearranged in ovarian carcinomas, but the pathogenetic consequences of this are not clearly understood. We performed microarray gene expression analysis on 12 ovarian carcinomas that carry a rearranged Chromosome 19 in their karyotype. These aberrant Chromosomes have previously been microdissected and analyzed by array-based CGH. In the current study, we wanted to explore whether the genomic alterations thus detected correlated with changes in gene expression. The microarray gene expression analysis gave information on 407 genes mapping in gained genomic regions on Chromosome 19, of which 92 showed association between DNA gain and upregulated expression. Of the genes showing this association, 39 (42%) showed gain in at least two samples. The majority of these 39 genes of interest (n = 24, 62%) encode zinc finger proteins, which otherwise make up only 15% of the approximately 1,400 genes on Chromosome 19. The strongest association was found for ZNF223 which was upregulated in samples with genomic gain compared with samples without gain. We suggest that DNA copy number changes brought about by rearrangements of Chromosome 19 contribute to ovarian carcinogenesis by leading to upregulation of ZNF223 and other zinc finger genes. © 2014 Wiley Periodicals, Inc.
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Array‐CGH analysis of microdissected Chromosome 19 markers in ovarian carcinoma identifies candidate target genes
Genes chromosomes & cancer, 2010Co-Authors: Francesca Micci, Lisbeth Haugom, Claes G. Tropé, Ragnhild A. Lothe, Rolf Inge Skotheim, Jorg Weimer, Vera M Abeler, Norbert Arnold, Anne Mette Eibak, Sverre HeimAbstract:Alterations of Chromosome 19 are among the most frequent cytogenetic changes in ovarian carcinomas. They usually occur as added extra material of unknown origin to 19p or, less frequently, 19q but sometimes as homogeneously staining regions. The precise nature of these markers, i.e., exactly which regions of Chromosome 19 are involved and from which Chromosome(s) the additional material comes, could only rarely be established. We have investigated by high resolution array-CGH a series of 29 Chromosome 19 markers after previous microdissection of ovarian carcinoma metaphases followed by FISH to determine where in Chromosome 19 the rearrangements took place as well as from which partner Chromosomes the additional material stems, obtaining informative results on 23 markers from 18 carcinomas. Along the entire Chromosome 19, a total of nine regions were found gained in 10 or more carcinomas (from 10 to 16) whereas 15 regions were gained in 6 to 10 markers. The most commonly gained region (16 markers) was observed in 19p13 between 20.80 Mbp and 20.85 Mbp from 19pter. According to the human genome 18 (hg18) NCBI 36, a total of 43 genes reside in the most commonly gained regions. Most of them (n = 31) code for zinc finger proteins. None of these genes is known to be involved in human neoplasia (the only exception is the ZNF91, which is found highly expressed in seminomas) but their frequent gain in the examined tumors makes all of them candidates for a pathogenetic role in ovarian carcinogenesis.
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reverse painting of microdissected Chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
Genes Chromosomes and Cancer, 2009Co-Authors: Francesca Micci, Lisbeth Haugom, Claes G. Tropé, Ragnhild A. Lothe, Rolf Inge Skotheim, Jorg Weimer, Regina Grunewald, Vera M Abeler, Ilvar Silins, Norbert ArnoldAbstract:Alterations of Chromosome bands 19p13 and 19q13 in the form of added extra material of unknown origin are among the most frequent cytogenetic changes in ovarian carcinomas. To investigate the chromosomal composition of the 19p+ and/or 19q+ markers, we selected for examination 26 ovarian carcinomas which by G-banding had one to four 19p+ and/or 19q+, in total 37 markers. These cases were then subjected to chromosomal microdissection with subsequent reverse painting, which gave informative results on 29 markers. The breakpoints on Chromosome 19 were located in both the short (p; n = 15) and the long (q; n = 10) arms, as well as in the centromeric (n = 2) and pericentromeric (n = 6) region. The analysis showed that many Chromosomes added material to Chromosome 19, but the Chromosome arms 11q, 21q, and 22q were particularly common donors. Homogeneously staining regions (hsr) were seen in only three markers, in all of them consisting of 19p material. Eighteen markers were derived from an unbalanced translocation involving Chromosome 19. In five markers, Chromosome 19 was rearranged with two Chromosomes. The most complex marker showed Chromosome 19 rearranged with three other Chromosomes, i.e., X, 13, and 16. In five markers, all of the additional material stemmed from Chromosome 19 itself. This is the first large Chromosome microdissection/FISH study of Chromosome 19 markers in ovarian carcinomas. A detailed map of the rearrangements should provide clues to the positions of oncogenes and potential fusion genes important in ovarian carcinogenesis.
Rolf Inge Skotheim - One of the best experts on this subject based on the ideXlab platform.
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Chromosome 19 rearrangements in ovarian carcinomas: Zinc finger genes are particularly targeted
Genes chromosomes & cancer, 2014Co-Authors: Marianne Lislerud Smebye, Anita Sveen, Lisbeth Haugom, Ben Davidson, Claes G. Tropé, Ragnhild A. Lothe, Sverre Heim, Rolf Inge Skotheim, Francesca MicciAbstract:Chromosome 19 is frequently rearranged in ovarian carcinomas, but the pathogenetic consequences of this are not clearly understood. We performed microarray gene expression analysis on 12 ovarian carcinomas that carry a rearranged Chromosome 19 in their karyotype. These aberrant Chromosomes have previously been microdissected and analyzed by array-based CGH. In the current study, we wanted to explore whether the genomic alterations thus detected correlated with changes in gene expression. The microarray gene expression analysis gave information on 407 genes mapping in gained genomic regions on Chromosome 19, of which 92 showed association between DNA gain and upregulated expression. Of the genes showing this association, 39 (42%) showed gain in at least two samples. The majority of these 39 genes of interest (n = 24, 62%) encode zinc finger proteins, which otherwise make up only 15% of the approximately 1,400 genes on Chromosome 19. The strongest association was found for ZNF223 which was upregulated in samples with genomic gain compared with samples without gain. We suggest that DNA copy number changes brought about by rearrangements of Chromosome 19 contribute to ovarian carcinogenesis by leading to upregulation of ZNF223 and other zinc finger genes. © 2014 Wiley Periodicals, Inc.
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Array‐CGH analysis of microdissected Chromosome 19 markers in ovarian carcinoma identifies candidate target genes
Genes chromosomes & cancer, 2010Co-Authors: Francesca Micci, Lisbeth Haugom, Claes G. Tropé, Ragnhild A. Lothe, Rolf Inge Skotheim, Jorg Weimer, Vera M Abeler, Norbert Arnold, Anne Mette Eibak, Sverre HeimAbstract:Alterations of Chromosome 19 are among the most frequent cytogenetic changes in ovarian carcinomas. They usually occur as added extra material of unknown origin to 19p or, less frequently, 19q but sometimes as homogeneously staining regions. The precise nature of these markers, i.e., exactly which regions of Chromosome 19 are involved and from which Chromosome(s) the additional material comes, could only rarely be established. We have investigated by high resolution array-CGH a series of 29 Chromosome 19 markers after previous microdissection of ovarian carcinoma metaphases followed by FISH to determine where in Chromosome 19 the rearrangements took place as well as from which partner Chromosomes the additional material stems, obtaining informative results on 23 markers from 18 carcinomas. Along the entire Chromosome 19, a total of nine regions were found gained in 10 or more carcinomas (from 10 to 16) whereas 15 regions were gained in 6 to 10 markers. The most commonly gained region (16 markers) was observed in 19p13 between 20.80 Mbp and 20.85 Mbp from 19pter. According to the human genome 18 (hg18) NCBI 36, a total of 43 genes reside in the most commonly gained regions. Most of them (n = 31) code for zinc finger proteins. None of these genes is known to be involved in human neoplasia (the only exception is the ZNF91, which is found highly expressed in seminomas) but their frequent gain in the examined tumors makes all of them candidates for a pathogenetic role in ovarian carcinogenesis.
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reverse painting of microdissected Chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
Genes Chromosomes and Cancer, 2009Co-Authors: Francesca Micci, Lisbeth Haugom, Claes G. Tropé, Ragnhild A. Lothe, Rolf Inge Skotheim, Jorg Weimer, Regina Grunewald, Vera M Abeler, Ilvar Silins, Norbert ArnoldAbstract:Alterations of Chromosome bands 19p13 and 19q13 in the form of added extra material of unknown origin are among the most frequent cytogenetic changes in ovarian carcinomas. To investigate the chromosomal composition of the 19p+ and/or 19q+ markers, we selected for examination 26 ovarian carcinomas which by G-banding had one to four 19p+ and/or 19q+, in total 37 markers. These cases were then subjected to chromosomal microdissection with subsequent reverse painting, which gave informative results on 29 markers. The breakpoints on Chromosome 19 were located in both the short (p; n = 15) and the long (q; n = 10) arms, as well as in the centromeric (n = 2) and pericentromeric (n = 6) region. The analysis showed that many Chromosomes added material to Chromosome 19, but the Chromosome arms 11q, 21q, and 22q were particularly common donors. Homogeneously staining regions (hsr) were seen in only three markers, in all of them consisting of 19p material. Eighteen markers were derived from an unbalanced translocation involving Chromosome 19. In five markers, Chromosome 19 was rearranged with two Chromosomes. The most complex marker showed Chromosome 19 rearranged with three other Chromosomes, i.e., X, 13, and 16. In five markers, all of the additional material stemmed from Chromosome 19 itself. This is the first large Chromosome microdissection/FISH study of Chromosome 19 markers in ovarian carcinomas. A detailed map of the rearrangements should provide clues to the positions of oncogenes and potential fusion genes important in ovarian carcinogenesis.
Lisbeth Haugom - One of the best experts on this subject based on the ideXlab platform.
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Chromosome 19 rearrangements in ovarian carcinomas: Zinc finger genes are particularly targeted
Genes chromosomes & cancer, 2014Co-Authors: Marianne Lislerud Smebye, Anita Sveen, Lisbeth Haugom, Ben Davidson, Claes G. Tropé, Ragnhild A. Lothe, Sverre Heim, Rolf Inge Skotheim, Francesca MicciAbstract:Chromosome 19 is frequently rearranged in ovarian carcinomas, but the pathogenetic consequences of this are not clearly understood. We performed microarray gene expression analysis on 12 ovarian carcinomas that carry a rearranged Chromosome 19 in their karyotype. These aberrant Chromosomes have previously been microdissected and analyzed by array-based CGH. In the current study, we wanted to explore whether the genomic alterations thus detected correlated with changes in gene expression. The microarray gene expression analysis gave information on 407 genes mapping in gained genomic regions on Chromosome 19, of which 92 showed association between DNA gain and upregulated expression. Of the genes showing this association, 39 (42%) showed gain in at least two samples. The majority of these 39 genes of interest (n = 24, 62%) encode zinc finger proteins, which otherwise make up only 15% of the approximately 1,400 genes on Chromosome 19. The strongest association was found for ZNF223 which was upregulated in samples with genomic gain compared with samples without gain. We suggest that DNA copy number changes brought about by rearrangements of Chromosome 19 contribute to ovarian carcinogenesis by leading to upregulation of ZNF223 and other zinc finger genes. © 2014 Wiley Periodicals, Inc.
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Array‐CGH analysis of microdissected Chromosome 19 markers in ovarian carcinoma identifies candidate target genes
Genes chromosomes & cancer, 2010Co-Authors: Francesca Micci, Lisbeth Haugom, Claes G. Tropé, Ragnhild A. Lothe, Rolf Inge Skotheim, Jorg Weimer, Vera M Abeler, Norbert Arnold, Anne Mette Eibak, Sverre HeimAbstract:Alterations of Chromosome 19 are among the most frequent cytogenetic changes in ovarian carcinomas. They usually occur as added extra material of unknown origin to 19p or, less frequently, 19q but sometimes as homogeneously staining regions. The precise nature of these markers, i.e., exactly which regions of Chromosome 19 are involved and from which Chromosome(s) the additional material comes, could only rarely be established. We have investigated by high resolution array-CGH a series of 29 Chromosome 19 markers after previous microdissection of ovarian carcinoma metaphases followed by FISH to determine where in Chromosome 19 the rearrangements took place as well as from which partner Chromosomes the additional material stems, obtaining informative results on 23 markers from 18 carcinomas. Along the entire Chromosome 19, a total of nine regions were found gained in 10 or more carcinomas (from 10 to 16) whereas 15 regions were gained in 6 to 10 markers. The most commonly gained region (16 markers) was observed in 19p13 between 20.80 Mbp and 20.85 Mbp from 19pter. According to the human genome 18 (hg18) NCBI 36, a total of 43 genes reside in the most commonly gained regions. Most of them (n = 31) code for zinc finger proteins. None of these genes is known to be involved in human neoplasia (the only exception is the ZNF91, which is found highly expressed in seminomas) but their frequent gain in the examined tumors makes all of them candidates for a pathogenetic role in ovarian carcinogenesis.
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reverse painting of microdissected Chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
Genes Chromosomes and Cancer, 2009Co-Authors: Francesca Micci, Lisbeth Haugom, Claes G. Tropé, Ragnhild A. Lothe, Rolf Inge Skotheim, Jorg Weimer, Regina Grunewald, Vera M Abeler, Ilvar Silins, Norbert ArnoldAbstract:Alterations of Chromosome bands 19p13 and 19q13 in the form of added extra material of unknown origin are among the most frequent cytogenetic changes in ovarian carcinomas. To investigate the chromosomal composition of the 19p+ and/or 19q+ markers, we selected for examination 26 ovarian carcinomas which by G-banding had one to four 19p+ and/or 19q+, in total 37 markers. These cases were then subjected to chromosomal microdissection with subsequent reverse painting, which gave informative results on 29 markers. The breakpoints on Chromosome 19 were located in both the short (p; n = 15) and the long (q; n = 10) arms, as well as in the centromeric (n = 2) and pericentromeric (n = 6) region. The analysis showed that many Chromosomes added material to Chromosome 19, but the Chromosome arms 11q, 21q, and 22q were particularly common donors. Homogeneously staining regions (hsr) were seen in only three markers, in all of them consisting of 19p material. Eighteen markers were derived from an unbalanced translocation involving Chromosome 19. In five markers, Chromosome 19 was rearranged with two Chromosomes. The most complex marker showed Chromosome 19 rearranged with three other Chromosomes, i.e., X, 13, and 16. In five markers, all of the additional material stemmed from Chromosome 19 itself. This is the first large Chromosome microdissection/FISH study of Chromosome 19 markers in ovarian carcinomas. A detailed map of the rearrangements should provide clues to the positions of oncogenes and potential fusion genes important in ovarian carcinogenesis.
Ragnhild A. Lothe - One of the best experts on this subject based on the ideXlab platform.
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Chromosome 19 rearrangements in ovarian carcinomas: Zinc finger genes are particularly targeted
Genes chromosomes & cancer, 2014Co-Authors: Marianne Lislerud Smebye, Anita Sveen, Lisbeth Haugom, Ben Davidson, Claes G. Tropé, Ragnhild A. Lothe, Sverre Heim, Rolf Inge Skotheim, Francesca MicciAbstract:Chromosome 19 is frequently rearranged in ovarian carcinomas, but the pathogenetic consequences of this are not clearly understood. We performed microarray gene expression analysis on 12 ovarian carcinomas that carry a rearranged Chromosome 19 in their karyotype. These aberrant Chromosomes have previously been microdissected and analyzed by array-based CGH. In the current study, we wanted to explore whether the genomic alterations thus detected correlated with changes in gene expression. The microarray gene expression analysis gave information on 407 genes mapping in gained genomic regions on Chromosome 19, of which 92 showed association between DNA gain and upregulated expression. Of the genes showing this association, 39 (42%) showed gain in at least two samples. The majority of these 39 genes of interest (n = 24, 62%) encode zinc finger proteins, which otherwise make up only 15% of the approximately 1,400 genes on Chromosome 19. The strongest association was found for ZNF223 which was upregulated in samples with genomic gain compared with samples without gain. We suggest that DNA copy number changes brought about by rearrangements of Chromosome 19 contribute to ovarian carcinogenesis by leading to upregulation of ZNF223 and other zinc finger genes. © 2014 Wiley Periodicals, Inc.
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Array‐CGH analysis of microdissected Chromosome 19 markers in ovarian carcinoma identifies candidate target genes
Genes chromosomes & cancer, 2010Co-Authors: Francesca Micci, Lisbeth Haugom, Claes G. Tropé, Ragnhild A. Lothe, Rolf Inge Skotheim, Jorg Weimer, Vera M Abeler, Norbert Arnold, Anne Mette Eibak, Sverre HeimAbstract:Alterations of Chromosome 19 are among the most frequent cytogenetic changes in ovarian carcinomas. They usually occur as added extra material of unknown origin to 19p or, less frequently, 19q but sometimes as homogeneously staining regions. The precise nature of these markers, i.e., exactly which regions of Chromosome 19 are involved and from which Chromosome(s) the additional material comes, could only rarely be established. We have investigated by high resolution array-CGH a series of 29 Chromosome 19 markers after previous microdissection of ovarian carcinoma metaphases followed by FISH to determine where in Chromosome 19 the rearrangements took place as well as from which partner Chromosomes the additional material stems, obtaining informative results on 23 markers from 18 carcinomas. Along the entire Chromosome 19, a total of nine regions were found gained in 10 or more carcinomas (from 10 to 16) whereas 15 regions were gained in 6 to 10 markers. The most commonly gained region (16 markers) was observed in 19p13 between 20.80 Mbp and 20.85 Mbp from 19pter. According to the human genome 18 (hg18) NCBI 36, a total of 43 genes reside in the most commonly gained regions. Most of them (n = 31) code for zinc finger proteins. None of these genes is known to be involved in human neoplasia (the only exception is the ZNF91, which is found highly expressed in seminomas) but their frequent gain in the examined tumors makes all of them candidates for a pathogenetic role in ovarian carcinogenesis.
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reverse painting of microdissected Chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
Genes Chromosomes and Cancer, 2009Co-Authors: Francesca Micci, Lisbeth Haugom, Claes G. Tropé, Ragnhild A. Lothe, Rolf Inge Skotheim, Jorg Weimer, Regina Grunewald, Vera M Abeler, Ilvar Silins, Norbert ArnoldAbstract:Alterations of Chromosome bands 19p13 and 19q13 in the form of added extra material of unknown origin are among the most frequent cytogenetic changes in ovarian carcinomas. To investigate the chromosomal composition of the 19p+ and/or 19q+ markers, we selected for examination 26 ovarian carcinomas which by G-banding had one to four 19p+ and/or 19q+, in total 37 markers. These cases were then subjected to chromosomal microdissection with subsequent reverse painting, which gave informative results on 29 markers. The breakpoints on Chromosome 19 were located in both the short (p; n = 15) and the long (q; n = 10) arms, as well as in the centromeric (n = 2) and pericentromeric (n = 6) region. The analysis showed that many Chromosomes added material to Chromosome 19, but the Chromosome arms 11q, 21q, and 22q were particularly common donors. Homogeneously staining regions (hsr) were seen in only three markers, in all of them consisting of 19p material. Eighteen markers were derived from an unbalanced translocation involving Chromosome 19. In five markers, Chromosome 19 was rearranged with two Chromosomes. The most complex marker showed Chromosome 19 rearranged with three other Chromosomes, i.e., X, 13, and 16. In five markers, all of the additional material stemmed from Chromosome 19 itself. This is the first large Chromosome microdissection/FISH study of Chromosome 19 markers in ovarian carcinomas. A detailed map of the rearrangements should provide clues to the positions of oncogenes and potential fusion genes important in ovarian carcinogenesis.
Claes G. Tropé - One of the best experts on this subject based on the ideXlab platform.
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Chromosome 19 rearrangements in ovarian carcinomas: Zinc finger genes are particularly targeted
Genes chromosomes & cancer, 2014Co-Authors: Marianne Lislerud Smebye, Anita Sveen, Lisbeth Haugom, Ben Davidson, Claes G. Tropé, Ragnhild A. Lothe, Sverre Heim, Rolf Inge Skotheim, Francesca MicciAbstract:Chromosome 19 is frequently rearranged in ovarian carcinomas, but the pathogenetic consequences of this are not clearly understood. We performed microarray gene expression analysis on 12 ovarian carcinomas that carry a rearranged Chromosome 19 in their karyotype. These aberrant Chromosomes have previously been microdissected and analyzed by array-based CGH. In the current study, we wanted to explore whether the genomic alterations thus detected correlated with changes in gene expression. The microarray gene expression analysis gave information on 407 genes mapping in gained genomic regions on Chromosome 19, of which 92 showed association between DNA gain and upregulated expression. Of the genes showing this association, 39 (42%) showed gain in at least two samples. The majority of these 39 genes of interest (n = 24, 62%) encode zinc finger proteins, which otherwise make up only 15% of the approximately 1,400 genes on Chromosome 19. The strongest association was found for ZNF223 which was upregulated in samples with genomic gain compared with samples without gain. We suggest that DNA copy number changes brought about by rearrangements of Chromosome 19 contribute to ovarian carcinogenesis by leading to upregulation of ZNF223 and other zinc finger genes. © 2014 Wiley Periodicals, Inc.
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Array‐CGH analysis of microdissected Chromosome 19 markers in ovarian carcinoma identifies candidate target genes
Genes chromosomes & cancer, 2010Co-Authors: Francesca Micci, Lisbeth Haugom, Claes G. Tropé, Ragnhild A. Lothe, Rolf Inge Skotheim, Jorg Weimer, Vera M Abeler, Norbert Arnold, Anne Mette Eibak, Sverre HeimAbstract:Alterations of Chromosome 19 are among the most frequent cytogenetic changes in ovarian carcinomas. They usually occur as added extra material of unknown origin to 19p or, less frequently, 19q but sometimes as homogeneously staining regions. The precise nature of these markers, i.e., exactly which regions of Chromosome 19 are involved and from which Chromosome(s) the additional material comes, could only rarely be established. We have investigated by high resolution array-CGH a series of 29 Chromosome 19 markers after previous microdissection of ovarian carcinoma metaphases followed by FISH to determine where in Chromosome 19 the rearrangements took place as well as from which partner Chromosomes the additional material stems, obtaining informative results on 23 markers from 18 carcinomas. Along the entire Chromosome 19, a total of nine regions were found gained in 10 or more carcinomas (from 10 to 16) whereas 15 regions were gained in 6 to 10 markers. The most commonly gained region (16 markers) was observed in 19p13 between 20.80 Mbp and 20.85 Mbp from 19pter. According to the human genome 18 (hg18) NCBI 36, a total of 43 genes reside in the most commonly gained regions. Most of them (n = 31) code for zinc finger proteins. None of these genes is known to be involved in human neoplasia (the only exception is the ZNF91, which is found highly expressed in seminomas) but their frequent gain in the examined tumors makes all of them candidates for a pathogenetic role in ovarian carcinogenesis.
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reverse painting of microdissected Chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
Genes Chromosomes and Cancer, 2009Co-Authors: Francesca Micci, Lisbeth Haugom, Claes G. Tropé, Ragnhild A. Lothe, Rolf Inge Skotheim, Jorg Weimer, Regina Grunewald, Vera M Abeler, Ilvar Silins, Norbert ArnoldAbstract:Alterations of Chromosome bands 19p13 and 19q13 in the form of added extra material of unknown origin are among the most frequent cytogenetic changes in ovarian carcinomas. To investigate the chromosomal composition of the 19p+ and/or 19q+ markers, we selected for examination 26 ovarian carcinomas which by G-banding had one to four 19p+ and/or 19q+, in total 37 markers. These cases were then subjected to chromosomal microdissection with subsequent reverse painting, which gave informative results on 29 markers. The breakpoints on Chromosome 19 were located in both the short (p; n = 15) and the long (q; n = 10) arms, as well as in the centromeric (n = 2) and pericentromeric (n = 6) region. The analysis showed that many Chromosomes added material to Chromosome 19, but the Chromosome arms 11q, 21q, and 22q were particularly common donors. Homogeneously staining regions (hsr) were seen in only three markers, in all of them consisting of 19p material. Eighteen markers were derived from an unbalanced translocation involving Chromosome 19. In five markers, Chromosome 19 was rearranged with two Chromosomes. The most complex marker showed Chromosome 19 rearranged with three other Chromosomes, i.e., X, 13, and 16. In five markers, all of the additional material stemmed from Chromosome 19 itself. This is the first large Chromosome microdissection/FISH study of Chromosome 19 markers in ovarian carcinomas. A detailed map of the rearrangements should provide clues to the positions of oncogenes and potential fusion genes important in ovarian carcinogenesis.