The Experts below are selected from a list of 180 Experts worldwide ranked by ideXlab platform

Kyung-sik Song - One of the best experts on this subject based on the ideXlab platform.

  • β-Secretase(BACE1) inhibitors from pomegranate (Punica granatum) husk
    Archives of Pharmacal Research, 2005
    Co-Authors: Hye-min Kwak, So-young Jeon, Bang-ho Sohng, Jong-guk Kim, Jin-man Lee, Kyung-bok Lee, Hyun-hee Jeong, Jong-moon Hur, Young-hwa Kang, Kyung-sik Song
    Abstract:

    In the course of screening for anti-dementia agents from natural products, two β-secretase (BACE1) inhibitors were isolated from the husk of pomegranate (Punica granatum) by activity-guided purification. They were identified as ellagic acid and punicalagin with IC_50 values of 3.9 x10^-6 and 4.1x10^-7 M and Ki values of 2.4x10^-5 and 5.9x10^-7 M, respectively. The compounds were non-competitive inhibitors with a substrate in the Dixon plot. Ellagic acid and punicalagin were less inhibitory to α-secretase (TACE) and other serine proteases such as ChymoTrypsin, Trypsin, and elastase, thus indicating that they were relatively specific inhibitors of BACE1.

  • β-Secretase(BACE1) inhibitors from pomegranate ( Punica granatum ) husk
    Archives of pharmacal research, 2005
    Co-Authors: Hye-min Kwak, So-young Jeon, Bang-ho Sohng, Jong-guk Kim, Jin-man Lee, Kyung-bok Lee, Hyun-hee Jeong, Jong-moon Hur, Young-hwa Kang, Kyung-sik Song
    Abstract:

    In the course of screening for anti-dementia agents from natural products, two beta-secretase (BACE1) inhibitors were isolated from the husk of pomegranate (Punica granatum) by activity-guided purification. They were identified as ellagic acid and punicalagin with IC50 values of 3.9 x10(-6) and 4.1x10(-7) M and Ki values of 2.4x10(-5) and 5.9x10(-7) M, respectively. The compounds were non-competitive inhibitors with a substrate in the Dixon plot. Ellagic acid and punicalagin were less inhibitory to alpha-secretase (TACE) and other serine proteases such as ChymoTrypsin, Trypsin, and elastase, thus indicating that they were relatively specific inhibitors of BACE1.

  • A β-Secretase (BACE1) Inhibitor Hispidin from the Mycelial Cultures of Phellinus linteus
    Planta medica, 2004
    Co-Authors: In-hye Park, So-young Jeon, Hee-ju Lee, Sang-in Kim, Kyung-sik Song
    Abstract:

    In the course of screening for anti-dementia agents from natural products, a beta-secretase (BACE1) inhibitor was isolated from the culture broth of Phellinus linteus and identified as hispidin. It showed an IC (50) value of 4.9 x 10 (-6) M and a Ki value of 8.4 x 10 (-6) M. The compound was a non-competitive inhibitor. Hispidin also inhibited a prolyl endopeptidase (IC (50) = 1.6 x 10 (-5) M, Ki = 2.4 x 10 (-5) M), but it was less inhibitory to alpha-secretase (TACE) and other serine proteases such as ChymoTrypsin, Trypsin, and elastase.

  • A prolyl endopeptidase-inhibiting antioxidant from Phyllanthus ussurensis.
    Archives of pharmacal research, 2003
    Co-Authors: Shin-kyo Chung, So-young Jeon, Hee-ju Lee, Sang-in Kim, Ji-ae Nam, Tai Ho Chung, Kyung-sik Song
    Abstract:

    A prolyl endopeptidase inhibitor was isolated from the ethyl acetate soluble fraction ofPhyllanthus ussurensis. The active compound was identified as an ellagitannin, corilagin. It was shown to non-competitively inhibit prolyl endopeptidase (PEP) with the IC50 value of 1.17x10-6 μM. TheKi value was 6.70x10-7 M. Corilagin was less inhibitory to other serine proteases such as ChymoTrypsin, Trypsin, and elastase, indicating that it was relatively a specific inhibitor of PEP. Corilagin also effectively inhibited reactive oxygen species such as hydroxide and superoxide anion radical, hydrogen peroxide, and DPPH. Especially, corilagin showed potent scavenging activity on the superoxide anion radical in the ESR method (IC50 = 3.79x10-6 M) as well as xanthine oxidase system.

  • A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex.
    Journal of natural products, 2002
    Co-Authors: Kyung-sik Song, Ilya Raskin
    Abstract:

    A new benzofuran dimer, 5,6,5‘,6‘-tetrahydroxy[3,3‘]bibenzofuranyl-2,2‘-dicarboxylic acid dimethyl ester (kynapcin-24), was isolated from Polyozellus multiflex and shown to noncompetitively inhibit prolyl endopeptidase (PEP), with an IC50 value of 1.14 μM. Kynapcin-24 was less inhibitory to other serine proteases such as ChymoTrypsin, Trypsin, and elastase.

So-young Jeon - One of the best experts on this subject based on the ideXlab platform.

  • β-Secretase(BACE1) inhibitors from pomegranate (Punica granatum) husk
    Archives of Pharmacal Research, 2005
    Co-Authors: Hye-min Kwak, So-young Jeon, Bang-ho Sohng, Jong-guk Kim, Jin-man Lee, Kyung-bok Lee, Hyun-hee Jeong, Jong-moon Hur, Young-hwa Kang, Kyung-sik Song
    Abstract:

    In the course of screening for anti-dementia agents from natural products, two β-secretase (BACE1) inhibitors were isolated from the husk of pomegranate (Punica granatum) by activity-guided purification. They were identified as ellagic acid and punicalagin with IC_50 values of 3.9 x10^-6 and 4.1x10^-7 M and Ki values of 2.4x10^-5 and 5.9x10^-7 M, respectively. The compounds were non-competitive inhibitors with a substrate in the Dixon plot. Ellagic acid and punicalagin were less inhibitory to α-secretase (TACE) and other serine proteases such as ChymoTrypsin, Trypsin, and elastase, thus indicating that they were relatively specific inhibitors of BACE1.

  • β-Secretase(BACE1) inhibitors from pomegranate ( Punica granatum ) husk
    Archives of pharmacal research, 2005
    Co-Authors: Hye-min Kwak, So-young Jeon, Bang-ho Sohng, Jong-guk Kim, Jin-man Lee, Kyung-bok Lee, Hyun-hee Jeong, Jong-moon Hur, Young-hwa Kang, Kyung-sik Song
    Abstract:

    In the course of screening for anti-dementia agents from natural products, two beta-secretase (BACE1) inhibitors were isolated from the husk of pomegranate (Punica granatum) by activity-guided purification. They were identified as ellagic acid and punicalagin with IC50 values of 3.9 x10(-6) and 4.1x10(-7) M and Ki values of 2.4x10(-5) and 5.9x10(-7) M, respectively. The compounds were non-competitive inhibitors with a substrate in the Dixon plot. Ellagic acid and punicalagin were less inhibitory to alpha-secretase (TACE) and other serine proteases such as ChymoTrypsin, Trypsin, and elastase, thus indicating that they were relatively specific inhibitors of BACE1.

  • A β-Secretase (BACE1) Inhibitor Hispidin from the Mycelial Cultures of Phellinus linteus
    Planta medica, 2004
    Co-Authors: In-hye Park, So-young Jeon, Hee-ju Lee, Sang-in Kim, Kyung-sik Song
    Abstract:

    In the course of screening for anti-dementia agents from natural products, a beta-secretase (BACE1) inhibitor was isolated from the culture broth of Phellinus linteus and identified as hispidin. It showed an IC (50) value of 4.9 x 10 (-6) M and a Ki value of 8.4 x 10 (-6) M. The compound was a non-competitive inhibitor. Hispidin also inhibited a prolyl endopeptidase (IC (50) = 1.6 x 10 (-5) M, Ki = 2.4 x 10 (-5) M), but it was less inhibitory to alpha-secretase (TACE) and other serine proteases such as ChymoTrypsin, Trypsin, and elastase.

  • A prolyl endopeptidase-inhibiting antioxidant from Phyllanthus ussurensis.
    Archives of pharmacal research, 2003
    Co-Authors: Shin-kyo Chung, So-young Jeon, Hee-ju Lee, Sang-in Kim, Ji-ae Nam, Tai Ho Chung, Kyung-sik Song
    Abstract:

    A prolyl endopeptidase inhibitor was isolated from the ethyl acetate soluble fraction ofPhyllanthus ussurensis. The active compound was identified as an ellagitannin, corilagin. It was shown to non-competitively inhibit prolyl endopeptidase (PEP) with the IC50 value of 1.17x10-6 μM. TheKi value was 6.70x10-7 M. Corilagin was less inhibitory to other serine proteases such as ChymoTrypsin, Trypsin, and elastase, indicating that it was relatively a specific inhibitor of PEP. Corilagin also effectively inhibited reactive oxygen species such as hydroxide and superoxide anion radical, hydrogen peroxide, and DPPH. Especially, corilagin showed potent scavenging activity on the superoxide anion radical in the ESR method (IC50 = 3.79x10-6 M) as well as xanthine oxidase system.

Yehudith Birk - One of the best experts on this subject based on the ideXlab platform.

Hye-min Kwak - One of the best experts on this subject based on the ideXlab platform.

  • β-Secretase(BACE1) inhibitors from pomegranate (Punica granatum) husk
    Archives of Pharmacal Research, 2005
    Co-Authors: Hye-min Kwak, So-young Jeon, Bang-ho Sohng, Jong-guk Kim, Jin-man Lee, Kyung-bok Lee, Hyun-hee Jeong, Jong-moon Hur, Young-hwa Kang, Kyung-sik Song
    Abstract:

    In the course of screening for anti-dementia agents from natural products, two β-secretase (BACE1) inhibitors were isolated from the husk of pomegranate (Punica granatum) by activity-guided purification. They were identified as ellagic acid and punicalagin with IC_50 values of 3.9 x10^-6 and 4.1x10^-7 M and Ki values of 2.4x10^-5 and 5.9x10^-7 M, respectively. The compounds were non-competitive inhibitors with a substrate in the Dixon plot. Ellagic acid and punicalagin were less inhibitory to α-secretase (TACE) and other serine proteases such as ChymoTrypsin, Trypsin, and elastase, thus indicating that they were relatively specific inhibitors of BACE1.

  • β-Secretase(BACE1) inhibitors from pomegranate ( Punica granatum ) husk
    Archives of pharmacal research, 2005
    Co-Authors: Hye-min Kwak, So-young Jeon, Bang-ho Sohng, Jong-guk Kim, Jin-man Lee, Kyung-bok Lee, Hyun-hee Jeong, Jong-moon Hur, Young-hwa Kang, Kyung-sik Song
    Abstract:

    In the course of screening for anti-dementia agents from natural products, two beta-secretase (BACE1) inhibitors were isolated from the husk of pomegranate (Punica granatum) by activity-guided purification. They were identified as ellagic acid and punicalagin with IC50 values of 3.9 x10(-6) and 4.1x10(-7) M and Ki values of 2.4x10(-5) and 5.9x10(-7) M, respectively. The compounds were non-competitive inhibitors with a substrate in the Dixon plot. Ellagic acid and punicalagin were less inhibitory to alpha-secretase (TACE) and other serine proteases such as ChymoTrypsin, Trypsin, and elastase, thus indicating that they were relatively specific inhibitors of BACE1.

Isaac Ishaaya - One of the best experts on this subject based on the ideXlab platform.