The Experts below are selected from a list of 1056 Experts worldwide ranked by ideXlab platform
H. Haghani - One of the best experts on this subject based on the ideXlab platform.
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Post menopausal women's sexual satisfaction: Effect of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum: A randomized controlled clinical trial
European Psychiatry, 2020Co-Authors: S. Taavoni, N. Nazem Ekbatani, S.a. Gooshegir, H. HaghaniAbstract:Sexual satisfaction decreases during postmenopause life and may improve by various methods of complementary therapy such as use of herbal medicine.AimTo asses the effect of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum on postmenopausal women's sexual satisfaction.MethodsIn this triple blind randomized control clinical trial, 80 healthy volunteer postmenopause women with age 50–60 years old in one of clinics of west of Tehran had been involved (year 2013–2014). Participants were randomly assigned to intervention and placebo group and received one month same shape capsules two times in a day. Tools of this study had two main parts of personal characteristics and sexual satisfaction. All ethical points were considered and approved by Ethics committee of Research Institute for Islamic & Complementary Medicine (RICM, IUMS).ResultsAfter a month intervention, there is significant increase in the mean score of sexual satisfaction between two groups (P = 0.01), but when sexual satisfaction compared with pre-menopausal time in two groups, t-test results showed no significant difference (P = 0.16).ConclusionsUse of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum two times a day for a month could improve sexual satisfaction in postmenopausal women. Referring to no significant change with comparing premenopause time, it sounds they have same satisfaction as premenopause time. There were no side effects during study and one month follow-up. It is suggested to do same research on sexual satisfaction and function with more month intervention.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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post menopausal women s sexual satisfaction effect of oral capsule of mixed tribulus terrestris zingiber officinale crocus sativus and Cinnamomum Verum a randomized controlled clinical trial
European Psychiatry, 2016Co-Authors: S. Taavoni, S.a. Gooshegir, Nazem N Ekbatani, H. HaghaniAbstract:Sexual satisfaction decreases during postmenopause life and may improve by various methods of complementary therapy such as use of herbal medicine. Aim To asses the effect of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum on postmenopausal women's sexual satisfaction. Methods In this triple blind randomized control clinical trial, 80 healthy volunteer postmenopause women with age 50–60 years old in one of clinics of west of Tehran had been involved (year 2013–2014). Participants were randomly assigned to intervention and placebo group and received one month same shape capsules two times in a day. Tools of this study had two main parts of personal characteristics and sexual satisfaction. All ethical points were considered and approved by Ethics committee of Research Institute for Islamic & Complementary Medicine (RICM, IUMS). Results After a month intervention, there is significant increase in the mean score of sexual satisfaction between two groups ( P = 0.01), but when sexual satisfaction compared with pre-menopausal time in two groups, t -test results showed no significant difference ( P = 0.16). Conclusions Use of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum two times a day for a month could improve sexual satisfaction in postmenopausal women. Referring to no significant change with comparing premenopause time, it sounds they have same satisfaction as premenopause time. There were no side effects during study and one month follow-up. It is suggested to do same research on sexual satisfaction and function with more month intervention.
S. Taavoni - One of the best experts on this subject based on the ideXlab platform.
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Post menopausal women's sexual satisfaction: Effect of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum: A randomized controlled clinical trial
European Psychiatry, 2020Co-Authors: S. Taavoni, N. Nazem Ekbatani, S.a. Gooshegir, H. HaghaniAbstract:Sexual satisfaction decreases during postmenopause life and may improve by various methods of complementary therapy such as use of herbal medicine.AimTo asses the effect of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum on postmenopausal women's sexual satisfaction.MethodsIn this triple blind randomized control clinical trial, 80 healthy volunteer postmenopause women with age 50–60 years old in one of clinics of west of Tehran had been involved (year 2013–2014). Participants were randomly assigned to intervention and placebo group and received one month same shape capsules two times in a day. Tools of this study had two main parts of personal characteristics and sexual satisfaction. All ethical points were considered and approved by Ethics committee of Research Institute for Islamic & Complementary Medicine (RICM, IUMS).ResultsAfter a month intervention, there is significant increase in the mean score of sexual satisfaction between two groups (P = 0.01), but when sexual satisfaction compared with pre-menopausal time in two groups, t-test results showed no significant difference (P = 0.16).ConclusionsUse of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum two times a day for a month could improve sexual satisfaction in postmenopausal women. Referring to no significant change with comparing premenopause time, it sounds they have same satisfaction as premenopause time. There were no side effects during study and one month follow-up. It is suggested to do same research on sexual satisfaction and function with more month intervention.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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post menopausal women s sexual satisfaction effect of oral capsule of mixed tribulus terrestris zingiber officinale crocus sativus and Cinnamomum Verum a randomized controlled clinical trial
European Psychiatry, 2016Co-Authors: S. Taavoni, S.a. Gooshegir, Nazem N Ekbatani, H. HaghaniAbstract:Sexual satisfaction decreases during postmenopause life and may improve by various methods of complementary therapy such as use of herbal medicine. Aim To asses the effect of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum on postmenopausal women's sexual satisfaction. Methods In this triple blind randomized control clinical trial, 80 healthy volunteer postmenopause women with age 50–60 years old in one of clinics of west of Tehran had been involved (year 2013–2014). Participants were randomly assigned to intervention and placebo group and received one month same shape capsules two times in a day. Tools of this study had two main parts of personal characteristics and sexual satisfaction. All ethical points were considered and approved by Ethics committee of Research Institute for Islamic & Complementary Medicine (RICM, IUMS). Results After a month intervention, there is significant increase in the mean score of sexual satisfaction between two groups ( P = 0.01), but when sexual satisfaction compared with pre-menopausal time in two groups, t -test results showed no significant difference ( P = 0.16). Conclusions Use of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum two times a day for a month could improve sexual satisfaction in postmenopausal women. Referring to no significant change with comparing premenopause time, it sounds they have same satisfaction as premenopause time. There were no side effects during study and one month follow-up. It is suggested to do same research on sexual satisfaction and function with more month intervention.
Emilia T Abraham - One of the best experts on this subject based on the ideXlab platform.
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studies on the antioxidant activities of cinnamon Cinnamomum Verum bark extracts through various in vitro models
Food Chemistry, 2006Co-Authors: Sindhu Mathew, Emilia T AbrahamAbstract:The antioxidant activities of the methanolic extract of Cinnamomum Verum barks (CBE) were evaluated with reference to antioxidant compounds like butylated hydroxyl anisole, trolox and ascorbic acid. By virtue of their hydrogen donating ability, all of the tested compounds and CBE exhibited reducing power. They were found to be potent in free radical scavenging activity especially against DPPH radicals and ABTS radical cations. The hydroxyl (OH) and superoxide radicals (O2-) were also scavenged by the tested compounds. CBE also exhibited metal chelating activity. The peroxidation inhibiting activity of CBE recorded using a linoleic acid emulsion system, showed very good antioxidant activity.
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in vitro antioxidant activity and scavenging effects of Cinnamomum Verum leaf extract assayed by different methodologies
Food and Chemical Toxicology, 2006Co-Authors: Sindhu Mathew, Emilia T AbrahamAbstract:The free radical scavenging capacity and antioxidant activities of the methanolic extract of Cinnamomum Verum leaf (CLE) were studied and compared to antioxidant compounds like trolox, butylated hydroxyl anisole, gallic acid and ascorbic acid. The CLE exhibited free radical scavenging activity, especially against DPPH radical and ABTS radical cation. They also exhibited reducing power and metal ion chelating activity, along with hydroxyl radical scavenging activity. The peroxidation inhibiting activity of CLE recorded using the linoleic acid emulsion system, showed very good antioxidant activity.
Jonathan Cherng - One of the best experts on this subject based on the ideXlab platform.
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Cinnamomum Verum ingredient 2 methoxycinnamaldehyde a new antiproliferative drug targeting topoisomerase i and ii in human lung squamous cell carcinoma nci h520 cells
European Journal of Cancer Prevention, 2017Co-Authors: Kuendaw Tsai, Shumei Yang, Hoyiu Wong, Tawei Chen, Jonathan CherngAbstract:Cinnamomum Verum has been used as a Chinese herbal medication. We investigated the antiproliferative effect of 2-methoxycinnamaldehyde (2-MCA), a constituent of the cortex of the plant, and the molecular biomarkers associated with tumorigenesis in human lung squamous cell carcinoma NCI-H520 cells. The effects of 2-MCA on cell growth, cytotoxicity, apoptosis, and topoisomerase I and II activities in human lung squamous cell carcinoma NCI-H520 cells were evaluated in vitro and in vivo. The results showed that 2-MCA inhibited proliferation and induced apoptosis as implicated by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase 3 and caspase 9, as well as morphological characteristics of apoptosis. Furthermore, 2-MCA also induced lysosomal vacuolation with elevated volume of acidic compartment and cytotoxicity, and inhibited topoisomerase I as well as II activities. Additional study showed the antiproliferative effect of 2-MCA in a nude mice model. In short, our data imply that the antiproliferative activity of 2-MCA in vitro involved downregulation of cell growth markers, both topoisomerase I and II, and upregulation of proapoptotic molecules, associated with increased lysosomal vacuolation. In vivo, 2-MCA reduced the tumor size, which could have had a significant clinical impact. Our data imply that 2-MCA may be a potential agent for chemoprevention as well as anticancer therapy.
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cuminaldehyde from Cinnamomum Verum induces cell death through targeting topoisomerase 1 and 2 in human colorectal adenocarcinoma colo 205 cells
Nutrients, 2016Co-Authors: Kuendaw Tsai, Shumei Yang, Hoyiu Wong, Tawei Chen, Jonathan Cherng, Kuoshen ChouAbstract:Cinnamomum Verum, also called true cinnamon tree, is employed to make the seasoning cinnamon. Furthermore, the plant has been used as a traditional Chinese herbal medication. We explored the anticancer effect of cuminaldehyde, an ingredient of the cortex of the plant, as well as the molecular biomarkers associated with carcinogenesis in human colorectal adenocarcinoma COLO 205 cells. The results show that cuminaldehyde suppressed growth and induced apoptosis, as proved by depletion of the mitochondrial membrane potential, activation of both caspase-3 and -9, and morphological features of apoptosis. Moreover, cuminaldehyde also led to lysosomal vacuolation with an upregulated volume of acidic compartment and cytotoxicity, together with inhibitions of both topoisomerase I and II activities. Additional study shows that the anticancer activity of cuminaldehyde was observed in the model of nude mice. Our results suggest that the anticancer activity of cuminaldehyde in vitro involved the suppression of cell proliferative markers, topoisomerase I as well as II, together with increase of pro-apoptotic molecules, associated with upregulated lysosomal vacuolation. On the other hand, in vivo, cuminaldehyde diminished the tumor burden that would have a significant clinical impact. Furthermore, similar effects were observed in other tested cell lines. In short, our data suggest that cuminaldehyde could be a drug for chemopreventive or anticancer therapy.
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Cinnamomum Verum component 2 methoxycinnamaldehyde a novel anticancer agent with both anti topoisomerase i and ii activities in human lung adenocarcinoma a549 cells in vitro and in vivo
Phytotherapy Research, 2016Co-Authors: Hoyiu Wong, Shumei Yang, Kuendaw Tsai, Tawei Chen, Jonathan Cherng, Kuoshen Chou, Chenmei ChangAbstract:Cinnamomum Verum is used to make the spice cinnamon and has been used as a traditional Chinese herbal medicine. We evaluated the anticancer effect of 2-methoxycinnamaldehyde (2-MCA), a constituent of the bark of the plant, and its underlying molecular biomarkers associated with carcinogenesis in human lung adenocarcinoma A549 cells. The results show that 2-MCA suppressed proliferation and induced apoptosis as indicated by an upregulation of pro-apoptotic Bax and Bak genes and downregulation of anti-apoptotic Bcl-2 and Bcl-XL genes, mitochondrial membrane potential loss, cytochrome c release, activation of caspase-3 and -9, and morphological characteristics of apoptosis, including plasma membrane blebbing and long comet tail. In addition, 2-MCA also induced lysosomal vacuolation with increased volume of acidic compartment (VAC) and suppressions of nuclear transcription factors nuclear factor-κB (NF-κB) and both topoisomerase I and II activities. Further study reveals that the growth-inhibitory effect of 2-MCA was also evident in a nude mice model. Taken together, the data suggest that the growth-inhibitory effect of 2-MCA against A549 cells is accompanied by downregulations of NF-κB binding activity and proliferative control involving apoptosis and both topoisomerase I and II activities, together with an upregulation of lysosomal vacuolation and VAC. Our data suggest that 2-MCA could be a potential agent for anticancer therapy. Copyright © 2015 John Wiley & Sons, Ltd.
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molecular mechanism of Cinnamomum Verum component cuminaldehyde inhibits cell growth and induces cell death in human lung squamous cell carcinoma nci h520 cells in vitro and in vivo
Journal of Cancer, 2016Co-Authors: Shumei Yang, Kuendaw Tsai, Hoyiu Wong, Tawei Chen, Jonathan CherngAbstract:Cinnamomum Verum is used to make the spice cinnamon and has been used as a traditional Chinese herbal medicine. We evaluated the effects and the molecular mechanisms of cuminaldehyde (CuA), a constituent of the bark of Cinnamomum Verum, on human lung squamous cell carcinoma NCI-H520 cells. Specifically, cell viability was evaluated by colorimetric assay; cytotoxicity by LDH release; apoptosis was determined by Western blotting, and morphological analysis with, acridine orange and neutral red stainings and comet assay; topoisomerase I activity was assessed using assay based upon DNA relaxation and topoisomerase II by DNA relaxation plus decatentation of kinetoplast DNA; lysosomal vacuolation and volume of acidic compartments (VAC) were evaluated with neutral red staining. The results show that CuA suppressed proliferation and induced apoptosis as indicated by an up-regulation of pro-apoptotic bax and bak genes and a down-regulation of anti-apoptotic bcl-2 and bcl-XL genes, mitochondrial membrane potential loss, cytochrome c release, activation of caspase 3 and 9, and morphological characteristics of apoptosis, including blebbing of the plasma membrane, nuclear condensation, fragmentation, apoptotic body formation, and comet with elevated tail intensity and moment. In addition, CuA also induced lysosomal vacuolation with increased VAC, cytotoxicity, as well as suppressions of both topoisomerase I and II activities in a dose-dependent manner. Further study revealed the growth-inhibitory effect of CuA was also evident in a nude mice model. Taken together, the data suggest that the growth-inhibitory effect of CuA against NCI-H520 cells is accompanied by downregulations of proliferative control involving apoptosis and both topoisomerase I and II activities, and upregulation of lysosomal with increased VAC and cytotoxicity. Similar effects were found in other cell lines, including human lung adenocarcinoma A549 cells and colorectal adenocarcinoma COLO 205 (results not shown). Our data suggest that CuA could be a potential agent for anticancer therapy.
S.a. Gooshegir - One of the best experts on this subject based on the ideXlab platform.
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Post menopausal women's sexual satisfaction: Effect of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum: A randomized controlled clinical trial
European Psychiatry, 2020Co-Authors: S. Taavoni, N. Nazem Ekbatani, S.a. Gooshegir, H. HaghaniAbstract:Sexual satisfaction decreases during postmenopause life and may improve by various methods of complementary therapy such as use of herbal medicine.AimTo asses the effect of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum on postmenopausal women's sexual satisfaction.MethodsIn this triple blind randomized control clinical trial, 80 healthy volunteer postmenopause women with age 50–60 years old in one of clinics of west of Tehran had been involved (year 2013–2014). Participants were randomly assigned to intervention and placebo group and received one month same shape capsules two times in a day. Tools of this study had two main parts of personal characteristics and sexual satisfaction. All ethical points were considered and approved by Ethics committee of Research Institute for Islamic & Complementary Medicine (RICM, IUMS).ResultsAfter a month intervention, there is significant increase in the mean score of sexual satisfaction between two groups (P = 0.01), but when sexual satisfaction compared with pre-menopausal time in two groups, t-test results showed no significant difference (P = 0.16).ConclusionsUse of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum two times a day for a month could improve sexual satisfaction in postmenopausal women. Referring to no significant change with comparing premenopause time, it sounds they have same satisfaction as premenopause time. There were no side effects during study and one month follow-up. It is suggested to do same research on sexual satisfaction and function with more month intervention.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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post menopausal women s sexual satisfaction effect of oral capsule of mixed tribulus terrestris zingiber officinale crocus sativus and Cinnamomum Verum a randomized controlled clinical trial
European Psychiatry, 2016Co-Authors: S. Taavoni, S.a. Gooshegir, Nazem N Ekbatani, H. HaghaniAbstract:Sexual satisfaction decreases during postmenopause life and may improve by various methods of complementary therapy such as use of herbal medicine. Aim To asses the effect of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum on postmenopausal women's sexual satisfaction. Methods In this triple blind randomized control clinical trial, 80 healthy volunteer postmenopause women with age 50–60 years old in one of clinics of west of Tehran had been involved (year 2013–2014). Participants were randomly assigned to intervention and placebo group and received one month same shape capsules two times in a day. Tools of this study had two main parts of personal characteristics and sexual satisfaction. All ethical points were considered and approved by Ethics committee of Research Institute for Islamic & Complementary Medicine (RICM, IUMS). Results After a month intervention, there is significant increase in the mean score of sexual satisfaction between two groups ( P = 0.01), but when sexual satisfaction compared with pre-menopausal time in two groups, t -test results showed no significant difference ( P = 0.16). Conclusions Use of oral capsule of mixed Tribulus Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum two times a day for a month could improve sexual satisfaction in postmenopausal women. Referring to no significant change with comparing premenopause time, it sounds they have same satisfaction as premenopause time. There were no side effects during study and one month follow-up. It is suggested to do same research on sexual satisfaction and function with more month intervention.