The Experts below are selected from a list of 41679 Experts worldwide ranked by ideXlab platform
K-r Shieh - One of the best experts on this subject based on the ideXlab platform.
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Abnormal expressions of Circadian-Clock and Circadian Clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice
International Journal of Obesity, 2010Co-Authors: M-c Hsieh, S-c Yang, H-l Tseng, L-l Hwang, C-t Chen, K-r ShiehAbstract:Objectives: Physiological and behavioral Circadian rhythmicities are exhibited by all mammals and are generated by intracellular levels of Circadian oscillators, which are composed of transcriptional/translational feedback loops involving a set of Circadian-Clock genes, such as Clock , Per1–3 , Cry1–2 , Bmal1 , Dbp , E4BP4 and CK1 ɛ. These Circadian-Clock genes play important roles in regulating Circadian rhythms and also energy homeostasis and metabolism. Determining whether obesity induced by high-fat diet affected the expressions of Circadian-Clock genes and their related genes in peripheral tissues, was the main focus of this study. To address this issue, we fed male C57BL/6 mice a high-fat diet for 11 months to induce obesity, hyperglycemic, hypercholesterolemic and hyperinsulinemic symptoms, and used quantitative real-time reverse transcription-PCR to measure gene expression levels. Results: We found that the expressions of Circadian-Clock genes and Circadian Clock-controlled genes, including Per1–3 , Cry1–2 , Bmal1 , Dbp , E4BP4 , CK1 ɛ, PEPCK , PDK4 and NHE3 , were altered in the livers and/or kidneys. Conclusions: These results indicate that obesity induced by high-fat diet alters the Circadian-Clock system, and obesity and metabolic syndrome are highly correlated with the expressions of Circadian-Clock genes and their downstream, Circadian Clock-controlled genes.
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Abnormal expressions of Circadian-Clock and Circadian Clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice
International Journal of Obesity, 2009Co-Authors: K-r ShiehAbstract:Abnormal expressions of Circadian-Clock and Circadian Clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice
M-c Hsieh - One of the best experts on this subject based on the ideXlab platform.
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Abnormal expressions of Circadian-Clock and Circadian Clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice
International Journal of Obesity, 2010Co-Authors: M-c Hsieh, S-c Yang, H-l Tseng, L-l Hwang, C-t Chen, K-r ShiehAbstract:Objectives: Physiological and behavioral Circadian rhythmicities are exhibited by all mammals and are generated by intracellular levels of Circadian oscillators, which are composed of transcriptional/translational feedback loops involving a set of Circadian-Clock genes, such as Clock , Per1–3 , Cry1–2 , Bmal1 , Dbp , E4BP4 and CK1 ɛ. These Circadian-Clock genes play important roles in regulating Circadian rhythms and also energy homeostasis and metabolism. Determining whether obesity induced by high-fat diet affected the expressions of Circadian-Clock genes and their related genes in peripheral tissues, was the main focus of this study. To address this issue, we fed male C57BL/6 mice a high-fat diet for 11 months to induce obesity, hyperglycemic, hypercholesterolemic and hyperinsulinemic symptoms, and used quantitative real-time reverse transcription-PCR to measure gene expression levels. Results: We found that the expressions of Circadian-Clock genes and Circadian Clock-controlled genes, including Per1–3 , Cry1–2 , Bmal1 , Dbp , E4BP4 , CK1 ɛ, PEPCK , PDK4 and NHE3 , were altered in the livers and/or kidneys. Conclusions: These results indicate that obesity induced by high-fat diet alters the Circadian-Clock system, and obesity and metabolic syndrome are highly correlated with the expressions of Circadian-Clock genes and their downstream, Circadian Clock-controlled genes.
S-c Yang - One of the best experts on this subject based on the ideXlab platform.
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Abnormal expressions of Circadian-Clock and Circadian Clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice
International Journal of Obesity, 2010Co-Authors: M-c Hsieh, S-c Yang, H-l Tseng, L-l Hwang, C-t Chen, K-r ShiehAbstract:Objectives: Physiological and behavioral Circadian rhythmicities are exhibited by all mammals and are generated by intracellular levels of Circadian oscillators, which are composed of transcriptional/translational feedback loops involving a set of Circadian-Clock genes, such as Clock , Per1–3 , Cry1–2 , Bmal1 , Dbp , E4BP4 and CK1 ɛ. These Circadian-Clock genes play important roles in regulating Circadian rhythms and also energy homeostasis and metabolism. Determining whether obesity induced by high-fat diet affected the expressions of Circadian-Clock genes and their related genes in peripheral tissues, was the main focus of this study. To address this issue, we fed male C57BL/6 mice a high-fat diet for 11 months to induce obesity, hyperglycemic, hypercholesterolemic and hyperinsulinemic symptoms, and used quantitative real-time reverse transcription-PCR to measure gene expression levels. Results: We found that the expressions of Circadian-Clock genes and Circadian Clock-controlled genes, including Per1–3 , Cry1–2 , Bmal1 , Dbp , E4BP4 , CK1 ɛ, PEPCK , PDK4 and NHE3 , were altered in the livers and/or kidneys. Conclusions: These results indicate that obesity induced by high-fat diet alters the Circadian-Clock system, and obesity and metabolic syndrome are highly correlated with the expressions of Circadian-Clock genes and their downstream, Circadian Clock-controlled genes.
C-t Chen - One of the best experts on this subject based on the ideXlab platform.
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Abnormal expressions of Circadian-Clock and Circadian Clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice
International Journal of Obesity, 2010Co-Authors: M-c Hsieh, S-c Yang, H-l Tseng, L-l Hwang, C-t Chen, K-r ShiehAbstract:Objectives: Physiological and behavioral Circadian rhythmicities are exhibited by all mammals and are generated by intracellular levels of Circadian oscillators, which are composed of transcriptional/translational feedback loops involving a set of Circadian-Clock genes, such as Clock , Per1–3 , Cry1–2 , Bmal1 , Dbp , E4BP4 and CK1 ɛ. These Circadian-Clock genes play important roles in regulating Circadian rhythms and also energy homeostasis and metabolism. Determining whether obesity induced by high-fat diet affected the expressions of Circadian-Clock genes and their related genes in peripheral tissues, was the main focus of this study. To address this issue, we fed male C57BL/6 mice a high-fat diet for 11 months to induce obesity, hyperglycemic, hypercholesterolemic and hyperinsulinemic symptoms, and used quantitative real-time reverse transcription-PCR to measure gene expression levels. Results: We found that the expressions of Circadian-Clock genes and Circadian Clock-controlled genes, including Per1–3 , Cry1–2 , Bmal1 , Dbp , E4BP4 , CK1 ɛ, PEPCK , PDK4 and NHE3 , were altered in the livers and/or kidneys. Conclusions: These results indicate that obesity induced by high-fat diet alters the Circadian-Clock system, and obesity and metabolic syndrome are highly correlated with the expressions of Circadian-Clock genes and their downstream, Circadian Clock-controlled genes.
L-l Hwang - One of the best experts on this subject based on the ideXlab platform.
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Abnormal expressions of Circadian-Clock and Circadian Clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice
International Journal of Obesity, 2010Co-Authors: M-c Hsieh, S-c Yang, H-l Tseng, L-l Hwang, C-t Chen, K-r ShiehAbstract:Objectives: Physiological and behavioral Circadian rhythmicities are exhibited by all mammals and are generated by intracellular levels of Circadian oscillators, which are composed of transcriptional/translational feedback loops involving a set of Circadian-Clock genes, such as Clock , Per1–3 , Cry1–2 , Bmal1 , Dbp , E4BP4 and CK1 ɛ. These Circadian-Clock genes play important roles in regulating Circadian rhythms and also energy homeostasis and metabolism. Determining whether obesity induced by high-fat diet affected the expressions of Circadian-Clock genes and their related genes in peripheral tissues, was the main focus of this study. To address this issue, we fed male C57BL/6 mice a high-fat diet for 11 months to induce obesity, hyperglycemic, hypercholesterolemic and hyperinsulinemic symptoms, and used quantitative real-time reverse transcription-PCR to measure gene expression levels. Results: We found that the expressions of Circadian-Clock genes and Circadian Clock-controlled genes, including Per1–3 , Cry1–2 , Bmal1 , Dbp , E4BP4 , CK1 ɛ, PEPCK , PDK4 and NHE3 , were altered in the livers and/or kidneys. Conclusions: These results indicate that obesity induced by high-fat diet alters the Circadian-Clock system, and obesity and metabolic syndrome are highly correlated with the expressions of Circadian-Clock genes and their downstream, Circadian Clock-controlled genes.
