The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform

Jorn Olsen - One of the best experts on this subject based on the ideXlab platform.

  • cancer risks in children with congenital malformations in the nervous and Circulatory System a population based cohort study
    Cancer Epidemiology, 2014
    Co-Authors: Yuelian Sun, Kim Overvad, Jorn Olsen
    Abstract:

    Abstract Aim We estimated the age and organ-specific cancer risk for children with a congenital malformation (CM) in the nervous or in the Circulatory System. Methods We identified 1,709,456 live born singletons in Denmark between 1 January 1977 and 31 December 2007 and excluded children with chromosomal birth defects. Information on CMs was obtained from the Danish National Hospital Register. Information on cancer occurrence was obtained from the Danish Cancer Registry. We applied Cox proportional hazards regression model to estimate hazard ratios (HR) for cancer. Children entered into the CM cohort on the day of birth regardless of when the CM was diagnosed or on the day of CM diagnosis in an alternative analysis. Results Overall, 4484 (0.26%) and 24,643 (1.44%) children were diagnosed with a CM in the nervous and in the Circulatory System, respectively. Compared with children without any CM, children with a CM in the nervous System had a 5.97 fold (95%CI [confidence interval]: 4.66–7.64) higher risk of cancer, including cancer in the central nervous System (HR = 18.84, 95%CI: 12.67–28.01), in the mesothelial and soft tissue (HR = 15.64, 95%CI: 7.99–30.60), in the skin (HR = 4.91, 95%CI: 2.19–11.0). The associations were stronger early in life. Children with a CM in the Circulatory System had a 2.64 fold (95%CI: 2.21–3.16) higher risk of cancer, including cancer in the lymphatic and haematopoietic tissues (HR = 3.22, 95%CI: 2.43–4.27) and cancer in the CNS (HR = 2.40, 95%CI: 1.43–4.02). Some of these associations were weaker in the alternative analysis. Children with subtypes of CM in the two Systems showed a higher cancer risk. Conclusions Children who were diagnosed with a CM in the nervous System had a substantially higher cancer risk especially early in life. Children diagnosed with a CM in the Circulatory System had a moderately higher cancer risk.

Yolanda Postigo Angón - One of the best experts on this subject based on the ideXlab platform.

  • Representations of the Human Circulatory System.
    Journal of Biological Education, 2009
    Co-Authors: Asunción López-manjón, Yolanda Postigo Angón
    Abstract:

    There is no agreement about the robustness of intuitive representations of the Circulatory System and their susceptibility to change by instruction. In this paper, we analyse to what extent students with varying degrees of biology instruction and different ages (High School Health Science and Social Science students and first and final year University Psychology students) have been able to change their intuitive beliefs into scientific representations of the workings of the human Circulatory System. We analysed two aspects of the representation of the Circulatory System: models of the Circulatory System (the relationship between the heart and lungs in the blood pathway) and the Circulatory System pattern (the blood pathway between organs). In relation to the models of the Circulatory System, we found differences among the different groups of students according to the amount of biological instruction they had. The majority of participants (High School Social Science students and both University Psychology ...

James F Antaki - One of the best experts on this subject based on the ideXlab platform.

  • elastance based control of a mock Circulatory System
    Annals of Biomedical Engineering, 2001
    Co-Authors: L A Baloa, J R Boston, James F Antaki
    Abstract:

    A new control strategy for a mock Circulatory System (MCS) has been developed to mimic the Starling response of the natural heart. The control scheme is based on Suga's elastance model, which is implemented using nested elastance and pressure feedback control Systems. The elastance control loop calculates the desired chamber pressure using a time-varying elastance function and the ventricular chamber volume signal. The pressure control loop regulates the chamber pressure according to this reference signal. Simulations and tests on MCS hardware showed that the elastance-based controller responds to changes in preload, afterload, and contractility in a manner similar to the natural heart. Since the elastance function is an arbitrary function of time, the controller allows modification of ventricular chamber contractility, giving researchers a new tool to mimic various pathological conditions which can be used in the evaluation of cardiac devices such as ventricular assist devices. © 2001 Biomedical Engineering Society.

John K Gilbert - One of the best experts on this subject based on the ideXlab platform.

  • students visualization of diagrams representing the human Circulatory System the use of spatial isomorphism and representational conventions
    International Journal of Science Education, 2015
    Co-Authors: M W Cheng, John K Gilbert
    Abstract:

    This study investigated students' interpretation of diagrams representing the human Circulatory System. We conducted an interview study with three students aged 14–15 (Year 10) who were studying biology in a Hong Kong school. During the interviews, students were asked to interpret diagrams and relationships between diagrams that represented aspects of the Circulatory System. All diagrams used in the interviews had been used by their teacher when teaching the topic. Students' interpretations were expressed by their verbal response and their drawing. Dual coding theory was used to interpret students' responses. There was evidence that one student relied on verbal recall as a strategy in interpreting diagrams. It was found that students might have relied unduly on similarities in spatial features, rather than on deeper meanings represented by conventions, of diagrams when they associated diagrams that represented different aspects of the Circulatory System. A pattern of students' understanding of structure–b...

Liu Huan-shun - One of the best experts on this subject based on the ideXlab platform.