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J. Molkentin - One of the best experts on this subject based on the ideXlab platform.
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C18 : 1, C18 : 2 and C18 : 3 trans and Cis Fatty Acid isomers including conjugated Cis δ9,trans δ11 linoleic Acid (CLA) as well as total fat composition of German human milk lipids
Die Nahrung, 1999Co-Authors: Dietz Precht, J. MolkentinAbstract:In particular with respect to infant nutrition knowledge of the current contents of trans Fatty Acids (TFA) and of conjugated linoleic Acid (CLA) in human milk lipids is of interest. After pre-separation by Ag-TLC 11 trans-C18 : 1 isomers could be quantified by GC with a mean total content of 2.40 ± 0.60 wt% in samples from 40 German women. For the positional isomers t4, t5, t6–8, t9, t10, t11, t12, t13, t14, t15 and t16 contents of 0.02, 0.02, 0.21, 0.37, 0.32, 0.68, 0.23, 0.15, 0.18, 0.09 and 0.14 wt% were established, with vaccenic Acid being the predominant isomer. Further, small trans-C14 : 1 and trans-C16 : 1 contents of 0.08% and 0.15% on average were found. As the trans-C18 : 1 isomers also the trans-C16 : 1 isomers of human milk lipids could for the first time be baseline-resolved by GC to a great extent. Moreover, besides a mean CLA (c9,t11) content of 0.40 ± 0.09% further 6 Cis/trans isomers of linoleic Acid with a total content of 1.07 ± 0.56% on average (w/o CLA) were determined. Further, 4 trans isomers of α-linolenic Acid could be baseline-resolved exhibiting a total content of 0.11%. Altogether German human milk lipids on average were found to contain 3.81 ± 0.97% TFA with a range of 2.38–6.03%. Direct connections between the dietary intake of trans-C18 : 1 isomers and the composition of human milk lipids could be established. The major Fatty Acids exhibited the following contents (wt%): C4: 0.16, C6: 0.18, C8: 0.06, C10: 0.58, C12: 3.12, C14: 6.43, C16: 25.28, C18: 7.41, C18 : 1 (total): 33.67, C18 : 2 (total): 10.63 and α-C18 : 3: 0.87.
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c18 1 c18 2 and c18 3 trans and Cis Fatty Acid isomers including conjugated Cis delta 9 trans delta 11 linoleic Acid cla as well as total fat composition of german human milk lipids
Nahrung-food, 1999Co-Authors: Dietz Precht, J. MolkentinAbstract:In particular with respect to infant nutrition knowledge of the current contents of trans Fatty Acids (TFA) and of conjugated linoleic Acid (CLA) in human milk lipids is of interest. After pre-separation by Ag-TLC 11 trans-C18 : 1 isomers could be quantified by GC with a mean total content of 2.40 ± 0.60 wt% in samples from 40 German women. For the positional isomers t4, t5, t6–8, t9, t10, t11, t12, t13, t14, t15 and t16 contents of 0.02, 0.02, 0.21, 0.37, 0.32, 0.68, 0.23, 0.15, 0.18, 0.09 and 0.14 wt% were established, with vaccenic Acid being the predominant isomer. Further, small trans-C14 : 1 and trans-C16 : 1 contents of 0.08% and 0.15% on average were found. As the trans-C18 : 1 isomers also the trans-C16 : 1 isomers of human milk lipids could for the first time be baseline-resolved by GC to a great extent. Moreover, besides a mean CLA (c9,t11) content of 0.40 ± 0.09% further 6 Cis/trans isomers of linoleic Acid with a total content of 1.07 ± 0.56% on average (w/o CLA) were determined. Further, 4 trans isomers of α-linolenic Acid could be baseline-resolved exhibiting a total content of 0.11%. Altogether German human milk lipids on average were found to contain 3.81 ± 0.97% TFA with a range of 2.38–6.03%. Direct connections between the dietary intake of trans-C18 : 1 isomers and the composition of human milk lipids could be established. The major Fatty Acids exhibited the following contents (wt%): C4: 0.16, C6: 0.18, C8: 0.06, C10: 0.58, C12: 3.12, C14: 6.43, C16: 25.28, C18: 7.41, C18 : 1 (total): 33.67, C18 : 2 (total): 10.63 and α-C18 : 3: 0.87.
Kentaro Murakami - One of the best experts on this subject based on the ideXlab platform.
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synergistic activation of type iii protein kinase c by Cis Fatty Acid and diacylglycerol
Biochemical Journal, 1992Co-Authors: Shu G Chen, Kentaro MurakamiAbstract:Micromolar concentrations of Cis-Fatty Acid synergistically activate type III protein kinase C with diacylglycerol. This synergistic effect occurs at low concentrations of Cis-Fatty Acid and diacylglycerol, and it is capable of inducing almost full activation of this protein kinase C subtype at a physiologically relevant Ca2+ concentration (2 microM). The synergistic activation mode can be observed even in the absence of Ca2+, but micromolar Ca2+ significantly enhances the type III protein kinase C activation. Cis-Fatty Acid also augments the diacylglycerol-induced activation of other subtypes (type I and II), although the effect is smaller than that observed in type III. Neither the diacylglycerol- nor the Cis-Fatty Acid-dependent mode of activation can fully activate any of these subtypes at a physiological concentration of Ca2+ (2 microM). Our results suggest that the generation of three second messengers, i.e. the increase in intracellular Ca2+ concentration and the generation of both Cis-Fatty Acid and diacylglycerol in the cell, may be necessary signals for protein kinase C activation, particularly for type III protein kinase C.
Dietz Precht - One of the best experts on this subject based on the ideXlab platform.
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C18 : 1, C18 : 2 and C18 : 3 trans and Cis Fatty Acid isomers including conjugated Cis δ9,trans δ11 linoleic Acid (CLA) as well as total fat composition of German human milk lipids
Die Nahrung, 1999Co-Authors: Dietz Precht, J. MolkentinAbstract:In particular with respect to infant nutrition knowledge of the current contents of trans Fatty Acids (TFA) and of conjugated linoleic Acid (CLA) in human milk lipids is of interest. After pre-separation by Ag-TLC 11 trans-C18 : 1 isomers could be quantified by GC with a mean total content of 2.40 ± 0.60 wt% in samples from 40 German women. For the positional isomers t4, t5, t6–8, t9, t10, t11, t12, t13, t14, t15 and t16 contents of 0.02, 0.02, 0.21, 0.37, 0.32, 0.68, 0.23, 0.15, 0.18, 0.09 and 0.14 wt% were established, with vaccenic Acid being the predominant isomer. Further, small trans-C14 : 1 and trans-C16 : 1 contents of 0.08% and 0.15% on average were found. As the trans-C18 : 1 isomers also the trans-C16 : 1 isomers of human milk lipids could for the first time be baseline-resolved by GC to a great extent. Moreover, besides a mean CLA (c9,t11) content of 0.40 ± 0.09% further 6 Cis/trans isomers of linoleic Acid with a total content of 1.07 ± 0.56% on average (w/o CLA) were determined. Further, 4 trans isomers of α-linolenic Acid could be baseline-resolved exhibiting a total content of 0.11%. Altogether German human milk lipids on average were found to contain 3.81 ± 0.97% TFA with a range of 2.38–6.03%. Direct connections between the dietary intake of trans-C18 : 1 isomers and the composition of human milk lipids could be established. The major Fatty Acids exhibited the following contents (wt%): C4: 0.16, C6: 0.18, C8: 0.06, C10: 0.58, C12: 3.12, C14: 6.43, C16: 25.28, C18: 7.41, C18 : 1 (total): 33.67, C18 : 2 (total): 10.63 and α-C18 : 3: 0.87.
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c18 1 c18 2 and c18 3 trans and Cis Fatty Acid isomers including conjugated Cis delta 9 trans delta 11 linoleic Acid cla as well as total fat composition of german human milk lipids
Nahrung-food, 1999Co-Authors: Dietz Precht, J. MolkentinAbstract:In particular with respect to infant nutrition knowledge of the current contents of trans Fatty Acids (TFA) and of conjugated linoleic Acid (CLA) in human milk lipids is of interest. After pre-separation by Ag-TLC 11 trans-C18 : 1 isomers could be quantified by GC with a mean total content of 2.40 ± 0.60 wt% in samples from 40 German women. For the positional isomers t4, t5, t6–8, t9, t10, t11, t12, t13, t14, t15 and t16 contents of 0.02, 0.02, 0.21, 0.37, 0.32, 0.68, 0.23, 0.15, 0.18, 0.09 and 0.14 wt% were established, with vaccenic Acid being the predominant isomer. Further, small trans-C14 : 1 and trans-C16 : 1 contents of 0.08% and 0.15% on average were found. As the trans-C18 : 1 isomers also the trans-C16 : 1 isomers of human milk lipids could for the first time be baseline-resolved by GC to a great extent. Moreover, besides a mean CLA (c9,t11) content of 0.40 ± 0.09% further 6 Cis/trans isomers of linoleic Acid with a total content of 1.07 ± 0.56% on average (w/o CLA) were determined. Further, 4 trans isomers of α-linolenic Acid could be baseline-resolved exhibiting a total content of 0.11%. Altogether German human milk lipids on average were found to contain 3.81 ± 0.97% TFA with a range of 2.38–6.03%. Direct connections between the dietary intake of trans-C18 : 1 isomers and the composition of human milk lipids could be established. The major Fatty Acids exhibited the following contents (wt%): C4: 0.16, C6: 0.18, C8: 0.06, C10: 0.58, C12: 3.12, C14: 6.43, C16: 25.28, C18: 7.41, C18 : 1 (total): 33.67, C18 : 2 (total): 10.63 and α-C18 : 3: 0.87.
Shu G Chen - One of the best experts on this subject based on the ideXlab platform.
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synergistic activation of type iii protein kinase c by Cis Fatty Acid and diacylglycerol
Biochemical Journal, 1992Co-Authors: Shu G Chen, Kentaro MurakamiAbstract:Micromolar concentrations of Cis-Fatty Acid synergistically activate type III protein kinase C with diacylglycerol. This synergistic effect occurs at low concentrations of Cis-Fatty Acid and diacylglycerol, and it is capable of inducing almost full activation of this protein kinase C subtype at a physiologically relevant Ca2+ concentration (2 microM). The synergistic activation mode can be observed even in the absence of Ca2+, but micromolar Ca2+ significantly enhances the type III protein kinase C activation. Cis-Fatty Acid also augments the diacylglycerol-induced activation of other subtypes (type I and II), although the effect is smaller than that observed in type III. Neither the diacylglycerol- nor the Cis-Fatty Acid-dependent mode of activation can fully activate any of these subtypes at a physiological concentration of Ca2+ (2 microM). Our results suggest that the generation of three second messengers, i.e. the increase in intracellular Ca2+ concentration and the generation of both Cis-Fatty Acid and diacylglycerol in the cell, may be necessary signals for protein kinase C activation, particularly for type III protein kinase C.
Jaehwan Lee - One of the best experts on this subject based on the ideXlab platform.
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effects of photosensitisation and autoxidation on the changes of volatile compounds and headspace oxygen in elaidic trans Fatty Acid and oleic Cis Fatty Acid
Food Chemistry, 2010Co-Authors: Jaemin Lee, Pahnshick Chang, Jaehwan LeeAbstract:Abstract Headspace volatiles and oxygen in elaidic or oleic Acids under methylene blue photosensitisation at 60 °C for 60 h were analysed by solid-phase microextraction (SPME)–gas chromatography (GC) with a mass selective detector (MS) and GC with a thermal conductivity detector (TCD), respectively. Headspace oxygen was significantly depleted in photosensitised samples compared to those in the dark ( p p t -2-undecenal, 1-octanol and 1-heptanol were greatly increased in both elaidic and oleic Acids under photosensitisation. Photosensitisation accelerated formation of volatiles in elaidic Acid more than in oleic Acid while oleic Acid absorbed more oxygen than elaidic Acid at 60 °C for 60 h.