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Maria Paula Cruz Schneider - One of the best experts on this subject based on the ideXlab platform.
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Data_Sheet_2_The Marine Mammal Class II Major Histocompatibility Complex Organization.FASTA
2019Co-Authors: Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz SchneiderAbstract:Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system one of the best tools aquatic mammals have for dealing with aquatic microbial threats. So far, only cetaceans have had their class II Major Histocompatibility Complex (MHC) organization characterized, despite the importance of MHC genes for adaptive immune responses. This study aims to characterize the organization of the marine mammal class II MHC using publicly available genomes. We located class II sequences in the genomes of one sirenian, four pinnipeds and eight cetaceans using NCBI-BLAST and reannotated the sequences using local BLAST search with exon and intron libraries. Scaffolds containing class II sequences were compared using dotplot analysis and introns were used for phylogenetic analysis. The manatee class II region shares overall synteny with other mammals, however most DR loci were translocated from the canonical location, past the extended class II region. Detailed analysis of the genomes of closely related taxa revealed that this presumed translocation is shared with all other living afrotherians. Other presumptive chromosome rearrangements in Afrotheria are the deletion of DQ loci in Afrosoricida and deletion of DP in E. telfairi. Pinnipeds share the main features of dog MHC: lack of a functional pair of DPA/DPB genes and inverted DRB locus between DQ and DO subregions. All cetaceans share the Cetartiodactyla inversion separating class II genes into two subregions: class IIa, with DR and DQ genes, and class IIb, with non-classic genes and a DRB pseudogene. These results point to three distinct and unheralded class II MHC structures in marine mammals: one canonical organization but lacking DP genes in pinnipeds; one bearing an inversion separating IIa and IIb subregions lacking DP genes found in cetaceans; and one with a translocation separating the most diverse class II gene from the MHC found in afrotherians and presumptive functional DR, DQ, and DP genes. Future functional research will reveal how these aquatic mammals cope with pathogen pressures with these divergent MHC organizations.
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Data_Sheet_1_The Marine Mammal Class II Major Histocompatibility Complex Organization.ZIP
2019Co-Authors: Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz SchneiderAbstract:Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system one of the best tools aquatic mammals have for dealing with aquatic microbial threats. So far, only cetaceans have had their class II Major Histocompatibility Complex (MHC) organization characterized, despite the importance of MHC genes for adaptive immune responses. This study aims to characterize the organization of the marine mammal class II MHC using publicly available genomes. We located class II sequences in the genomes of one sirenian, four pinnipeds and eight cetaceans using NCBI-BLAST and reannotated the sequences using local BLAST search with exon and intron libraries. Scaffolds containing class II sequences were compared using dotplot analysis and introns were used for phylogenetic analysis. The manatee class II region shares overall synteny with other mammals, however most DR loci were translocated from the canonical location, past the extended class II region. Detailed analysis of the genomes of closely related taxa revealed that this presumed translocation is shared with all other living afrotherians. Other presumptive chromosome rearrangements in Afrotheria are the deletion of DQ loci in Afrosoricida and deletion of DP in E. telfairi. Pinnipeds share the main features of dog MHC: lack of a functional pair of DPA/DPB genes and inverted DRB locus between DQ and DO subregions. All cetaceans share the Cetartiodactyla inversion separating class II genes into two subregions: class IIa, with DR and DQ genes, and class IIb, with non-classic genes and a DRB pseudogene. These results point to three distinct and unheralded class II MHC structures in marine mammals: one canonical organization but lacking DP genes in pinnipeds; one bearing an inversion separating IIa and IIb subregions lacking DP genes found in cetaceans; and one with a translocation separating the most diverse class II gene from the MHC found in afrotherians and presumptive functional DR, DQ, and DP genes. Future functional research will reveal how these aquatic mammals cope with pathogen pressures with these divergent MHC organizations.
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Table_2_The Marine Mammal Class II Major Histocompatibility Complex Organization.XLSX
2019Co-Authors: Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz SchneiderAbstract:Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system one of the best tools aquatic mammals have for dealing with aquatic microbial threats. So far, only cetaceans have had their class II Major Histocompatibility Complex (MHC) organization characterized, despite the importance of MHC genes for adaptive immune responses. This study aims to characterize the organization of the marine mammal class II MHC using publicly available genomes. We located class II sequences in the genomes of one sirenian, four pinnipeds and eight cetaceans using NCBI-BLAST and reannotated the sequences using local BLAST search with exon and intron libraries. Scaffolds containing class II sequences were compared using dotplot analysis and introns were used for phylogenetic analysis. The manatee class II region shares overall synteny with other mammals, however most DR loci were translocated from the canonical location, past the extended class II region. Detailed analysis of the genomes of closely related taxa revealed that this presumed translocation is shared with all other living afrotherians. Other presumptive chromosome rearrangements in Afrotheria are the deletion of DQ loci in Afrosoricida and deletion of DP in E. telfairi. Pinnipeds share the main features of dog MHC: lack of a functional pair of DPA/DPB genes and inverted DRB locus between DQ and DO subregions. All cetaceans share the Cetartiodactyla inversion separating class II genes into two subregions: class IIa, with DR and DQ genes, and class IIb, with non-classic genes and a DRB pseudogene. These results point to three distinct and unheralded class II MHC structures in marine mammals: one canonical organization but lacking DP genes in pinnipeds; one bearing an inversion separating IIa and IIb subregions lacking DP genes found in cetaceans; and one with a translocation separating the most diverse class II gene from the MHC found in afrotherians and presumptive functional DR, DQ, and DP genes. Future functional research will reveal how these aquatic mammals cope with pathogen pressures with these divergent MHC organizations.
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The Marine Mammal Class II Major Histocompatibility Complex Organization
Frontiers Media S.A., 2019Co-Authors: Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz SchneiderAbstract:Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system one of the best tools aquatic mammals have for dealing with aquatic microbial threats. So far, only cetaceans have had their class II Major Histocompatibility Complex (MHC) organization characterized, despite the importance of MHC genes for adaptive immune responses. This study aims to characterize the organization of the marine mammal class II MHC using publicly available genomes. We located class II sequences in the genomes of one sirenian, four pinnipeds and eight cetaceans using NCBI-BLAST and reannotated the sequences using local BLAST search with exon and intron libraries. Scaffolds containing class II sequences were compared using dotplot analysis and introns were used for phylogenetic analysis. The manatee class II region shares overall synteny with other mammals, however most DR loci were translocated from the canonical location, past the extended class II region. Detailed analysis of the genomes of closely related taxa revealed that this presumed translocation is shared with all other living afrotherians. Other presumptive chromosome rearrangements in Afrotheria are the deletion of DQ loci in Afrosoricida and deletion of DP in E. telfairi. Pinnipeds share the main features of dog MHC: lack of a functional pair of DPA/DPB genes and inverted DRB locus between DQ and DO subregions. All cetaceans share the Cetartiodactyla inversion separating class II genes into two subregions: class IIa, with DR and DQ genes, and class IIb, with non-classic genes and a DRB pseudogene. These results point to three distinct and unheralded class II MHC structures in marine mammals: one canonical organization but lacking DP genes in pinnipeds; one bearing an inversion separating IIa and IIb subregions lacking DP genes found in cetaceans; and one with a translocation separating the most diverse class II gene from the MHC found in afrotherians and presumptive functional DR, DQ, and DP genes. Future functional research will reveal how these aquatic mammals cope with pathogen pressures with these divergent MHC organizations
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Data_Sheet_11_The Marine Mammal Class II Major Histocompatibility Complex Organization.FASTA
2019Co-Authors: Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz SchneiderAbstract:Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system one of the best tools aquatic mammals have for dealing with aquatic microbial threats. So far, only cetaceans have had their class II Major Histocompatibility Complex (MHC) organization characterized, despite the importance of MHC genes for adaptive immune responses. This study aims to characterize the organization of the marine mammal class II MHC using publicly available genomes. We located class II sequences in the genomes of one sirenian, four pinnipeds and eight cetaceans using NCBI-BLAST and reannotated the sequences using local BLAST search with exon and intron libraries. Scaffolds containing class II sequences were compared using dotplot analysis and introns were used for phylogenetic analysis. The manatee class II region shares overall synteny with other mammals, however most DR loci were translocated from the canonical location, past the extended class II region. Detailed analysis of the genomes of closely related taxa revealed that this presumed translocation is shared with all other living afrotherians. Other presumptive chromosome rearrangements in Afrotheria are the deletion of DQ loci in Afrosoricida and deletion of DP in E. telfairi. Pinnipeds share the main features of dog MHC: lack of a functional pair of DPA/DPB genes and inverted DRB locus between DQ and DO subregions. All cetaceans share the Cetartiodactyla inversion separating class II genes into two subregions: class IIa, with DR and DQ genes, and class IIb, with non-classic genes and a DRB pseudogene. These results point to three distinct and unheralded class II MHC structures in marine mammals: one canonical organization but lacking DP genes in pinnipeds; one bearing an inversion separating IIa and IIb subregions lacking DP genes found in cetaceans; and one with a translocation separating the most diverse class II gene from the MHC found in afrotherians and presumptive functional DR, DQ, and DP genes. Future functional research will reveal how these aquatic mammals cope with pathogen pressures with these divergent MHC organizations.
Jun Wang - One of the best experts on this subject based on the ideXlab platform.
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accurate prediction of protein structural class using auto covariance transformation of psi blast profiles
Amino Acids, 2012Co-Authors: Taigang Liu, Xiaoqi Zheng, Xingbo Geng, Jun WangAbstract:Computational prediction of protein structural class based solely on sequence data remains a challenging problem in protein science. Existing methods differ in the protein sequence representation models and prediction engines adopted. In this study, a powerful feature extraction method, which combines position-specific score matrix (PSSM) with auto covariance (AC) transformation, is introduced. Thus, a sample protein is represented by a series of discrete components, which could partially incorporate the long-range sequence order information and evolutionary information reflected from the PSI-BLAST profile. To verify the performance of our method, jackknife cross-validation tests are performed on four widely used benchmark datasets. Comparison of our results with existing methods shows that our method provides the state-of-the-art performance for structural class prediction. A Web server that implements the proposed method is freely available at http://202.194.133.5/xinxi/AAC_PSSM_AC/index.htm.
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prediction of protein structural class for low similarity sequences using support vector machine and psi blast profile
Biochimie, 2010Co-Authors: Taigang Liu, Xiaoqi Zheng, Jun WangAbstract:Knowledge of structural class plays an important role in understanding protein folding patterns. In this study, a simple and powerful computational method, which combines support vector machine with PSI-BLAST profile, is proposed to predict protein structural class for low-similarity sequences. The evolution information encoding in the PSI-BLAST profiles is converted into a series of fixed-length feature vectors by extracting amino acid composition and dipeptide composition from the profiles. The resulting vectors are then fed to a support vector machine classifier for the prediction of protein structural class. To evaluate the performance of the proposed method, jackknife cross-validation tests are performed on two widely used benchmark datasets, 1189 (containing 1092 proteins) and 25PDB (containing 1673 proteins) with sequence similarity lower than 40% and 25%, respectively. The overall accuracies attain 70.7% and 72.9% for 1189 and 25PDB datasets, respectively. Comparison of our results with other methods shows that our method is very promising to predict protein structural class particularly for low-similarity datasets and may at least play an important complementary role to existing methods.
Samir Siksek - One of the best experts on this subject based on the ideXlab platform.
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Class field theory, Diophantine analysis and the asymptotic Fermat's Last Theorem
Advances in Mathematics, 2020Co-Authors: Nuno Freitas, Alain Kraus, Samir SiksekAbstract:Abstract Recent results of Freitas, Kraus, Şengun and Siksek, give sufficient criteria for the asymptotic Fermat's Last Theorem to hold over a specific number field. Those works in turn build on many deep theorems in arithmetic geometry. In this paper we combine the aforementioned results with techniques from class field theory, the theory of p-groups and p-extensions, Diophantine approximation and linear forms in logarithms, to establish the asymptotic Fermat's Last Theorem for many infinite families of number fields, and for thousands of number fields of small degree. For example, we prove the effective asymptotic Fermat's Last Theorem for the infinite family of fields Q ( ζ 2 r ) + where r ≥ 2 .
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Class field theory, Diophantine analysis and the asymptotic Fermat's Last Theorem
arXiv: Number Theory, 2019Co-Authors: Nuno Freitas, Alain Kraus, Samir SiksekAbstract:Recent results of Freitas, Kraus, Sengun and Siksek, give sufficient criteria for the asymptotic Fermat's Last Theorem to hold over a specific number field. Those works in turn build on many deep theorems in arithmetic geometry. In this paper we combine the aforementioned results with techniques from class field theory, the theory of p-groups and p-extensions, Diophantine approximation and linear forms in logarithms, to establish the asymptotic Fermat's Last Theorem for many infinite families of number fields, and for thousands of number fields of small degree. For example, we prove the effective asymptotic Fermat's Last Theorem for the infinite family of fields $\mathbb{Q}(\zeta_{2^r})^+$.
Breanna Breaux - One of the best experts on this subject based on the ideXlab platform.
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Data_Sheet_2_The Marine Mammal Class II Major Histocompatibility Complex Organization.FASTA
2019Co-Authors: Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz SchneiderAbstract:Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system one of the best tools aquatic mammals have for dealing with aquatic microbial threats. So far, only cetaceans have had their class II Major Histocompatibility Complex (MHC) organization characterized, despite the importance of MHC genes for adaptive immune responses. This study aims to characterize the organization of the marine mammal class II MHC using publicly available genomes. We located class II sequences in the genomes of one sirenian, four pinnipeds and eight cetaceans using NCBI-BLAST and reannotated the sequences using local BLAST search with exon and intron libraries. Scaffolds containing class II sequences were compared using dotplot analysis and introns were used for phylogenetic analysis. The manatee class II region shares overall synteny with other mammals, however most DR loci were translocated from the canonical location, past the extended class II region. Detailed analysis of the genomes of closely related taxa revealed that this presumed translocation is shared with all other living afrotherians. Other presumptive chromosome rearrangements in Afrotheria are the deletion of DQ loci in Afrosoricida and deletion of DP in E. telfairi. Pinnipeds share the main features of dog MHC: lack of a functional pair of DPA/DPB genes and inverted DRB locus between DQ and DO subregions. All cetaceans share the Cetartiodactyla inversion separating class II genes into two subregions: class IIa, with DR and DQ genes, and class IIb, with non-classic genes and a DRB pseudogene. These results point to three distinct and unheralded class II MHC structures in marine mammals: one canonical organization but lacking DP genes in pinnipeds; one bearing an inversion separating IIa and IIb subregions lacking DP genes found in cetaceans; and one with a translocation separating the most diverse class II gene from the MHC found in afrotherians and presumptive functional DR, DQ, and DP genes. Future functional research will reveal how these aquatic mammals cope with pathogen pressures with these divergent MHC organizations.
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Data_Sheet_1_The Marine Mammal Class II Major Histocompatibility Complex Organization.ZIP
2019Co-Authors: Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz SchneiderAbstract:Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system one of the best tools aquatic mammals have for dealing with aquatic microbial threats. So far, only cetaceans have had their class II Major Histocompatibility Complex (MHC) organization characterized, despite the importance of MHC genes for adaptive immune responses. This study aims to characterize the organization of the marine mammal class II MHC using publicly available genomes. We located class II sequences in the genomes of one sirenian, four pinnipeds and eight cetaceans using NCBI-BLAST and reannotated the sequences using local BLAST search with exon and intron libraries. Scaffolds containing class II sequences were compared using dotplot analysis and introns were used for phylogenetic analysis. The manatee class II region shares overall synteny with other mammals, however most DR loci were translocated from the canonical location, past the extended class II region. Detailed analysis of the genomes of closely related taxa revealed that this presumed translocation is shared with all other living afrotherians. Other presumptive chromosome rearrangements in Afrotheria are the deletion of DQ loci in Afrosoricida and deletion of DP in E. telfairi. Pinnipeds share the main features of dog MHC: lack of a functional pair of DPA/DPB genes and inverted DRB locus between DQ and DO subregions. All cetaceans share the Cetartiodactyla inversion separating class II genes into two subregions: class IIa, with DR and DQ genes, and class IIb, with non-classic genes and a DRB pseudogene. These results point to three distinct and unheralded class II MHC structures in marine mammals: one canonical organization but lacking DP genes in pinnipeds; one bearing an inversion separating IIa and IIb subregions lacking DP genes found in cetaceans; and one with a translocation separating the most diverse class II gene from the MHC found in afrotherians and presumptive functional DR, DQ, and DP genes. Future functional research will reveal how these aquatic mammals cope with pathogen pressures with these divergent MHC organizations.
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Table_2_The Marine Mammal Class II Major Histocompatibility Complex Organization.XLSX
2019Co-Authors: Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz SchneiderAbstract:Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system one of the best tools aquatic mammals have for dealing with aquatic microbial threats. So far, only cetaceans have had their class II Major Histocompatibility Complex (MHC) organization characterized, despite the importance of MHC genes for adaptive immune responses. This study aims to characterize the organization of the marine mammal class II MHC using publicly available genomes. We located class II sequences in the genomes of one sirenian, four pinnipeds and eight cetaceans using NCBI-BLAST and reannotated the sequences using local BLAST search with exon and intron libraries. Scaffolds containing class II sequences were compared using dotplot analysis and introns were used for phylogenetic analysis. The manatee class II region shares overall synteny with other mammals, however most DR loci were translocated from the canonical location, past the extended class II region. Detailed analysis of the genomes of closely related taxa revealed that this presumed translocation is shared with all other living afrotherians. Other presumptive chromosome rearrangements in Afrotheria are the deletion of DQ loci in Afrosoricida and deletion of DP in E. telfairi. Pinnipeds share the main features of dog MHC: lack of a functional pair of DPA/DPB genes and inverted DRB locus between DQ and DO subregions. All cetaceans share the Cetartiodactyla inversion separating class II genes into two subregions: class IIa, with DR and DQ genes, and class IIb, with non-classic genes and a DRB pseudogene. These results point to three distinct and unheralded class II MHC structures in marine mammals: one canonical organization but lacking DP genes in pinnipeds; one bearing an inversion separating IIa and IIb subregions lacking DP genes found in cetaceans; and one with a translocation separating the most diverse class II gene from the MHC found in afrotherians and presumptive functional DR, DQ, and DP genes. Future functional research will reveal how these aquatic mammals cope with pathogen pressures with these divergent MHC organizations.
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The Marine Mammal Class II Major Histocompatibility Complex Organization
Frontiers Media S.A., 2019Co-Authors: Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz SchneiderAbstract:Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system one of the best tools aquatic mammals have for dealing with aquatic microbial threats. So far, only cetaceans have had their class II Major Histocompatibility Complex (MHC) organization characterized, despite the importance of MHC genes for adaptive immune responses. This study aims to characterize the organization of the marine mammal class II MHC using publicly available genomes. We located class II sequences in the genomes of one sirenian, four pinnipeds and eight cetaceans using NCBI-BLAST and reannotated the sequences using local BLAST search with exon and intron libraries. Scaffolds containing class II sequences were compared using dotplot analysis and introns were used for phylogenetic analysis. The manatee class II region shares overall synteny with other mammals, however most DR loci were translocated from the canonical location, past the extended class II region. Detailed analysis of the genomes of closely related taxa revealed that this presumed translocation is shared with all other living afrotherians. Other presumptive chromosome rearrangements in Afrotheria are the deletion of DQ loci in Afrosoricida and deletion of DP in E. telfairi. Pinnipeds share the main features of dog MHC: lack of a functional pair of DPA/DPB genes and inverted DRB locus between DQ and DO subregions. All cetaceans share the Cetartiodactyla inversion separating class II genes into two subregions: class IIa, with DR and DQ genes, and class IIb, with non-classic genes and a DRB pseudogene. These results point to three distinct and unheralded class II MHC structures in marine mammals: one canonical organization but lacking DP genes in pinnipeds; one bearing an inversion separating IIa and IIb subregions lacking DP genes found in cetaceans; and one with a translocation separating the most diverse class II gene from the MHC found in afrotherians and presumptive functional DR, DQ, and DP genes. Future functional research will reveal how these aquatic mammals cope with pathogen pressures with these divergent MHC organizations
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Data_Sheet_11_The Marine Mammal Class II Major Histocompatibility Complex Organization.FASTA
2019Co-Authors: Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz SchneiderAbstract:Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system one of the best tools aquatic mammals have for dealing with aquatic microbial threats. So far, only cetaceans have had their class II Major Histocompatibility Complex (MHC) organization characterized, despite the importance of MHC genes for adaptive immune responses. This study aims to characterize the organization of the marine mammal class II MHC using publicly available genomes. We located class II sequences in the genomes of one sirenian, four pinnipeds and eight cetaceans using NCBI-BLAST and reannotated the sequences using local BLAST search with exon and intron libraries. Scaffolds containing class II sequences were compared using dotplot analysis and introns were used for phylogenetic analysis. The manatee class II region shares overall synteny with other mammals, however most DR loci were translocated from the canonical location, past the extended class II region. Detailed analysis of the genomes of closely related taxa revealed that this presumed translocation is shared with all other living afrotherians. Other presumptive chromosome rearrangements in Afrotheria are the deletion of DQ loci in Afrosoricida and deletion of DP in E. telfairi. Pinnipeds share the main features of dog MHC: lack of a functional pair of DPA/DPB genes and inverted DRB locus between DQ and DO subregions. All cetaceans share the Cetartiodactyla inversion separating class II genes into two subregions: class IIa, with DR and DQ genes, and class IIb, with non-classic genes and a DRB pseudogene. These results point to three distinct and unheralded class II MHC structures in marine mammals: one canonical organization but lacking DP genes in pinnipeds; one bearing an inversion separating IIa and IIb subregions lacking DP genes found in cetaceans; and one with a translocation separating the most diverse class II gene from the MHC found in afrotherians and presumptive functional DR, DQ, and DP genes. Future functional research will reveal how these aquatic mammals cope with pathogen pressures with these divergent MHC organizations.
Rodríguez Alfaro, Gustavo Alejandro - One of the best experts on this subject based on the ideXlab platform.
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Relación del edentulismo con la calidad de vida en adultos mayores de los distritos de Moche y Salaverry, 2018.
Universidad Privada Antenor Orrego - UPAO, 2019Co-Authors: Rodríguez Alfaro, Gustavo AlejandroAbstract:Determinar la relación del edentulismo con la calidad de vida en adultos mayores de los distritos de Moche y Salaverry, 2018. Material y Método: El estudio fue de corte transversal, se evaluó a 92 adultos mayores. Se empleó Test de OHIP para determinar la calidad de vida y clasificación de Kennedy para determinar la pérdida dental. Resultados: Se encontró según Kennedy que el mayor porcentaje de edentulismo fue en maxilar inferior (16%) en Clase I-M1. Según calidad de vida se encontró en nivel moderado (72%). Según enfermedad sistémica, fue en maxilar inferior en Clase I-M1 en pacientes con hipertensión siendo moderado (12%) en calidad de vida. Según grado de instrucción, fue en maxilar superior en Clase II-M2 (7%) y maxilar inferior en Clase I-M1 (7%) con primaria completa, presentando impacto moderado en calidad de vida. Según edad, lo obtuvo el maxilar superior en Clase II-M2 (11%) en pacientes con 71-81 años, presentando impacto alto. Conclusión: Si existe relación entre edentulismo y calidad de vida.To determine the relationship of edentulism with quality of life in older adults in the districts of Moche and Salaverry, 2018. Material and Method: The study was cross-sectional and 92 elderly adults were evaluated. The OHIP Test was used to determine the quality of life and the Kennedy classification to determine tooth loss. Results: According to Kennedy, it was found that the highest percentage of edentulism was in the lower jaw, which presented 16% in Class I-M1. According to the quality of life, it was found at a moderate level (72%). According to systemic disease, the highest percentage was in the lower maxilla in Class I-M1 in patients with hypertension, being moderate (12%) in their quality of life. According to educational level, the highest percentage was in the upper jaw in Class II-M2 (7%) and lower jaw in Class I-M1 (7%) with complete primary, presenting a moderate impact on their quality of life. According to age, the highest percentage was obtained in the upper maxilla in Class II-M2 (11%) in patients aged 71-81 years, presenting high impact Conclusion: If there is a relationship between edentulism and quality of life.Tesi
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Relación del Edentulismo con la calidad de vida en adultos mayores de los distritos de Moche y Salaverry, 2018.
Universidad Privada Antenor Orrego - UPAO, 2019Co-Authors: Rodríguez Alfaro, Gustavo AlejandroAbstract:Objective: To determine the relationship of edentulism with quality of life in older adults in the districts of Moche and Salaverry, 2018. Material and Method: The study was cross-sectional and 92 elderly adults were evaluated. The OHIP Test was used to determine the quality of life and the Kennedy classification to determine tooth loss. Results: According to Kennedy, it was found that the highest percentage of edentulism was in the lower jaw, which presented 16% in Class I-M1. According to the quality of life, it was found at a moderate level (72%). According to systemic disease, the highest percentage was in the lower maxilla in Class I-M1 in patients with hypertension, being moderate (12%) in their quality of life. According to educational level, the highest percentage was in the upper jaw in Class II-M2 (7%) and lower jaw in Class I-M1 (7%) with complete primary, presenting a moderate impact on their quality of life. According to age, the highest percentage was obtained in the upper maxilla in Class II-M2 (11%) in patients aged 71-81 years, presenting high impact Conclusion: If there is a relationship between edentulism and quality of life.TesisObjetivo: Determinar la relación del edentulismo con la calidad de vida en adultos mayores de los distritos de Moche y Salaverry, 2018. Material y Método: El estudio fue de corte transversal, se evaluó a 92 adultos mayores. Se empleó Test de OHIP para determinar la calidad de vida y clasificación de Kennedy para determinar la pérdida dental. Resultados: Se encontró según Kennedy que el mayor porcentaje de edentulismo fue en maxilar inferior (16%) en Clase I-M1. Según calidad de vida se encontró en nivel moderado (72%). Según enfermedad sistémica, fue en maxilar inferior en Clase I-M1 en pacientes con hipertensión siendo moderado (12%) en calidad de vida. Según grado de instrucción, fue en maxilar superior en Clase II-M2 (7%) y maxilar inferior en Clase I-M1 (7%) con primaria completa, presentando impacto moderado en calidad de vida. Según edad, lo obtuvo el maxilar superior en Clase II-M2 (11%) en pacientes con 71-81 años, presentando impacto alto. Conclusión: Si existe relación entre edentulismo y calidad de vida