The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform

Ken-ichi Kimura - One of the best experts on this subject based on the ideXlab platform.

  • a novel ca2 signal transduction inhibitor kujione a isolated from medium polar fractions of kuji amber
    Phytochemistry Letters, 2020
    Co-Authors: Junpei Abe, Hiroyuki Koshino, Nozomu Shimoda, Ken-ichi Kimura
    Abstract:

    Abstract Five new and one unsual known bioactive compounds have been isolated from the methanol extract of Kuji amber which was subjected to silica gel column chromatography in order to yield lipophilic compounds. A new Clerodane Derivative, named Kujione A (15-nor-2-oxo-3-cleroden-13-ol), was isolated from the medium polar fractions. This was done using Kujione A’s growth-restoring activity against a mutant Saccharomyces cerevisiae strain (zds1Δ erg3Δ pdr1/3Δ) that is hypersensitive with respect to Ca²+-signal transduction. The structure was elucidated by spectroscopic data, HREIMS, along with 1D- and 2D-NMR, among others. 15-norClerodane has been categorized as a new and distinct compound because it has a conjugated carbonyl functional group; it has not been found in isolated constituents from Kuji amber.

Aj Marsaioli - One of the best experts on this subject based on the ideXlab platform.

  • Isolation and synthesis of a new Clerodane from Echinodorus grandiflorus
    Inglaterra, 2015
    Co-Authors: Costa M, Tanaka Cma, Pm Imamura, Aj Marsaioli
    Abstract:

    A new Clerodane Derivative, (-)-16-hydroxycleroda-3,13-dien-16,15-olide-18-oic acid, (4a alpha,6 alpha,8a alpha) 1-carboxy-5(S)-[2(2,5-dihydro-5-hydroxy-2-oxo-4-furanyl)ethyl-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalene was isolated as a minor component of the polar fractions of the leaves of E. grandiflorus. The structure was determined by spectroscopy (IR, MS, 1D and 2D H-1 and C-13 NMR). The absolute configuration was determined by a hemisynthesis using (+)-hardwickiic acid methyl ester, from commercial copaiba oil, as starting material. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.50111712

Junpei Abe - One of the best experts on this subject based on the ideXlab platform.

  • a novel ca2 signal transduction inhibitor kujione a isolated from medium polar fractions of kuji amber
    Phytochemistry Letters, 2020
    Co-Authors: Junpei Abe, Hiroyuki Koshino, Nozomu Shimoda, Ken-ichi Kimura
    Abstract:

    Abstract Five new and one unsual known bioactive compounds have been isolated from the methanol extract of Kuji amber which was subjected to silica gel column chromatography in order to yield lipophilic compounds. A new Clerodane Derivative, named Kujione A (15-nor-2-oxo-3-cleroden-13-ol), was isolated from the medium polar fractions. This was done using Kujione A’s growth-restoring activity against a mutant Saccharomyces cerevisiae strain (zds1Δ erg3Δ pdr1/3Δ) that is hypersensitive with respect to Ca²+-signal transduction. The structure was elucidated by spectroscopic data, HREIMS, along with 1D- and 2D-NMR, among others. 15-norClerodane has been categorized as a new and distinct compound because it has a conjugated carbonyl functional group; it has not been found in isolated constituents from Kuji amber.

Costa M - One of the best experts on this subject based on the ideXlab platform.

  • Isolation and synthesis of a new Clerodane from Echinodorus grandiflorus
    Inglaterra, 2015
    Co-Authors: Costa M, Tanaka Cma, Pm Imamura, Aj Marsaioli
    Abstract:

    A new Clerodane Derivative, (-)-16-hydroxycleroda-3,13-dien-16,15-olide-18-oic acid, (4a alpha,6 alpha,8a alpha) 1-carboxy-5(S)-[2(2,5-dihydro-5-hydroxy-2-oxo-4-furanyl)ethyl-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalene was isolated as a minor component of the polar fractions of the leaves of E. grandiflorus. The structure was determined by spectroscopy (IR, MS, 1D and 2D H-1 and C-13 NMR). The absolute configuration was determined by a hemisynthesis using (+)-hardwickiic acid methyl ester, from commercial copaiba oil, as starting material. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.50111712

Hiroyuki Koshino - One of the best experts on this subject based on the ideXlab platform.

  • a novel ca2 signal transduction inhibitor kujione a isolated from medium polar fractions of kuji amber
    Phytochemistry Letters, 2020
    Co-Authors: Junpei Abe, Hiroyuki Koshino, Nozomu Shimoda, Ken-ichi Kimura
    Abstract:

    Abstract Five new and one unsual known bioactive compounds have been isolated from the methanol extract of Kuji amber which was subjected to silica gel column chromatography in order to yield lipophilic compounds. A new Clerodane Derivative, named Kujione A (15-nor-2-oxo-3-cleroden-13-ol), was isolated from the medium polar fractions. This was done using Kujione A’s growth-restoring activity against a mutant Saccharomyces cerevisiae strain (zds1Δ erg3Δ pdr1/3Δ) that is hypersensitive with respect to Ca²+-signal transduction. The structure was elucidated by spectroscopic data, HREIMS, along with 1D- and 2D-NMR, among others. 15-norClerodane has been categorized as a new and distinct compound because it has a conjugated carbonyl functional group; it has not been found in isolated constituents from Kuji amber.