The Experts below are selected from a list of 471 Experts worldwide ranked by ideXlab platform
Michael H Gold - One of the best experts on this subject based on the ideXlab platform.
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sub group analyses from a trial of a fixed combination of Clindamycin Phosphate 1 2 and benzoyl peroxide 3 75 gel for the treatment of moderate to severe acne vulgaris
The Journal of clinical and aesthetic dermatology, 2015Co-Authors: Michael H Gold, Andrew KorotzerAbstract:Background: Acne vulgaris is commonplace and can be difficult to manage. Providing an effective and well-tolerated treatment may lead to improved adherence, increased patient satisfaction, and improved clinical outcomes. Methods: A review of efficacy, safety, and cutaneous tolerability of Clindamycin Phosphate 1.2%-benzoyl peroxide 3.75% gel in 498 patients with moderate-to-severe acne vulgaris enrolled in a multicenter Phase III study randomized to receive active or vehicle once daily for 12 weeks, including the most recent post-hoc analyses. Results: Significantly superior reductions in lesion counts were observed with Clindamycin Phosphate 1.2%-benzoyl peroxide 3.75% gel from Week 4, with median percent reductions in inflammatory and noninflammatory lesions from baseline of 68.4 and 57.9 percent, respectively (bothp<0.001 versus vehicle). More than half (55.1%) of the severe acne vulgaris patients treated with Clindamycin Phosphate 1.2%-benzoyl peroxide 3.75% gel achieved ≥2-grade improvement from baseline in their Evaluator’s Global Severity Score, and almost a third of the adolescent acne vulgaris patients (32.4%) achieved at least a marked improvement in their acne vulgaris as early as Week 2. In adult female acne overall treatments success was achieved in 52.7 percent of patients treated with Clindamycin Phosphate 1.2%-benzoyl peroxide 3.75% gel. Overall, and in the specific subpopulations, Clindamycin Phosphate 1.2%-benzoyl peroxide 3.75% gel was well-tolerated with a similar adverse event profile to vehicle. Limitations: Post-hoc analyses from a single clinical trial with demographic imbalances that could potentially confound the results. Conclusion: Clindamycin Phosphate 1.2%-benzoyl peroxide 3.75% gel appears to be effective in treating acne across various clinically relevant sub-groups.
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a new once daily optimized fixed combination of Clindamycin Phosphate 1 2 and low concentration benzoyl peroxide 2 5 gel for the treatment of moderate to severe acne
The Journal of clinical and aesthetic dermatology, 2009Co-Authors: Michael H GoldAbstract:Acne vulgaris affects 40 to 50 million people in the United States.1 Current evidence suggests it is a result of increased sebum production, follicular hyperkeratinization, and proliferation of Propionibacterium acnes compounded by host responses to the proinflammatory activities of P. acnes.2 As a result, combination therapy targeting the multiple components of acne is now commonplace. Two commonly used topical acne medications are Clindamycin and benzoyl peroxide (BPO). Clindamycin improves acne by reducing the levels of P. acnes and decreasing inflammation.3 BPO is a safe and effective agent and is not associated with antimicrobial resistance.2 In addition, BPO has anticomedogenic and keratolytic properties.4,5 Fixed combination products of Clindamycin 1% and BPO 5% have been widely accepted and used for the treatment of acne. Many studies have shown that the combination of Clindamycin 1% with BPO 5% is superior to each individual active ingredient.6–8 The primary limitation of the BPO component in these fixed combinations is that, in certain patients, it may cause concentration-dependent cutaneous irritation and dryness.2 A small subset of patients can also have allergic contact dermatitis in response to BPO.9 In addition, surfactants, preservatives, and high levels of organic solvents, including alcohols, often used in combination with BPO, are potential irritants on their own.10,11 Alcohols and surfactants disrupt membrane lipid bilayers of the epidermal barrier, which affect the permeability barrier leading to xerotic conditions and can also result, with chronic use, in epidermal cytotoxicity and increased irri tancy.10,12 Preservatives are sensitizing in a subset of the patient population.13
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clinical safety and efficacy studies of a novel formulation combining 1 2 Clindamycin Phosphate and 0 025 tretinoin for the treatment of acne vulgaris
Journal of Drugs in Dermatology, 2007Co-Authors: Joel Schlessinger, James J. Leyden, Michael H Gold, Alan Menter, Craig L Leonardi, Lawrence F Eichenfield, Todd R Plott, Mitchell WortzmanAbstract:Clindamycin Phosphate 1.2% and tretinoin 0.025% gel (CLIN/RA gel [ZIANA Gel]) is a novel topical combination agent approved by the FDA for the treatment of acne vulgaris in patients 12 years of age or older. A solution of Clindamycin Phosphate 1.2% combined with partially solubilized and crystalline tretinoin 0.025% suspended in an aqueous-based, alcohol-free gel formulation, CLIN/RA gel was studied in 2 randomized, vehicle-controlled trials involving more than 4,500 patients. Efficacy results from these studies showed that treatment with the combination significantly reduced lesion counts and improved patients' overall appearance to a greater extent than the individual components. Individual ingredients and the combination were well-tolerated. Among those treated with the combination formulation, discontinuation rates due to adverse events were 1% or less.
Zijie Feng - One of the best experts on this subject based on the ideXlab platform.
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establishment and evaluation of the novel tetramethylammonium l hydroxyproline chiral ionic liquid synergistic system based on Clindamycin Phosphate for enantioseparation by capillary electrophoresis
Chirality, 2015Co-Authors: Jiaquan Chen, Qi Zhang, Jinjing Zhang, Zijie FengAbstract:Much attention has been paid to chiral ionic liquids (ILs) in analytical chemistry, especially its application in capillary electrophoresis (CE) enantioseparation. However, the investigation of chiral ionic liquids synergistic systems based on antibiotic chiral selectors has been reported in only one article. In this work, a novel chiral ionic liquid, tetramethylammonium-L-hydroxyproline (TMA-L-Hyp), was applied for the first time in CE chiral separation to evaluate its potential synergistic effect with Clindamycin Phosphate (CP) as the chiral selector. As observed, significantly improved separation was obtained in this TMA-L-Hyp/CP synergistic system compared to TMA-L-Hyp or a CP single system. Several primary factors that might influence the separation were investigated, including CP concentration, TMA-L-Hyp concentration, buffer pH, types and concentrations of organic modifier, applied voltage, and capillary temperature. The best results were obtained with a 40 mM borax buffer (pH 7.6) containing 30 mM TMA-L-Hyp, 80 mM CP, and 20% (v/v) methanol, while the applied voltage and temperature were set at 20 kV and 20°C, respectively. Chirality 27:598–604, 2015. © 2015 Wiley Periodicals, Inc.
Feng Zijie - One of the best experts on this subject based on the ideXlab platform.
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Establishment and Evaluation of the Novel Tetramethylammonium-L-Hydroxyproline Chiral Ionic Liquid Synergistic System Based on Clindamycin Phosphate for Enantioseparation by Capillary Electrophoresis
CHIRALITY, 2015Co-Authors: Xu Guangfu, Qi Zhang, Du Yingxiang, Du Fan, Chen Jiaquan, Yu Tao, Zhang Jinjing, Du Shuaijing, Feng ZijieAbstract:Much attention has been paid to chiral ionic liquids (ILs) in analytical chemistry, especially its application in capillary electrophoresis (CE) enantioseparation. However, the investigation of chiral ionic liquids synergistic systems based on antibiotic chiral selectors has been reported in only one article. In this work, a novel chiral ionic liquid, tetramethylammonium-L-hydroxyproline (TMA-L-Hyp), was applied for the first time in CE chiral separation to evaluate its potential synergistic effect with Clindamycin Phosphate (CP) as the chiral selector. As observed, significantly improved separation was obtained in this TMA-L-Hyp/CP synergistic system compared to TMA-L-Hyp or a CP single system. Several primary factors that might influence the separation were investigated, including CP concentration, TMA-L-Hyp concentration, buffer pH, types and concentrations of organic modifier, applied voltage, and capillary temperature. The best results were obtained with a 40 mM borax buffer (pH 7.6) containing 30 mM TMA-L-Hyp, 80 mM CP, and 20% (v/v) methanol, while the applied voltage and temperature were set at 20 kV and 20 degrees C, respectively. Chirality 27:598-604, 2015. (c) 2015 Wiley Periodicals, Inc.National Natural Science Foundation of China [81373378, 81072610]; Natural Science Foundation of Jiangsu Province [BK20141353]; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)SCI(E)PubMedARTICLEdu_yingxiang@126.com9598-6042
Qi Zhang - One of the best experts on this subject based on the ideXlab platform.
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establishment and evaluation of the novel tetramethylammonium l hydroxyproline chiral ionic liquid synergistic system based on Clindamycin Phosphate for enantioseparation by capillary electrophoresis
Chirality, 2015Co-Authors: Jiaquan Chen, Qi Zhang, Jinjing Zhang, Zijie FengAbstract:Much attention has been paid to chiral ionic liquids (ILs) in analytical chemistry, especially its application in capillary electrophoresis (CE) enantioseparation. However, the investigation of chiral ionic liquids synergistic systems based on antibiotic chiral selectors has been reported in only one article. In this work, a novel chiral ionic liquid, tetramethylammonium-L-hydroxyproline (TMA-L-Hyp), was applied for the first time in CE chiral separation to evaluate its potential synergistic effect with Clindamycin Phosphate (CP) as the chiral selector. As observed, significantly improved separation was obtained in this TMA-L-Hyp/CP synergistic system compared to TMA-L-Hyp or a CP single system. Several primary factors that might influence the separation were investigated, including CP concentration, TMA-L-Hyp concentration, buffer pH, types and concentrations of organic modifier, applied voltage, and capillary temperature. The best results were obtained with a 40 mM borax buffer (pH 7.6) containing 30 mM TMA-L-Hyp, 80 mM CP, and 20% (v/v) methanol, while the applied voltage and temperature were set at 20 kV and 20°C, respectively. Chirality 27:598–604, 2015. © 2015 Wiley Periodicals, Inc.
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Establishment and Evaluation of the Novel Tetramethylammonium-L-Hydroxyproline Chiral Ionic Liquid Synergistic System Based on Clindamycin Phosphate for Enantioseparation by Capillary Electrophoresis
CHIRALITY, 2015Co-Authors: Xu Guangfu, Qi Zhang, Du Yingxiang, Du Fan, Chen Jiaquan, Yu Tao, Zhang Jinjing, Du Shuaijing, Feng ZijieAbstract:Much attention has been paid to chiral ionic liquids (ILs) in analytical chemistry, especially its application in capillary electrophoresis (CE) enantioseparation. However, the investigation of chiral ionic liquids synergistic systems based on antibiotic chiral selectors has been reported in only one article. In this work, a novel chiral ionic liquid, tetramethylammonium-L-hydroxyproline (TMA-L-Hyp), was applied for the first time in CE chiral separation to evaluate its potential synergistic effect with Clindamycin Phosphate (CP) as the chiral selector. As observed, significantly improved separation was obtained in this TMA-L-Hyp/CP synergistic system compared to TMA-L-Hyp or a CP single system. Several primary factors that might influence the separation were investigated, including CP concentration, TMA-L-Hyp concentration, buffer pH, types and concentrations of organic modifier, applied voltage, and capillary temperature. The best results were obtained with a 40 mM borax buffer (pH 7.6) containing 30 mM TMA-L-Hyp, 80 mM CP, and 20% (v/v) methanol, while the applied voltage and temperature were set at 20 kV and 20 degrees C, respectively. Chirality 27:598-604, 2015. (c) 2015 Wiley Periodicals, Inc.National Natural Science Foundation of China [81373378, 81072610]; Natural Science Foundation of Jiangsu Province [BK20141353]; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)SCI(E)PubMedARTICLEdu_yingxiang@126.com9598-6042
Jiaquan Chen - One of the best experts on this subject based on the ideXlab platform.
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establishment and evaluation of the novel tetramethylammonium l hydroxyproline chiral ionic liquid synergistic system based on Clindamycin Phosphate for enantioseparation by capillary electrophoresis
Chirality, 2015Co-Authors: Jiaquan Chen, Qi Zhang, Jinjing Zhang, Zijie FengAbstract:Much attention has been paid to chiral ionic liquids (ILs) in analytical chemistry, especially its application in capillary electrophoresis (CE) enantioseparation. However, the investigation of chiral ionic liquids synergistic systems based on antibiotic chiral selectors has been reported in only one article. In this work, a novel chiral ionic liquid, tetramethylammonium-L-hydroxyproline (TMA-L-Hyp), was applied for the first time in CE chiral separation to evaluate its potential synergistic effect with Clindamycin Phosphate (CP) as the chiral selector. As observed, significantly improved separation was obtained in this TMA-L-Hyp/CP synergistic system compared to TMA-L-Hyp or a CP single system. Several primary factors that might influence the separation were investigated, including CP concentration, TMA-L-Hyp concentration, buffer pH, types and concentrations of organic modifier, applied voltage, and capillary temperature. The best results were obtained with a 40 mM borax buffer (pH 7.6) containing 30 mM TMA-L-Hyp, 80 mM CP, and 20% (v/v) methanol, while the applied voltage and temperature were set at 20 kV and 20°C, respectively. Chirality 27:598–604, 2015. © 2015 Wiley Periodicals, Inc.