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Xie Kangyun - One of the best experts on this subject based on the ideXlab platform.

  • Clinical Effect of local prophylactic application of mtx in laparoscopic linear salpingostomy
    2006
    Co-Authors: Xie Kangyun
    Abstract:

    Objective To explore the Clinical Effect of local prophylactic application of methotrexate(MTX) in laparoscopic linear salpingostomy. Methods The data of 102 women with confirmed unruptured tubal pregnancy and desire to conceive were collected.They were divided into two groups: the study group(local application of MTX in the operation,n=51) and the control group(without application of MTX,n=51).The demographic data,the incidence of persistent ectopic pregnancy(PEP)postoperation,and the hysterosalpingography(HSG) 3 months(postoperation) were analysed,and the side Effects of the study group were observed. Results There was 1 case of PEP in the study group and 9 cases in the control group(2.0% vs 17.6%,P0.001).Ninety-three women were examined with HSG(n=48 in the study group and n=45 in the control group),and there was no significant diffe-(rence) in the uni-and bilateral tubal patency between the two groups(62.5% vs 71.1%,P0.05).There were no obvious side Effects such as nausea,vomit and dental ulcer in the study group. Conclusion Patients who were treated with local MTX injection during the laparoscopic linear salpingostomy present less incidence of PEP with no obvious side Effects.

  • Clinical Effect of local prophylactic application of mtx in laparoscopic linear salpingostomy
    2006
    Co-Authors: Xie Kangyun
    Abstract:

    Objective To explore the Clinical Effect of local prophylactic application of methotrexate(MTX) in laparoscopic linear salpingostomy. Methods The data of 102 women with confirmed unruptured tubal pregnancy and desire to conceive were collected.They were divided into two groups: the study group(local application of MTX in the operation,n=51) and the control group(without application of MTX,n=51).The demographic data,the incidence of persistent ectopic pregnancy(PEP)postoperation,and the hysterosalpingography(HSG) 3 months(postoperation) were analysed,and the side Effects of the study group were observed. Results There was 1 case of PEP in the study group and 9 cases in the control group(2.0% vs 17.6%,P0.001).Ninety-three women were examined with HSG(n=48 in the study group and n=45 in the control group),and there was no significant diffe-(rence) in the uni-and bilateral tubal patency between the two groups(62.5% vs 71.1%,P0.05).There were no obvious side Effects such as nausea,vomit and dental ulcer in the study group. Conclusion Patients who were treated with local MTX injection during the laparoscopic linear salpingostomy present less incidence of PEP with no obvious side Effects.

Zhao Binjie - One of the best experts on this subject based on the ideXlab platform.

  • Clinical Effect of edaravone combined with nimodipine in the treatment of the non operative cerebral contusion and laceration
    2012
    Co-Authors: Zhao Binjie
    Abstract:

    Objective To explore the Clinical Effect of edaravone combined with nimodipine in the treatment of cerebral contusin and laceration. Methods Ninety-seven patients with the non-operative cerebral contusin and laceration in our hospital from Sep. 2010 to Mar. 2012 were divided into the study group (n=49) and the control group (n=48). Patients in the control group were treated with nimodipine pumped into the vein, while those in the study group were given edaravone daily in static drops based on the control group. Five days after treatment, the Clinical efficacy and Clinical neurological defect were scored. CT examinations were performed on the third and fifth day after treatment. The changes in cerebral edema volume were compared between the two groups. Results The Clinical efficacy of the study group was significantly better than that in the control group (with the total Effective rates 95.9% and 83.3%, respectively, P0.05). The Clinical neurological defect scores were significantly improved in the study group than the control group (t=2.357, P0.05). The brain edema significantly less serious in the study group (t=2.436, P0.05). Conclusion In the treatment of the non-operative cerebral contusion and laceration, edaravone combined with nimodipine can help clear away free radical, reduce cerebral edema, and improve patients’ symptoms and the curative Effect.

Struys Michel - One of the best experts on this subject based on the ideXlab platform.

  • Safety and Clinical Effect of i.v. infusion of cyclopropyl-methoxycarbonyl etomidate (ABP-700), a soft analogue of etomidate, in healthy subjects
    2018
    Co-Authors: Bi Valk, Ar Absalom, Meyer P, Meier S, Den Daas, Van Amsterdam K, Ja Campagna, Sp Sweeney, Struys Michel
    Abstract:

    Background: Cyclopropyl-methoxycarbonyl metomidate, or ABP-700, is a second generation analogue of etomidate, developed to retain etomidate's beneficial haemodynamic and respiratory profile but diminishing its suppression of the adrenocortical axis. The objective of this study was to characterise the safety and efficacy of 30-min continuous infusions of ABP-700, and to assess its Effect on haemodynamics and the adrenocortical response in healthy human volunteers. Methods: Five cohorts involving 40 subjects received increasing infusion doses of ABP-700, propofol 60 mu g kg(-1) min(-1) or placebo. Safety was evaluated through adverse event (AE) monitoring, safety laboratory tests, and arterial blood gasses. Haemodynamic and respiratory stability were assessed by continuous monitoring. Adrenocortical function was analysed by adrenocorticotropic hormone (ACTH) stimulation tests. Clinical Effect was measured using the modified observer's assessment of alertness/sedation (MOAA/S) and continuous bispectral index monitoring. Results: No serious AEs were reported. Haemodynamic and respiratory Effects included mild dose-dependent tachycardia, slightly elevated blood pressure, and no centrally mediated apnoea. Upon stimulation with ACTH, no adrenocortical depression was observed in any subject. Involuntary muscle movements (IMM) were reported, which were more extensive with higher dosing regimens. Higher dosages of ABP-700 were associated with deeper sedation and increased likelihood of sedation. Time to onset of Clinical Effect was variable throughout the cohorts and recovery was swift. Conclusions: Infusions of ABP-700 showed a dose-dependent hypnotic Effect, and did not cause severe hypotension, severe respiratory depression, or adrenocortical suppression. The presentation and nature of IMM is a matter of concern

Struys M M R F - One of the best experts on this subject based on the ideXlab platform.

  • Safety and Clinical Effect of i.v. infusion of cyclopropyl-methoxycarbonyl etomidate (ABP-700), a soft analogue of etomidate, in healthy subjects
    2018
    Co-Authors: Valk B, Meyer P, Meier S, Den Daas, Van Amsterdam K, Absalom A R, Campagna J A, Sweeney S P, Struys M M R F
    Abstract:

    BACKGROUND: Cyclopropyl-methoxycarbonyl metomidate, or ABP-700, is a second generation analogue of etomidate, developed to retain etomidate's beneficial haemodynamic and respiratory profile but diminishing its suppression of the adrenocortical axis. The objective of this study was to characterise the safety and efficacy of 30-min continuous infusions of ABP-700, and to assess its Effect on haemodynamics and the adrenocortical response in healthy human volunteers. METHODS: Five cohorts involving 40 subjects received increasing infusion doses of ABP-700, propofol 60 μg kg-1 min-1 or placebo. Safety was evaluated through adverse event (AE) monitoring, safety laboratory tests, and arterial blood gasses. Haemodynamic and respiratory stability were assessed by continuous monitoring. Adrenocortical function was analysed by adrenocorticotropic hormone (ACTH) stimulation tests. Clinical Effect was measured using the modified observer's assessment of alertness/sedation (MOAA/S) and continuous bispectral index monitoring. RESULTS: No serious AEs were reported. Haemodynamic and respiratory Effects included mild dose-dependent tachycardia, slightly elevated blood pressure, and no centrally mediated apnoea. Upon stimulation with ACTH, no adrenocortical depression was observed in any subject. Involuntary muscle movements (IMM) were reported, which were more extensive with higher dosing regimens. Higher dosages of ABP-700 were associated with deeper sedation and increased likelihood of sedation. Time to onset of Clinical Effect was variable throughout the cohorts and recovery was swift. CONCLUSIONS: Infusions of ABP-700 showed a dose-dependent hypnotic Effect, and did not cause severe hypotension, severe respiratory depression, or adrenocortical suppression. The presentation and nature of IMM is a matter of concern. Clinical TRIAL REGISTRATION: NTR4735

Qingzhu Nie - One of the best experts on this subject based on the ideXlab platform.

  • Clinical Effect of viscocanalostomy with 90°trabeculotomy for primary congenital glaucoma
    2016
    Co-Authors: Lei Cao, Chen-wei Liu, Qingzhu Nie
    Abstract:

    AIM:To evaluate the Clinical Effect of viscocanalostomy combined with 90°trabeculotomy in patients with primary congenital glaucoma(PCG). METHODS:A total of 37 patients(50 eyes)with primary congenital glaucoma were included in the prospective and randomized trial. These patients were divided into two groups, the study group and the contral group. Viscocanalostomy combined with 90° trabeculotomy was performed in 25 eyes as the study group and 180° trabeculotomy in the other 25 eyes as the control group. The outcomes were measured respectively, including preoperative and postoperative intraocular pressure(IOP), corneal diameter and cup/disc ratio detected by Schiots tonometer, compass and ophthalmoscope respectively when patients were under sedation by chloralic hydras coloclysis. All patients were followed up at 1wk, 1, 3 and 6mo. RESULTS:IOP decreased respectively from preoperative 30.74±4.68mmHg in the study group and 31.96±5.15mmHg in the control group to postoperative 7.51±3.68 and 8.47±2.66mmHg, 11.79±1.84 and 13.88±6.32mmHg, 13.97±2.76 and 15.74±3.20mmHg, 14.51±0.97 and 16.51±2.44mmHg at 1wk, 1, 3 and 6mo. The differences were statistically significant(P

  • Clinical Effect of improved viscocanalostomy for the treatment of primary congenital glaucoma
    2012
    Co-Authors: Zhili Liu, Lei Cao, Qingzhu Nie
    Abstract:

    AIM To evaluate the Clinical Effect of improved viscocanalostomy in patients with primary congenital glaucoma. METHODS Retrospective analysis of improved viscocanalostomy was performed on 51 eyes of 42 patients with primary congenital glaucoma. The outcome evaluation included postoperative intraocular pressure(IOP), corneal diameter, cup/disc ratio and complications. All patients were followed up at week 1, month 1, 3, 6 and 12. RESULTS The results revealed that postoperative IOP was decreased from (38.57±13.61)mmHg to (10.53±3.91)mmHg, (14.89±5.26)mmHg, (15.42±5.11)mmHg, (13.82±3.46)mmHg, (13.16±5.29)mmHg at follow-up time of 1 week, 1, 3, 6, 12 months (P<0.001). The postoperative corneal diameter was decreased significantly (P=0.002); The mean cup/dish ratio wasn't significantly different (P=0.148) before and after the surgery, the cup/dish ratio of successful surgery was evidently decreased (preoperative 0.7±0.2, postoperative 0.6±0.3, P=0.007), but the complications like as unformed anterior chamber were not observed. The mean follow-up period was 12 months. CONCLUSION Improved viscocanalostomy improves the Clinical Effects of the patients with primary congenital glaucoma, such as higher success rates, lower postoperative mean IOP and fewer complications.