The Experts below are selected from a list of 689880 Experts worldwide ranked by ideXlab platform
Daniel B.f. Saris - One of the best experts on this subject based on the ideXlab platform.
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is magnetic resonance imaging reliable in predicting Clinical Outcome after articular cartilage repair of the knee a systematic review and meta analysis
American Journal of Sports Medicine, 2013Co-Authors: Tommy S. De Windt, Mats Brittberg, Goetz H Welsch, Stefan Marlovits, Lucienne A Vonk, Daniel B.f. Saris, Siegfried TrattnigAbstract:Background: While MRI can provide a detailed morphological evaluation after articular cartilage repair, its additional value in determining Clinical Outcome has yet to be determined. Purpose: To evaluate the correlation between MRI and Clinical Outcome after cartilage repair and to identify parameters that are most important in determining Clinical Outcome. Study Design: Systematic review and meta-analysis. Methods: A systematic search was performed in Embase, MEDLINE, and the Cochrane Collaboration. Articles were screened for relevance and appraised for quality. Guidelines in the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Statement were used. Chi-square tests were performed to find variables that could determine correlation between Clinical and radiological parameters. Results: A total of 32 articles (total number of patients, 1019) were included. A majority (81%) were case series or cohort studies that used similar standardized MRI techniques. The mean Coleman score was 63 (range, 42-96). For the majority of MRI parameters, limited or no correlation was found. Nine studies (28%) found a correlation between Clinical Outcome and the composite magnetic resonance observation of cartilage repair tissue (MOCART) or Henderson score and 7 (22%) with defect fill. In 5 studies, a weak to moderate correlation was found between Clinical Outcome and the T2 index (mean Pearson coefficient r = .53). Conclusion: Strong evidence to determine whether morphological MRI is reliable in predicting Clinical Outcome after cartilage repair is lacking. Future research aiming specifically at Clinical sensitivity of advanced morphological and biochemical MRI techniques after articular cartilage repair could be of great importance to the field.
Nima Etminan - One of the best experts on this subject based on the ideXlab platform.
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effect of pharmaceutical treatment on vasospasm delayed cerebral ischemia and Clinical Outcome in patients with aneurysmal subarachnoid hemorrhage a systematic review and meta analysis
Journal of Cerebral Blood Flow and Metabolism, 2011Co-Authors: Nima Etminan, Mervyn D I Vergouwen, Don Ilodigwe, Loch R MacdonaldAbstract:As it is often assumed that delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is caused by vasospasm, Clinical trials often focus on prevention of vasospasm with the aim to improve Clinical Outcome. However, the role of vasospasm in the pathogenesis of DCI and Clinical Outcome is possibly smaller than previously assumed. We performed a systematic review and meta-analysis on all randomized, double-blind, placebo-controlled trials that studied the effect of pharmaceutical preventive strategies on vasospasm, DCI, and Clinical Outcome in SAH patients to further investigate the relationship between vasospasm and Clinical Outcome. Effect sizes were expressed in pooled risk ratio (RR) estimates with corresponding 95% confidence intervals (CI). A total of 14 studies randomizing 4,235 patients were included. Despite a reduction of vasospasm (RR 0.80 (95% CI 0.70 to 0.92)), no statistically significant effect on poor Outcome was observed (RR 0.93 (95% CI 0.85 to 1.03)). The variety of DCI definitions did not justify pooling the DCI data. We conclude that pharmaceutical treatments have significantly decreased the incidence of vasospasm, but not of poor Clinical Outcome. This dissociation between vasospasm and Clinical Outcome could result from methodological problems, sample size, insensitivity of Clinical Outcome measures, or from mechanisms other than vasospasm that also contribute to poor Outcome.
Galal Z. Said - One of the best experts on this subject based on the ideXlab platform.
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Flexor hallucis longus transfer Clinical Outcome through a single incision for chronic Achilles tendon rupture
International Orthopaedics, 2018Co-Authors: Hossam M.a. Abubeih, Mohamed Khaled, Waleed Riad Saleh, Galal Z. SaidAbstract:Purpose The aim of this study is to evaluate the Clinical Outcome of single-incision flexor hallucis longus tendon transfer in chronic Achilles tendon rupture.
Loch R Macdonald - One of the best experts on this subject based on the ideXlab platform.
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effect of pharmaceutical treatment on vasospasm delayed cerebral ischemia and Clinical Outcome in patients with aneurysmal subarachnoid hemorrhage a systematic review and meta analysis
Journal of Cerebral Blood Flow and Metabolism, 2011Co-Authors: Nima Etminan, Mervyn D I Vergouwen, Don Ilodigwe, Loch R MacdonaldAbstract:As it is often assumed that delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is caused by vasospasm, Clinical trials often focus on prevention of vasospasm with the aim to improve Clinical Outcome. However, the role of vasospasm in the pathogenesis of DCI and Clinical Outcome is possibly smaller than previously assumed. We performed a systematic review and meta-analysis on all randomized, double-blind, placebo-controlled trials that studied the effect of pharmaceutical preventive strategies on vasospasm, DCI, and Clinical Outcome in SAH patients to further investigate the relationship between vasospasm and Clinical Outcome. Effect sizes were expressed in pooled risk ratio (RR) estimates with corresponding 95% confidence intervals (CI). A total of 14 studies randomizing 4,235 patients were included. Despite a reduction of vasospasm (RR 0.80 (95% CI 0.70 to 0.92)), no statistically significant effect on poor Outcome was observed (RR 0.93 (95% CI 0.85 to 1.03)). The variety of DCI definitions did not justify pooling the DCI data. We conclude that pharmaceutical treatments have significantly decreased the incidence of vasospasm, but not of poor Clinical Outcome. This dissociation between vasospasm and Clinical Outcome could result from methodological problems, sample size, insensitivity of Clinical Outcome measures, or from mechanisms other than vasospasm that also contribute to poor Outcome.
G Berni - One of the best experts on this subject based on the ideXlab platform.
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short term Clinical Outcome of patients with acute pulmonary embolism normal blood pressure and echocardiographic right ventricular dysfunction
Circulation, 2000Co-Authors: Stefano Grifoni, Gennaro Santoro, Iacopo Olivotto, Paolo Cecchini, Filippo Pieralli, Alberto Camaiti, Alberto Conti, Giancarlo Agnelli, G BerniAbstract:Background—The role of echocardiographic right ventricular (RV) dysfunction in predicting Clinical Outcome in Clinically stable patients with pulmonary embolism (PE) is undefined. In this study, we assessed the prevalence and Clinical Outcome of normotensive patients with RV dysfunction among a broad spectrum of PE patients. Methods and Results—This prospective Clinical Outcome study included cohort of 209 consecutive patients (age, 65±15 years) with documented PE. Acute RV dysfunction was diagnosed in the presence of ≥1 of the following: RV dilatation (without hypertrophy), paradox septal systolic motion, and Doppler evidence of pulmonary hypertension. Four groups were identified: 28 patients presenting with shock or cardiac arrest (13%), 19 hypotensive patients without shock (9%), 65 normotensive patients with echocardiographic RV dysfunction (31%), and 97 normotensive patients without RV dysfunction (47%). Among normotensive patients with RV dysfunction, 6 (10%) developed PE-related shock after admissi...
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short term Clinical Outcome of patients with acute pulmonary embolism normal blood pressure and echocardiographic right ventricular dysfunction
Circulation, 2000Co-Authors: Stefano Grifoni, Gennaro Santoro, Iacopo Olivotto, Paolo Cecchini, Filippo Pieralli, Alberto Camaiti, Alberto Conti, Giancarlo Agnelli, G BerniAbstract:Background—The role of echocardiographic right ventricular (RV) dysfunction in predicting Clinical Outcome in Clinically stable patients with pulmonary embolism (PE) is undefined. In this study, we assessed the prevalence and Clinical Outcome of normotensive patients with RV dysfunction among a broad spectrum of PE patients. Methods and Results—This prospective Clinical Outcome study included cohort of 209 consecutive patients (age, 65±15 years) with documented PE. Acute RV dysfunction was diagnosed in the presence of ≥1 of the following: RV dilatation (without hypertrophy), paradox septal systolic motion, and Doppler evidence of pulmonary hypertension. Four groups were identified: 28 patients presenting with shock or cardiac arrest (13%), 19 hypotensive patients without shock (9%), 65 normotensive patients with echocardiographic RV dysfunction (31%), and 97 normotensive patients without RV dysfunction (47%). Among normotensive patients with RV dysfunction, 6 (10%) developed PE-related shock after admissi...
