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Peter J. Grant - One of the best experts on this subject based on the ideXlab platform.

  • Coagulation Factor XIII and cardiovascular disease in uk asian patients undergoing coronary angiography
    Thrombosis and Haemostasis, 2001
    Co-Authors: Darren Warner, Michael W. Mansfield, Peter J. Grant
    Abstract:

    Possession of the Coagulation Factor XIII Val34Leu (FXIIIVal34Leu) polymorphism is associated with protection against myocardial infarction (MI) in Caucasians, in the absence of features of insulin resistance. The role of this polymorphism in the UK Asian population, with its high prevalence of insulin resistance and ischaemic heart disease, is unknown. We investigated the frequency of genotypes at this polymorphism, and measures of circulating FXIII in a group of UK Asians attending for coronary angiography. Genotype at the FXIIIVal34Leu polymorphism was not associated with MI. FXIII B-subunit levels correlated with waist: hip ratio (r = 0.19, p 0.005), HbA1c (r = 0.18, p 0.05), fasting triglycerides (r = 0.21, p 0.005), total cholesterol (r = 0.29, p 0.0005) and PAI-1 antigen (r = 0.24, p 0.005). An association between FXIIIVal34Leu and FXIII cross-linking activity was confirmed in these subjects (one-way ANOVA p 0.0005). This evidence does not support the hypothesis that FXIIIVal34Leu is protective against MI in the UK Asian population. FXIII B-subunit levels are strongly linked to risk Factors for cardiovascular disease, suggesting an underlying association with insulin resistance.

  • Coagulation Factor XIII and Cardiovascular Disease in UK Asian Patients Undergoing Coronary Angiography
    Thrombosis and haemostasis, 2001
    Co-Authors: Darren Warner, Michael W. Mansfield, Peter J. Grant
    Abstract:

    Possession of the Coagulation Factor XIII Val34Leu (FXIIIVal34Leu) polymorphism is associated with protection against myocardial infarction (MI) in Caucasians, in the absence of features of insulin resistance. The role of this polymorphism in the UK Asian population, with its high prevalence of insulin resistance and ischaemic heart disease, is unknown. We investigated the frequency of genotypes at this polymorphism, and measures of circulating FXIII in a group of UK Asians attending for coronary angiography. Genotype at the FXIIIVal34Leu polymorphism was not associated with MI. FXIII B-subunit levels correlated with waist: hip ratio (r = 0.19, p

Mohammad Mehdi Akhondi - One of the best experts on this subject based on the ideXlab platform.

  • investigating association of three polymorphisms of Coagulation Factor XIII and recurrent pregnancy loss
    American Journal of Reproductive Immunology, 2010
    Co-Authors: Mahmood Jedditehrani, Raheleh Torabi, Afsaneh Mohammadzadeh, Soheila Arefi, Mohammad Keramatipour, Hojjat Zeraati, A H Zarnani, Mohammad Mehdi Akhondi
    Abstract:

    Citation Jeddi-Tehrani M, Torabi R, Mohammadzadeh A, Arefi S, Keramatipour M, Zeraati H, Zarnani AH, Akhondi MM, Mahmoudian J, Mahmoudi AR, Zarei S. Investigating association of three polymorphisms of Coagulation Factor XIII and recurrent pregnancy loss. Am J Reprod Immunol 2010; 64: 212–217 Problem  Among important suspected causes of thrombophilia in women with recurrent pregnancy loss (RPL) are the polymorphisms of Coagulation Factor XIII (FXIII) gene. We performed a case–control study on the association between three polymorphisms of Factor XIII (FXIII G103T, FXIII A614T and FXIII C1694T) and RPL in Iranian women. Method of study  DNA samples from peripheral blood of 100 female patients with at least two recurrent abortions, as case group, and 100 healthy women with history of at least two successful deliveries were subjected to PCR-RFLP, and the frequencies of the polymorphisms were calculated and compared between the two groups. Results  The prevalence of FXIII G103T polymorphism was 29% in the case group and 17% in the control group (P = 0.158). The frequencies of FXIII A614T and FXIII C1694T were 84% and 66% in the case group and 48% and 31% in the control group (P < 0.001 and P < 0.001), respectively. The two latter polymorphisms are associated with RPL in Iranian women and increase the risk of RPL. A correlation was also found between FXIII A614T and FXIII C1694T polymorphisms (P < 0.001). Conclusion  We suggest the evaluation of FXIII A614T and FXIII C1694T polymorphisms in women with RPL.

  • Investigating Association of Three Polymorphisms of Coagulation Factor XIII and Recurrent Pregnancy Loss.
    American journal of reproductive immunology (New York N.Y. : 1989), 2010
    Co-Authors: Mahmood Jeddi-tehrani, Raheleh Torabi, Afsaneh Mohammadzadeh, Soheila Arefi, Mohammad Keramatipour, Hojjat Zeraati, A H Zarnani, Mohammad Mehdi Akhondi, Jafar Mahmoudian, Ahmad Reza Mahmoudi
    Abstract:

    Citation Jeddi-Tehrani M, Torabi R, Mohammadzadeh A, Arefi S, Keramatipour M, Zeraati H, Zarnani AH, Akhondi MM, Mahmoudian J, Mahmoudi AR, Zarei S. Investigating association of three polymorphisms of Coagulation Factor XIII and recurrent pregnancy loss. Am J Reprod Immunol 2010; 64: 212–217 Problem  Among important suspected causes of thrombophilia in women with recurrent pregnancy loss (RPL) are the polymorphisms of Coagulation Factor XIII (FXIII) gene. We performed a case–control study on the association between three polymorphisms of Factor XIII (FXIII G103T, FXIII A614T and FXIII C1694T) and RPL in Iranian women. Method of study  DNA samples from peripheral blood of 100 female patients with at least two recurrent abortions, as case group, and 100 healthy women with history of at least two successful deliveries were subjected to PCR-RFLP, and the frequencies of the polymorphisms were calculated and compared between the two groups. Results  The prevalence of FXIII G103T polymorphism was 29% in the case group and 17% in the control group (P = 0.158). The frequencies of FXIII A614T and FXIII C1694T were 84% and 66% in the case group and 48% and 31% in the control group (P 

David S Siscovick - One of the best experts on this subject based on the ideXlab platform.

  • polymorphisms of Coagulation Factor XIII subunit a and risk of nonfatal hemorrhagic stroke in young white women
    Stroke, 2001
    Co-Authors: Alex P Reiner, Stephen M Schwartz, Michele B Frank, W T Longstreth, Lucia A Hindorff, Gayle Teramura, Frits R Rosendaal, Lakshmi K Gaur, Bruce M Psaty, David S Siscovick
    Abstract:

    Background and Purpose — Although family studies have suggested a genetic influence on hemorrhagic stroke, the underlying genetic risk Factors remain poorly defined. Coagulation Factor XIII, which is involved in hemostasis, fibrinolysis, vascular remodeling, and tissue repair, represents a candidate gene for hemorrhagic stroke. We assessed the potential role of 3 Factor XIII subunit A coding–sequence polymorphisms, along with a promoter polymorphism of plasminogen activator inhibitor-1 (PAI-1, which is also involved in fibrin stabilization and vascular remodeling), in young white women with hemorrhagic stroke. Methods — Genotype analysis for Factor XIII subunit A Val34Leu, Tyr204Phe, and Pro564Leu and for PAI-1 −675 4G/5G was performed in a population-based case-control study of 42 white women aged <45 years with nonfatal hemorrhagic stroke and 345 demographically similar control subjects. Results — Compared with the respective homozygous wild-type genotypes, the Tyr204/Phe204 genotypes (age-adjusted odds ratio [OR] 2.9, 95% 95% CI 1.1 to 7.5) and the Leu564/Leu564 genotype (OR 4.3, 95% CI 1.4 to 13.7) were each associated with an increased risk of nonfatal hemorrhagic stroke. The risk estimate associated with the Phe204 variant was highest in women with subarachnoid hemorrhage and in nonsmokers, whereas the risk estimate of the Leu564/Leu564 genotype was highest in women with intracerebral hemorrhage and in smokers. Women who carried either the Phe204 allele or the Leu564/Leu564 genotype in combination with the PAI-1 5G/5G genotype had a nearly 20-fold increased risk of hemorrhagic stroke (OR 18.9, 95% CI 3.8 to 95.1). Conclusions — Our findings suggest that the Phe204 and Leu564 variants of Coagulation Factor XIII may be markers for genetic susceptibility to hemorrhagic stroke in women aged <45 years.

  • Polymorphisms of Coagulation Factor XIII Subunit A and Risk of Nonfatal Hemorrhagic Stroke in Young White Women
    Stroke, 2001
    Co-Authors: Alex P Reiner, Stephen M Schwartz, Michele B Frank, W T Longstreth, Lucia A Hindorff, Gayle Teramura, Frits R Rosendaal, Lakshmi K Gaur, Bruce M Psaty, David S Siscovick
    Abstract:

    Background and Purpose — Although family studies have suggested a genetic influence on hemorrhagic stroke, the underlying genetic risk Factors remain poorly defined. Coagulation Factor XIII, which is involved in hemostasis, fibrinolysis, vascular remodeling, and tissue repair, represents a candidate gene for hemorrhagic stroke. We assessed the potential role of 3 Factor XIII subunit A coding–sequence polymorphisms, along with a promoter polymorphism of plasminogen activator inhibitor-1 (PAI-1, which is also involved in fibrin stabilization and vascular remodeling), in young white women with hemorrhagic stroke. Methods — Genotype analysis for Factor XIII subunit A Val34Leu, Tyr204Phe, and Pro564Leu and for PAI-1 −675 4G/5G was performed in a population-based case-control study of 42 white women aged

A H Zarnani - One of the best experts on this subject based on the ideXlab platform.

  • investigating association of three polymorphisms of Coagulation Factor XIII and recurrent pregnancy loss
    American Journal of Reproductive Immunology, 2010
    Co-Authors: Mahmood Jedditehrani, Raheleh Torabi, Afsaneh Mohammadzadeh, Soheila Arefi, Mohammad Keramatipour, Hojjat Zeraati, A H Zarnani, Mohammad Mehdi Akhondi
    Abstract:

    Citation Jeddi-Tehrani M, Torabi R, Mohammadzadeh A, Arefi S, Keramatipour M, Zeraati H, Zarnani AH, Akhondi MM, Mahmoudian J, Mahmoudi AR, Zarei S. Investigating association of three polymorphisms of Coagulation Factor XIII and recurrent pregnancy loss. Am J Reprod Immunol 2010; 64: 212–217 Problem  Among important suspected causes of thrombophilia in women with recurrent pregnancy loss (RPL) are the polymorphisms of Coagulation Factor XIII (FXIII) gene. We performed a case–control study on the association between three polymorphisms of Factor XIII (FXIII G103T, FXIII A614T and FXIII C1694T) and RPL in Iranian women. Method of study  DNA samples from peripheral blood of 100 female patients with at least two recurrent abortions, as case group, and 100 healthy women with history of at least two successful deliveries were subjected to PCR-RFLP, and the frequencies of the polymorphisms were calculated and compared between the two groups. Results  The prevalence of FXIII G103T polymorphism was 29% in the case group and 17% in the control group (P = 0.158). The frequencies of FXIII A614T and FXIII C1694T were 84% and 66% in the case group and 48% and 31% in the control group (P < 0.001 and P < 0.001), respectively. The two latter polymorphisms are associated with RPL in Iranian women and increase the risk of RPL. A correlation was also found between FXIII A614T and FXIII C1694T polymorphisms (P < 0.001). Conclusion  We suggest the evaluation of FXIII A614T and FXIII C1694T polymorphisms in women with RPL.

  • Investigating Association of Three Polymorphisms of Coagulation Factor XIII and Recurrent Pregnancy Loss.
    American journal of reproductive immunology (New York N.Y. : 1989), 2010
    Co-Authors: Mahmood Jeddi-tehrani, Raheleh Torabi, Afsaneh Mohammadzadeh, Soheila Arefi, Mohammad Keramatipour, Hojjat Zeraati, A H Zarnani, Mohammad Mehdi Akhondi, Jafar Mahmoudian, Ahmad Reza Mahmoudi
    Abstract:

    Citation Jeddi-Tehrani M, Torabi R, Mohammadzadeh A, Arefi S, Keramatipour M, Zeraati H, Zarnani AH, Akhondi MM, Mahmoudian J, Mahmoudi AR, Zarei S. Investigating association of three polymorphisms of Coagulation Factor XIII and recurrent pregnancy loss. Am J Reprod Immunol 2010; 64: 212–217 Problem  Among important suspected causes of thrombophilia in women with recurrent pregnancy loss (RPL) are the polymorphisms of Coagulation Factor XIII (FXIII) gene. We performed a case–control study on the association between three polymorphisms of Factor XIII (FXIII G103T, FXIII A614T and FXIII C1694T) and RPL in Iranian women. Method of study  DNA samples from peripheral blood of 100 female patients with at least two recurrent abortions, as case group, and 100 healthy women with history of at least two successful deliveries were subjected to PCR-RFLP, and the frequencies of the polymorphisms were calculated and compared between the two groups. Results  The prevalence of FXIII G103T polymorphism was 29% in the case group and 17% in the control group (P = 0.158). The frequencies of FXIII A614T and FXIII C1694T were 84% and 66% in the case group and 48% and 31% in the control group (P 

Mohammad Keramatipour - One of the best experts on this subject based on the ideXlab platform.

  • investigating association of three polymorphisms of Coagulation Factor XIII and recurrent pregnancy loss
    American Journal of Reproductive Immunology, 2010
    Co-Authors: Mahmood Jedditehrani, Raheleh Torabi, Afsaneh Mohammadzadeh, Soheila Arefi, Mohammad Keramatipour, Hojjat Zeraati, A H Zarnani, Mohammad Mehdi Akhondi
    Abstract:

    Citation Jeddi-Tehrani M, Torabi R, Mohammadzadeh A, Arefi S, Keramatipour M, Zeraati H, Zarnani AH, Akhondi MM, Mahmoudian J, Mahmoudi AR, Zarei S. Investigating association of three polymorphisms of Coagulation Factor XIII and recurrent pregnancy loss. Am J Reprod Immunol 2010; 64: 212–217 Problem  Among important suspected causes of thrombophilia in women with recurrent pregnancy loss (RPL) are the polymorphisms of Coagulation Factor XIII (FXIII) gene. We performed a case–control study on the association between three polymorphisms of Factor XIII (FXIII G103T, FXIII A614T and FXIII C1694T) and RPL in Iranian women. Method of study  DNA samples from peripheral blood of 100 female patients with at least two recurrent abortions, as case group, and 100 healthy women with history of at least two successful deliveries were subjected to PCR-RFLP, and the frequencies of the polymorphisms were calculated and compared between the two groups. Results  The prevalence of FXIII G103T polymorphism was 29% in the case group and 17% in the control group (P = 0.158). The frequencies of FXIII A614T and FXIII C1694T were 84% and 66% in the case group and 48% and 31% in the control group (P < 0.001 and P < 0.001), respectively. The two latter polymorphisms are associated with RPL in Iranian women and increase the risk of RPL. A correlation was also found between FXIII A614T and FXIII C1694T polymorphisms (P < 0.001). Conclusion  We suggest the evaluation of FXIII A614T and FXIII C1694T polymorphisms in women with RPL.

  • Investigating Association of Three Polymorphisms of Coagulation Factor XIII and Recurrent Pregnancy Loss.
    American journal of reproductive immunology (New York N.Y. : 1989), 2010
    Co-Authors: Mahmood Jeddi-tehrani, Raheleh Torabi, Afsaneh Mohammadzadeh, Soheila Arefi, Mohammad Keramatipour, Hojjat Zeraati, A H Zarnani, Mohammad Mehdi Akhondi, Jafar Mahmoudian, Ahmad Reza Mahmoudi
    Abstract:

    Citation Jeddi-Tehrani M, Torabi R, Mohammadzadeh A, Arefi S, Keramatipour M, Zeraati H, Zarnani AH, Akhondi MM, Mahmoudian J, Mahmoudi AR, Zarei S. Investigating association of three polymorphisms of Coagulation Factor XIII and recurrent pregnancy loss. Am J Reprod Immunol 2010; 64: 212–217 Problem  Among important suspected causes of thrombophilia in women with recurrent pregnancy loss (RPL) are the polymorphisms of Coagulation Factor XIII (FXIII) gene. We performed a case–control study on the association between three polymorphisms of Factor XIII (FXIII G103T, FXIII A614T and FXIII C1694T) and RPL in Iranian women. Method of study  DNA samples from peripheral blood of 100 female patients with at least two recurrent abortions, as case group, and 100 healthy women with history of at least two successful deliveries were subjected to PCR-RFLP, and the frequencies of the polymorphisms were calculated and compared between the two groups. Results  The prevalence of FXIII G103T polymorphism was 29% in the case group and 17% in the control group (P = 0.158). The frequencies of FXIII A614T and FXIII C1694T were 84% and 66% in the case group and 48% and 31% in the control group (P