The Experts below are selected from a list of 192 Experts worldwide ranked by ideXlab platform
James J Ferguson - One of the best experts on this subject based on the ideXlab platform.
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relation between procedural activated Coagulation Time and outcome after percutaneous transluminal coronary angioplasty
Journal of the American College of Cardiology, 1994Co-Authors: James J Ferguson, Kathryn G Dougherty, Carlos M Gaos, Howard S Bush, Kathryn Marsh, Richard D LeachmanAbstract:Objectives. The purpose of this study was to determine whether a low procedural activated Coagulation Time is associated with a high rate of in-hospital complications and to identify whether there is an activated Coagulation Time range that may be associated with a low rate of complications. Background. In recent years the activated Coagulation Time has come into widespread use for monitoring antiCoagulation in the catheterization laboratory. However, considerable controversy exists as to the standards by which to judge “adequate” antiCoagulation for interventional procedures. Methods. From a total of 1,469 consecutive patients with percutaneous transluminal coronary angioplasty, we retrospectively identified 103 (Group I, 7% of the overall population) with major complications of death or emergency or urgent coronary artery bypass graft surgery and compared them with 400 patients without complications (Group II). Group I patients had more high risk clinical characteristics, such as type B and C lesions, class III and IV angina, recent myocardial infarction and recent thrombolytic treatment. Activated Coagulation Times were compared between Groups I and II at baseline, after administration of 10,000 U of heparin and at the end of the procedure. Results. There were no differences in baseline activated Coagulation Times between Groups I and II. Group I had significantly lower activated Coagulation Times after heparin therapy and at the end of the procedure: 61% 300 s; 279 of Group II had activated Coagulation Times 27% 300 s (p 300 s. Conclusions. A diminished activated Coagulation Time response to an initial bolus of heparin is associated with major in-hospital complications after coronary angioplasty, although patients with complications did have a higher risk before the procedure. It remains to be determined whether there is an ideal “target” activated Coagulation Time for interventional procedures.
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comparison of hemochron and hemotec activated Coagulation Time target values during percutaneous transluminal coronary angioplasty
Journal of the American College of Cardiology, 1994Co-Authors: Amilcar Avendano, James J FergusonAbstract:Objectives. The aim of this study was to determine whether activated Coagulation Time measurements from Hemochrem and HemoTec machines can be used interchangeably and whether similar activated Coagulation Time target ranges for adequate antiCoagulation can be applied to both machines. Background. Adequate antiCoagulation is necessary for the safe performance of intravascular interventions such as percutaneous transluminal coronary angioplasty. In current practice, antiCoagulation status is frequently assessed by way of the activated Coagulation Time one of two commercially available systems, HemoTec and Hemochron. Each one employs a different technique to determine the Time of clot formation; however, the same terget activated Coagulation Time values for adequate antiCoagulation have been used interchangeably in published studies. Methods. A total of 311 paired samples were compared in 113 high risk patients undergoing angioplasty enrolled in a randomized trial of a platelet glycoprotein IIb/IIIa receptor antibody. Simultaneous activated Coagulation Time measurements were obtained before and after administration of heparin, and the difference between the values of both machines was calculated. The relation between the Hemochron and HemoTec values was determined by using linear regression analysis. All activated Coagulation Time measurements were classified as either therapeutic or subtherapeutic using an arbitrary activated Coagulation Time target of 300 s. Results. There was a correlation between values from the two machines (r = 0.86), but the Hemochron values were consistently higher than the HemoTec values by a mean value ± SD of 28 ± 29%, with wide individual variation. After heparin administration, there was a signaificant (p < 0.0001) difference between the number of measurements classified as therapeutic by HemoTec (53%) and by Hemochron (94%). Conclusions. HemoTec and Hemochron activated Coagulation Time measurements cannot be used interchangeably. Appropriate target activated Coagulation Time ranges to determine adequate antiCoagulation during coronary angioplasty need to be established for both machines; the target range for one machine should not be extrapolated to the other.
Chunggyu Park - One of the best experts on this subject based on the ideXlab platform.
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reference values of hematology chemistry electrolytes blood gas Coagulation Time and urinalysis in the chinese rhesus macaques macaca mulatta
Xenotransplantation, 2012Co-Authors: Jun Seop Shin, Won Young Jung, Chunggyu ParkAbstract:Lee J-I, Shin J-S, Lee J-E, Jung W-Y, Lee G, Kim M-S, Park C-G, Kim S-J. Reference values of hematology, chemistry, electrolytes, blood gas, Coagulation Time, and urinalysis in the Chinese rhesus macaques (Macaca mulatta). Xenotransplantation 2012; 19: 244–248.. © 2012 John Wiley & Sons A/S. Abstract: Background: Due to increasing preclinical study using the rhesus monkeys, the physiological data of these monkeys are very important for the objective evaluation of experimental results. Here, we report the physiological values of the Chinese rhesus monkeys acclimated under a well-controlled laboratory environment. Methods: Seventy healthy rhesus monkeys of both genders (29 males and 41 females) were used in this study. Available data on hematology, serum biochemistry, electrolytes, blood gas, Coagulation Time, urinalysis, water consumption, urine volume, and body weight were examined. Results: The lymphocyte values were 1.5–2.5 Times higher than the neutrophil values in both genders. In serum biochemistry, there was no significant difference between the two genders. Interestingly, the values of alkaline phosphatase from the monkeys were very high. According to isoenzyme analysis, the percentage of alkaline phosphatase that originated from the bone was 60%, and this value was significantly higher than that from the liver (39%, P = 0.020). Conclusion: Physiological data are very important parameters that can be directly and indirectly related to organ function (e.g. islet, kidney, liver, heart, etc.) in the transplantation model. In this respect, our data constitute valuable references for preclinical study using the Chinese rhesus monkeys.
Zhang Zheng-ling - One of the best experts on this subject based on the ideXlab platform.
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Influence on Bleeding Time and Coagulation Time in Mice of carbonized Aahesive Rehmannia Root and Prepared Rehmannia Root
Chinese Archives of Traditional Chinese Medicine, 2020Co-Authors: Zhang Zheng-lingAbstract:Objective:To research the influence on bleeding Time and Coagulation Time in mice of carbonized Aahesive Rehmannia Root and carbonized Prepared Rehmannia Root in order to to provide an initial experimental basis for further exploration of its bleeding-stoppling mechanism.Method:ICR mice were experimental animals,tail method and the capillary method were used to measure the influence on bleeding Time and Coagulation Time of Aahesive Rehmannia Root,Prepared Rehmannia Root,carbonized Aahesive Rehmannia Root,and carbonized Prepared Rehmannia Root.Results:Compared with the saline group,Aahesive Rehmannia Root,carbonized Aahesive Rehmannia Root and carbonized Prepared Rehmannia Root were able to significantly shorten the bleeding Time(P0.01) and Coagulation Time(P0.01);compared with Aahesive Rehmannia Root group,carbonized Aahesive Rehmannia Root Tuber can significantly shorten the bleeding Time(P0.05) and Coagulation Time(P0.05);compared with Prepared Rehmannia Root group,carbonized Prepared Rehmannia Root can significantly reduce bleeding Time in mice(P0.01) and Coagulation Time(P0.01).Conclusion:Carbonized Aahesive Rehmannia Root Tuber and carbonized Prepared Rehmannia Root both have a certain role in hemostasis,and Aahesive Rehmannia Root enhanced function of hemostasis after carbonization,Prepared Rehmannia Root can have function of hemostasis after carbonization.
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Effect of carbonized Aahesive Rehmannia Root Tuber and Prepared Rehmannia Root on bleeding Time and Coagulation Time in mice
China Journal of Traditional Chinese Medicine and Pharmacy, 2020Co-Authors: Zhang Zheng-lingAbstract:Objective: To research the effect of carbonized Aahesive Rehmannia Root Tuber,carbonized Prepared Rehmannia Root on bleeding Time and Coagulation Time of mice,in order to provide an initial experimental basis for exploring the stop bleeding and processing mechanism of carbonized Aahesive Rehmannia Root Tuber,carbonized Prepared Rehmannia Root.Methods: Selecting ICR mice as experimental animals,using docking method and the capillary tube method to measure bleeding Time and Coagulation Time of Aahesive Rehmannia Root Tuber,Prepared Rehmannia Root,carbonized Aahesive Rehmannia Root Tuber,carbonized Prepared Rehmannia Root,carbonized Aahesive Rehmannia Root Tuber by calcining,carbonized Prepared Rehmannia Root by calcining.Results: Compared with the 0.9% saline group,Aahesive Rehmannia Root Tuber,carbonized Aahesive Rehmannia Root Tuber and carbonized Prepared Rehmannia Root were able to significantly shorten the bleeding Time and Coagulation Time of mice(P0.01);and carbonized Aahesive Rehmannia Root Tuber by calcining,carbonized Prepared Rehmannia Root by calcining can significantly shorten the bleeding Time in mice and Coagulation Time(P0.05);Compared with the Aahesive Rehmannia Root Tuber group,carbonized Aahesive Rehmannia Root Tuber and carbonized Aahesive Rehmannia Root Tuber by calcining can significantly reduce bleeding Time in mice and Coagulation Time(P0.05);Compared with the Prepared Rehmannia Root group,carbonized Prepared Rehmannia Root and carbonized Prepared Rehmannia Root by calcining can significantly reduce bleeding Time in mice and Coagulation Time(P0.01).Conclusion: Carbonized Aahesive Rehmannia Root Tuber and carbonized Prepared Rehmannia Root all have a certain role in hemostasis,and Aahesive Rehmannia Root Tuber enhanced hemostasis after carbonizing,Prepared Rehmannia Root resulting from hemostasis after carbonizing,and there are not signicant difference between different carbonizing methods to hemostasis of carbonized Aahesive Rehmannia Root Tuber and carbonized Prepared Rehmannia Root.
Giovanni Bittante - One of the best experts on this subject based on the ideXlab platform.
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modeling rennet Coagulation Time and curd firmness of milk
Journal of Dairy Science, 2011Co-Authors: Giovanni BittanteAbstract:Abstract Milk Coagulation properties (MCP) are traditionally expressed using rennet Coagulation Time (RCT), Time to curd firmness (CF) of 20mm (k 20 ), and CF 30min after enzyme addition (a 30 ) values, all of which are single-point measures taken from the output of computerized renneting meters, such as the Formagraph. Thus, traditional MCP use only some of the available information. Moreover, because of the worldwide spreading of breeds such as the Holstein-Friesian, characterized by late-coagulating milk, it happens often that some samples do not coagulate at all, that a 30 is strongly and negatively related to RCT, and that k 20 is not measurable. The aim of the present work was to model CF as a function of Time (CF t , mm) over a 30-min interval. The model tested was C F t = C F P × 1 − e − k C F × \( t − R C T \) , where CF P (mm) is the potential asymptotical CF at an infinite Time, k CF (min −1 ) is the curd firming rate constant, and RCT is measured inminutes. The CF t model was initially applied to data of milk of each of 105 Brown Swiss cows from 7 herds, each sampled once (trial 1). Four samples did not coagulate within 30min. Eighty-seven of the 101 individual equations obtained fit the CF data of milk samples very well, even though the samples differed in composition, and were produced by cows of different ages and days in milk, reared on different farms (coefficient of determination >0.99; average residual standard deviation=0.21mm). Samples with a very late RCT (slowly coagulating samples) yielded so few observational data points that curve parameters could not be precisely estimated. The repeatability of CF t equation parameters was estimated using data obtained from 5 replicates of each of 2 samples of bulk milk from 5 Holstein-Friesian cows analyzed every day for 5 consecutive days (trial 2). Repeatability of RCT was better than that of the other 2 parameters. Moreover, traditional MCP values (RCT, a 30 , and k 20 ) can be obtained from the individual CF t equations, using all available information. The MCP estimated from equations were very similar to the single-point measures yielded by the computerized renneting meter (coefficient of determination >0.97), but repeatability was slightly better. The model allowed the estimation of k 20 for samples with a very late Coagulation or with very slow curd firming. Finally, the 3 novel parameters used to assess different milk samples were less interdependent than are the traditional measures, and their practical and scientific utility requires further study.
Richard D Leachman - One of the best experts on this subject based on the ideXlab platform.
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relation between procedural activated Coagulation Time and outcome after percutaneous transluminal coronary angioplasty
Journal of the American College of Cardiology, 1994Co-Authors: James J Ferguson, Kathryn G Dougherty, Carlos M Gaos, Howard S Bush, Kathryn Marsh, Richard D LeachmanAbstract:Objectives. The purpose of this study was to determine whether a low procedural activated Coagulation Time is associated with a high rate of in-hospital complications and to identify whether there is an activated Coagulation Time range that may be associated with a low rate of complications. Background. In recent years the activated Coagulation Time has come into widespread use for monitoring antiCoagulation in the catheterization laboratory. However, considerable controversy exists as to the standards by which to judge “adequate” antiCoagulation for interventional procedures. Methods. From a total of 1,469 consecutive patients with percutaneous transluminal coronary angioplasty, we retrospectively identified 103 (Group I, 7% of the overall population) with major complications of death or emergency or urgent coronary artery bypass graft surgery and compared them with 400 patients without complications (Group II). Group I patients had more high risk clinical characteristics, such as type B and C lesions, class III and IV angina, recent myocardial infarction and recent thrombolytic treatment. Activated Coagulation Times were compared between Groups I and II at baseline, after administration of 10,000 U of heparin and at the end of the procedure. Results. There were no differences in baseline activated Coagulation Times between Groups I and II. Group I had significantly lower activated Coagulation Times after heparin therapy and at the end of the procedure: 61% 300 s; 279 of Group II had activated Coagulation Times 27% 300 s (p 300 s. Conclusions. A diminished activated Coagulation Time response to an initial bolus of heparin is associated with major in-hospital complications after coronary angioplasty, although patients with complications did have a higher risk before the procedure. It remains to be determined whether there is an ideal “target” activated Coagulation Time for interventional procedures.