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Jost B. Jonas - One of the best experts on this subject based on the ideXlab platform.

  • Coats Disease and retrobulbar haemodynamics
    Acta Ophthalmologica, 2016
    Co-Authors: Qi Zhao, Xiao-yan Peng, Wenli Yang, Dongjun Li, Jost B. Jonas
    Abstract:

    Purpose To study the retrobulbar haemodynamics in patients with Coats’ Disease. Methods The clinical study included 43 patients with Coats’ Disease. Using colour Doppler imaging, we measured the blood flow velocity in the ophthalmic artery (OA), central retinal artery (CRA) and posterior ciliary arteries (PCA), and recorded the peak systolic velocity (PSV), end diastolic velocity (EDV), time averaged maximum velocity (TAMX), pulsatility index (PI) and resistance indexes (RI). The unaffected contralateral eyes served as control group. The Disease was graded into four stages. Results Compared to the contralateral eyes, the Coats’ Disease affected eyes showed for the CRA a significant decrease in PSV (7.08 ± 1.38 cm/s versus 8.64 ± 1.45 cm/s; p < 0.001), EDV (2.03 ± 0.41 cm/s versus 2.52 ± 0.62 cm/s; p < 0.001) and TAMX (3.67 ± 0.96 cm/s versus 4.40 ± 1.22 cm/s; p = 0.003) and for the PCA a significant decrease in PSV (9.15 ± 1.87 cm/s versus 10.14 ± 1.61 cm/s; p = 0.01). Subgroup analysis revealed that the decrease in haemodynamic parameters existed mainly in patients with stage 3A2 and stage 3B of Coats' Disease. Conclusions As measured by colour Doppler imaging, the retrobulbar blood vessels showed decreased haemodynamic parameters in patients with Coats’ Disease on the affected side as compared to the contralateral unaffected side, in particular in advanced stages of the Disease. Future studies may address the causes and effects of these haemodynamic changes.

  • Coats' Disease and retrobulbar haemodynamics.
    Acta Ophthalmologica, 2015
    Co-Authors: Qi Zhao, Xiao-yan Peng, Wenli Yang, Dongjun Li, Jost B. Jonas
    Abstract:

    Purpose To study the retrobulbar haemodynamics in patients with Coats’ Disease. Methods The clinical study included 43 patients with Coats’ Disease. Using colour Doppler imaging, we measured the blood flow velocity in the ophthalmic artery (OA), central retinal artery (CRA) and posterior ciliary arteries (PCA), and recorded the peak systolic velocity (PSV), end diastolic velocity (EDV), time averaged maximum velocity (TAMX), pulsatility index (PI) and resistance indexes (RI). The unaffected contralateral eyes served as control group. The Disease was graded into four stages. Results Compared to the contralateral eyes, the Coats’ Disease affected eyes showed for the CRA a significant decrease in PSV (7.08 ± 1.38 cm/s versus 8.64 ± 1.45 cm/s; p 

  • vascular endothelial growth factor in Coats Disease
    Acta Ophthalmologica, 2014
    Co-Authors: Qi Zhao, Xiao-yan Peng, Jost B. Jonas, Feng-hua Chen, Yong-peng Zhang, Lian Wang
    Abstract:

    . Purpose:  To examine whether vascular endothelial growth factor (VEGF) as one of the most important intraocular cytokines for angiogenesis and increased vascular permeability is associated with Coats’ Disease. Methods:  The clinical interventional study included 28 patients with Coats’ Disease and seven control patients with congenital cataract. During intraocular surgery, we obtained aqueous humour samples in which the VEGF concentration was measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Coats’ Disease was graded into four stages. Results:  The mean aqueous VEGF level was significantly higher in the Coats’ study group than in the control group (158 ± 88 versus 97 ± 21 pg/ml; p = 0.002). The VEGF concentrations increased significantly (p < 0.001) from 91 ± 32 pg/ml in Coats’ Disease stage 2 to 100 ± 37 pg/ml in stage 3A1, 185 ± 56 pg/ml in stage 3A2 to 256 ± 93 pg/ml in patients with stage 3B. Vascular endothelial growth factor concentrations in Coats’ stage 2 and 3A1 did not differ significantly from the values in the control group. Parallel to the association with the stage of the Diseases, the VEGF concentrations were significantly (p < 0.001) correlated with extent of exudative retinal detachment. Conclusions:  Increasing severity of Coats’ Disease is significantly associated with intraocular VEGF concentrations. These results favour the intravitreal application of anti-VEGF drugs as medical therapy of Coats’ Diseases.

  • Vascular endothelial growth factor in Coats' Disease.
    Acta Ophthalmologica, 2013
    Co-Authors: Qi Zhao, Xiao-yan Peng, Feng-hua Chen, Yong-peng Zhang, Lian Wang, Jost B. Jonas
    Abstract:

    . Purpose:  To examine whether vascular endothelial growth factor (VEGF) as one of the most important intraocular cytokines for angiogenesis and increased vascular permeability is associated with Coats’ Disease. Methods:  The clinical interventional study included 28 patients with Coats’ Disease and seven control patients with congenital cataract. During intraocular surgery, we obtained aqueous humour samples in which the VEGF concentration was measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Coats’ Disease was graded into four stages. Results:  The mean aqueous VEGF level was significantly higher in the Coats’ study group than in the control group (158 ± 88 versus 97 ± 21 pg/ml; p = 0.002). The VEGF concentrations increased significantly (p 

Qi Zhao - One of the best experts on this subject based on the ideXlab platform.

  • Coats Disease and retrobulbar haemodynamics
    Acta Ophthalmologica, 2016
    Co-Authors: Qi Zhao, Xiao-yan Peng, Wenli Yang, Dongjun Li, Jost B. Jonas
    Abstract:

    Purpose To study the retrobulbar haemodynamics in patients with Coats’ Disease. Methods The clinical study included 43 patients with Coats’ Disease. Using colour Doppler imaging, we measured the blood flow velocity in the ophthalmic artery (OA), central retinal artery (CRA) and posterior ciliary arteries (PCA), and recorded the peak systolic velocity (PSV), end diastolic velocity (EDV), time averaged maximum velocity (TAMX), pulsatility index (PI) and resistance indexes (RI). The unaffected contralateral eyes served as control group. The Disease was graded into four stages. Results Compared to the contralateral eyes, the Coats’ Disease affected eyes showed for the CRA a significant decrease in PSV (7.08 ± 1.38 cm/s versus 8.64 ± 1.45 cm/s; p < 0.001), EDV (2.03 ± 0.41 cm/s versus 2.52 ± 0.62 cm/s; p < 0.001) and TAMX (3.67 ± 0.96 cm/s versus 4.40 ± 1.22 cm/s; p = 0.003) and for the PCA a significant decrease in PSV (9.15 ± 1.87 cm/s versus 10.14 ± 1.61 cm/s; p = 0.01). Subgroup analysis revealed that the decrease in haemodynamic parameters existed mainly in patients with stage 3A2 and stage 3B of Coats' Disease. Conclusions As measured by colour Doppler imaging, the retrobulbar blood vessels showed decreased haemodynamic parameters in patients with Coats’ Disease on the affected side as compared to the contralateral unaffected side, in particular in advanced stages of the Disease. Future studies may address the causes and effects of these haemodynamic changes.

  • Coats' Disease and retrobulbar haemodynamics.
    Acta Ophthalmologica, 2015
    Co-Authors: Qi Zhao, Xiao-yan Peng, Wenli Yang, Dongjun Li, Jost B. Jonas
    Abstract:

    Purpose To study the retrobulbar haemodynamics in patients with Coats’ Disease. Methods The clinical study included 43 patients with Coats’ Disease. Using colour Doppler imaging, we measured the blood flow velocity in the ophthalmic artery (OA), central retinal artery (CRA) and posterior ciliary arteries (PCA), and recorded the peak systolic velocity (PSV), end diastolic velocity (EDV), time averaged maximum velocity (TAMX), pulsatility index (PI) and resistance indexes (RI). The unaffected contralateral eyes served as control group. The Disease was graded into four stages. Results Compared to the contralateral eyes, the Coats’ Disease affected eyes showed for the CRA a significant decrease in PSV (7.08 ± 1.38 cm/s versus 8.64 ± 1.45 cm/s; p 

  • vascular endothelial growth factor in Coats Disease
    Acta Ophthalmologica, 2014
    Co-Authors: Qi Zhao, Xiao-yan Peng, Jost B. Jonas, Feng-hua Chen, Yong-peng Zhang, Lian Wang
    Abstract:

    . Purpose:  To examine whether vascular endothelial growth factor (VEGF) as one of the most important intraocular cytokines for angiogenesis and increased vascular permeability is associated with Coats’ Disease. Methods:  The clinical interventional study included 28 patients with Coats’ Disease and seven control patients with congenital cataract. During intraocular surgery, we obtained aqueous humour samples in which the VEGF concentration was measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Coats’ Disease was graded into four stages. Results:  The mean aqueous VEGF level was significantly higher in the Coats’ study group than in the control group (158 ± 88 versus 97 ± 21 pg/ml; p = 0.002). The VEGF concentrations increased significantly (p < 0.001) from 91 ± 32 pg/ml in Coats’ Disease stage 2 to 100 ± 37 pg/ml in stage 3A1, 185 ± 56 pg/ml in stage 3A2 to 256 ± 93 pg/ml in patients with stage 3B. Vascular endothelial growth factor concentrations in Coats’ stage 2 and 3A1 did not differ significantly from the values in the control group. Parallel to the association with the stage of the Diseases, the VEGF concentrations were significantly (p < 0.001) correlated with extent of exudative retinal detachment. Conclusions:  Increasing severity of Coats’ Disease is significantly associated with intraocular VEGF concentrations. These results favour the intravitreal application of anti-VEGF drugs as medical therapy of Coats’ Diseases.

  • Vascular endothelial growth factor in Coats' Disease.
    Acta Ophthalmologica, 2013
    Co-Authors: Qi Zhao, Xiao-yan Peng, Feng-hua Chen, Yong-peng Zhang, Lian Wang, Jost B. Jonas
    Abstract:

    . Purpose:  To examine whether vascular endothelial growth factor (VEGF) as one of the most important intraocular cytokines for angiogenesis and increased vascular permeability is associated with Coats’ Disease. Methods:  The clinical interventional study included 28 patients with Coats’ Disease and seven control patients with congenital cataract. During intraocular surgery, we obtained aqueous humour samples in which the VEGF concentration was measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Coats’ Disease was graded into four stages. Results:  The mean aqueous VEGF level was significantly higher in the Coats’ study group than in the control group (158 ± 88 versus 97 ± 21 pg/ml; p = 0.002). The VEGF concentrations increased significantly (p 

Yanrong Jiang - One of the best experts on this subject based on the ideXlab platform.

  • differences in aqueous concentrations of cytokines in paediatric and adult patients with Coats Disease
    Acta Ophthalmologica, 2017
    Co-Authors: Jing Feng, Xiaoxue Zheng, Bing Li, Yanrong Jiang
    Abstract:

    Purpose To investigate the differential aqueous concentrations of vascular endothelia growth factor (VEGF) and inflammatory cytokines in paediatric and adult patients with Coats' Disease. Methods A total of 20 eyes of 20 patients with Coats' Disease, 12 eyes of 12 paediatric patients, and eight eyes of eight adult patients, six patients (six eyes) with congenital cataract as the paediatric control group and 10 patients (10 eyes) with senile cataract as the adult control group were examined. Aqueous humour samples were assessed for interleukin-6, -8, -1β (IL-6, IL-8, IL-1β, respectively), basic fibroblast growth factor, monocyte chemo-attractant protein 1, tumour necrosis factor alpha and VEGF by multiplex bead assay. Results Significantly, higher concentrations of VEGF, IL-6 and IL-1β were found in the paediatric patients with Coats' Disease (p = 0.001, p = 0.004 and p = 0.006). Concentration of VEGF in the paediatric patients with Stage 3B of Coats' Disease was significantly higher than that of Stage 3A (p = 0.010). In the adult patients with Coats' Disease, the aqueous levels of IL-6 and IL-1β were significantly higher than that of the controls (p = 0.012, and p = 0.005). The concentration of IL-6 was significantly linearly associated with the extent of exudative retinal detachment (p = 0.003, R = 0.892). Conclusions Increasing severity of Coats' Disease is significantly associated with intraocular VEGF concentration in the paediatric patients. And IL-6 may be involved with the inflammatory process in the adult patients with Coats' Disease.

  • the effect of intravitreal bevacizumab injection as the initial treatment for Coats Disease
    Graefes Archive for Clinical and Experimental Ophthalmology, 2014
    Co-Authors: Xiaoxue Zheng, Yanrong Jiang
    Abstract:

    Background In Coats’ Disease, the most recent development in the treatment has been the intravitreal injection of anti-VEGF agents. The purpose of this article was to evaluate the effect of intravitreal bevacizumab as the initial treatment for Coats’ Disease in children and adults.

  • resolution of total retinal detachment in Coats Disease with intravitreal injection of bevacizumab
    Graefes Archive for Clinical and Experimental Ophthalmology, 2011
    Co-Authors: Tong Zhao, Kai Wang, Yanrong Jiang
    Abstract:

    Dear Editor Coats’ Disease is a nonhereditary condition of primary retinal telangiectasia that is characterized by dilation and tortuosity of retinal blood vessels, multiple aneurysms, and exudates. Coats’ Disease is usually unilateral, affects young boys, and causes severe visual loss due to exudative retinal detachment. Routine photocoagulation, cryotherapy, and even surgery may have poor therapeutic effects for total retinal detachment. We report a case of Coats’ Disease with total retinal detachment that demonstrated a remarkable response to intravitreal bevacizumab injection. A 3-year-old Chinese boy presented with a 2-year history of left eye squinting. The corneal light reflection test showed a 15° exotropia of the left eye, which could not be corrected. The grating visual acuity of the right eye was 0.2, and the left eye did not respond to stimuli. Examination under anesthesia showed total retinal detachment of the left eye, with extensive subretinal exudates accompanied by dilated tortuous vessels (Fig. 1a), and the intraocular pressures were 14 mmHg bilaterally. Type-B ultrasonography indicated total retinal detachment of the left eye (Fig. 2a). A diagnosis of Coats’ Disease stage 3B was made via Shields’ classification [1]. After receiving consent from the boy’s parents for a trial of off-label use of bevacizumab, we performed intravitreal bevacizumab injection (1.25 mg/0.05 ml) three times at 6week intervals. Eight weeks after the last injection, the dilated vessels were alleviated, and the subretinal exudates and fluid were decreased (Fig. 1b). Type-B ultrasonography revealed a significant anatomical improvement of the retina compared with pre-injection, with only a small range of superior retinal detachment. Within 15 weeks after the last injection, the corrected visual acuity of the left eye was 20/ 125 and Type-B ultrasonography showed further resolution of the retinal detachment (Fig. 2b). Diagnosing Coats’ Disease is a lengthy process, and there is still confusion about the definition. The most widely accepted diagnostic criteria of Coats’ Disease include idiopathic retinal telangiectasia, intraretinal and subretinal exudation, and frequent exudative retinal detachment without vitreous or retinal traction. Coats’ Disease has no clear etiopathogenisis, but it is widely accepted that it is related to a defect in the development of the retinal vessels. Vascular endothelial growth factor (VEGF) plays an important role in the development of retinal vessels. Although basic investigations of Coats’ Disease are rare, it is believed that VEGF induced by hypoxia may be part of the pathogenesis, considering the evidence of elevated intravitreal VEGF levels of a patient with stage 4 Coats’ Disease [2, 3]. The hypothesis suggests anti-VEGF therapies, which have been used in tumors and some neovascular Diseases in ophthalmology, as possible therapies for Coats’ Disease. Bevacizumab, a full-length humanized recombinant antibody against VEGF, is one of the anti-VEGF agents under consideration. There have been several encouraging reports about treating Coats’ Disease with bevacizumab combined with triamcinolone injection or laser treatment [4–6]. To our knowledge, this is the first report of treating total retinal detachment caused by Coats’ Disease using Financial support None.

Carol L Shields - One of the best experts on this subject based on the ideXlab platform.

  • visual acuity outcomes in Coats Disease by classification stage in 160 patients
    British Journal of Ophthalmology, 2020
    Co-Authors: Carol L Shields, Sanika Udyaver, Lauren A Dalvin, Hatice Tuba Atalay, Chloe Tl Khoo, Mehdi Mazloumi, Jerry A Shields
    Abstract:

    Purpose To assess visual outcomes of Coats Disease by classification stage. Methods A retrospective review was conducted on consecutive patients with Coats Disease, classified according to Shields classification and with available Snellen visual acuity before and after treatment. Results There were 160 eyes with Coats Disease (stage 1 (n=2) vs stage 2A (n=17) vs stage 2B (n=22) vs stage 3A1 (n=26) vs stage 3A2 (n=40) vs stage 3B (n=42) vs stage 4 (n=9) vs stage 5 (n=2)). By comparison, more advanced stage showed greater frequency of poor presenting visual acuity ( Conclusion Visual acuity in eyes with Coats Disease parallels staging with more advanced stage demonstrating poorer visual acuity at presentation and final visit.

  • Coats Disease an overview of classification management and outcomes
    Indian Journal of Ophthalmology, 2019
    Co-Authors: Carol L Shields, Santosh G Honavar, Jerry A Shields
    Abstract:

    Coats Disease is an idiopathic retinal vascular disorder with retinal telangiectasia with intraretinal and/or subretinal exudation without appreciable retinal or vitreal traction. The condition is sporadic with no associated systemic abnormalities. Unilateral involvement in young males is the typical presentation with most cases being diagnosed in the first and second decade of life. Younger the patient, more severe is the presentation and poorer the visual outcome. The management varies with the stage of the Disease. Over the years, we have shifted from enucleation to a more conservative approach for the treatment of Coats Disease with laser photocoagulation, cryotherapy and surgery for retinal detachment achieving good outcomes. The anti-VEGF agents have come into the scene as important form of adjuvant treatment along with the traditional management options. This article describes the clinical features, underlying pathology, classification and staging, the complications and the management of Coats Disease and gives an overview of the changing trends in treatment and outcomes spanning across five decades.

  • serum hypercoagulability states in Coats Disease
    Clinical Ophthalmology, 2017
    Co-Authors: Fariba Ghassemi, Carol L Shields, Masoumeh Mohebbi, Mehdi Nili Ahmadabadi, Fatemeh Morsali, Siamak Sabour
    Abstract:

    PURPOSE: The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats' Disease versus a normal control group. MATERIALS AND METHODS: In this comparative case series, 22 consecutive patients with Coats' Disease and 19 non-Coats' patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 and June 2014 were included. Laboratory data for hypercoagulability states and common viral and protozoan infections were investigated. RESULTS: The mean age for the Coats' group was 14.5 years (median 8 years, range: 2 months to 59 years), and for the control group it was 30.6 years (median 17 years, range: 2-82 years). In patients aged 10 years or younger, anticytomegalovirus immunoglobulin G (IgG) (P≤0.01), homocysteine (P=0.03), and serum beta globulin (P<0.001) were associated with Coats' Disease. In those older than 10 years, higher serum protein S (P=0.04), beta globulin (P=0.05), and gamma globulin (P=0.04) were related to Coats' diagnosis. After adjusting for sex and age as confounding factors, only beta globulin was found to be associated with Coats' Disease in logistic regression analysis (odds ratio: 1.8, 95% confidence interval: 1.0-3.1, P=0.02). CONCLUSION: Serum beta globulin levels appear to be elevated in patients with Coats' Disease.

  • Serum hypercoagulability states in Coats’ Disease
    Clinical Ophthalmology, 2017
    Co-Authors: Fariba Ghassemi, Carol L Shields, Masoumeh Mohebbi, Mehdi Nili Ahmadabadi, Fatemeh Morsali, Siamak Sabour
    Abstract:

    PURPOSE: The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats' Disease versus a normal control group. MATERIALS AND METHODS: In this comparative case series, 22 consecutive patients with Coats' Disease and 19 non-Coats' patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 and June 2014 were included. Laboratory data for hypercoagulability states and common viral and protozoan infections were investigated. RESULTS: The mean age for the Coats' group was 14.5 years (median 8 years, range: 2 months to 59 years), and for the control group it was 30.6 years (median 17 years, range: 2-82 years). In patients aged 10 years or younger, anticytomegalovirus immunoglobulin G (IgG) (P≤0.01), homocysteine (P=0.03), and serum beta globulin (P

  • retinoblastoma in an eye with features of Coats Disease
    Journal of Pediatric Ophthalmology & Strabismus, 2006
    Co-Authors: Carol L Shields, Yusuf Uysal, Raquel Benevides, Ralph C Eagle, Barry Malloy, Jerry A Shields
    Abstract:

    : A 44-month-old girl developed retinal detachment with extensive telangiectasia and "light bulb" aneurysms suggestive of Coats' Disease. However, underlying and within the retina was diffuse retinoblastoma. Diffuse infiltrative retinoblastoma can manifest features of Coats' Disease and could lead to diagnostic confusion.

Xiao-yan Peng - One of the best experts on this subject based on the ideXlab platform.

  • Coats Disease and retrobulbar haemodynamics
    Acta Ophthalmologica, 2016
    Co-Authors: Qi Zhao, Xiao-yan Peng, Wenli Yang, Dongjun Li, Jost B. Jonas
    Abstract:

    Purpose To study the retrobulbar haemodynamics in patients with Coats’ Disease. Methods The clinical study included 43 patients with Coats’ Disease. Using colour Doppler imaging, we measured the blood flow velocity in the ophthalmic artery (OA), central retinal artery (CRA) and posterior ciliary arteries (PCA), and recorded the peak systolic velocity (PSV), end diastolic velocity (EDV), time averaged maximum velocity (TAMX), pulsatility index (PI) and resistance indexes (RI). The unaffected contralateral eyes served as control group. The Disease was graded into four stages. Results Compared to the contralateral eyes, the Coats’ Disease affected eyes showed for the CRA a significant decrease in PSV (7.08 ± 1.38 cm/s versus 8.64 ± 1.45 cm/s; p < 0.001), EDV (2.03 ± 0.41 cm/s versus 2.52 ± 0.62 cm/s; p < 0.001) and TAMX (3.67 ± 0.96 cm/s versus 4.40 ± 1.22 cm/s; p = 0.003) and for the PCA a significant decrease in PSV (9.15 ± 1.87 cm/s versus 10.14 ± 1.61 cm/s; p = 0.01). Subgroup analysis revealed that the decrease in haemodynamic parameters existed mainly in patients with stage 3A2 and stage 3B of Coats' Disease. Conclusions As measured by colour Doppler imaging, the retrobulbar blood vessels showed decreased haemodynamic parameters in patients with Coats’ Disease on the affected side as compared to the contralateral unaffected side, in particular in advanced stages of the Disease. Future studies may address the causes and effects of these haemodynamic changes.

  • Coats' Disease and retrobulbar haemodynamics.
    Acta Ophthalmologica, 2015
    Co-Authors: Qi Zhao, Xiao-yan Peng, Wenli Yang, Dongjun Li, Jost B. Jonas
    Abstract:

    Purpose To study the retrobulbar haemodynamics in patients with Coats’ Disease. Methods The clinical study included 43 patients with Coats’ Disease. Using colour Doppler imaging, we measured the blood flow velocity in the ophthalmic artery (OA), central retinal artery (CRA) and posterior ciliary arteries (PCA), and recorded the peak systolic velocity (PSV), end diastolic velocity (EDV), time averaged maximum velocity (TAMX), pulsatility index (PI) and resistance indexes (RI). The unaffected contralateral eyes served as control group. The Disease was graded into four stages. Results Compared to the contralateral eyes, the Coats’ Disease affected eyes showed for the CRA a significant decrease in PSV (7.08 ± 1.38 cm/s versus 8.64 ± 1.45 cm/s; p 

  • vascular endothelial growth factor in Coats Disease
    Acta Ophthalmologica, 2014
    Co-Authors: Qi Zhao, Xiao-yan Peng, Jost B. Jonas, Feng-hua Chen, Yong-peng Zhang, Lian Wang
    Abstract:

    . Purpose:  To examine whether vascular endothelial growth factor (VEGF) as one of the most important intraocular cytokines for angiogenesis and increased vascular permeability is associated with Coats’ Disease. Methods:  The clinical interventional study included 28 patients with Coats’ Disease and seven control patients with congenital cataract. During intraocular surgery, we obtained aqueous humour samples in which the VEGF concentration was measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Coats’ Disease was graded into four stages. Results:  The mean aqueous VEGF level was significantly higher in the Coats’ study group than in the control group (158 ± 88 versus 97 ± 21 pg/ml; p = 0.002). The VEGF concentrations increased significantly (p < 0.001) from 91 ± 32 pg/ml in Coats’ Disease stage 2 to 100 ± 37 pg/ml in stage 3A1, 185 ± 56 pg/ml in stage 3A2 to 256 ± 93 pg/ml in patients with stage 3B. Vascular endothelial growth factor concentrations in Coats’ stage 2 and 3A1 did not differ significantly from the values in the control group. Parallel to the association with the stage of the Diseases, the VEGF concentrations were significantly (p < 0.001) correlated with extent of exudative retinal detachment. Conclusions:  Increasing severity of Coats’ Disease is significantly associated with intraocular VEGF concentrations. These results favour the intravitreal application of anti-VEGF drugs as medical therapy of Coats’ Diseases.

  • Vascular endothelial growth factor in Coats' Disease.
    Acta Ophthalmologica, 2013
    Co-Authors: Qi Zhao, Xiao-yan Peng, Feng-hua Chen, Yong-peng Zhang, Lian Wang, Jost B. Jonas
    Abstract:

    . Purpose:  To examine whether vascular endothelial growth factor (VEGF) as one of the most important intraocular cytokines for angiogenesis and increased vascular permeability is associated with Coats’ Disease. Methods:  The clinical interventional study included 28 patients with Coats’ Disease and seven control patients with congenital cataract. During intraocular surgery, we obtained aqueous humour samples in which the VEGF concentration was measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Coats’ Disease was graded into four stages. Results:  The mean aqueous VEGF level was significantly higher in the Coats’ study group than in the control group (158 ± 88 versus 97 ± 21 pg/ml; p = 0.002). The VEGF concentrations increased significantly (p