The Experts below are selected from a list of 159 Experts worldwide ranked by ideXlab platform

Dong-hoon Shin - One of the best experts on this subject based on the ideXlab platform.

  • protective effects of daidzein on oxidative stress induced neurotoxicity and scopolamine mediated Cognitive Defect
    Journal of Food Science, 2005
    Co-Authors: Ho Jin, Young-min Suh, Soojung Choi, M.j. Kim, N.s. Mun, H.k. Kim, E.k. Kim, Dong-hoon Shin
    Abstract:

    ABSTRACT: To investigate the effect of daidzein, a major isoflavone constituent isolated from Pueraria thunbergiana (an arrowroot), on the oxidative damage and the scopolamine-induced Cognitive deficit, in vitro cell viability assays and in vivo behavioral tests were performed. Using 3 assays 3-(4,5-dimethylthiazol-2-yl)–2,5-diphenyl tetrazolium bromide (MTT) reduction, lactate dehydrogenase release, and trypan blue exclusion) daidzein showed cell protective effects on oxidative stress-induced cytotoxicity. Administration of daidzein to mice significantly reversed the scopolamine-induced learning and memory impairment in a passive avoidance test. Injection of scopolamine to mice impaired performance in the passive avoidance test (43% decrease). In contrast, mice treated with daidzein before scopolamine injection were protected from this change (higher than the control value). These results suggest that daidzein's neuronal cell protective activities reduce the scopolamine-induced Cognitive deficit and that its anti-amnesic effect might be due to the activation of choline acetyltransferase.

  • Protective Effects of Daidzein on Oxidative Stress‐Induced Neurotoxicity and Scopolamine‐Mediated Cognitive Defect
    Journal of Food Science, 2005
    Co-Authors: Ho Jin, Young-min Suh, Soojung Choi, M.j. Kim, N.s. Mun, H.k. Kim, E.k. Kim, Dong-hoon Shin
    Abstract:

    ABSTRACT: To investigate the effect of daidzein, a major isoflavone constituent isolated from Pueraria thunbergiana (an arrowroot), on the oxidative damage and the scopolamine-induced Cognitive deficit, in vitro cell viability assays and in vivo behavioral tests were performed. Using 3 assays 3-(4,5-dimethylthiazol-2-yl)–2,5-diphenyl tetrazolium bromide (MTT) reduction, lactate dehydrogenase release, and trypan blue exclusion) daidzein showed cell protective effects on oxidative stress-induced cytotoxicity. Administration of daidzein to mice significantly reversed the scopolamine-induced learning and memory impairment in a passive avoidance test. Injection of scopolamine to mice impaired performance in the passive avoidance test (43% decrease). In contrast, mice treated with daidzein before scopolamine injection were protected from this change (higher than the control value). These results suggest that daidzein's neuronal cell protective activities reduce the scopolamine-induced Cognitive deficit and that its anti-amnesic effect might be due to the activation of choline acetyltransferase.

E.k. Kim - One of the best experts on this subject based on the ideXlab platform.

  • protective effects of daidzein on oxidative stress induced neurotoxicity and scopolamine mediated Cognitive Defect
    Journal of Food Science, 2005
    Co-Authors: Ho Jin, Young-min Suh, Soojung Choi, M.j. Kim, N.s. Mun, H.k. Kim, E.k. Kim, Dong-hoon Shin
    Abstract:

    ABSTRACT: To investigate the effect of daidzein, a major isoflavone constituent isolated from Pueraria thunbergiana (an arrowroot), on the oxidative damage and the scopolamine-induced Cognitive deficit, in vitro cell viability assays and in vivo behavioral tests were performed. Using 3 assays 3-(4,5-dimethylthiazol-2-yl)–2,5-diphenyl tetrazolium bromide (MTT) reduction, lactate dehydrogenase release, and trypan blue exclusion) daidzein showed cell protective effects on oxidative stress-induced cytotoxicity. Administration of daidzein to mice significantly reversed the scopolamine-induced learning and memory impairment in a passive avoidance test. Injection of scopolamine to mice impaired performance in the passive avoidance test (43% decrease). In contrast, mice treated with daidzein before scopolamine injection were protected from this change (higher than the control value). These results suggest that daidzein's neuronal cell protective activities reduce the scopolamine-induced Cognitive deficit and that its anti-amnesic effect might be due to the activation of choline acetyltransferase.

  • Protective Effects of Daidzein on Oxidative Stress‐Induced Neurotoxicity and Scopolamine‐Mediated Cognitive Defect
    Journal of Food Science, 2005
    Co-Authors: Ho Jin, Young-min Suh, Soojung Choi, M.j. Kim, N.s. Mun, H.k. Kim, E.k. Kim, Dong-hoon Shin
    Abstract:

    ABSTRACT: To investigate the effect of daidzein, a major isoflavone constituent isolated from Pueraria thunbergiana (an arrowroot), on the oxidative damage and the scopolamine-induced Cognitive deficit, in vitro cell viability assays and in vivo behavioral tests were performed. Using 3 assays 3-(4,5-dimethylthiazol-2-yl)–2,5-diphenyl tetrazolium bromide (MTT) reduction, lactate dehydrogenase release, and trypan blue exclusion) daidzein showed cell protective effects on oxidative stress-induced cytotoxicity. Administration of daidzein to mice significantly reversed the scopolamine-induced learning and memory impairment in a passive avoidance test. Injection of scopolamine to mice impaired performance in the passive avoidance test (43% decrease). In contrast, mice treated with daidzein before scopolamine injection were protected from this change (higher than the control value). These results suggest that daidzein's neuronal cell protective activities reduce the scopolamine-induced Cognitive deficit and that its anti-amnesic effect might be due to the activation of choline acetyltransferase.

Ho Jin - One of the best experts on this subject based on the ideXlab platform.

  • protective effects of daidzein on oxidative stress induced neurotoxicity and scopolamine mediated Cognitive Defect
    Journal of Food Science, 2005
    Co-Authors: Ho Jin, Young-min Suh, Soojung Choi, M.j. Kim, N.s. Mun, H.k. Kim, E.k. Kim, Dong-hoon Shin
    Abstract:

    ABSTRACT: To investigate the effect of daidzein, a major isoflavone constituent isolated from Pueraria thunbergiana (an arrowroot), on the oxidative damage and the scopolamine-induced Cognitive deficit, in vitro cell viability assays and in vivo behavioral tests were performed. Using 3 assays 3-(4,5-dimethylthiazol-2-yl)–2,5-diphenyl tetrazolium bromide (MTT) reduction, lactate dehydrogenase release, and trypan blue exclusion) daidzein showed cell protective effects on oxidative stress-induced cytotoxicity. Administration of daidzein to mice significantly reversed the scopolamine-induced learning and memory impairment in a passive avoidance test. Injection of scopolamine to mice impaired performance in the passive avoidance test (43% decrease). In contrast, mice treated with daidzein before scopolamine injection were protected from this change (higher than the control value). These results suggest that daidzein's neuronal cell protective activities reduce the scopolamine-induced Cognitive deficit and that its anti-amnesic effect might be due to the activation of choline acetyltransferase.

  • Protective Effects of Daidzein on Oxidative Stress‐Induced Neurotoxicity and Scopolamine‐Mediated Cognitive Defect
    Journal of Food Science, 2005
    Co-Authors: Ho Jin, Young-min Suh, Soojung Choi, M.j. Kim, N.s. Mun, H.k. Kim, E.k. Kim, Dong-hoon Shin
    Abstract:

    ABSTRACT: To investigate the effect of daidzein, a major isoflavone constituent isolated from Pueraria thunbergiana (an arrowroot), on the oxidative damage and the scopolamine-induced Cognitive deficit, in vitro cell viability assays and in vivo behavioral tests were performed. Using 3 assays 3-(4,5-dimethylthiazol-2-yl)–2,5-diphenyl tetrazolium bromide (MTT) reduction, lactate dehydrogenase release, and trypan blue exclusion) daidzein showed cell protective effects on oxidative stress-induced cytotoxicity. Administration of daidzein to mice significantly reversed the scopolamine-induced learning and memory impairment in a passive avoidance test. Injection of scopolamine to mice impaired performance in the passive avoidance test (43% decrease). In contrast, mice treated with daidzein before scopolamine injection were protected from this change (higher than the control value). These results suggest that daidzein's neuronal cell protective activities reduce the scopolamine-induced Cognitive deficit and that its anti-amnesic effect might be due to the activation of choline acetyltransferase.

Young-min Suh - One of the best experts on this subject based on the ideXlab platform.

  • protective effects of daidzein on oxidative stress induced neurotoxicity and scopolamine mediated Cognitive Defect
    Journal of Food Science, 2005
    Co-Authors: Ho Jin, Young-min Suh, Soojung Choi, M.j. Kim, N.s. Mun, H.k. Kim, E.k. Kim, Dong-hoon Shin
    Abstract:

    ABSTRACT: To investigate the effect of daidzein, a major isoflavone constituent isolated from Pueraria thunbergiana (an arrowroot), on the oxidative damage and the scopolamine-induced Cognitive deficit, in vitro cell viability assays and in vivo behavioral tests were performed. Using 3 assays 3-(4,5-dimethylthiazol-2-yl)–2,5-diphenyl tetrazolium bromide (MTT) reduction, lactate dehydrogenase release, and trypan blue exclusion) daidzein showed cell protective effects on oxidative stress-induced cytotoxicity. Administration of daidzein to mice significantly reversed the scopolamine-induced learning and memory impairment in a passive avoidance test. Injection of scopolamine to mice impaired performance in the passive avoidance test (43% decrease). In contrast, mice treated with daidzein before scopolamine injection were protected from this change (higher than the control value). These results suggest that daidzein's neuronal cell protective activities reduce the scopolamine-induced Cognitive deficit and that its anti-amnesic effect might be due to the activation of choline acetyltransferase.

  • Protective Effects of Daidzein on Oxidative Stress‐Induced Neurotoxicity and Scopolamine‐Mediated Cognitive Defect
    Journal of Food Science, 2005
    Co-Authors: Ho Jin, Young-min Suh, Soojung Choi, M.j. Kim, N.s. Mun, H.k. Kim, E.k. Kim, Dong-hoon Shin
    Abstract:

    ABSTRACT: To investigate the effect of daidzein, a major isoflavone constituent isolated from Pueraria thunbergiana (an arrowroot), on the oxidative damage and the scopolamine-induced Cognitive deficit, in vitro cell viability assays and in vivo behavioral tests were performed. Using 3 assays 3-(4,5-dimethylthiazol-2-yl)–2,5-diphenyl tetrazolium bromide (MTT) reduction, lactate dehydrogenase release, and trypan blue exclusion) daidzein showed cell protective effects on oxidative stress-induced cytotoxicity. Administration of daidzein to mice significantly reversed the scopolamine-induced learning and memory impairment in a passive avoidance test. Injection of scopolamine to mice impaired performance in the passive avoidance test (43% decrease). In contrast, mice treated with daidzein before scopolamine injection were protected from this change (higher than the control value). These results suggest that daidzein's neuronal cell protective activities reduce the scopolamine-induced Cognitive deficit and that its anti-amnesic effect might be due to the activation of choline acetyltransferase.

H.k. Kim - One of the best experts on this subject based on the ideXlab platform.

  • protective effects of daidzein on oxidative stress induced neurotoxicity and scopolamine mediated Cognitive Defect
    Journal of Food Science, 2005
    Co-Authors: Ho Jin, Young-min Suh, Soojung Choi, M.j. Kim, N.s. Mun, H.k. Kim, E.k. Kim, Dong-hoon Shin
    Abstract:

    ABSTRACT: To investigate the effect of daidzein, a major isoflavone constituent isolated from Pueraria thunbergiana (an arrowroot), on the oxidative damage and the scopolamine-induced Cognitive deficit, in vitro cell viability assays and in vivo behavioral tests were performed. Using 3 assays 3-(4,5-dimethylthiazol-2-yl)–2,5-diphenyl tetrazolium bromide (MTT) reduction, lactate dehydrogenase release, and trypan blue exclusion) daidzein showed cell protective effects on oxidative stress-induced cytotoxicity. Administration of daidzein to mice significantly reversed the scopolamine-induced learning and memory impairment in a passive avoidance test. Injection of scopolamine to mice impaired performance in the passive avoidance test (43% decrease). In contrast, mice treated with daidzein before scopolamine injection were protected from this change (higher than the control value). These results suggest that daidzein's neuronal cell protective activities reduce the scopolamine-induced Cognitive deficit and that its anti-amnesic effect might be due to the activation of choline acetyltransferase.

  • Protective Effects of Daidzein on Oxidative Stress‐Induced Neurotoxicity and Scopolamine‐Mediated Cognitive Defect
    Journal of Food Science, 2005
    Co-Authors: Ho Jin, Young-min Suh, Soojung Choi, M.j. Kim, N.s. Mun, H.k. Kim, E.k. Kim, Dong-hoon Shin
    Abstract:

    ABSTRACT: To investigate the effect of daidzein, a major isoflavone constituent isolated from Pueraria thunbergiana (an arrowroot), on the oxidative damage and the scopolamine-induced Cognitive deficit, in vitro cell viability assays and in vivo behavioral tests were performed. Using 3 assays 3-(4,5-dimethylthiazol-2-yl)–2,5-diphenyl tetrazolium bromide (MTT) reduction, lactate dehydrogenase release, and trypan blue exclusion) daidzein showed cell protective effects on oxidative stress-induced cytotoxicity. Administration of daidzein to mice significantly reversed the scopolamine-induced learning and memory impairment in a passive avoidance test. Injection of scopolamine to mice impaired performance in the passive avoidance test (43% decrease). In contrast, mice treated with daidzein before scopolamine injection were protected from this change (higher than the control value). These results suggest that daidzein's neuronal cell protective activities reduce the scopolamine-induced Cognitive deficit and that its anti-amnesic effect might be due to the activation of choline acetyltransferase.