The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Susan M Courtney - One of the best experts on this subject based on the ideXlab platform.
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disrupted neural synchrony mediates the relationship between white matter integrity and Cognitive Performance in older adults
Cerebral Cortex, 2020Co-Authors: Thomas Hinault, Michael A Kraut, Arnold B Bakker, Alain Dagher, Susan M CourtneyAbstract:Our main goal was to determine the influence of white matter integrity on the dynamic coupling between brain regions and the individual variability of Cognitive Performance in older adults. Electroencephalography was recorded while participants performed a task specifically designed to engage working memory and inhibitory processes, and the associations among functional activity, structural integrity, and Cognitive Performance were assessed. We found that the association between white matter microstructural integrity and Cognitive functioning with aging is mediated by time-varying alpha and gamma phase-locking value. Specifically, better preservation of the inferior fronto-occipital fasciculus in older individuals drives faster task-related modulations of alpha and gamma long-range phase-locking value between the inferior frontal gyrus and occipital lobe and lower local phase-amplitude coupling in occipital lobes, which in turn drives better Cognitive control Performance. Our results help delineate the role of individual variability of white matter microstructure in dynamic synchrony and Cognitive Performance during normal aging.
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disrupted neural synchrony mediates the relationship between white matter integrity and Cognitive Performance in older adults
bioRxiv, 2019Co-Authors: Thomas Hinault, Michael A Kraut, Arnold B Bakker, Alain Dagher, Susan M CourtneyAbstract:Our main goal was to determine the influence of white matter integrity on the dynamic coupling between brain regions and the individual variability of Cognitive Performance in older adults. EEG was recorded while participants performed a task specifically designed to engage working memory and inhibitory processes, and the associations among functional activity, structural integrity, and Cognitive Performance were assessed. We found that the association between white matter microstructural integrity and Cognitive functioning with aging is mediated by time-varying alpha and gamma phase-locking value (PLV). Specifically, older individuals with better preservation of the inferior fronto-occipital fasciculus showed greater task-related modulations of alpha and gamma long-range PLV between the inferior frontal gyrus and occipital lobe, lower local phase-amplitude coupling in occipital lobes, and better Cognitive control Performance. Our results help delineate the role of individual variability of white matter microstructure in dynamic synchrony and Cognitive Performance during normal aging, and show that even small reductions in white matter integrity can lead to altered communications between brain regions, which in turn can result in reduced efficiency of Cognitive functioning.
Thomas Hinault - One of the best experts on this subject based on the ideXlab platform.
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disrupted neural synchrony mediates the relationship between white matter integrity and Cognitive Performance in older adults
Cerebral Cortex, 2020Co-Authors: Thomas Hinault, Michael A Kraut, Arnold B Bakker, Alain Dagher, Susan M CourtneyAbstract:Our main goal was to determine the influence of white matter integrity on the dynamic coupling between brain regions and the individual variability of Cognitive Performance in older adults. Electroencephalography was recorded while participants performed a task specifically designed to engage working memory and inhibitory processes, and the associations among functional activity, structural integrity, and Cognitive Performance were assessed. We found that the association between white matter microstructural integrity and Cognitive functioning with aging is mediated by time-varying alpha and gamma phase-locking value. Specifically, better preservation of the inferior fronto-occipital fasciculus in older individuals drives faster task-related modulations of alpha and gamma long-range phase-locking value between the inferior frontal gyrus and occipital lobe and lower local phase-amplitude coupling in occipital lobes, which in turn drives better Cognitive control Performance. Our results help delineate the role of individual variability of white matter microstructure in dynamic synchrony and Cognitive Performance during normal aging.
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disrupted neural synchrony mediates the relationship between white matter integrity and Cognitive Performance in older adults
bioRxiv, 2019Co-Authors: Thomas Hinault, Michael A Kraut, Arnold B Bakker, Alain Dagher, Susan M CourtneyAbstract:Our main goal was to determine the influence of white matter integrity on the dynamic coupling between brain regions and the individual variability of Cognitive Performance in older adults. EEG was recorded while participants performed a task specifically designed to engage working memory and inhibitory processes, and the associations among functional activity, structural integrity, and Cognitive Performance were assessed. We found that the association between white matter microstructural integrity and Cognitive functioning with aging is mediated by time-varying alpha and gamma phase-locking value (PLV). Specifically, older individuals with better preservation of the inferior fronto-occipital fasciculus showed greater task-related modulations of alpha and gamma long-range PLV between the inferior frontal gyrus and occipital lobe, lower local phase-amplitude coupling in occipital lobes, and better Cognitive control Performance. Our results help delineate the role of individual variability of white matter microstructure in dynamic synchrony and Cognitive Performance during normal aging, and show that even small reductions in white matter integrity can lead to altered communications between brain regions, which in turn can result in reduced efficiency of Cognitive functioning.
Arnold B Bakker - One of the best experts on this subject based on the ideXlab platform.
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disrupted neural synchrony mediates the relationship between white matter integrity and Cognitive Performance in older adults
Cerebral Cortex, 2020Co-Authors: Thomas Hinault, Michael A Kraut, Arnold B Bakker, Alain Dagher, Susan M CourtneyAbstract:Our main goal was to determine the influence of white matter integrity on the dynamic coupling between brain regions and the individual variability of Cognitive Performance in older adults. Electroencephalography was recorded while participants performed a task specifically designed to engage working memory and inhibitory processes, and the associations among functional activity, structural integrity, and Cognitive Performance were assessed. We found that the association between white matter microstructural integrity and Cognitive functioning with aging is mediated by time-varying alpha and gamma phase-locking value. Specifically, better preservation of the inferior fronto-occipital fasciculus in older individuals drives faster task-related modulations of alpha and gamma long-range phase-locking value between the inferior frontal gyrus and occipital lobe and lower local phase-amplitude coupling in occipital lobes, which in turn drives better Cognitive control Performance. Our results help delineate the role of individual variability of white matter microstructure in dynamic synchrony and Cognitive Performance during normal aging.
-
disrupted neural synchrony mediates the relationship between white matter integrity and Cognitive Performance in older adults
bioRxiv, 2019Co-Authors: Thomas Hinault, Michael A Kraut, Arnold B Bakker, Alain Dagher, Susan M CourtneyAbstract:Our main goal was to determine the influence of white matter integrity on the dynamic coupling between brain regions and the individual variability of Cognitive Performance in older adults. EEG was recorded while participants performed a task specifically designed to engage working memory and inhibitory processes, and the associations among functional activity, structural integrity, and Cognitive Performance were assessed. We found that the association between white matter microstructural integrity and Cognitive functioning with aging is mediated by time-varying alpha and gamma phase-locking value (PLV). Specifically, older individuals with better preservation of the inferior fronto-occipital fasciculus showed greater task-related modulations of alpha and gamma long-range PLV between the inferior frontal gyrus and occipital lobe, lower local phase-amplitude coupling in occipital lobes, and better Cognitive control Performance. Our results help delineate the role of individual variability of white matter microstructure in dynamic synchrony and Cognitive Performance during normal aging, and show that even small reductions in white matter integrity can lead to altered communications between brain regions, which in turn can result in reduced efficiency of Cognitive functioning.
Tomi Laitinen - One of the best experts on this subject based on the ideXlab platform.
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cardiovascular risk factors from childhood and midlife Cognitive Performance the young finns study
Journal of the American College of Cardiology, 2017Co-Authors: Suvi P Rovio, Katja Pahkala, Jaakko Nevalainen, Markus Juonala, Pia Salo, Mika Kahonen, Nina Hutrikahonen, Terho Lehtimaki, Eero Jokinen, Tomi LaitinenAbstract:Abstract Background In adults, high blood pressure (BP), adverse serum lipids, and smoking associate with Cognitive deficits. The effects of these risk factors from childhood on midlife Cognitive Performance are unknown. Objectives This study sought to investigate the associations between childhood/adolescence cardiovascular risk factors and midlife Cognitive Performance. Methods From 1980, a population-based cohort of 3,596 children (baseline age: 3 to 18 years) have been followed for 31 years in 3- to 9-year intervals. BP, serum lipids, body mass index, and smoking were assessed in all follow-ups. Cumulative exposure as the area under the curve for each risk factor was determined in childhood (6 to 12 years), adolescence (12 to 18 years), and young adulthood (18 to 24 years). In 2011, Cognitive testing was performed in 2,026 participants aged 34 to 49 years. Results High systolic BP, elevated serum total-cholesterol, and smoking from childhood were independently associated with worse midlife Cognitive Performance, especially memory and learning. The number of early life risk factors, including high levels (extreme 75th percentile for cumulative risk exposure between ages 6 and 24 years) of systolic BP, total-cholesterol, and smoking associated inversely with midlife visual and episodic memory and visuospatial associative learning (–0.140 standard deviations per risk factor, p Conclusions Cumulative burden of cardiovascular risk factors from childhood/adolescence associate with worse midlife Cognitive Performance independent of adulthood exposure.
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Cognitive Performance in young adulthood and midlife relations with age sex and education the cardiovascular risk in young finns study
Neuropsychology (journal), 2016Co-Authors: Suvi P Rovio, Katja Pahkala, Jaakko Nevalainen, Markus Juonala, Pia Salo, Mika Kahonen, Nina Hutrikahonen, Terho Lehtimaki, Eero Jokinen, Tomi LaitinenAbstract:OBJECTIVE Age, education, and sex associate with Cognitive Performance. We investigated associations between age, sex, education, and Cognitive Performance in young or middle-aged adults and evaluated data reduction methods to optimally capture Cognitive Performance in our population-based data. METHOD This study is part of the Cardiovascular Risk in Young Finns Study. The 3,596 randomly selected subjects (aged 3-18 years in 1980) have been followed up for 30 years. In 2011, a computer-based Cognitive testing battery (the Cambridge Neuropsychological Test Automated Battery [CANTAB]) was used to assess several Cognitive domains. Principal component analysis, categorical and standardized classifications were applied to the Cognitive data. RESULTS Among 34- to 49-year-old participants, Cognitive Performance declined with age, while education associated with better Cognitive functions in several Cognitive domains. Men had higher Performance on all Cognitive domains except visual or episodic memory, in which women outperformed men. The results were similar regardless of the data reduction method used. CONCLUSIONS The associations between sex, age, education, and Cognitive Performance are already apparent in young adulthood or middle age. Principal component analyses, categorical and standardized classifications are useful tools to analyze CANTAB Cognitive data. (PsycINFO Database Record
Masaki Fukunaga - One of the best experts on this subject based on the ideXlab platform.
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respiratory modulation of Cognitive Performance during the retrieval process
PLOS ONE, 2018Co-Authors: Nozomu H Nakamura, Masaki FukunagaAbstract:Recent research suggests that Cognitive Performance might be altered by the respiratory-synchronized activity generated in the brain. Previous human studies, however, have yielded inconsistent results when assessing task Performance during distinct respiratory phases (inspiratory phase vs. expiratory phase). We therefore tested whether Cognitive Performance was regulated based on the timing of breathing components (e.g., expiratory-to-inspiratory (EI) phase transition) during the retrieval process. To determine the role of respiration in Performance, the present study employed healthy subjects (n = 18) in a delayed matching-to-sample visual recognition task where a test cue was given in the respiratory phase-locked (Phased) or regularly paced (Non-phased) presentation paradigm. During the Phased session but not during the Non-phased session, the response time (RT) of the task increased by 466 ms (p = 0.003), and accuracy decreased by 21.4% (p = 0.004) when the retrieval process encompassed the EI transition. Breathing-dependent changes were particularly prominent when the EI transition occurred during the middle step of the retrieval process. Meanwhile, changes in the RT and accuracy were not observed when the retrieval process encompassed the inspiratory-to-expiratory phase transition. This is the first time that a certain phase transition in the respiratory cycle has been shown to modulate Performance on a time scale of several seconds in a Cognitive task. We propose that attenuation of these breathing-dependent Cognitive fluctuations might be crucial for the maintenance and stability of successful Performance in daily life and sports.
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respiratory modulation of Cognitive Performance during the retrieval process
PLOS ONE, 2018Co-Authors: Nozomu H Nakamura, Masaki FukunagaAbstract:Recent research suggests that Cognitive Performance might be altered by the respiratory-synchronized activity generated in the brain. Previous human studies, however, have yielded inconsistent results when assessing task Performance during distinct respiratory phases (inspiratory phase vs. expiratory phase). We therefore tested whether Cognitive Performance was regulated based on the timing of breathing components (e.g., expiratory-to-inspiratory (EI) phase transition) during the retrieval process. To determine the role of respiration in Performance, the present study employed healthy subjects (n = 18) in a delayed matching-to-sample visual recognition task where a test cue was given in the respiratory phase-locked (Phased) or regularly paced (Non-phased) presentation paradigm. During the Phased session but not during the Non-phased session, the response time (RT) of the task increased by 466 ms (p = 0.003), and accuracy decreased by 21.4% (p = 0.004) when the retrieval process encompassed the EI transition. Breathing-dependent changes were particularly prominent when the EI transition occurred during the middle step of the retrieval process. Meanwhile, changes in the RT and accuracy were not observed when the retrieval process encompassed the inspiratory-to-expiratory phase transition. This is the first time that a certain phase transition in the respiratory cycle has been shown to modulate Performance on a time scale of several seconds in a Cognitive task. We propose that attenuation of these breathing-dependent Cognitive fluctuations might be crucial for the maintenance and stability of successful Performance in daily life and sports.