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Ochuko L Erukainure - One of the best experts on this subject based on the ideXlab platform.
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Cola Nitida kola nuts attenuates hepatic injury in type 2 diabetes by improving antioxidant and cholinergic dysfunctions and dysregulated lipid metabolism
Endocrine‚ Metabolic & Immune Disorders-Drug Targets, 2020Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Veronica F Salau, Neil A Koorbanally, Shahidul IslamAbstract:Background The therapeutic effect of Cola Nitida hot infusion against diabetes hepatic injury was investigated in livers of diabetic rats. Cola Nitida was infused in boiling water and concentrated. Methods The concentrated infusion was administered to T2D rats at low and high dose (150 and 300 mg/kg body weight (bw) respectively). The normal group (positive control) and another diabetic group (negative control) were administered distilled water, while metformin served as the standard drug. A toxic group consisting of normal rats was administered high dose of C. Nitida. After 6 weeks, the rats were sacrificed, and their livers collected. They were assayed for oxidative stress markers, myeloperoxidase, acetylcholinesterase and ATPase activities. Hepatic lipid metabolites were profiled with GC-MS and their metabolic pathways analyzed using the MetaboAnalyst 4.0 online server. Results Treatment with C. Nitida caused a significant elevation of glutathione level and SOD activity, while concomitantly inhibiting lipid peroxidation, myeloperoxidase, acetylcholinesterase and ATPase activities in hepatic tissues of the rats. Treatment with C. Nitida also caused significant depletion of diabetes-generated lipid metabolites, with concomitant generation of fatty esters and steroids as well as inactivation of diabetes-activated pathways. Conclusion These data demonstrate the therapeutic effect of C. Nitida against diabetic hepatotoxicity in diabetic rats.
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the antidiabetic properties of the hot water extract of kola nut Cola Nitida vent schott endl in type 2 diabetic rats
Journal of Ethnopharmacology, 2019Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Omamuyovwi M Ijomone, Collins U Ibeji, Chika I Chukwuma, Shahidul IslamAbstract:Abstract Ethnopharmacological relevance Cola Nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes. Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. Nitida seeds in type 2 diabetic rats. Methods Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6 wk and thereafter, blood glucose, insulin level, lipid profile, pancreatic β-cell function, perfusion and morphology, redox imbalance, glycolytic and cholinergic enzymes, as well as of caspase-3 and Nrf2 expressions were measured. Results Treatment with the extract led to significant depletion of blood glucose, serum triglycerides, LDL-cholesterol, fructosamine, ALT, and uric acids, while elevating serum insulin and HDL-cholesterol levels. The infusion also significantly (p Conclusion These results insinuate the antidiabetic activities of C. Nitida hot water extract and may be attributed to the NMR-identified compounds.
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The antidiabetic properties of the hot water extract of kola nut (Cola Nitida (Vent.) Schott & Endl.) in type 2 diabetic rats.
Journal of Ethnopharmacology, 2019Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Omamuyovwi M Ijomone, Collins U Ibeji, Chika I Chukwuma, Shahidul IslamAbstract:Abstract Ethnopharmacological relevance Cola Nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes. Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. Nitida seeds in type 2 diabetic rats. Methods Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6 wk and thereafter, blood glucose, insulin level, lipid profile, pancreatic β-cell function, perfusion and morphology, redox imbalance, glycolytic and cholinergic enzymes, as well as of caspase-3 and Nrf2 expressions were measured. Results Treatment with the extract led to significant depletion of blood glucose, serum triglycerides, LDL-cholesterol, fructosamine, ALT, and uric acids, while elevating serum insulin and HDL-cholesterol levels. The infusion also significantly (p Conclusion These results insinuate the antidiabetic activities of C. Nitida hot water extract and may be attributed to the NMR-identified compounds.
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hyperglycemia induced oxidative brain injury therapeutic effects of Cola Nitida infusion against redox imbalance cerebellar neuronal insults and upregulated nrf2 expression in type 2 diabetic rats
Food and Chemical Toxicology, 2019Co-Authors: Ochuko L Erukainure, Omamuyovwi M Ijomone, Chika I Chukwuma, Olajumoke A Oyebode, Michael Aschner, Md Shahidul IslamAbstract:Abstract The therapeutic effect of the hot water infusion of Cola Nitida against hyperglycemia-induced neurotoxicity, cerebellar neurodegeneration and elemental deregulations was investigated in fructose-streptozotocin induced rat model of type 2 diabetes (T2D). A diabetic group was administered drinking water, two other diabetic groups were treated with C. Nitida at 150 and 300 mg/kg bodyweight respectively, while another group was administered metformin (200 mg/kg bodyweight). Two other groups consisting of normal rats, were administered drinking water and C. Nitida (300 mg/kg bodyweight). After 6 weeks of treatment, their brains were collected. Treatment with C. Nitida led to suppression of oxidative stress, significantly elevating reduced glutathione (GSH) levels, superoxide dismutase and catalase activities, concomitant with depletion of malondialdehyde (MDA) levels. Acetylcholinesterase and ATPase activities were significantly inhibited in C. Nitida-treated diabetic rats. Histological and microscopic analysis also revealed a restorative effect of C. Nitida on T2D-altered distribution of elements, neurons and axonal nodes. Treatment with C. Nitida also led to significant inhibition of Nrf2 expression in the cerebellar cortex. These results suggest the therapeutic effects of C. Nitida in maintenance of the neuronal integrity and antioxidant status of the brain in T2D. These neuroprotective activities can be attributed to the identified alkaloid, caffeine in the infusion.
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caffeine rich infusion from Cola Nitida kola nut inhibits major carbohydrate catabolic enzymes abates redox imbalance and modulates oxidative dysregulated metabolic pathways and metabolites in fe2 induced hepatic toxicity
Biomedicine & Pharmacotherapy, 2017Co-Authors: Ochuko L Erukainure, Neil A Koorbanally, Olajumoke A Oyebode, Mxolisi K Sokhela, Md Shahidul IslamAbstract:Abstract The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola Nitida were investigated using in vitro, ex vivo and in silico models. C. Nitida was infused in boiling water and allowed to cool before concentrating at 50 °C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p 0.05) scavenging 2,2′-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p L -Arginine, L -tyrosine, Citric acid and Decanoic acid in infusion-treated tissues. Pathway analysis of the identified metabolites revealed the presence of 21 metabolic pathways involved in normal hepatic tissues, 12 in oxidative injured tissues and 17 in the treated tissues. Treatment with the infusion restored 4 metabolic pathways common to the normal tissue and further activated 4 additional pathways. Prediction of oral toxicity of caffeine showed it to belong to class 3, with a LD50 of 127 mg/kg. Its toxicity target was predicted as Adenosine Receptor A2a. It was also predicted to be an inhibitor of CYP1A2. These results suggest the antioxidative and antidiabetic properties of C. Nitida infusion, with caffeine as the major constituent.
Shahidul Islam - One of the best experts on this subject based on the ideXlab platform.
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Cola Nitida kola nuts attenuates hepatic injury in type 2 diabetes by improving antioxidant and cholinergic dysfunctions and dysregulated lipid metabolism
Endocrine‚ Metabolic & Immune Disorders-Drug Targets, 2020Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Veronica F Salau, Neil A Koorbanally, Shahidul IslamAbstract:Background The therapeutic effect of Cola Nitida hot infusion against diabetes hepatic injury was investigated in livers of diabetic rats. Cola Nitida was infused in boiling water and concentrated. Methods The concentrated infusion was administered to T2D rats at low and high dose (150 and 300 mg/kg body weight (bw) respectively). The normal group (positive control) and another diabetic group (negative control) were administered distilled water, while metformin served as the standard drug. A toxic group consisting of normal rats was administered high dose of C. Nitida. After 6 weeks, the rats were sacrificed, and their livers collected. They were assayed for oxidative stress markers, myeloperoxidase, acetylcholinesterase and ATPase activities. Hepatic lipid metabolites were profiled with GC-MS and their metabolic pathways analyzed using the MetaboAnalyst 4.0 online server. Results Treatment with C. Nitida caused a significant elevation of glutathione level and SOD activity, while concomitantly inhibiting lipid peroxidation, myeloperoxidase, acetylcholinesterase and ATPase activities in hepatic tissues of the rats. Treatment with C. Nitida also caused significant depletion of diabetes-generated lipid metabolites, with concomitant generation of fatty esters and steroids as well as inactivation of diabetes-activated pathways. Conclusion These data demonstrate the therapeutic effect of C. Nitida against diabetic hepatotoxicity in diabetic rats.
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the antidiabetic properties of the hot water extract of kola nut Cola Nitida vent schott endl in type 2 diabetic rats
Journal of Ethnopharmacology, 2019Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Omamuyovwi M Ijomone, Collins U Ibeji, Chika I Chukwuma, Shahidul IslamAbstract:Abstract Ethnopharmacological relevance Cola Nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes. Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. Nitida seeds in type 2 diabetic rats. Methods Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6 wk and thereafter, blood glucose, insulin level, lipid profile, pancreatic β-cell function, perfusion and morphology, redox imbalance, glycolytic and cholinergic enzymes, as well as of caspase-3 and Nrf2 expressions were measured. Results Treatment with the extract led to significant depletion of blood glucose, serum triglycerides, LDL-cholesterol, fructosamine, ALT, and uric acids, while elevating serum insulin and HDL-cholesterol levels. The infusion also significantly (p Conclusion These results insinuate the antidiabetic activities of C. Nitida hot water extract and may be attributed to the NMR-identified compounds.
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The antidiabetic properties of the hot water extract of kola nut (Cola Nitida (Vent.) Schott & Endl.) in type 2 diabetic rats.
Journal of Ethnopharmacology, 2019Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Omamuyovwi M Ijomone, Collins U Ibeji, Chika I Chukwuma, Shahidul IslamAbstract:Abstract Ethnopharmacological relevance Cola Nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes. Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. Nitida seeds in type 2 diabetic rats. Methods Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6 wk and thereafter, blood glucose, insulin level, lipid profile, pancreatic β-cell function, perfusion and morphology, redox imbalance, glycolytic and cholinergic enzymes, as well as of caspase-3 and Nrf2 expressions were measured. Results Treatment with the extract led to significant depletion of blood glucose, serum triglycerides, LDL-cholesterol, fructosamine, ALT, and uric acids, while elevating serum insulin and HDL-cholesterol levels. The infusion also significantly (p Conclusion These results insinuate the antidiabetic activities of C. Nitida hot water extract and may be attributed to the NMR-identified compounds.
Chika I Chukwuma - One of the best experts on this subject based on the ideXlab platform.
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the antidiabetic properties of the hot water extract of kola nut Cola Nitida vent schott endl in type 2 diabetic rats
Journal of Ethnopharmacology, 2019Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Omamuyovwi M Ijomone, Collins U Ibeji, Chika I Chukwuma, Shahidul IslamAbstract:Abstract Ethnopharmacological relevance Cola Nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes. Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. Nitida seeds in type 2 diabetic rats. Methods Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6 wk and thereafter, blood glucose, insulin level, lipid profile, pancreatic β-cell function, perfusion and morphology, redox imbalance, glycolytic and cholinergic enzymes, as well as of caspase-3 and Nrf2 expressions were measured. Results Treatment with the extract led to significant depletion of blood glucose, serum triglycerides, LDL-cholesterol, fructosamine, ALT, and uric acids, while elevating serum insulin and HDL-cholesterol levels. The infusion also significantly (p Conclusion These results insinuate the antidiabetic activities of C. Nitida hot water extract and may be attributed to the NMR-identified compounds.
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The antidiabetic properties of the hot water extract of kola nut (Cola Nitida (Vent.) Schott & Endl.) in type 2 diabetic rats.
Journal of Ethnopharmacology, 2019Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Omamuyovwi M Ijomone, Collins U Ibeji, Chika I Chukwuma, Shahidul IslamAbstract:Abstract Ethnopharmacological relevance Cola Nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes. Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. Nitida seeds in type 2 diabetic rats. Methods Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6 wk and thereafter, blood glucose, insulin level, lipid profile, pancreatic β-cell function, perfusion and morphology, redox imbalance, glycolytic and cholinergic enzymes, as well as of caspase-3 and Nrf2 expressions were measured. Results Treatment with the extract led to significant depletion of blood glucose, serum triglycerides, LDL-cholesterol, fructosamine, ALT, and uric acids, while elevating serum insulin and HDL-cholesterol levels. The infusion also significantly (p Conclusion These results insinuate the antidiabetic activities of C. Nitida hot water extract and may be attributed to the NMR-identified compounds.
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hyperglycemia induced oxidative brain injury therapeutic effects of Cola Nitida infusion against redox imbalance cerebellar neuronal insults and upregulated nrf2 expression in type 2 diabetic rats
Food and Chemical Toxicology, 2019Co-Authors: Ochuko L Erukainure, Omamuyovwi M Ijomone, Chika I Chukwuma, Olajumoke A Oyebode, Michael Aschner, Md Shahidul IslamAbstract:Abstract The therapeutic effect of the hot water infusion of Cola Nitida against hyperglycemia-induced neurotoxicity, cerebellar neurodegeneration and elemental deregulations was investigated in fructose-streptozotocin induced rat model of type 2 diabetes (T2D). A diabetic group was administered drinking water, two other diabetic groups were treated with C. Nitida at 150 and 300 mg/kg bodyweight respectively, while another group was administered metformin (200 mg/kg bodyweight). Two other groups consisting of normal rats, were administered drinking water and C. Nitida (300 mg/kg bodyweight). After 6 weeks of treatment, their brains were collected. Treatment with C. Nitida led to suppression of oxidative stress, significantly elevating reduced glutathione (GSH) levels, superoxide dismutase and catalase activities, concomitant with depletion of malondialdehyde (MDA) levels. Acetylcholinesterase and ATPase activities were significantly inhibited in C. Nitida-treated diabetic rats. Histological and microscopic analysis also revealed a restorative effect of C. Nitida on T2D-altered distribution of elements, neurons and axonal nodes. Treatment with C. Nitida also led to significant inhibition of Nrf2 expression in the cerebellar cortex. These results suggest the therapeutic effects of C. Nitida in maintenance of the neuronal integrity and antioxidant status of the brain in T2D. These neuroprotective activities can be attributed to the identified alkaloid, caffeine in the infusion.
Omamuyovwi M Ijomone - One of the best experts on this subject based on the ideXlab platform.
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the antidiabetic properties of the hot water extract of kola nut Cola Nitida vent schott endl in type 2 diabetic rats
Journal of Ethnopharmacology, 2019Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Omamuyovwi M Ijomone, Collins U Ibeji, Chika I Chukwuma, Shahidul IslamAbstract:Abstract Ethnopharmacological relevance Cola Nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes. Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. Nitida seeds in type 2 diabetic rats. Methods Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6 wk and thereafter, blood glucose, insulin level, lipid profile, pancreatic β-cell function, perfusion and morphology, redox imbalance, glycolytic and cholinergic enzymes, as well as of caspase-3 and Nrf2 expressions were measured. Results Treatment with the extract led to significant depletion of blood glucose, serum triglycerides, LDL-cholesterol, fructosamine, ALT, and uric acids, while elevating serum insulin and HDL-cholesterol levels. The infusion also significantly (p Conclusion These results insinuate the antidiabetic activities of C. Nitida hot water extract and may be attributed to the NMR-identified compounds.
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The antidiabetic properties of the hot water extract of kola nut (Cola Nitida (Vent.) Schott & Endl.) in type 2 diabetic rats.
Journal of Ethnopharmacology, 2019Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Omamuyovwi M Ijomone, Collins U Ibeji, Chika I Chukwuma, Shahidul IslamAbstract:Abstract Ethnopharmacological relevance Cola Nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes. Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. Nitida seeds in type 2 diabetic rats. Methods Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6 wk and thereafter, blood glucose, insulin level, lipid profile, pancreatic β-cell function, perfusion and morphology, redox imbalance, glycolytic and cholinergic enzymes, as well as of caspase-3 and Nrf2 expressions were measured. Results Treatment with the extract led to significant depletion of blood glucose, serum triglycerides, LDL-cholesterol, fructosamine, ALT, and uric acids, while elevating serum insulin and HDL-cholesterol levels. The infusion also significantly (p Conclusion These results insinuate the antidiabetic activities of C. Nitida hot water extract and may be attributed to the NMR-identified compounds.
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hyperglycemia induced oxidative brain injury therapeutic effects of Cola Nitida infusion against redox imbalance cerebellar neuronal insults and upregulated nrf2 expression in type 2 diabetic rats
Food and Chemical Toxicology, 2019Co-Authors: Ochuko L Erukainure, Omamuyovwi M Ijomone, Chika I Chukwuma, Olajumoke A Oyebode, Michael Aschner, Md Shahidul IslamAbstract:Abstract The therapeutic effect of the hot water infusion of Cola Nitida against hyperglycemia-induced neurotoxicity, cerebellar neurodegeneration and elemental deregulations was investigated in fructose-streptozotocin induced rat model of type 2 diabetes (T2D). A diabetic group was administered drinking water, two other diabetic groups were treated with C. Nitida at 150 and 300 mg/kg bodyweight respectively, while another group was administered metformin (200 mg/kg bodyweight). Two other groups consisting of normal rats, were administered drinking water and C. Nitida (300 mg/kg bodyweight). After 6 weeks of treatment, their brains were collected. Treatment with C. Nitida led to suppression of oxidative stress, significantly elevating reduced glutathione (GSH) levels, superoxide dismutase and catalase activities, concomitant with depletion of malondialdehyde (MDA) levels. Acetylcholinesterase and ATPase activities were significantly inhibited in C. Nitida-treated diabetic rats. Histological and microscopic analysis also revealed a restorative effect of C. Nitida on T2D-altered distribution of elements, neurons and axonal nodes. Treatment with C. Nitida also led to significant inhibition of Nrf2 expression in the cerebellar cortex. These results suggest the therapeutic effects of C. Nitida in maintenance of the neuronal integrity and antioxidant status of the brain in T2D. These neuroprotective activities can be attributed to the identified alkaloid, caffeine in the infusion.
Olakunle Sanni - One of the best experts on this subject based on the ideXlab platform.
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Cola Nitida kola nuts attenuates hepatic injury in type 2 diabetes by improving antioxidant and cholinergic dysfunctions and dysregulated lipid metabolism
Endocrine‚ Metabolic & Immune Disorders-Drug Targets, 2020Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Veronica F Salau, Neil A Koorbanally, Shahidul IslamAbstract:Background The therapeutic effect of Cola Nitida hot infusion against diabetes hepatic injury was investigated in livers of diabetic rats. Cola Nitida was infused in boiling water and concentrated. Methods The concentrated infusion was administered to T2D rats at low and high dose (150 and 300 mg/kg body weight (bw) respectively). The normal group (positive control) and another diabetic group (negative control) were administered distilled water, while metformin served as the standard drug. A toxic group consisting of normal rats was administered high dose of C. Nitida. After 6 weeks, the rats were sacrificed, and their livers collected. They were assayed for oxidative stress markers, myeloperoxidase, acetylcholinesterase and ATPase activities. Hepatic lipid metabolites were profiled with GC-MS and their metabolic pathways analyzed using the MetaboAnalyst 4.0 online server. Results Treatment with C. Nitida caused a significant elevation of glutathione level and SOD activity, while concomitantly inhibiting lipid peroxidation, myeloperoxidase, acetylcholinesterase and ATPase activities in hepatic tissues of the rats. Treatment with C. Nitida also caused significant depletion of diabetes-generated lipid metabolites, with concomitant generation of fatty esters and steroids as well as inactivation of diabetes-activated pathways. Conclusion These data demonstrate the therapeutic effect of C. Nitida against diabetic hepatotoxicity in diabetic rats.
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the antidiabetic properties of the hot water extract of kola nut Cola Nitida vent schott endl in type 2 diabetic rats
Journal of Ethnopharmacology, 2019Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Omamuyovwi M Ijomone, Collins U Ibeji, Chika I Chukwuma, Shahidul IslamAbstract:Abstract Ethnopharmacological relevance Cola Nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes. Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. Nitida seeds in type 2 diabetic rats. Methods Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6 wk and thereafter, blood glucose, insulin level, lipid profile, pancreatic β-cell function, perfusion and morphology, redox imbalance, glycolytic and cholinergic enzymes, as well as of caspase-3 and Nrf2 expressions were measured. Results Treatment with the extract led to significant depletion of blood glucose, serum triglycerides, LDL-cholesterol, fructosamine, ALT, and uric acids, while elevating serum insulin and HDL-cholesterol levels. The infusion also significantly (p Conclusion These results insinuate the antidiabetic activities of C. Nitida hot water extract and may be attributed to the NMR-identified compounds.
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The antidiabetic properties of the hot water extract of kola nut (Cola Nitida (Vent.) Schott & Endl.) in type 2 diabetic rats.
Journal of Ethnopharmacology, 2019Co-Authors: Ochuko L Erukainure, Olakunle Sanni, Omamuyovwi M Ijomone, Collins U Ibeji, Chika I Chukwuma, Shahidul IslamAbstract:Abstract Ethnopharmacological relevance Cola Nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes. Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. Nitida seeds in type 2 diabetic rats. Methods Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6 wk and thereafter, blood glucose, insulin level, lipid profile, pancreatic β-cell function, perfusion and morphology, redox imbalance, glycolytic and cholinergic enzymes, as well as of caspase-3 and Nrf2 expressions were measured. Results Treatment with the extract led to significant depletion of blood glucose, serum triglycerides, LDL-cholesterol, fructosamine, ALT, and uric acids, while elevating serum insulin and HDL-cholesterol levels. The infusion also significantly (p Conclusion These results insinuate the antidiabetic activities of C. Nitida hot water extract and may be attributed to the NMR-identified compounds.