The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform
Maureen Neitz - One of the best experts on this subject based on the ideXlab platform.
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gene therapy for red green Colour Blindness in adult primates
Nature, 2009Co-Authors: Katherine Mancuso, Matthew C. Mauck, Jay Neitz, James A. Kuchenbecker, William W. Hauswirth, Thomas B Connor, Maureen NeitzAbstract:Red-green Colour Blindness, which results from the absence of either the long- (L) or middle- (M) wavelength-sensitive visual photopigments, is the most common single locus genetic disorder. Here, the possibility of curing Colour Blindness using gene therapy was explored in experiments on adult monkeys that had been Colour blind since birth. A third type of cone pigment was added to dichromatic retinas, providing the receptoral basis for trichromatic Colour vision. This opened a new avenue to explore the requirements for establishing the neural circuits for a new dimension of Colour sensation. Classic visual deprivation experiments1 have led to the expectation that neural connections established during development would not appropriately process an input that was not present from birth. Therefore, it was believed that treatment of congenital vision disorders would be ineffective unless administered to the very young. Here, however, addition of a third opsin in adult red-green Colour-deficient primates was sufficient to produce trichromatic Colour vision behaviour. Thus, trichromacy can arise from a single addition of a third cone class and it does not require an early developmental process. This provides a positive outlook for the potential of gene therapy to cure adult vision disorders.
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Gene therapy for red–green Colour Blindness in adult primates
Nature, 2009Co-Authors: Katherine Mancuso, Matthew C. Mauck, Jay Neitz, James A. Kuchenbecker, William W. Hauswirth, Thomas B Connor, Qiuhong Li, Maureen NeitzAbstract:Red-green Colour Blindness, which results from the absence of either the long- (L) or middle- (M) wavelength-sensitive visual photopigments, is the most common single locus genetic disorder. Here, the possibility of curing Colour Blindness using gene therapy was explored in experiments on adult monkeys that had been Colour blind since birth. A third type of cone pigment was added to dichromatic retinas, providing the receptoral basis for trichromatic Colour vision. This opened a new avenue to explore the requirements for establishing the neural circuits for a new dimension of Colour sensation. Classic visual deprivation experiments1 have led to the expectation that neural connections established during development would not appropriately process an input that was not present from birth. Therefore, it was believed that treatment of congenital vision disorders would be ineffective unless administered to the very young. Here, however, addition of a third opsin in adult red-green Colour-deficient primates was sufficient to produce trichromatic Colour vision behaviour. Thus, trichromacy can arise from a single addition of a third cone class and it does not require an early developmental process. This provides a positive outlook for the potential of gene therapy to cure adult vision disorders.
Katherine Mancuso - One of the best experts on this subject based on the ideXlab platform.
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gene therapy for red green Colour Blindness in adult primates
Nature, 2009Co-Authors: Katherine Mancuso, Matthew C. Mauck, Jay Neitz, James A. Kuchenbecker, William W. Hauswirth, Thomas B Connor, Maureen NeitzAbstract:Red-green Colour Blindness, which results from the absence of either the long- (L) or middle- (M) wavelength-sensitive visual photopigments, is the most common single locus genetic disorder. Here, the possibility of curing Colour Blindness using gene therapy was explored in experiments on adult monkeys that had been Colour blind since birth. A third type of cone pigment was added to dichromatic retinas, providing the receptoral basis for trichromatic Colour vision. This opened a new avenue to explore the requirements for establishing the neural circuits for a new dimension of Colour sensation. Classic visual deprivation experiments1 have led to the expectation that neural connections established during development would not appropriately process an input that was not present from birth. Therefore, it was believed that treatment of congenital vision disorders would be ineffective unless administered to the very young. Here, however, addition of a third opsin in adult red-green Colour-deficient primates was sufficient to produce trichromatic Colour vision behaviour. Thus, trichromacy can arise from a single addition of a third cone class and it does not require an early developmental process. This provides a positive outlook for the potential of gene therapy to cure adult vision disorders.
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Gene therapy for red–green Colour Blindness in adult primates
Nature, 2009Co-Authors: Katherine Mancuso, Matthew C. Mauck, Jay Neitz, James A. Kuchenbecker, William W. Hauswirth, Thomas B Connor, Qiuhong Li, Maureen NeitzAbstract:Red-green Colour Blindness, which results from the absence of either the long- (L) or middle- (M) wavelength-sensitive visual photopigments, is the most common single locus genetic disorder. Here, the possibility of curing Colour Blindness using gene therapy was explored in experiments on adult monkeys that had been Colour blind since birth. A third type of cone pigment was added to dichromatic retinas, providing the receptoral basis for trichromatic Colour vision. This opened a new avenue to explore the requirements for establishing the neural circuits for a new dimension of Colour sensation. Classic visual deprivation experiments1 have led to the expectation that neural connections established during development would not appropriately process an input that was not present from birth. Therefore, it was believed that treatment of congenital vision disorders would be ineffective unless administered to the very young. Here, however, addition of a third opsin in adult red-green Colour-deficient primates was sufficient to produce trichromatic Colour vision behaviour. Thus, trichromacy can arise from a single addition of a third cone class and it does not require an early developmental process. This provides a positive outlook for the potential of gene therapy to cure adult vision disorders.
Gaynor S. Paton - One of the best experts on this subject based on the ideXlab platform.
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The effect of Colour Blindness on seismic interpretation
First Break, 2017Co-Authors: Gaynor S. PatonAbstract:Colour perception is an intrinsic part of visual cognition and affects how we understand the images that we see. Colour is now a fundamental part of how we display seismic reflectivity and attribute data, but not everyone sees Colour in the same way. Colour deficiencies (or Colour Blindness) alters our perception of an image, and this study investigates whether Colour deficiency also alters the interpretation of geological features in seismic data.
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The Effect of Colour Blindness on Seismic Interpretation
78th EAGE Conference and Exhibition 2016, 2016Co-Authors: Gaynor S. PatonAbstract:Colour is an integral part of how we interpret everything that we see, and it is also fundamental to how we communicate with each other, especially when trying to transfer information through reports, presentations and meetings. Colour Blindness is caused by a reduction in the number of cones in the eye, the cells responsible for our detection of Colour, and affects about 8% of the population. The principal question this study aimed to investigate was the impact that Colour Blindness might have on interpretation effectiveness. Four different interpretation tests were performed by the volunteers, each one aimed at investigating a different aspect of the decision making process that could be influenced by Colour perception. Each test was a task that is commonly performed as part of a seismic interpretation workflow. What this study has shown is that there are differences in how individuals with a Colour deficiency interpret seismic data when compared to individuals with full Colour vision.
James A. Kuchenbecker - One of the best experts on this subject based on the ideXlab platform.
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gene therapy for red green Colour Blindness in adult primates
Nature, 2009Co-Authors: Katherine Mancuso, Matthew C. Mauck, Jay Neitz, James A. Kuchenbecker, William W. Hauswirth, Thomas B Connor, Maureen NeitzAbstract:Red-green Colour Blindness, which results from the absence of either the long- (L) or middle- (M) wavelength-sensitive visual photopigments, is the most common single locus genetic disorder. Here, the possibility of curing Colour Blindness using gene therapy was explored in experiments on adult monkeys that had been Colour blind since birth. A third type of cone pigment was added to dichromatic retinas, providing the receptoral basis for trichromatic Colour vision. This opened a new avenue to explore the requirements for establishing the neural circuits for a new dimension of Colour sensation. Classic visual deprivation experiments1 have led to the expectation that neural connections established during development would not appropriately process an input that was not present from birth. Therefore, it was believed that treatment of congenital vision disorders would be ineffective unless administered to the very young. Here, however, addition of a third opsin in adult red-green Colour-deficient primates was sufficient to produce trichromatic Colour vision behaviour. Thus, trichromacy can arise from a single addition of a third cone class and it does not require an early developmental process. This provides a positive outlook for the potential of gene therapy to cure adult vision disorders.
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Gene therapy for red–green Colour Blindness in adult primates
Nature, 2009Co-Authors: Katherine Mancuso, Matthew C. Mauck, Jay Neitz, James A. Kuchenbecker, William W. Hauswirth, Thomas B Connor, Qiuhong Li, Maureen NeitzAbstract:Red-green Colour Blindness, which results from the absence of either the long- (L) or middle- (M) wavelength-sensitive visual photopigments, is the most common single locus genetic disorder. Here, the possibility of curing Colour Blindness using gene therapy was explored in experiments on adult monkeys that had been Colour blind since birth. A third type of cone pigment was added to dichromatic retinas, providing the receptoral basis for trichromatic Colour vision. This opened a new avenue to explore the requirements for establishing the neural circuits for a new dimension of Colour sensation. Classic visual deprivation experiments1 have led to the expectation that neural connections established during development would not appropriately process an input that was not present from birth. Therefore, it was believed that treatment of congenital vision disorders would be ineffective unless administered to the very young. Here, however, addition of a third opsin in adult red-green Colour-deficient primates was sufficient to produce trichromatic Colour vision behaviour. Thus, trichromacy can arise from a single addition of a third cone class and it does not require an early developmental process. This provides a positive outlook for the potential of gene therapy to cure adult vision disorders.
William W. Hauswirth - One of the best experts on this subject based on the ideXlab platform.
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gene therapy for red green Colour Blindness in adult primates
Nature, 2009Co-Authors: Katherine Mancuso, Matthew C. Mauck, Jay Neitz, James A. Kuchenbecker, William W. Hauswirth, Thomas B Connor, Maureen NeitzAbstract:Red-green Colour Blindness, which results from the absence of either the long- (L) or middle- (M) wavelength-sensitive visual photopigments, is the most common single locus genetic disorder. Here, the possibility of curing Colour Blindness using gene therapy was explored in experiments on adult monkeys that had been Colour blind since birth. A third type of cone pigment was added to dichromatic retinas, providing the receptoral basis for trichromatic Colour vision. This opened a new avenue to explore the requirements for establishing the neural circuits for a new dimension of Colour sensation. Classic visual deprivation experiments1 have led to the expectation that neural connections established during development would not appropriately process an input that was not present from birth. Therefore, it was believed that treatment of congenital vision disorders would be ineffective unless administered to the very young. Here, however, addition of a third opsin in adult red-green Colour-deficient primates was sufficient to produce trichromatic Colour vision behaviour. Thus, trichromacy can arise from a single addition of a third cone class and it does not require an early developmental process. This provides a positive outlook for the potential of gene therapy to cure adult vision disorders.
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Gene therapy for red–green Colour Blindness in adult primates
Nature, 2009Co-Authors: Katherine Mancuso, Matthew C. Mauck, Jay Neitz, James A. Kuchenbecker, William W. Hauswirth, Thomas B Connor, Qiuhong Li, Maureen NeitzAbstract:Red-green Colour Blindness, which results from the absence of either the long- (L) or middle- (M) wavelength-sensitive visual photopigments, is the most common single locus genetic disorder. Here, the possibility of curing Colour Blindness using gene therapy was explored in experiments on adult monkeys that had been Colour blind since birth. A third type of cone pigment was added to dichromatic retinas, providing the receptoral basis for trichromatic Colour vision. This opened a new avenue to explore the requirements for establishing the neural circuits for a new dimension of Colour sensation. Classic visual deprivation experiments1 have led to the expectation that neural connections established during development would not appropriately process an input that was not present from birth. Therefore, it was believed that treatment of congenital vision disorders would be ineffective unless administered to the very young. Here, however, addition of a third opsin in adult red-green Colour-deficient primates was sufficient to produce trichromatic Colour vision behaviour. Thus, trichromacy can arise from a single addition of a third cone class and it does not require an early developmental process. This provides a positive outlook for the potential of gene therapy to cure adult vision disorders.