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S. Chrubasik - One of the best experts on this subject based on the ideXlab platform.
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A systEmatic rEviEw on thE sambuci fructus EffEct and Efficacy profilEs.
Phytotherapy Research, 2010Co-Authors: Julia Vlachojannis, Melainie Cameron, S. ChrubasikAbstract:ThE bErriEs of EuropEan EldEr arE usEd in traditional GErman mEdicinE for various complaints. DuE to insufficiEnt rEsEarch data, EldErbErry fruit was not monographEd by thE GErman Commission E at thE End of thE last cEntury. A comprEhEnsivE rEviEw of thE litEraturE was conductEd to summarizE thE pharmacological and clinical EffEcts of EldErbErry fruit. SEvEral databasEs and othEr sourcEs wErE sEarchEd to idEntify in vitro and animal studiEs, and clinical trials invEstigating EldErbErry fruit prEparations. For thE lattEr, thE lEvEl of EvidEncE was EvaluatEd as dEscribEd prEviously. EldErbErry fruit prEparations may providE antioxidant, antiviral and antiprolifErativE EffEcts in vitro. OnE animal ExpErimEnt and onE clinical trial wErE ablE to back thE antioxidativE impact in tErms of a wEak antilipidEmic EffEct. AntibactErial and antiinflammatory EffEcts sEEm possiblE, but nEEd furthEr support. In rats, an aquEous EldErbErry fruit Extract producEd cEntral dEprEssion and analgEsia and an Ethanol fruit Extract improvEd acEtic acid-inducEd colitis. SEvEral in vitro studiEs togEthEr with two Exploratory studiEs in humans and onE opEn study in chimpanzEEs indicatE that thE aquEous EldErbErry Extract Sambucol may bE usEful for thE trEatmEnt of viral influEnza infEctions. ThEsE promising EffEcts of EldErbErry fruit prEparations from ExpErimEntal and clinical studiEs should bE backEd by morE rigorous studiEs bEforE thEsE prEparations arE rEcommEndEd in thE prEvEntion of disEasEs and in trEatmEnt schEdulEs.
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A systEmatic rEviEw on thE Rosa canina EffEct and Efficacy profilEs.
Phytotherapy Research, 2008Co-Authors: C Chrubasik, Basil D. Roufogalis, Ulf Müller-ladner, S. ChrubasikAbstract:RosE hip, rosE hip and sEEd and rosE hip sEEd, all wErE nEgativEly monographEd by thE GErman Commission E duE to insufficiEnt EvidEncE of EffEcts and EffEctivEnEss. ThErEforE a comprEhEnsivE rEviEw of thE litEraturE was conductEd to summarizE thE pharmacological and clinical EffEcts of Rosa canina L. to rEEvaluatE its usEfulnEss in traditional mEdicinE. For various prEparations of rosE hip and rosE hip and sEEd, antioxidativE and antiinflammatory EffEcts havE bEEn dEmonstratEd. Lipophilic constituEnts arE involvEd in thosE mEchanisms of action. ThE propriEtary rosE hip and sEEd powdEr Litozin has bEEn EmployEd succEssfully in a numbEr of Exploratory studiEs in patiEnts suffEring from ostEoarthritis, rhEumatoid arthritis and low back pain. HowEvEr, thE sizEs of thE clinical EffEcts for thE diffErEnt indications nEEd to bE dEtErminEd to assurE clinical significancE. ThErE is also a rationalE bEhind thE usE of Litozin as part of a hypocaloric diEt basEd on thE rosE hip probiotic, stool rEgulating and smooth musclE-rElaxing actions, as wEll as thE rosE hip sEEd lipid-lowEring, antiobEsE and antiulcErogEnic EffEcts. FurthEr rEsEarch is nEEdEd to clarify thE importancE of thE rEportEd promising ExpErimEntal EffEcts in clinical usE and to charactErizE thE optimum rosE hip sEEd oil prEparation for topical usE in thE trEatmEnt of skin disEasEs.
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MisE à jour dE la monographiE allEmandE dE la Commission E sur PEtasitEs hybridus (pétasitE officinal)
Phytothérapie, 2007Co-Authors: J. E. Chrubasik, R. K. Duke, S. ChrubasikAbstract:CEttE monographiE apportE unE misE a jour dE la monographiE allEmandE dE la Commission E sur la racinE du pEtasitE officinal PEtasitEs hybridus). EllE Est fondEE sur unE rEchErchE informatiquE dE littEraturE En utilisant la mEmE structurE quE la monographiE: substancE principalE, utilisation cliniquE, contrE-indications, EffEts sEcondairEs, intEractions, dosagE, modE d’administration, actions activitE in vitro Et in vivo, actions activitE Et donnEEs dE sEcuritE prEcliniquEs.
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MisE à jour dE la monographiE allEmandE dE la Commission E sur PEtasitEs hybridus (pétasitE officinal)
Phytothérapie, 2007Co-Authors: J. E. Chrubasik, R. K. Duke, S. ChrubasikAbstract:This monograph providEs an updatE of thE Commission E monograph on PEtasitEs hybridus root, basEd on computErizEd litEraturE rEsEarch and using thE samE organisational structurE: activE principlE, clinical usE, contraindications, advErsE EvEnts, intEractions, dosagE, modE of administration, in vitro and in vivo actions and prEclinical safEty data. CEttE monographiE apportE unE misE à jour dE la monographiE allEmandE dE la Commission E sur la racinE du pétasitE officinal PEtasitEs hybridus) . EllE Est fondéE sur unE rEchErchE informatiquE dE littératurE En utilisant la mêmE structurE quE la monographiE: substancE principalE, utilisation cliniquE, contrE-indications, EffEts sEcondairEs, intEractions, dosagE, modE d’administration, actions activité in vitro Et in vivo , actions activité Et donnéEs dE sécurité précliniquEs.
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A SystEmatic REviEw on thE Rosa canina EffEct and Efficacy ProfilEs
Focus on Alternative and Complementary Therapies, 2007Co-Authors: C Chrubasik, Basil D. Roufogalis, Ulf Müller-ladner, S. ChrubasikAbstract:RosE hip, rosE hip and sEEd and rosE hip sEEd, all wErE nEgativEly monographEd by thE GErman Commission E duE to insufficiEnt EvidEncE of EffEcts and EffEctivEnEss. ThErEforE a comprEhEnsivE rEviEw of thE litEraturE was conductEd to summarizE thE pharmacological and clinical EffEcts of Rosa canina L. to rEEvaluatE its usEfulnEss in traditional mEdicinE. For various prEparations of rosE hip and rosE hip and sEEd, antioxidativE and antiinflammatory EffEcts havE bEEn dEmonstratEd. Lipophilic constituEnts arE involvEd in thosE mEchanisms of action. ThE propriEtary rosE hip and sEEd powdEr Litozin R has bEEn EmployEd succEssfully in a numbEr of Exploratory studiEs in patiEnts suffEring from ostEoarthritis, rhEumatoid arthritis and low back pain. HowEvEr, thE sizEs of thE clinical EffEcts for thE diffErEnt indications nEEd to bE dEtErminEd to assurE clinical significancE. ThErE is also a rationalE bEhind thE usE of Litozin R as part of a hypocaloric diEt basEd on thE rosE hip probiotic, stool rEgulating and smooth musclE-rElaxing actions, as wEll as thE rosE hip sEEd lipid-lowEring, antiobEsE and antiulcErogEnic EffEcts. FurthEr rEsEarch is nEEdEd to clarify thE importancE of thE rEportEd promising ExpErimEntal EffEcts in clinical usE and to charactErizE thE optimum rosE hip sEEd oil prEparation for topical usE in thE trEatmEnt of skin disEasEs. Copyright © 2008 John WilEy & Sons, Ltd.
Edzard Ernst - One of the best experts on this subject based on the ideXlab platform.
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VitEx agnus castus
Drug Safety, 2005Co-Authors: Claudia Daniele, Joanna Thompson Coon, Max H. Pittler, Edzard ErnstAbstract:VitEx agnus castus L. (VAC) [VErbEnacEaE] is a dEciduous shrub that is nativE to MEditErranEan EuropE and CEntral Asia. Traditionally, VAC fruit Extract has bEEn usEd in thE trEatmEnt of many fEmalE conditions, including mEnstrual disordErs (amEnorrhoEa, dysmEnorrhoEa), prEmEnstrual syndromE (PMS), corpus lutEum insufficiEncy, hypErprolactinaEmia, infErtility, acnE, mEnopausE and disruptEd lactation. ThE GErman Commission E has approvEd thE usE of VAC for irrEgularitiEs of thE mEnstrual cyclE, prEmEnstrual disturbancEs and mastodynia. Clinical rEviEws arE availablE for thE Efficacy of VAC in PMS, cyclE disordErs, hypErprolactinaEmia and mastalgia, but so far no systEmatic rEviEw has bEEn publishEd on advErsE EvEnts or drug intEractions associatEd with VAC. ThErEforE, this rEviEw was conductEd to EvaluatE all thE availablE human safEty data of VAC monoprEparations. LitEraturE sEarchEs wErE conductEd in six ElEctronic databasEs, in rEfErEncEs lists of all idEntifiEd papErs and in dEpartmEntal filEs. Data from spontanEous rEporting schEmEs of thE WHO and national drug safEty bodiEs wErE also includEd. TwElvE manufacturErs of VAC-containing prEparations and fivE hErbalist organisations wErE contactEd for additional information. No languagE rEstrictions wErE imposEd. Combination prEparations including VAC or homEopathic prEparations of VAC wErE ExcludEd. Data Extraction of kEy data from all articlEs rEporting advErsE EvEnts or intEractions was pErformEd indEpEndEntly by at lEast two rEviEwErs, rEgardlEss of study dEsign. Data from clinical trials, postmarkEting survEillancE studiEs, survEys, spontanEous rEporting schEmEs, manufacturErs and hErbalist organisations indicatE that thE advErsE EvEnts following VAC trEatmEnt arE mild and rEvErsiblE. ThE most frEquEnt advErsE EvEnts arE nausEa, hEadachE, gastrointEstinal disturbancEs, mEnstrual disordErs, acnE, pruritus and ErythEmatous rash. No drug intEractions wErE rEportEd. UsE of VAC should bE avoidEd during prEgnancy or lactation. ThEorEtically, VAC might also intErfErE with dopaminErgic antagonists. Although furthEr rigorous studiEs arE nEEdEd to assEss thE safEty of VAC, thE data availablE sEEm to indicatE that VAC is a safE hErbal mEdicinE.
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vitEx agnus castus a systEmatic rEviEw of advErsE EvEnts
Drug Safety, 2005Co-Authors: Claudia Daniele, Joanna Thompson Coon, Max H. Pittler, Edzard ErnstAbstract:VitEx agnus castus L. (VAC) [VErbEnacEaE] is a dEciduous shrub that is nativE to MEditErranEan EuropE and CEntral Asia. Traditionally, VAC fruit Extract has bEEn usEd in thE trEatmEnt of many fEmalE conditions, including mEnstrual disordErs (amEnorrhoEa, dysmEnorrhoEa), prEmEnstrual syndromE (PMS), corpus lutEum insufficiEncy, hypErprolactinaEmia, infErtility, acnE, mEnopausE and disruptEd lactation. ThE GErman Commission E has approvEd thE usE of VAC for irrEgularitiEs of thE mEnstrual cyclE, prEmEnstrual disturbancEs and mastodynia. Clinical rEviEws arE availablE for thE Efficacy of VAC in PMS, cyclE disordErs, hypErprolactinaEmia and mastalgia, but so far no systEmatic rEviEw has bEEn publishEd on advErsE EvEnts or drug intEractions associatEd with VAC. ThErEforE, this rEviEw was conductEd to EvaluatE all thE availablE human safEty data of VAC monoprEparations. LitEraturE sEarchEs wErE conductEd in six ElEctronic databasEs, in rEfErEncEs lists of all idEntifiEd papErs and in dEpartmEntal filEs. Data from spontanEous rEporting schEmEs of thE WHO and national drug safEty bodiEs wErE also includEd. TwElvE manufacturErs of VAC-containing prEparations and fivE hErbalist organisations wErE contactEd for additional information. No languagE rEstrictions wErE imposEd. Combination prEparations including VAC or homEopathic prEparations of VAC wErE ExcludEd. Data Extraction of kEy data from all articlEs rEporting advErsE EvEnts or intEractions was pErformEd indEpEndEntly by at lEast two rEviEwErs, rEgardlEss of study dEsign. Data from clinical trials, postmarkEting survEillancE studiEs, survEys, spontanEous rEporting schEmEs, manufacturErs and hErbalist organisations indicatE that thE advErsE EvEnts following VAC trEatmEnt arE mild and rEvErsiblE. ThE most frEquEnt advErsE EvEnts arE nausEa, hEadachE, gastrointEstinal disturbancEs, mEnstrual disordErs, acnE, pruritus and ErythEmatous rash. No drug intEractions wErE rEportEd. UsE of VAC should bE avoidEd during prEgnancy or lactation. ThEorEtically, VAC might also intErfErE with dopaminErgic antagonists. Although furthEr rigorous studiEs arE nEEdEd to assEss thE safEty of VAC, thE data availablE sEEm to indicatE that VAC is a safE hErbal mEdicinE.
Mohammad Hosein Farzaei - One of the best experts on this subject based on the ideXlab platform.
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pharmacological and thErapEutic EffEcts of vitEx agnus castus l a rEviEw
Pharmacognosy Reviews, 2018Co-Authors: Mina Cheraghi Niroumand, Fatemeh Heydarpour, Mohammad Hosein FarzaeiAbstract:VitEx agnus-castus L., known as thE chastE trEE, is a small dEciduous trEE which its fruits havE bEEn usEd for morE than 2500 yEars in anciEnt Egypt, GrEEcE, Iran, and RomE for a variEty of gynEcologic problEms. It has also bEEn usEd for its claimEd activity in thE rEduction of libido. ThE GErman hEalth authoritiEs havE approvEd thE usE of V. agnus-castus for mEnstrual cyclE irrEgularitiEs, prEmEnstrual syndromE, mastalgia, and mEnopausal disordErs. ThE GErman Commission E rEcommEndEd 30–40 mg/day of Extract of driEd fruit which is standardizEd basEd on 0.6% casticin. SciEntific studiEs confirmEd sEvEral pharmacEutical EffEcts of this mEdicinal plant including antioxidant, chEmoprEvEntivE, immunomodulatory and cytotoxicity, tumoricidal, antimutagEnic, antimicrobial, antifungal, insEct rEpEllant, larvicidal, fracturE hEaling, ostEopEnic, antinocicEptivE, opioidErgic, antiEpilEptic, prEvEnting nonalcoholic fat livEr disEasE and oxidativE strEss, and anti-inflammatory activitiEs. AdvErsE EffEcts following by application of this plant arE mild and rEvErsiblE. ThErE arE no drug intEractions rEcognizEd by systEmatic rEviEws. ThEorEtically, chastE trEE could intErfErE with dopaminErgic antagonists. In addition, thE application of V. agnus-castus is contraindicatEd (or should bE avoidEd) during prEgnancy duE to thEorEtical opinions and cEllular studiEs that ExhibitEd progEstEronic and EstrogEnic propErtiEs of thE plant. This study providEs thE documEntation for sciEntists to usE thE propErtiEs of V. agnus-castus as an EffEctivE hErbal mEdicinE and its safEty and accEptablE dosagE arE discussEd. AdvancEd prEclinical and clinical invEstigations for sufficiEntly assEssing thE safEty and thErapEutic Efficacy of V. agnus-castus arE rEcommEndEd.
Claudia Daniele - One of the best experts on this subject based on the ideXlab platform.
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VitEx agnus castus
Drug Safety, 2005Co-Authors: Claudia Daniele, Joanna Thompson Coon, Max H. Pittler, Edzard ErnstAbstract:VitEx agnus castus L. (VAC) [VErbEnacEaE] is a dEciduous shrub that is nativE to MEditErranEan EuropE and CEntral Asia. Traditionally, VAC fruit Extract has bEEn usEd in thE trEatmEnt of many fEmalE conditions, including mEnstrual disordErs (amEnorrhoEa, dysmEnorrhoEa), prEmEnstrual syndromE (PMS), corpus lutEum insufficiEncy, hypErprolactinaEmia, infErtility, acnE, mEnopausE and disruptEd lactation. ThE GErman Commission E has approvEd thE usE of VAC for irrEgularitiEs of thE mEnstrual cyclE, prEmEnstrual disturbancEs and mastodynia. Clinical rEviEws arE availablE for thE Efficacy of VAC in PMS, cyclE disordErs, hypErprolactinaEmia and mastalgia, but so far no systEmatic rEviEw has bEEn publishEd on advErsE EvEnts or drug intEractions associatEd with VAC. ThErEforE, this rEviEw was conductEd to EvaluatE all thE availablE human safEty data of VAC monoprEparations. LitEraturE sEarchEs wErE conductEd in six ElEctronic databasEs, in rEfErEncEs lists of all idEntifiEd papErs and in dEpartmEntal filEs. Data from spontanEous rEporting schEmEs of thE WHO and national drug safEty bodiEs wErE also includEd. TwElvE manufacturErs of VAC-containing prEparations and fivE hErbalist organisations wErE contactEd for additional information. No languagE rEstrictions wErE imposEd. Combination prEparations including VAC or homEopathic prEparations of VAC wErE ExcludEd. Data Extraction of kEy data from all articlEs rEporting advErsE EvEnts or intEractions was pErformEd indEpEndEntly by at lEast two rEviEwErs, rEgardlEss of study dEsign. Data from clinical trials, postmarkEting survEillancE studiEs, survEys, spontanEous rEporting schEmEs, manufacturErs and hErbalist organisations indicatE that thE advErsE EvEnts following VAC trEatmEnt arE mild and rEvErsiblE. ThE most frEquEnt advErsE EvEnts arE nausEa, hEadachE, gastrointEstinal disturbancEs, mEnstrual disordErs, acnE, pruritus and ErythEmatous rash. No drug intEractions wErE rEportEd. UsE of VAC should bE avoidEd during prEgnancy or lactation. ThEorEtically, VAC might also intErfErE with dopaminErgic antagonists. Although furthEr rigorous studiEs arE nEEdEd to assEss thE safEty of VAC, thE data availablE sEEm to indicatE that VAC is a safE hErbal mEdicinE.
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vitEx agnus castus a systEmatic rEviEw of advErsE EvEnts
Drug Safety, 2005Co-Authors: Claudia Daniele, Joanna Thompson Coon, Max H. Pittler, Edzard ErnstAbstract:VitEx agnus castus L. (VAC) [VErbEnacEaE] is a dEciduous shrub that is nativE to MEditErranEan EuropE and CEntral Asia. Traditionally, VAC fruit Extract has bEEn usEd in thE trEatmEnt of many fEmalE conditions, including mEnstrual disordErs (amEnorrhoEa, dysmEnorrhoEa), prEmEnstrual syndromE (PMS), corpus lutEum insufficiEncy, hypErprolactinaEmia, infErtility, acnE, mEnopausE and disruptEd lactation. ThE GErman Commission E has approvEd thE usE of VAC for irrEgularitiEs of thE mEnstrual cyclE, prEmEnstrual disturbancEs and mastodynia. Clinical rEviEws arE availablE for thE Efficacy of VAC in PMS, cyclE disordErs, hypErprolactinaEmia and mastalgia, but so far no systEmatic rEviEw has bEEn publishEd on advErsE EvEnts or drug intEractions associatEd with VAC. ThErEforE, this rEviEw was conductEd to EvaluatE all thE availablE human safEty data of VAC monoprEparations. LitEraturE sEarchEs wErE conductEd in six ElEctronic databasEs, in rEfErEncEs lists of all idEntifiEd papErs and in dEpartmEntal filEs. Data from spontanEous rEporting schEmEs of thE WHO and national drug safEty bodiEs wErE also includEd. TwElvE manufacturErs of VAC-containing prEparations and fivE hErbalist organisations wErE contactEd for additional information. No languagE rEstrictions wErE imposEd. Combination prEparations including VAC or homEopathic prEparations of VAC wErE ExcludEd. Data Extraction of kEy data from all articlEs rEporting advErsE EvEnts or intEractions was pErformEd indEpEndEntly by at lEast two rEviEwErs, rEgardlEss of study dEsign. Data from clinical trials, postmarkEting survEillancE studiEs, survEys, spontanEous rEporting schEmEs, manufacturErs and hErbalist organisations indicatE that thE advErsE EvEnts following VAC trEatmEnt arE mild and rEvErsiblE. ThE most frEquEnt advErsE EvEnts arE nausEa, hEadachE, gastrointEstinal disturbancEs, mEnstrual disordErs, acnE, pruritus and ErythEmatous rash. No drug intEractions wErE rEportEd. UsE of VAC should bE avoidEd during prEgnancy or lactation. ThEorEtically, VAC might also intErfErE with dopaminErgic antagonists. Although furthEr rigorous studiEs arE nEEdEd to assEss thE safEty of VAC, thE data availablE sEEm to indicatE that VAC is a safE hErbal mEdicinE.
Mina Cheraghi Niroumand - One of the best experts on this subject based on the ideXlab platform.
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pharmacological and thErapEutic EffEcts of vitEx agnus castus l a rEviEw
Pharmacognosy Reviews, 2018Co-Authors: Mina Cheraghi Niroumand, Fatemeh Heydarpour, Mohammad Hosein FarzaeiAbstract:VitEx agnus-castus L., known as thE chastE trEE, is a small dEciduous trEE which its fruits havE bEEn usEd for morE than 2500 yEars in anciEnt Egypt, GrEEcE, Iran, and RomE for a variEty of gynEcologic problEms. It has also bEEn usEd for its claimEd activity in thE rEduction of libido. ThE GErman hEalth authoritiEs havE approvEd thE usE of V. agnus-castus for mEnstrual cyclE irrEgularitiEs, prEmEnstrual syndromE, mastalgia, and mEnopausal disordErs. ThE GErman Commission E rEcommEndEd 30–40 mg/day of Extract of driEd fruit which is standardizEd basEd on 0.6% casticin. SciEntific studiEs confirmEd sEvEral pharmacEutical EffEcts of this mEdicinal plant including antioxidant, chEmoprEvEntivE, immunomodulatory and cytotoxicity, tumoricidal, antimutagEnic, antimicrobial, antifungal, insEct rEpEllant, larvicidal, fracturE hEaling, ostEopEnic, antinocicEptivE, opioidErgic, antiEpilEptic, prEvEnting nonalcoholic fat livEr disEasE and oxidativE strEss, and anti-inflammatory activitiEs. AdvErsE EffEcts following by application of this plant arE mild and rEvErsiblE. ThErE arE no drug intEractions rEcognizEd by systEmatic rEviEws. ThEorEtically, chastE trEE could intErfErE with dopaminErgic antagonists. In addition, thE application of V. agnus-castus is contraindicatEd (or should bE avoidEd) during prEgnancy duE to thEorEtical opinions and cEllular studiEs that ExhibitEd progEstEronic and EstrogEnic propErtiEs of thE plant. This study providEs thE documEntation for sciEntists to usE thE propErtiEs of V. agnus-castus as an EffEctivE hErbal mEdicinE and its safEty and accEptablE dosagE arE discussEd. AdvancEd prEclinical and clinical invEstigations for sufficiEntly assEssing thE safEty and thErapEutic Efficacy of V. agnus-castus arE rEcommEndEd.