The Experts below are selected from a list of 22473 Experts worldwide ranked by ideXlab platform
Shoji Yamanaka - One of the best experts on this subject based on the ideXlab platform.
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aberrant nuclear localization and gene mutation of beta catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Hitoshi Kitamura, Yoji Nagashima, Shoji YamanakaAbstract:Aberrant Nuclear Localization and Gene Mutation of β-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules
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aberrant nuclear localization and gene mutation of β catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Hitoshi Kitamura, Yoji Nagashima, Shoji YamanakaAbstract:Aberrant Nuclear Localization and Gene Mutation of β-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules
Yukio Nakatani - One of the best experts on this subject based on the ideXlab platform.
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aberrant nuclear localization and gene mutation of beta catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Takaaki Ito, Hitoshi Kitamura, Yoji NagashimaAbstract:The salient histopathologic features of low-grade adenocarcinoma of the fetal lung type (L-FLAC)/well-differentiated fetal adenocarcinoma (WDFA) include complex glandular structures and morules with biotin-rich optically clear nuclei. Interestingly, these characteristic features are shared by the cribriform-morular variant of papillary thyroid carcinoma, whose morphology is identical to that of familial adenomatous polyposis (FAP)-associated thyroid carcinoma. Furthermore, the single reported case of lung cancer associated with FAP was L-FLAC/WDFA. These observations lead us to hypothesize that up-regulation of the Wnt signaling pathway underlies the development of L-FLAC/WDFA. To verify this hypothesis, 11 cases of L-FLAC/WDFA, including the one FAP-associated case, eight cases of high-grade adenocarcinoma of the fetal lung type (H-FLAC), 24 cases of conventional pulmonary adenocarcinoma (CAC), and 13 fetal lungs were immunostained for beta-catenin. All cases of L-FLAC/WDFA showed predominantly aberrant nuclear/cytoplasmic expression, especially in budding glands and morules, whereas six of eight cases (75%) of H-FLAC and all but one case (96%) of CAC showed predominantly membranous expression. Fetal lungs showed nuclear/cytoplasmic expression restricted to the distal branching airway epithelium. Mutational analysis of exon 3 of the beta-catenin gene in five sporadic cases of L-FLAC/WDFA showed a point mutation at codon 34 and codon 37 in two cases, respectively. The present study indicates that up-regulating disturbances in the Wnt signaling pathway, including mutation of the beta-catenin gene, underlie tumorigenesis of L-FLAC/WDFA. The expression pattern of beta-catenin in L-FLAC/WDFA resembles that of the developing fetal lung airway. With the expression pattern of beta-catenin as a marker, most cases of H-FLAC as well as CAC appear to have different oncogenic pathways from cases of L-FLAC/WDFA. The present study together with other available data also suggests that abnormal up-regulation of the Wnt signaling pathway may be a Common Denominator for the development of tumors with morular formation from a variety of anatomic sites.
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aberrant nuclear localization and gene mutation of beta catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Hitoshi Kitamura, Yoji Nagashima, Shoji YamanakaAbstract:Aberrant Nuclear Localization and Gene Mutation of β-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules
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aberrant nuclear localization and gene mutation of β catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Hitoshi Kitamura, Yoji Nagashima, Shoji YamanakaAbstract:Aberrant Nuclear Localization and Gene Mutation of β-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules
Yoji Nagashima - One of the best experts on this subject based on the ideXlab platform.
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aberrant nuclear localization and gene mutation of beta catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Takaaki Ito, Hitoshi Kitamura, Yoji NagashimaAbstract:The salient histopathologic features of low-grade adenocarcinoma of the fetal lung type (L-FLAC)/well-differentiated fetal adenocarcinoma (WDFA) include complex glandular structures and morules with biotin-rich optically clear nuclei. Interestingly, these characteristic features are shared by the cribriform-morular variant of papillary thyroid carcinoma, whose morphology is identical to that of familial adenomatous polyposis (FAP)-associated thyroid carcinoma. Furthermore, the single reported case of lung cancer associated with FAP was L-FLAC/WDFA. These observations lead us to hypothesize that up-regulation of the Wnt signaling pathway underlies the development of L-FLAC/WDFA. To verify this hypothesis, 11 cases of L-FLAC/WDFA, including the one FAP-associated case, eight cases of high-grade adenocarcinoma of the fetal lung type (H-FLAC), 24 cases of conventional pulmonary adenocarcinoma (CAC), and 13 fetal lungs were immunostained for beta-catenin. All cases of L-FLAC/WDFA showed predominantly aberrant nuclear/cytoplasmic expression, especially in budding glands and morules, whereas six of eight cases (75%) of H-FLAC and all but one case (96%) of CAC showed predominantly membranous expression. Fetal lungs showed nuclear/cytoplasmic expression restricted to the distal branching airway epithelium. Mutational analysis of exon 3 of the beta-catenin gene in five sporadic cases of L-FLAC/WDFA showed a point mutation at codon 34 and codon 37 in two cases, respectively. The present study indicates that up-regulating disturbances in the Wnt signaling pathway, including mutation of the beta-catenin gene, underlie tumorigenesis of L-FLAC/WDFA. The expression pattern of beta-catenin in L-FLAC/WDFA resembles that of the developing fetal lung airway. With the expression pattern of beta-catenin as a marker, most cases of H-FLAC as well as CAC appear to have different oncogenic pathways from cases of L-FLAC/WDFA. The present study together with other available data also suggests that abnormal up-regulation of the Wnt signaling pathway may be a Common Denominator for the development of tumors with morular formation from a variety of anatomic sites.
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aberrant nuclear localization and gene mutation of beta catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Hitoshi Kitamura, Yoji Nagashima, Shoji YamanakaAbstract:Aberrant Nuclear Localization and Gene Mutation of β-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules
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aberrant nuclear localization and gene mutation of β catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Hitoshi Kitamura, Yoji Nagashima, Shoji YamanakaAbstract:Aberrant Nuclear Localization and Gene Mutation of β-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules
Yoshiaki Inayama - One of the best experts on this subject based on the ideXlab platform.
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aberrant nuclear localization and gene mutation of beta catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Takaaki Ito, Hitoshi Kitamura, Yoji NagashimaAbstract:The salient histopathologic features of low-grade adenocarcinoma of the fetal lung type (L-FLAC)/well-differentiated fetal adenocarcinoma (WDFA) include complex glandular structures and morules with biotin-rich optically clear nuclei. Interestingly, these characteristic features are shared by the cribriform-morular variant of papillary thyroid carcinoma, whose morphology is identical to that of familial adenomatous polyposis (FAP)-associated thyroid carcinoma. Furthermore, the single reported case of lung cancer associated with FAP was L-FLAC/WDFA. These observations lead us to hypothesize that up-regulation of the Wnt signaling pathway underlies the development of L-FLAC/WDFA. To verify this hypothesis, 11 cases of L-FLAC/WDFA, including the one FAP-associated case, eight cases of high-grade adenocarcinoma of the fetal lung type (H-FLAC), 24 cases of conventional pulmonary adenocarcinoma (CAC), and 13 fetal lungs were immunostained for beta-catenin. All cases of L-FLAC/WDFA showed predominantly aberrant nuclear/cytoplasmic expression, especially in budding glands and morules, whereas six of eight cases (75%) of H-FLAC and all but one case (96%) of CAC showed predominantly membranous expression. Fetal lungs showed nuclear/cytoplasmic expression restricted to the distal branching airway epithelium. Mutational analysis of exon 3 of the beta-catenin gene in five sporadic cases of L-FLAC/WDFA showed a point mutation at codon 34 and codon 37 in two cases, respectively. The present study indicates that up-regulating disturbances in the Wnt signaling pathway, including mutation of the beta-catenin gene, underlie tumorigenesis of L-FLAC/WDFA. The expression pattern of beta-catenin in L-FLAC/WDFA resembles that of the developing fetal lung airway. With the expression pattern of beta-catenin as a marker, most cases of H-FLAC as well as CAC appear to have different oncogenic pathways from cases of L-FLAC/WDFA. The present study together with other available data also suggests that abnormal up-regulation of the Wnt signaling pathway may be a Common Denominator for the development of tumors with morular formation from a variety of anatomic sites.
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aberrant nuclear localization and gene mutation of beta catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Hitoshi Kitamura, Yoji Nagashima, Shoji YamanakaAbstract:Aberrant Nuclear Localization and Gene Mutation of β-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules
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aberrant nuclear localization and gene mutation of β catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Hitoshi Kitamura, Yoji Nagashima, Shoji YamanakaAbstract:Aberrant Nuclear Localization and Gene Mutation of β-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules
Keisuke Kato - One of the best experts on this subject based on the ideXlab platform.
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aberrant nuclear localization and gene mutation of beta catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Takaaki Ito, Hitoshi Kitamura, Yoji NagashimaAbstract:The salient histopathologic features of low-grade adenocarcinoma of the fetal lung type (L-FLAC)/well-differentiated fetal adenocarcinoma (WDFA) include complex glandular structures and morules with biotin-rich optically clear nuclei. Interestingly, these characteristic features are shared by the cribriform-morular variant of papillary thyroid carcinoma, whose morphology is identical to that of familial adenomatous polyposis (FAP)-associated thyroid carcinoma. Furthermore, the single reported case of lung cancer associated with FAP was L-FLAC/WDFA. These observations lead us to hypothesize that up-regulation of the Wnt signaling pathway underlies the development of L-FLAC/WDFA. To verify this hypothesis, 11 cases of L-FLAC/WDFA, including the one FAP-associated case, eight cases of high-grade adenocarcinoma of the fetal lung type (H-FLAC), 24 cases of conventional pulmonary adenocarcinoma (CAC), and 13 fetal lungs were immunostained for beta-catenin. All cases of L-FLAC/WDFA showed predominantly aberrant nuclear/cytoplasmic expression, especially in budding glands and morules, whereas six of eight cases (75%) of H-FLAC and all but one case (96%) of CAC showed predominantly membranous expression. Fetal lungs showed nuclear/cytoplasmic expression restricted to the distal branching airway epithelium. Mutational analysis of exon 3 of the beta-catenin gene in five sporadic cases of L-FLAC/WDFA showed a point mutation at codon 34 and codon 37 in two cases, respectively. The present study indicates that up-regulating disturbances in the Wnt signaling pathway, including mutation of the beta-catenin gene, underlie tumorigenesis of L-FLAC/WDFA. The expression pattern of beta-catenin in L-FLAC/WDFA resembles that of the developing fetal lung airway. With the expression pattern of beta-catenin as a marker, most cases of H-FLAC as well as CAC appear to have different oncogenic pathways from cases of L-FLAC/WDFA. The present study together with other available data also suggests that abnormal up-regulation of the Wnt signaling pathway may be a Common Denominator for the development of tumors with morular formation from a variety of anatomic sites.
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aberrant nuclear localization and gene mutation of beta catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Hitoshi Kitamura, Yoji Nagashima, Shoji YamanakaAbstract:Aberrant Nuclear Localization and Gene Mutation of β-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules
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aberrant nuclear localization and gene mutation of β catenin in low grade adenocarcinoma of fetal lung type up regulation of the wnt signaling pathway may be a Common Denominator for the development of tumors that form morules
Modern Pathology, 2002Co-Authors: Yukio Nakatani, Katsuhiko Masudo, Yohei Miyagi, Yoshiaki Inayama, Naomi Kawano, Yukichi Tanaka, Keisuke Kato, Hitoshi Kitamura, Yoji Nagashima, Shoji YamanakaAbstract:Aberrant Nuclear Localization and Gene Mutation of β-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules