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G L Redlich - One of the best experts on this subject based on the ideXlab platform.

  • the sap from euphorbia peplus is effective against human nonmelanoma skin cancers
    British Journal of Dermatology, 2011
    Co-Authors: Jonathan Ramsay, Andreas Suhrbier, James Harrison Aylward, Steven M Ogbourne, Sarahjane Cozzi, Michael Poulsen, Kathryn C Baumann, P Welburn, G L Redlich
    Abstract:

    BACKGROUND: The sap from Euphorbia peplus, commonly known as petty spurge in the U.K. or radium weed in Australia, has been used as a traditional treatment for a number of cancers. OBJECTIVE: To determine the effectiveness of E. peplus sap in a phase I/II clinical study for the topical treatment of basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and intraepidermal carcinomas (IEC). METHODS: Thirty-six patients, who had refused, failed or were unsuitable for conventional treatment, were enrolled in a phase I/II clinical study. A total of 48 skin cancer lesions were treated topically with 100-300 μL of E. peplus sap once daily for 3 days. RESULTS: The complete clinical response rates at 1 month were 82% (n = 28) for BCC, 94% (n = 16) for IEC and 75% (n = 4) for SCC. After a mean follow-up of 15 months these rates were 57%, 75% and 50%, respectively. For superficial lesions 2 cm in diameter), are comparable with existing nonsurgical treatments. An active ingredient of E. peplus sap has been identified as ingenol mebutate (PEP005). This clinical study affirms Community Experience with E. peplus sap, and supports further clinical development of PEP005 for the treatment of BCC, SCC and IEC.

  • the sap from euphorbia peplus is effective against human nonmelanoma skin cancers
    British Journal of Dermatology, 2011
    Co-Authors: Jonathan Ramsay, Andreas Suhrbier, James Harrison Aylward, Steven M Ogbourne, Sarahjane Cozzi, Michael Poulsen, Kathryn C Baumann, P Welburn, G L Redlich
    Abstract:

    Summary Background  The sap from Euphorbia peplus, commonly known as petty spurge in the U.K. or radium weed in Australia, has been used as a traditional treatment for a number of cancers. Objective  To determine the effectiveness of E. peplus sap in a phase I/II clinical study for the topical treatment of basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and intraepidermal carcinomas (IEC). Methods  Thirty-six patients, who had refused, failed or were unsuitable for conventional treatment, were enrolled in a phase I/II clinical study. A total of 48 skin cancer lesions were treated topically with 100–300 μL of E. peplus sap once daily for 3 days. Results  The complete clinical response rates at 1 month were 82% (n = 28) for BCC, 94% (n = 16) for IEC and 75% (n = 4) for SCC. After a mean follow-up of 15 months these rates were 57%, 75% and 50%, respectively. For superficial lesions < 16 mm, the response rates after follow-up were 100% for IEC (n = 10) and 78% for BCC (n = 9). Conclusions  The clinical responses for these relatively unfavourable lesions (43% had failed previous treatments, 35% were situated in the head and neck region and 30% were > 2 cm in diameter), are comparable with existing nonsurgical treatments. An active ingredient of E. peplus sap has been identified as ingenol mebutate (PEP005). This clinical study affirms Community Experience with E. peplus sap, and supports further clinical development of PEP005 for the treatment of BCC, SCC and IEC.

Andreas Suhrbier - One of the best experts on this subject based on the ideXlab platform.

  • the sap from euphorbia peplus is effective against human nonmelanoma skin cancers
    British Journal of Dermatology, 2011
    Co-Authors: Jonathan Ramsay, Andreas Suhrbier, James Harrison Aylward, Steven M Ogbourne, Sarahjane Cozzi, Michael Poulsen, Kathryn C Baumann, P Welburn, G L Redlich
    Abstract:

    BACKGROUND: The sap from Euphorbia peplus, commonly known as petty spurge in the U.K. or radium weed in Australia, has been used as a traditional treatment for a number of cancers. OBJECTIVE: To determine the effectiveness of E. peplus sap in a phase I/II clinical study for the topical treatment of basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and intraepidermal carcinomas (IEC). METHODS: Thirty-six patients, who had refused, failed or were unsuitable for conventional treatment, were enrolled in a phase I/II clinical study. A total of 48 skin cancer lesions were treated topically with 100-300 μL of E. peplus sap once daily for 3 days. RESULTS: The complete clinical response rates at 1 month were 82% (n = 28) for BCC, 94% (n = 16) for IEC and 75% (n = 4) for SCC. After a mean follow-up of 15 months these rates were 57%, 75% and 50%, respectively. For superficial lesions 2 cm in diameter), are comparable with existing nonsurgical treatments. An active ingredient of E. peplus sap has been identified as ingenol mebutate (PEP005). This clinical study affirms Community Experience with E. peplus sap, and supports further clinical development of PEP005 for the treatment of BCC, SCC and IEC.

  • the sap from euphorbia peplus is effective against human nonmelanoma skin cancers
    British Journal of Dermatology, 2011
    Co-Authors: Jonathan Ramsay, Andreas Suhrbier, James Harrison Aylward, Steven M Ogbourne, Sarahjane Cozzi, Michael Poulsen, Kathryn C Baumann, P Welburn, G L Redlich
    Abstract:

    Summary Background  The sap from Euphorbia peplus, commonly known as petty spurge in the U.K. or radium weed in Australia, has been used as a traditional treatment for a number of cancers. Objective  To determine the effectiveness of E. peplus sap in a phase I/II clinical study for the topical treatment of basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and intraepidermal carcinomas (IEC). Methods  Thirty-six patients, who had refused, failed or were unsuitable for conventional treatment, were enrolled in a phase I/II clinical study. A total of 48 skin cancer lesions were treated topically with 100–300 μL of E. peplus sap once daily for 3 days. Results  The complete clinical response rates at 1 month were 82% (n = 28) for BCC, 94% (n = 16) for IEC and 75% (n = 4) for SCC. After a mean follow-up of 15 months these rates were 57%, 75% and 50%, respectively. For superficial lesions < 16 mm, the response rates after follow-up were 100% for IEC (n = 10) and 78% for BCC (n = 9). Conclusions  The clinical responses for these relatively unfavourable lesions (43% had failed previous treatments, 35% were situated in the head and neck region and 30% were > 2 cm in diameter), are comparable with existing nonsurgical treatments. An active ingredient of E. peplus sap has been identified as ingenol mebutate (PEP005). This clinical study affirms Community Experience with E. peplus sap, and supports further clinical development of PEP005 for the treatment of BCC, SCC and IEC.

Jonathan Ramsay - One of the best experts on this subject based on the ideXlab platform.

  • the sap from euphorbia peplus is effective against human nonmelanoma skin cancers
    British Journal of Dermatology, 2011
    Co-Authors: Jonathan Ramsay, Andreas Suhrbier, James Harrison Aylward, Steven M Ogbourne, Sarahjane Cozzi, Michael Poulsen, Kathryn C Baumann, P Welburn, G L Redlich
    Abstract:

    BACKGROUND: The sap from Euphorbia peplus, commonly known as petty spurge in the U.K. or radium weed in Australia, has been used as a traditional treatment for a number of cancers. OBJECTIVE: To determine the effectiveness of E. peplus sap in a phase I/II clinical study for the topical treatment of basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and intraepidermal carcinomas (IEC). METHODS: Thirty-six patients, who had refused, failed or were unsuitable for conventional treatment, were enrolled in a phase I/II clinical study. A total of 48 skin cancer lesions were treated topically with 100-300 μL of E. peplus sap once daily for 3 days. RESULTS: The complete clinical response rates at 1 month were 82% (n = 28) for BCC, 94% (n = 16) for IEC and 75% (n = 4) for SCC. After a mean follow-up of 15 months these rates were 57%, 75% and 50%, respectively. For superficial lesions 2 cm in diameter), are comparable with existing nonsurgical treatments. An active ingredient of E. peplus sap has been identified as ingenol mebutate (PEP005). This clinical study affirms Community Experience with E. peplus sap, and supports further clinical development of PEP005 for the treatment of BCC, SCC and IEC.

  • the sap from euphorbia peplus is effective against human nonmelanoma skin cancers
    British Journal of Dermatology, 2011
    Co-Authors: Jonathan Ramsay, Andreas Suhrbier, James Harrison Aylward, Steven M Ogbourne, Sarahjane Cozzi, Michael Poulsen, Kathryn C Baumann, P Welburn, G L Redlich
    Abstract:

    Summary Background  The sap from Euphorbia peplus, commonly known as petty spurge in the U.K. or radium weed in Australia, has been used as a traditional treatment for a number of cancers. Objective  To determine the effectiveness of E. peplus sap in a phase I/II clinical study for the topical treatment of basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and intraepidermal carcinomas (IEC). Methods  Thirty-six patients, who had refused, failed or were unsuitable for conventional treatment, were enrolled in a phase I/II clinical study. A total of 48 skin cancer lesions were treated topically with 100–300 μL of E. peplus sap once daily for 3 days. Results  The complete clinical response rates at 1 month were 82% (n = 28) for BCC, 94% (n = 16) for IEC and 75% (n = 4) for SCC. After a mean follow-up of 15 months these rates were 57%, 75% and 50%, respectively. For superficial lesions < 16 mm, the response rates after follow-up were 100% for IEC (n = 10) and 78% for BCC (n = 9). Conclusions  The clinical responses for these relatively unfavourable lesions (43% had failed previous treatments, 35% were situated in the head and neck region and 30% were > 2 cm in diameter), are comparable with existing nonsurgical treatments. An active ingredient of E. peplus sap has been identified as ingenol mebutate (PEP005). This clinical study affirms Community Experience with E. peplus sap, and supports further clinical development of PEP005 for the treatment of BCC, SCC and IEC.

James Harrison Aylward - One of the best experts on this subject based on the ideXlab platform.

  • the sap from euphorbia peplus is effective against human nonmelanoma skin cancers
    British Journal of Dermatology, 2011
    Co-Authors: Jonathan Ramsay, Andreas Suhrbier, James Harrison Aylward, Steven M Ogbourne, Sarahjane Cozzi, Michael Poulsen, Kathryn C Baumann, P Welburn, G L Redlich
    Abstract:

    BACKGROUND: The sap from Euphorbia peplus, commonly known as petty spurge in the U.K. or radium weed in Australia, has been used as a traditional treatment for a number of cancers. OBJECTIVE: To determine the effectiveness of E. peplus sap in a phase I/II clinical study for the topical treatment of basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and intraepidermal carcinomas (IEC). METHODS: Thirty-six patients, who had refused, failed or were unsuitable for conventional treatment, were enrolled in a phase I/II clinical study. A total of 48 skin cancer lesions were treated topically with 100-300 μL of E. peplus sap once daily for 3 days. RESULTS: The complete clinical response rates at 1 month were 82% (n = 28) for BCC, 94% (n = 16) for IEC and 75% (n = 4) for SCC. After a mean follow-up of 15 months these rates were 57%, 75% and 50%, respectively. For superficial lesions 2 cm in diameter), are comparable with existing nonsurgical treatments. An active ingredient of E. peplus sap has been identified as ingenol mebutate (PEP005). This clinical study affirms Community Experience with E. peplus sap, and supports further clinical development of PEP005 for the treatment of BCC, SCC and IEC.

  • the sap from euphorbia peplus is effective against human nonmelanoma skin cancers
    British Journal of Dermatology, 2011
    Co-Authors: Jonathan Ramsay, Andreas Suhrbier, James Harrison Aylward, Steven M Ogbourne, Sarahjane Cozzi, Michael Poulsen, Kathryn C Baumann, P Welburn, G L Redlich
    Abstract:

    Summary Background  The sap from Euphorbia peplus, commonly known as petty spurge in the U.K. or radium weed in Australia, has been used as a traditional treatment for a number of cancers. Objective  To determine the effectiveness of E. peplus sap in a phase I/II clinical study for the topical treatment of basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and intraepidermal carcinomas (IEC). Methods  Thirty-six patients, who had refused, failed or were unsuitable for conventional treatment, were enrolled in a phase I/II clinical study. A total of 48 skin cancer lesions were treated topically with 100–300 μL of E. peplus sap once daily for 3 days. Results  The complete clinical response rates at 1 month were 82% (n = 28) for BCC, 94% (n = 16) for IEC and 75% (n = 4) for SCC. After a mean follow-up of 15 months these rates were 57%, 75% and 50%, respectively. For superficial lesions < 16 mm, the response rates after follow-up were 100% for IEC (n = 10) and 78% for BCC (n = 9). Conclusions  The clinical responses for these relatively unfavourable lesions (43% had failed previous treatments, 35% were situated in the head and neck region and 30% were > 2 cm in diameter), are comparable with existing nonsurgical treatments. An active ingredient of E. peplus sap has been identified as ingenol mebutate (PEP005). This clinical study affirms Community Experience with E. peplus sap, and supports further clinical development of PEP005 for the treatment of BCC, SCC and IEC.

Steven M Ogbourne - One of the best experts on this subject based on the ideXlab platform.

  • the sap from euphorbia peplus is effective against human nonmelanoma skin cancers
    British Journal of Dermatology, 2011
    Co-Authors: Jonathan Ramsay, Andreas Suhrbier, James Harrison Aylward, Steven M Ogbourne, Sarahjane Cozzi, Michael Poulsen, Kathryn C Baumann, P Welburn, G L Redlich
    Abstract:

    BACKGROUND: The sap from Euphorbia peplus, commonly known as petty spurge in the U.K. or radium weed in Australia, has been used as a traditional treatment for a number of cancers. OBJECTIVE: To determine the effectiveness of E. peplus sap in a phase I/II clinical study for the topical treatment of basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and intraepidermal carcinomas (IEC). METHODS: Thirty-six patients, who had refused, failed or were unsuitable for conventional treatment, were enrolled in a phase I/II clinical study. A total of 48 skin cancer lesions were treated topically with 100-300 μL of E. peplus sap once daily for 3 days. RESULTS: The complete clinical response rates at 1 month were 82% (n = 28) for BCC, 94% (n = 16) for IEC and 75% (n = 4) for SCC. After a mean follow-up of 15 months these rates were 57%, 75% and 50%, respectively. For superficial lesions 2 cm in diameter), are comparable with existing nonsurgical treatments. An active ingredient of E. peplus sap has been identified as ingenol mebutate (PEP005). This clinical study affirms Community Experience with E. peplus sap, and supports further clinical development of PEP005 for the treatment of BCC, SCC and IEC.

  • the sap from euphorbia peplus is effective against human nonmelanoma skin cancers
    British Journal of Dermatology, 2011
    Co-Authors: Jonathan Ramsay, Andreas Suhrbier, James Harrison Aylward, Steven M Ogbourne, Sarahjane Cozzi, Michael Poulsen, Kathryn C Baumann, P Welburn, G L Redlich
    Abstract:

    Summary Background  The sap from Euphorbia peplus, commonly known as petty spurge in the U.K. or radium weed in Australia, has been used as a traditional treatment for a number of cancers. Objective  To determine the effectiveness of E. peplus sap in a phase I/II clinical study for the topical treatment of basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and intraepidermal carcinomas (IEC). Methods  Thirty-six patients, who had refused, failed or were unsuitable for conventional treatment, were enrolled in a phase I/II clinical study. A total of 48 skin cancer lesions were treated topically with 100–300 μL of E. peplus sap once daily for 3 days. Results  The complete clinical response rates at 1 month were 82% (n = 28) for BCC, 94% (n = 16) for IEC and 75% (n = 4) for SCC. After a mean follow-up of 15 months these rates were 57%, 75% and 50%, respectively. For superficial lesions < 16 mm, the response rates after follow-up were 100% for IEC (n = 10) and 78% for BCC (n = 9). Conclusions  The clinical responses for these relatively unfavourable lesions (43% had failed previous treatments, 35% were situated in the head and neck region and 30% were > 2 cm in diameter), are comparable with existing nonsurgical treatments. An active ingredient of E. peplus sap has been identified as ingenol mebutate (PEP005). This clinical study affirms Community Experience with E. peplus sap, and supports further clinical development of PEP005 for the treatment of BCC, SCC and IEC.