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Timothy A Linksvayer - One of the best experts on this subject based on the ideXlab platform.

  • Comparative Genomics identifies putative signatures of sociality in spiders
    Genome Biology and Evolution, 2020
    Co-Authors: Chao Tong, Gabriella M Najm, Noa Pinterwollman, Jonathan N Pruitt, Timothy A Linksvayer
    Abstract:

    Comparative Genomics has begun to elucidate the genomic basis of social life in insects, but insight into the genomic basis of spider sociality has lagged behind. To begin, to characterize genomic signatures associated with the evolution of social life in spiders, we performed one of the first spider Comparative Genomics studies including five solitary species and two social species, representing two independent origins of sociality in the genus Stegodyphus. We found that the two social spider species had a large expansion of gene families associated with transport and metabolic processes and an elevated genome-wide rate of molecular evolution compared with the five solitary spider species. Genes that were rapidly evolving in the two social species relative to the five solitary species were enriched for transport, behavior, and immune functions, whereas genes that were rapidly evolving in the solitary species were enriched for energy metabolism processes. Most rapidly evolving genes in the social species Stegodyphus dumicola were broadly expressed across four tissues and enriched for transport functions, but 12 rapidly evolving genes showed brain-specific expression and were enriched for social behavioral processes. Altogether, our study identifies putative genomic signatures and potential candidate genes associated with spider sociality. These results indicate that future spider Comparative genomic studies, including broader sampling and additional independent origins of sociality, can further clarify the genomic causes and consequences of social life.

  • Comparative Genomics identifies putative signatures of sociality in spiders
    bioRxiv, 2019
    Co-Authors: Chao Tong, Gabriella M Najm, Noa Pinterwollman, Jonathan N Pruitt, Timothy A Linksvayer
    Abstract:

    Comparative Genomics has begun to elucidate the genomic basis of social life in insects but insight into the genomic basis of spider sociality has lagged behind. To begin to characterize genomic signatures associated with the evolution of social life in spiders, we performed one of the first spider Comparative Genomics studies including five solitary species and two social species, representing two independent origins of sociality in the genus Stegodyphus. We found that the two social spider species had a large expansion of gene families associated with transport and metabolic processes and an elevated genome-wide rate of molecular evolution compared with the five solitary spider species. Genes that were rapidly evolving in the two social species relative to the five solitary species were enriched for transport, behavior, and immune functions, while genes that were rapidly evolving in the solitary species were enriched for energy metabolism processes. Most rapidly evolving genes in the social species S. dumicola were broadly expressed across four tissues and enriched for transport functions, but 12 rapidly evolving genes showed brain-specific expression and were enriched for social behavioral processes. Altogether, our study identifies putative genomic signatures and potential candidate genes associated with spider sociality. These results indicate that future spider Comparative genomic studies, including broader sampling and additional independent origins of sociality, can further clarify the genomic causes and consequences of social life.

Avril Coghlan - One of the best experts on this subject based on the ideXlab platform.

  • Comparative Genomics of the major parasitic worms
    Nature Genetics, 2019
    Co-Authors: Avril Coghlan, Rahul Tyagi, James A. Cotton, Nancy Holroyd, Bruce A. Rosa, Isheng Jason Tsai, Dominik R. Laetsch, Robin N. Beech, Tim A. Day, Kymberlie Hallsworth-pepin
    Abstract:

    Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad Comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This Comparative Genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms.

  • Comparative Genomics of the major parasitic worms
    Nature Genetics, 2019
    Co-Authors: Avril Coghlan, Rahul Tyagi, Nancy Holroyd, Bruce A. Rosa, Isheng Jason Tsai, Dominik R. Laetsch, Robin N. Beech, Tim A. Day, James Cotton, Kymberlie Hallsworthpepin
    Abstract:

    Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report the broadest Comparative study to date of the genomes of parasitic and non-parasitic worms, involving 81. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritised new potential drug targets and compounds for testing. This Comparative Genomics resource provides a much needed boost for the research community to understand and combat parasitic worms.

Kymberlie Hallsworthpepin - One of the best experts on this subject based on the ideXlab platform.

  • Comparative Genomics of the major parasitic worms
    Nature Genetics, 2019
    Co-Authors: Avril Coghlan, Rahul Tyagi, Nancy Holroyd, Bruce A. Rosa, Isheng Jason Tsai, Dominik R. Laetsch, Robin N. Beech, Tim A. Day, James Cotton, Kymberlie Hallsworthpepin
    Abstract:

    Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report the broadest Comparative study to date of the genomes of parasitic and non-parasitic worms, involving 81. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritised new potential drug targets and compounds for testing. This Comparative Genomics resource provides a much needed boost for the research community to understand and combat parasitic worms.

Kymberlie Hallsworth-pepin - One of the best experts on this subject based on the ideXlab platform.

  • Comparative Genomics of the major parasitic worms
    Nature Genetics, 2019
    Co-Authors: Avril Coghlan, Rahul Tyagi, James A. Cotton, Nancy Holroyd, Bruce A. Rosa, Isheng Jason Tsai, Dominik R. Laetsch, Robin N. Beech, Tim A. Day, Kymberlie Hallsworth-pepin
    Abstract:

    Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad Comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This Comparative Genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms.

Dominik R. Laetsch - One of the best experts on this subject based on the ideXlab platform.

  • Comparative Genomics of the major parasitic worms
    Nature Genetics, 2019
    Co-Authors: Avril Coghlan, Rahul Tyagi, James A. Cotton, Nancy Holroyd, Bruce A. Rosa, Isheng Jason Tsai, Dominik R. Laetsch, Robin N. Beech, Tim A. Day, Kymberlie Hallsworth-pepin
    Abstract:

    Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad Comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This Comparative Genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms.

  • Comparative Genomics of the major parasitic worms
    Nature Genetics, 2019
    Co-Authors: Avril Coghlan, Rahul Tyagi, Nancy Holroyd, Bruce A. Rosa, Isheng Jason Tsai, Dominik R. Laetsch, Robin N. Beech, Tim A. Day, James Cotton, Kymberlie Hallsworthpepin
    Abstract:

    Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report the broadest Comparative study to date of the genomes of parasitic and non-parasitic worms, involving 81. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritised new potential drug targets and compounds for testing. This Comparative Genomics resource provides a much needed boost for the research community to understand and combat parasitic worms.