The Experts below are selected from a list of 2802 Experts worldwide ranked by ideXlab platform
Eleanor M. Riley - One of the best experts on this subject based on the ideXlab platform.
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The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:The laboratory mouse is the workhorse of Immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, Comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system. Laboratory mice are the cornerstone of Immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.
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the Comparative Immunology of wild and laboratory mice mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Elizabeth King, Eleanor M. RileyAbstract:Laboratory mice are the cornerstone of Immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.
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The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:The laboratory mouse is the workhorse of Immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, Comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system.
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Supplementary Data for: "The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus"
2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:A complete immunological data set of 460 wild mice that was produced as part of a study to comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice.
Stephen Abolins - One of the best experts on this subject based on the ideXlab platform.
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The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:The laboratory mouse is the workhorse of Immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, Comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system. Laboratory mice are the cornerstone of Immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.
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the Comparative Immunology of wild and laboratory mice mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Elizabeth King, Eleanor M. RileyAbstract:Laboratory mice are the cornerstone of Immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.
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The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:The laboratory mouse is the workhorse of Immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, Comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system.
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Supplementary Data for: "The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus"
2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:A complete immunological data set of 460 wild mice that was produced as part of a study to comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice.
John G. Raynes - One of the best experts on this subject based on the ideXlab platform.
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The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:The laboratory mouse is the workhorse of Immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, Comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system. Laboratory mice are the cornerstone of Immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.
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the Comparative Immunology of wild and laboratory mice mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Elizabeth King, Eleanor M. RileyAbstract:Laboratory mice are the cornerstone of Immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.
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The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:The laboratory mouse is the workhorse of Immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, Comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system.
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Supplementary Data for: "The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus"
2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:A complete immunological data set of 460 wild mice that was produced as part of a study to comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice.
Julius C. R. Hafalla - One of the best experts on this subject based on the ideXlab platform.
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The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:The laboratory mouse is the workhorse of Immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, Comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system. Laboratory mice are the cornerstone of Immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.
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the Comparative Immunology of wild and laboratory mice mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Elizabeth King, Eleanor M. RileyAbstract:Laboratory mice are the cornerstone of Immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.
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The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:The laboratory mouse is the workhorse of Immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, Comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system.
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Supplementary Data for: "The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus"
2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:A complete immunological data set of 460 wild mice that was produced as part of a study to comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice.
Luke Lazarou - One of the best experts on this subject based on the ideXlab platform.
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The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:The laboratory mouse is the workhorse of Immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, Comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system. Laboratory mice are the cornerstone of Immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.
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the Comparative Immunology of wild and laboratory mice mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Elizabeth King, Eleanor M. RileyAbstract:Laboratory mice are the cornerstone of Immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.
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The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus
Nature Communications, 2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:The laboratory mouse is the workhorse of Immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, Comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system.
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Supplementary Data for: "The Comparative Immunology of wild and laboratory mice, Mus musculus domesticus"
2017Co-Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. RileyAbstract:A complete immunological data set of 460 wild mice that was produced as part of a study to comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice.