The Experts below are selected from a list of 56223 Experts worldwide ranked by ideXlab platform
Neha Shah - One of the best experts on this subject based on the ideXlab platform.
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Completion Rate and side effect profile of three month isoniazid and rifapentine treatment for latent tuberculosis infection in an urban county jail
Open Forum Infectious Diseases, 2016Co-Authors: Maria Juarezreyes, Mark Gallivan, Alexander Chyorny, Linda Okeeffe, Neha ShahAbstract:In an urban jail population, 3 months of isoniazid and rifapentine (3HP) was associated with an 85% latent tuberculosis infection treatment Completion Rate compared with 18% in a standard 9-month isoniazid treatment group. Among the 91 patients who started 3HP therapy, there were 2 treatment discontinuations from adverse drug reactions.
Zhuan Liao - One of the best experts on this subject based on the ideXlab platform.
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magnetic steering of capsule endoscopy improves small bowel capsule endoscopy Completion Rate
Digestive Diseases and Sciences, 2019Co-Authors: Yuanyuan Luo, Jun Pan, Yizhi Chen, Xi Jiang, Wenbin Zou, Yangyang Qian, Wei Zhou, Xiao Liu, Zhuan LiaoAbstract:Capsule endoscopy is currently available as a noninvasive and effective diagnostic modality to identify small bowel abnormalities, with a Completion Rate to the cecum between 75.1 and 95.6%. A novel magnetically controlled capsule endoscopy (MCE) system could facilitate passage of the capsule through the pylorus, thereby reducing the gastric transit time (GTT). We performed this study to determine whether magnetic steering could improve the capsule endoscopy Completion Rate (CECR) compared to standard protocol. Patients referred for MCE in our center from June 2017 to November 2017 were prospectively enrolled. Magnetic steering of the capsule through the pylorus was performed after standard gastric examination. CECR, GTT, pyloric transit time (PTT), and rapid gastric transit (GTT ≤ 30 min) Rate were compared with a historical control group enrolled from January 2017 to May 2017. CECR was significantly higher in the intervention group (n = 107) than control group (n = 120) (100% vs. 94.2%, P = 0.02), with a significantly shorter GTT (22.2 vs. 84.5 min, P < 0.001) and PTT (4.4 vs. 56.7 min, P < 0.001). Rapid gastric transit Rate in the intervention group was significantly higher than the control group (58.9% vs. 15.0%, P < 0.001). There were no statistical differences in the diagnostic yields between the two groups. Magnetic steering of capsule endoscopy improves small bowel CECR by reducing GTT, adding further support to MCE as a practical tool for noninvasive examination of both the stomach and small bowel. Trial registration ClinicalTrials.gov, ID: NCT03482661.
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Completion Rate and diagnostic yield of small bowel capsule endoscopy 1 vs 2 frames per second
Endoscopy, 2010Co-Authors: Zhuan LiaoAbstract:BACKGROUND AND STUDY AIMS Currently, the default frame Rate for capsule endoscopy is usually set at 2 frames per second (fps). We postulated that setting the frame Rate at 1 fps for the whole procedure would save battery life and increase the Completion Rate without compromising the diagnostic yield. The aim of this study was to compare the Completion Rates and diagnostic yield of capsule endoscopy performed with frame Rates of 1 fps and 2 fps. PATIENTS AND METHODS The OMOM capsule endoscopy system was used. The procedure was performed according to the manufacturer's instructions, and the frame Rate was set at 1 fps in one group and at 2 fps in the other group for the whole procedure. The Completion Rate, total operating time, and diagnostic yield in the two groups were measured and compared. RESULTS A total of 107 patients were randomized to either the 1 fps group (n = 54) or the 2 fps group (control, n = 53). There was no significant difference in sex, age, indications, and gastric transit time between the two groups. The mean total operating time was significantly longer in the 1 fps group than in the 2 fps group (758 +/- 79 minutes vs. 456 +/- 67 minutes, P < 0.001). The Completion Rate and diagnostic yield were significantly higher in the 1 fps group than in the 2 fps group (96.2 % vs. 70.6 %, P < 0.001; 40.7 % vs. 18.9 %, P = 0.013, respectively). CONCLUSIONS Setting the frame Rate of the capsule endoscope at 1 fps for the whole procedure increases the Completion Rate by prolonging the capsule's total operating time; the diagnostic yield does seem to be at least as high as with 2 fps.
Jan J Koornstra - One of the best experts on this subject based on the ideXlab platform.
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Completion Rate of small bowel capsule endoscopy is higher after erythromycin compared to domperidone
BMC Gastroenterology, 2014Co-Authors: Jessie Westerhof, Rinse K Weersma, Reinier A Hoedemaker, Jan J KoornstraAbstract:Background In up to 30 percent of small bowel capsule endoscopy procedures, the capsule does not reach the cecum within recording time. A prolonged gastric transit time has been recognized as a risk factor for incomplete capsule endoscopy. The aim of this study was to analyze if a single dose of orally administered erythromycin prior to capsule endoscopy results in a higher Completion Rate compared to orally administered domperidone.
John N Plevris - One of the best experts on this subject based on the ideXlab platform.
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the use of domperidone increases the Completion Rate of small bowel capsule endoscopy does this come at the expense of diagnostic yield
Journal of Clinical Gastroenterology, 2015Co-Authors: Anastasios Koulaouzidis, Stavros Dimitriadis, Sarah Douglas, John N PlevrisAbstract:Background The Completion Rate (CR) of small bowel capsule endoscopy (SBCE) has been reported at 81.3% to 84.8%. Prokinetic agents are used to increase CR and (theoretically) diagnostic yield (DY). Domperidone has not been widely used in SBCE; unlike metoclopramide, it lacks extrapyramidal adverse effects. Objectives This was a retrospective study. This study aimed to assess gastric transit time (GTT), small bowel transit time (SBTT), and the CR of SBCE when using domperidone. Furthermore, we aimed to compare the CR of 2 different SBCE systems (MiroCam, PillCam). Consecutive SBCE examinations (January 2008 to October 2012) from a tertiary referral center were analyzed. Results In the aforementioned period, a total of 635 SBCE examinations were performed: 379/635 (59.7%) with PillCamSB and 256 (40.3%) with MiroCam. In 437/635 (68.8%) examinations, liquid domperidone (5 mg) was administered for capsule ingestion, whereas 198 (31.2%) ingested the capsule without any domperidone. Although the 2 groups were comparable, the median age of patients who received domperidone was higher compared with patients who did not receive (58 vs. 48 y, P=0.027). In our cohort, the overall CR of SBCE was 88.9%. The 2 SBCE systems showed equivalent CR (PillCamSB 88.9%, MiroCam 89.1%; P =0.96). The use of liquid domperidone increased CR (91.1% vs. 84.3%; P =0.042). Interestingly, the use of domperidone with PillCamSB was associated with reduced DY for vascular, inflammatory, and polyps/mass-type lesions. This effect was not seen in the MiroCam group. Furthermore, the median GTT and the median SBTT did not differ between the 2 groups (GTT/SBTT with domperidone 26.0'/221.0' and without 29.0'/228.0', respectively; P=0.461/P=0.477). A higher CR was noted when domperidone was used with PillCamSB (93.0% vs. 89.5%, P=0.012) than with MiroCam (84.4% vs. 83.3%, P=0.08). Limitations The major limitations of this study were the retrospective design of the study and limited numbers on MiroCam with no domperidone. Conclusions In conclusion, the use of domperidone increases the CR of SBCE with PillCamSB. However, this increase does not translate into higher DY. A smart, tailored approach, which may include domperidone, purgatives, and real-time viewers, may be used in the clinical practice to improve DY until technology delivering capsules with much longer battery time becomes available.
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do prokinetics influence the Completion Rate in small bowel capsule endoscopy a systematic review and meta analysis
Current Medical Research and Opinion, 2013Co-Authors: Anastasios Koulaouzidis, Andry Giannakou, Diana E Yung, Konstantinos J Dabos, John N PlevrisAbstract:AbstractBackground:The use of purging for bowel cleansing prior to small-bowel capsule endoscopy (SBCE) has now been established in clinical practice. Despite that, the number of incomplete SBCEs is still around 15–20%. To date, the use of prokinetics in SBCE – aiming to improve Completion Rate (CR) – remains a contentious issue resulting in lack of consensus among capsule experts.Methods:Extensive medical literature searches were conducted (to November 2012), using suitable MeSH terms and keywords, in search of studies that compared capsule ingestion with prokinetic agents vs. controls or placebo. We examined the effects of prokinetic administration on SBCE CR (primary end point), as well as on the following secondary end points: diagnostic yield (DY), gastric transit time (GTT) and small-bowel transit time (SBTT) by meta-analysis of all relevant studies.Results:A total of 17 eligible studies (14 prospective, 3 retrospective) were identified, including 1028 individuals who ingested the capsule with no pr...
Jeffrey R Starke - One of the best experts on this subject based on the ideXlab platform.
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Completion Rate and safety of tuberculosis infection treatment with shorter regimens
Pediatrics, 2018Co-Authors: Andrea T Cruz, Jeffrey R StarkeAbstract:BACKGROUND: The traditional treatment of tuberculosis (TB) infection (9 months of daily isoniazid [9H]) is safe but Completion Rates of METHODS: This was a retrospective cohort study (2014–2017) of children (0–18 years old) seen at a children’s TB clinic in a low-incidence nation. We compared the frequency of Completion and adverse events (AEs) in children receiving 3HP, 4R, and 9H; the latter 2 regimens could be administered by families (termed self-administered therapy [SAT]) or as directly observed preventive therapy (DOPT); 3HP was always administered under DOPT. RESULTS: TB infection treatment was started in 667 children: 283 (42.4%) 3HP, 252 (37.8%) 9H, and 132 (19.8%) 4R. Only 52% of children receiving 9H via SAT completed therapy. Children receiving 3HP were more likely to complete therapy than the 9H (SAT) group (odds ratio [OR] 27.4, 95% confidence interval [CI]: 11.8–63.7). Multivariate analyses found receipt of medication under DOPT (OR: 5.72, 95% CI: 3.47–9.43), increasing age (OR: 1.09, 95% CI: 1.02–1.17), and the absence of any AE (OR: 1.70, 95% CI: 0.26–0.60) to be associated with completing therapy. AEs were more common in the 9H group (OR: 2.51, 95% CI: 1.48–4.32). Two (0.9%) children receiving 9H developed hepatotoxicity; no child receiving 3HP or 4R developed hepatotoxicity. CONCLUSIONS: Shorter regimens are associated with increased Completion Rates and fewer AEs than 9H.