The Experts below are selected from a list of 104598 Experts worldwide ranked by ideXlab platform
David H. Ingbar - One of the best experts on this subject based on the ideXlab platform.
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Cell-specific signal transduction pathways regulating Na+-K+-ATPase. Focus on “Short-term effects of thyroid hormones on the Na+-K+-ATPase activity of chick embryo hepatocytes during development: focus on signal transduction”
American journal of physiology. Cell physiology, 2008Co-Authors: Jianxun Lei, Maneesh Bhargava, David H. IngbarAbstract:the na+-k+-atpase is a Complex Integral membrane protein that carries out active transport of sodium and potassium across the cell plasma membrane, maintaining the ionic gradients. Each subunit has multiple isozymes that are expressed in tissue and developmental specific fashion. In addition to
Pubudu P Handakumbura - One of the best experts on this subject based on the ideXlab platform.
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an arabidopsis gene regulatory network for secondary cell wall synthesis
Nature, 2015Co-Authors: Mallorie Taylorteeples, M De Lucas, Gina M Turco, Ted Toal, Allison Gaudinier, N F Young, Gina M Trabucco, Mike T Veling, R Lamothe, Pubudu P HandakumburaAbstract:The plant cell wall is an important factor for determining cell shape, function and response to the environment. Secondary cell walls, such as those found in xylem, are composed of cellulose, hemicelluloses and lignin and account for the bulk of plant biomass. The coordination between transcriptional regulation of synthesis for each polymer is Complex and vital to cell function. A regulatory hierarchy of developmental switches has been proposed, although the full complement of regulators remains unknown. Here we present a protein-DNA network between Arabidopsis thaliana transcription factors and secondary cell wall metabolic genes with gene expression regulated by a series of feed-forward loops. This model allowed us to develop and validate new hypotheses about secondary wall gene regulation under abiotic stress. Distinct stresses are able to perturb targeted genes to potentially promote functional adaptation. These interactions will serve as a foundation for understanding the regulation of a Complex, Integral plant component.
Semyon Alesker - One of the best experts on this subject based on the ideXlab platform.
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Hard Lefschetz Theorem for Valuations, Complex Integral Geometry, and Unitarily Invariant Valuations
Journal of Differential Geometry, 2003Co-Authors: Semyon AleskerAbstract:We obtain new general results on the structure of the space of translation invariant continuous valuations on convex sets (a version of the hard Lefschetz theorem). Using these and our previous results we obtain explicit characterization of unitarily invariant translation invariant continuous valuations. It implies new Integral geometric formulas for real submanifolds in Hermitian spaces generalizing the classical kinematic formulas in Euclidean
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Hard Lefschetz theorem for valuations, Complex Integral geometry, and unitarily invariant valuations
arXiv: Metric Geometry, 2002Co-Authors: Semyon AleskerAbstract:We obtain new general results on the structure of the space of translation invariant continuous valuations on convex sets (a version of the hard Lefschetz theorem). Using these and our previous results we obtain explicit characterization of unitarily invariant translation invariant continuous valuations. It implies new Integral geometric formulas for real submanifolds in Hermitian spaces generalizing the classical kinematic formulas in Euclidean spaces due to Poincar\'e, Chern, Santal\'o, and others.
Shikha Nangia - One of the best experts on this subject based on the ideXlab platform.
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the ghrelin o acyltransferase structure reveals a catalytic channel for transmembrane hormone acylation
Journal of Biological Chemistry, 2019Co-Authors: Maria B Campana, Flaviyan Jerome Irudayanathan, Tasha R Davis, Kayleigh R Mcgoverngooch, Rosemary Loftus, Mohammad Ashkar, Najae Escoffery, Melissa Navarro, Michelle A Sieburg, Shikha NangiaAbstract:Integral membrane proteins represent a large and diverse portion of the proteome and are often recalcitrant to purification, impeding studies essential for understanding protein structure and function. By combining co-evolutionary constraints and computational modeling with biochemical validation through site-directed mutagenesis and enzyme activity assays, we demonstrate here a synergistic approach to structurally model purification-resistant topologically Complex Integral membrane proteins. We report the first structural model of a eukaryotic membrane-bound O-acyltransferase (MBOAT), ghrelin O-acyltransferase (GOAT), which modifies the metabolism-regulating hormone ghrelin. Our structure, generated in the absence of any experimental structural data, revealed an unanticipated strategy for transmembrane protein acylation with catalysis occurring in an internal channel connecting the endoplasmic reticulum lumen and cytoplasm. This finding validated the power of our approach to generate predictive structural models for other experimentally challenging Integral membrane proteins. Our results illuminate novel aspects of membrane protein function and represent key steps for advancing structure-guided inhibitor design to target therapeutically important but experimentally intractable membrane proteins.
Jianxun Lei - One of the best experts on this subject based on the ideXlab platform.
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Cell-specific signal transduction pathways regulating Na+-K+-ATPase. Focus on “Short-term effects of thyroid hormones on the Na+-K+-ATPase activity of chick embryo hepatocytes during development: focus on signal transduction”
American journal of physiology. Cell physiology, 2008Co-Authors: Jianxun Lei, Maneesh Bhargava, David H. IngbarAbstract:the na+-k+-atpase is a Complex Integral membrane protein that carries out active transport of sodium and potassium across the cell plasma membrane, maintaining the ionic gradients. Each subunit has multiple isozymes that are expressed in tissue and developmental specific fashion. In addition to