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Dean C. Carlow - One of the best experts on this subject based on the ideXlab platform.

  • Data from the analytical performance of the Abaxis Piccolo Xpress point of care analyzer in whole blood, serum, and plasma
    Elsevier, 2018
    Co-Authors: Kazunori Murata, Laurel Glaser, Mary Nardiello, Lakshmi V. Ramanathan, Dean C. Carlow
    Abstract:

    The objective of this study was to examine the analytical performance of 14 Comprehensive Metabolic Panel analytes on the Abaxis Piccolo Xpress® Point of Care analyzer in serum, plasma, and whole blood. A method comparison was performed on all three specimen types intended for use on the Piccolo Xpress®: serum, heparinized plasma, and whole blood. This data is also presented in Murata et al. (2015) [1]. This article includes the actual Bland-Altman bias plots of the difference in results obtained for analytes in the Comprehensive Metabolic Panel from the Abaxis Piccolo Xpress and the comparison instrument, the Ortho Vitros. Keywords: Clinical chemistry, Point-of care testin

  • Data from the analytical performance of the Abaxis Piccolo Xpress point of care analyzer in whole blood, serum, and plasma.
    Data in brief, 2017
    Co-Authors: Kazunori Murata, Laurel Glaser, Mary Nardiello, Lakshmi V. Ramanathan, Dean C. Carlow
    Abstract:

    The objective of this study was to examine the analytical performance of 14 Comprehensive Metabolic Panel analytes on the Abaxis Piccolo Xpress® Point of Care analyzer in serum, plasma, and whole blood. A method comparison was performed on all three specimen types intended for use on the Piccolo Xpress®: serum, heparinized plasma, and whole blood. This data is also presented in Murata et al. (2015) [1]. This article includes the actual Bland-Altman bias plots of the difference in results obtained for analytes in the Comprehensive Metabolic Panel from the Abaxis Piccolo Xpress and the comparison instrument, the Ortho Vitros.

  • Analytical performance of the Abaxis Piccolo Xpress® point of care analyzer in whole blood, serum, and plasma.
    Clinical biochemistry, 2015
    Co-Authors: Kazunori Murata, Laurel Glaser, Mary Nardiello, Lakshmi V. Ramanathan, Shaun Richardson, Dean C. Carlow
    Abstract:

    Abstract Objectives To examine the analytical performance of 14 Comprehensive Metabolic Panel analytes on the Abaxis Piccolo Xpress® Point of Care analyzer in serum, plasma, and whole blood. Design and methods Precision was evaluated by running two levels of control material over multiple days. Linearity was evaluated using material provided by the manufacturer and the College of American Pathologists (CAP) linearity surveys. Accuracy was evaluated by comparing the results from 60 patient specimens on the Piccolo Xpress® with the Ortho Vitros® 5600 analyzer. The method comparison was performed on all three specimen types intended for use on the Piccolo Xpress®: serum, heparinized plasma, and whole blood. Manufacturer suggested reference ranges for all 14 analytes were tested in serum and plasma specimens from 23 healthy volunteers. Results High precision (CV ≤ 10%) was noted for all the analytes. Linearity was found to span the clinically useful range for all analytes. The method comparison demonstrated minimal proportional bias and good correlation for most of the analytes in all three matrices tested. The only exceptions were for sodium and total CO 2 , for which either significant proportional bias and/or poor correlation was noted in all three matrices. Significant bias was noted for AST in serum as well as for total bilirubin in plasma and whole blood. Conclusion The Piccolo Xpress® allows for the delivery of CMP results in a footprint small enough to be stored in a biological safety cabinet, while providing satisfactory performance for the majority of analytes.

Adam J. Singer - One of the best experts on this subject based on the ideXlab platform.

  • Use of a Comprehensive Metabolic Panel Point-of-Care Test to Reduce Length of Stay in the Emergency Department: A Randomized Controlled Trial
    Annals of emergency medicine, 2012
    Co-Authors: Ji Yeon Jang, Sang Do Shin, Eui Jung Lee, Chang Bae Park, Kyoung Jun Song, Adam J. Singer
    Abstract:

    Study objective Awaiting results from laboratory testing may sometimes be a rate-limiting step in emergency department (ED) throughput prolonging length of stay and contributing to crowding. We determine whether introduction of a Comprehensive Metabolic Panel point-of-care test can reduce ED length of stay compared with traditional central laboratory testing. Methods We performed a randomized, controlled trial among 10,244 noncritically ill ED patients aged 15 years and older whose physicians ordered a Comprehensive Metabolic Panel at a single, large, academic, urban medical center. Participants were randomly assigned to performance of a Comprehensive Metabolic Panel by a point-of-care test (n=5,154) or central laboratory testing (n=5,090). The primary outcome was length of stay in the ED. Results A point-of-care test reduced median ED length of stay among all study patients by 22 minutes (median 350 minutes [interquartile range 206 to 1,002 minutes] with point-of-care test versus median 372 minutes [interquartile range 217 to 1,150 minutes] with central laboratory testing; median difference 22 minutes; 95% confidence interval [CI] 4 to 40 minutes). A point-of-care test also reduced ED length of stay in patients discharged to home (256 versus 268 minutes; median difference 12 minutes; 95% CI 2 to 22 minutes) and with an Emergency Severity Index triage level of 3 (333 versus 355 minutes; median difference 22 minutes; 95% CI 4 to 40 minutes). Conclusion Use of a point-of-care test for a Comprehensive Metabolic Panel reduced ED length of stay compared with central laboratory testing in the adult ED of a single academic center.

Kazunori Murata - One of the best experts on this subject based on the ideXlab platform.

  • Data from the analytical performance of the Abaxis Piccolo Xpress point of care analyzer in whole blood, serum, and plasma
    Elsevier, 2018
    Co-Authors: Kazunori Murata, Laurel Glaser, Mary Nardiello, Lakshmi V. Ramanathan, Dean C. Carlow
    Abstract:

    The objective of this study was to examine the analytical performance of 14 Comprehensive Metabolic Panel analytes on the Abaxis Piccolo Xpress® Point of Care analyzer in serum, plasma, and whole blood. A method comparison was performed on all three specimen types intended for use on the Piccolo Xpress®: serum, heparinized plasma, and whole blood. This data is also presented in Murata et al. (2015) [1]. This article includes the actual Bland-Altman bias plots of the difference in results obtained for analytes in the Comprehensive Metabolic Panel from the Abaxis Piccolo Xpress and the comparison instrument, the Ortho Vitros. Keywords: Clinical chemistry, Point-of care testin

  • Data from the analytical performance of the Abaxis Piccolo Xpress point of care analyzer in whole blood, serum, and plasma.
    Data in brief, 2017
    Co-Authors: Kazunori Murata, Laurel Glaser, Mary Nardiello, Lakshmi V. Ramanathan, Dean C. Carlow
    Abstract:

    The objective of this study was to examine the analytical performance of 14 Comprehensive Metabolic Panel analytes on the Abaxis Piccolo Xpress® Point of Care analyzer in serum, plasma, and whole blood. A method comparison was performed on all three specimen types intended for use on the Piccolo Xpress®: serum, heparinized plasma, and whole blood. This data is also presented in Murata et al. (2015) [1]. This article includes the actual Bland-Altman bias plots of the difference in results obtained for analytes in the Comprehensive Metabolic Panel from the Abaxis Piccolo Xpress and the comparison instrument, the Ortho Vitros.

  • Analytical performance of the Abaxis Piccolo Xpress® point of care analyzer in whole blood, serum, and plasma.
    Clinical biochemistry, 2015
    Co-Authors: Kazunori Murata, Laurel Glaser, Mary Nardiello, Lakshmi V. Ramanathan, Shaun Richardson, Dean C. Carlow
    Abstract:

    Abstract Objectives To examine the analytical performance of 14 Comprehensive Metabolic Panel analytes on the Abaxis Piccolo Xpress® Point of Care analyzer in serum, plasma, and whole blood. Design and methods Precision was evaluated by running two levels of control material over multiple days. Linearity was evaluated using material provided by the manufacturer and the College of American Pathologists (CAP) linearity surveys. Accuracy was evaluated by comparing the results from 60 patient specimens on the Piccolo Xpress® with the Ortho Vitros® 5600 analyzer. The method comparison was performed on all three specimen types intended for use on the Piccolo Xpress®: serum, heparinized plasma, and whole blood. Manufacturer suggested reference ranges for all 14 analytes were tested in serum and plasma specimens from 23 healthy volunteers. Results High precision (CV ≤ 10%) was noted for all the analytes. Linearity was found to span the clinically useful range for all analytes. The method comparison demonstrated minimal proportional bias and good correlation for most of the analytes in all three matrices tested. The only exceptions were for sodium and total CO 2 , for which either significant proportional bias and/or poor correlation was noted in all three matrices. Significant bias was noted for AST in serum as well as for total bilirubin in plasma and whole blood. Conclusion The Piccolo Xpress® allows for the delivery of CMP results in a footprint small enough to be stored in a biological safety cabinet, while providing satisfactory performance for the majority of analytes.

Brad S. Karon - One of the best experts on this subject based on the ideXlab platform.

  • Is It Time to Remove Total Calcium from the Basic and Comprehensive Metabolic Panels? Assessing the Effects of American Medical Association-Approved Chemical Test Panels on Laboratory Utilization
    Clinical chemistry, 2020
    Co-Authors: Brooke M. Katzman, Sandra C. Bryant, Brad S. Karon
    Abstract:

    Background The necessity of individual tests within the most commonly used disease-oriented test Panels has not been well established. We evaluated test-ordering practices for total calcium, both before and after implementation of American Medical Association (AMA)-approved Panels (basic Metabolic Panel [BMP] and Comprehensive Metabolic Panel [CMP]) in our electronic ordering system. Methods We performed a retrospective review of all total calcium orders placed during April and June 2018, before and after implementation of the Panels. Orders from inpatient, outpatient, and emergency department (ED) care units were totaled, and the percentage of abnormal test results was calculated. We then queried institutional databases to determine the number of unique patients with calcium-related diagnoses and compared the rates from a 5-month period both before and after implementation of the Panels. Results Total test volumes and tests per unique patient increased by more than 3-fold after implementation of calcium-containing AMA-approved Panels, with the majority of those orders coming from BMPs and CMPs. The rate of low calcium values increased because of the shift toward more inpatient testing; however, the percentage of abnormal results within each patient population (inpatient, outpatient, ED) decreased. The prevalence of hypo- and hypercalcemia-related diagnoses among patients in the 5 months after implementation did not change significantly (1.29% before implementation vs 1.27% after implementation). Conclusions Implementation of BMPs and CMPs dramatically increased total calcium testing volumes without changing the rate of calcium-related diagnoses. The results suggest that the increase in total calcium orders associated with Panel-based testing largely constitutes excess or unnecessary testing.

Eric T. Stoopler - One of the best experts on this subject based on the ideXlab platform.

  • Recurrent Oral Mucosal Ulcerations and Gingival Edema
    JAMA Dermatology, 2014
    Co-Authors: Faizan Alawi, Martin S. Greenberg, Eric T. Stoopler
    Abstract:

    Awhite woman in her 50s presented for evaluation of recurrent gingival ulcers of 8 years’ duration. She reported that at the time of initial onset, multiple painful ulcers had appeared on the anterior maxillary gingiva. She stated that the lesions had resolved spontaneously without treatment but recurred 8 years later as swelling and ulceration of themaxillary and mandibular gingiva. She denied involvement of cutaneous surfaces and reported a history of ligneous conjunctivitis since childhood (Figure, A). Her medical history was significant for hypothyroidism, seizures, and functional heart murmur. Medications included levothyroxine sodium, mometasone furoate, levocetirizine, and benzonatate. Review of systems was significant for easy bruising and prolonged bleeding. Intraoral examination revealed generalized mild edema with rolled margins of the maxillary and mandibular gingiva accompanied by nodular ulceration of the left maxillary gingiva (Figure, B). Biopsy specimens were obtained from the gingival ulcer (Figure, C and D) and buccal mucosa for routine histological and direct immunofluorescence analysis, respectively. Also obtained were a complete blood cell count with differential and Comprehensive Metabolic Panel; no abnormal findings were identified. A