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Gerald M Reaven - One of the best experts on this subject based on the ideXlab platform.
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can the plasma ConcentRation Ratio of triglyceride high density lipoprotein cholesterol identify individuals at high risk of cardiovascular disease during 40 year follow up
Metabolic Syndrome and Related Disorders, 2018Co-Authors: Lars Lind, Erik Ingelsson, Johan Arnlov, Johan Sundstrom, Bjorn Zethelius, Gerald M ReavenAbstract:Abstract Background: The plasma ConcentRation Ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) is a simple way to estimate insulin resistance. We aimed to evaluate the TG/HDL...
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can the plasma ConcentRation Ratio of triglyceride high density lipoprotein cholesterol identify individuals at high risk of cardiovascular disease during 40 year follow up
Metabolic Syndrome and Related Disorders, 2018Co-Authors: Lars Lind, Erik Ingelsson, Johan Arnlov, Johan Sundstrom, Bjorn Zethelius, Gerald M ReavenAbstract:Abstract Background: The plasma ConcentRation Ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) is a simple way to estimate insulin resistance. We aimed to evaluate the TG/HDL-C Ratio as a simple clinical way to identify apparently healthy individuals with insulin resistance and enhanced risk of future cardiovascular disease (CVD). Methods: One thousand seven hundred twenty men, aged 50 years, free from diabetes and CVD when evaluated at baseline in 1970–1974 were followed for 40 years regarding incident CVD (myocardial infarction and/or ischemic stroke, n = 576). Results: Participants with a high TG/HDL-C Ratio (highest quartile >1.8) at baseline were more insulin resistant, with a significantly more adverse cardiometabolic risk profile (P < 0.001) at baseline, compared with those with a lower Ratio. This group also showed an increased risk of CVD [hazard Ratio, HR 1.47 (95% confidence interval 1.26–1.93) P < 0.001]. Fourteen percent of subjects with metabolic syndrome, in whom insu...
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triglyceride high density lipoprotein cholesterol ConcentRation Ratio identifies accentuated cardio metabolic risk
Endocrine Practice, 2015Co-Authors: John Armato, Gerald M Reaven, Ronald RubyAbstract:Purpose: Plasma triglyceride/high-density lipoprotein cholesterol Ratios (TG/HDL-C) have been shown to identify apparently healthy individuals at increased cardio-metabolic risk. This study evaluates the utility of this approach in patients at risk of developing diabetes.Methods: Individuals (n=1010) in a private practice identified at increased risk of type 2 diabetes (T2DM) by American Association of Clinical Endocrinologist criteria, were evaluated. Subjects had measurements of body mass index (BMI), blood pressure (BP), lipid/lipoprotein ConcentRations, highly sensitive C-reactive protein (hs-CRP), and glucose, insulin and c-peptide ConcentRations during a 75gm, glucose challenge. The TG/HDL-C Ratio was used to stratify individuals into high (highest quartile) vs. low (lowest 3 quartiles) risk categories.Results: TG/HDL-C Ratios identifying the highest quartile differed in men (≥ 3.0) and women (≥ 2.0). Using these cut-points, the high risk group for men and women had significantly higher BP, a more a...
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ability of the plasma ConcentRation Ratio of triglyceride high density lipoprotein cholesterol to identify increased cardio metabolic risk in an east asian population
Diabetes Research and Clinical Practice, 2014Co-Authors: Ki Chul Sung, Gerald M Reaven, Sun H KimAbstract:Abstract Aim The plasma ConcentRation Ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) has identified increased cardio-metabolic risk and outcome in European populations. The goal of this study was to see if this Ratio would also have clinical utility in identifying cardio-metabolic risk in an East Asian population. Methods Measurements of various cardio-metabolic risk factors, including coronary calcium scores, were available on 12,166 apparently healthy Korean adults. Approximately 25% of men and women with the highest TG/HDL-C Ratios were classified as being at high cardio-metabolic risk, and their risk factor profiles compared to the remainder of the population, as well as to individuals with the metabolic syndrome (MetS). Results High cardio-metabolic risk (upper 25%) was defined as a TG/HDL-C Ratio ≥3.5 (men) or ≥2.0 (women), and all cardio-metabolic risk factors measured, including coronary calcium scores, were significantly more adverse when compared to individuals beneath these cut-points. Although cardio-metabolic risk profiles appeared reasonably comparable in subjects identified by either a high TG/HDL-C or a diagnosis of MetS, use of the TG/HDL-C increased the numbers at high risk. Conclusion Evidence that determination of the plasma TG/HDL-C ConcentRation Ratio provides a simple way to identify individual at increased cardio-metabolic risk has been extended to an East Asian population. The ability of an elevated TG/HDL-C Ratio to accomplish this goal is comparable to that achieved using the more complicated MetS criteria.
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relation among the plasma triglyceride high density lipoprotein cholesterol ConcentRation Ratio insulin resistance and associated cardio metabolic risk factors in men and women
American Journal of Cardiology, 2012Co-Authors: Martin R Salazar, Horacio A Carbajal, Walter G Espeche, Carlos Leiva E Sisnieguez, Eduardo Balbin, Carlos A Dulbecco, Marcelo Aizpurua, Alberto G Marillet, Gerald M ReavenAbstract:Results of recent studies using the Ratio of plasma triglyceride (TG) to high-density lipoprotein (HDL) cholesterol ConcentRation to identify insulin-resistant patients at increased cardiometabolic risk have emphasized that the cut point used for this purpose will vary with race. Because TG and HDL cholesterol ConcentRations vary with gender, this analysis was initiated to define gender-specific plasma TG/HDL cholesterol ConcentRation Ratios that best identified high-risk subjects among women (n = 1,102) and men (n = 464) of primarily European ancestry. Insulin resistance was defined as the 25% of the population with the highest values for fasting plasma insulin ConcentRation and homeostasis model assessment of insulin resistance. Using TG/HDL ConcentRation Ratios >2.5 in women and >3.5 in men identified subgroups of men and women that were comparable in terms of insulin resistance and associated cardiometabolic risk, with significantly higher values for fasting plasma insulin, homeostasis model assessment of insulin resistance, blood pressure, body mass index, waist circumference, and glucose and TG ConcentRations and lower HDL cholesterol ConcentRations than in women and men below these cut points. The sensitivity and specificity of these gender-specific cut points to identify insulin-resistant subjects were about 40% and about 80%, respectively. In conclusion, the plasma TG/HDL cholesterol ConcentRation Ratio that identifies patients who are insulin resistant and at significantly greater cardiometabolic risk varies between men and women.
Johan Arnlov - One of the best experts on this subject based on the ideXlab platform.
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can the plasma ConcentRation Ratio of triglyceride high density lipoprotein cholesterol identify individuals at high risk of cardiovascular disease during 40 year follow up
Metabolic Syndrome and Related Disorders, 2018Co-Authors: Lars Lind, Erik Ingelsson, Johan Arnlov, Johan Sundstrom, Bjorn Zethelius, Gerald M ReavenAbstract:Abstract Background: The plasma ConcentRation Ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) is a simple way to estimate insulin resistance. We aimed to evaluate the TG/HDL...
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can the plasma ConcentRation Ratio of triglyceride high density lipoprotein cholesterol identify individuals at high risk of cardiovascular disease during 40 year follow up
Metabolic Syndrome and Related Disorders, 2018Co-Authors: Lars Lind, Erik Ingelsson, Johan Arnlov, Johan Sundstrom, Bjorn Zethelius, Gerald M ReavenAbstract:Abstract Background: The plasma ConcentRation Ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) is a simple way to estimate insulin resistance. We aimed to evaluate the TG/HDL-C Ratio as a simple clinical way to identify apparently healthy individuals with insulin resistance and enhanced risk of future cardiovascular disease (CVD). Methods: One thousand seven hundred twenty men, aged 50 years, free from diabetes and CVD when evaluated at baseline in 1970–1974 were followed for 40 years regarding incident CVD (myocardial infarction and/or ischemic stroke, n = 576). Results: Participants with a high TG/HDL-C Ratio (highest quartile >1.8) at baseline were more insulin resistant, with a significantly more adverse cardiometabolic risk profile (P < 0.001) at baseline, compared with those with a lower Ratio. This group also showed an increased risk of CVD [hazard Ratio, HR 1.47 (95% confidence interval 1.26–1.93) P < 0.001]. Fourteen percent of subjects with metabolic syndrome, in whom insu...
Yinhu Wu - One of the best experts on this subject based on the ideXlab platform.
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an efficient microalgal biomass harvesting method with a high ConcentRation Ratio using the polymer surfactant aggregates process
Algal Research-Biomass Biofuels and Bioproducts, 2018Co-Authors: Yinhu Wu, Licheng Shen, Hongying Hu, Nicholas P Hankins, Wei E HuangAbstract:Abstract The high cost and energy consumption related to the downstream harvesting and dewatering process is one of the most important bottlenecks limiting the commercial production of microalgal bioenergy. In this study, a novel microalgal biomass harvesting technique has been developed using polymer surfactant aggregates (PSAs). This approach has been applied to three different microalgal strains and two cynobacterial strains with a recovery efficiency of over 80%. In particular, the recovery efficiency of Chlorella sp. ZTY4 with a biomass ConcentRation of 1.43 g·L− 1 can be as high as 99.9% using 360 mg·L− 1 poly (acrylic acid) (PAA) and 4 mM (1432 mg·L− 1) cetylpyridinium chloride (CPC). In addition, with this PAA and CPC dosage, the recovery efficiency of Chlorella sp. ZTY4 remains above 90% for biomass ConcentRations up to 2.5 g·L− 1. Furthermore, the water content in the harvested biomass is below 70% with a corresponding ConcentRation Ratio of 231. The total flocculation time needed for this technique is 20 min. The optimum dosage Ratio for PAA to CPC ranges from 90 to 100 mg/mmol. Based on these results, an efficient harvesting method with a high ConcentRation Ratio is proposed to simplify the whole downstream harvesting and dewatering processes of microalgal biomass.
Wei E Huang - One of the best experts on this subject based on the ideXlab platform.
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an efficient microalgal biomass harvesting method with a high ConcentRation Ratio using the polymer surfactant aggregates process
Algal Research-Biomass Biofuels and Bioproducts, 2018Co-Authors: Yinhu Wu, Licheng Shen, Hongying Hu, Nicholas P Hankins, Wei E HuangAbstract:Abstract The high cost and energy consumption related to the downstream harvesting and dewatering process is one of the most important bottlenecks limiting the commercial production of microalgal bioenergy. In this study, a novel microalgal biomass harvesting technique has been developed using polymer surfactant aggregates (PSAs). This approach has been applied to three different microalgal strains and two cynobacterial strains with a recovery efficiency of over 80%. In particular, the recovery efficiency of Chlorella sp. ZTY4 with a biomass ConcentRation of 1.43 g·L− 1 can be as high as 99.9% using 360 mg·L− 1 poly (acrylic acid) (PAA) and 4 mM (1432 mg·L− 1) cetylpyridinium chloride (CPC). In addition, with this PAA and CPC dosage, the recovery efficiency of Chlorella sp. ZTY4 remains above 90% for biomass ConcentRations up to 2.5 g·L− 1. Furthermore, the water content in the harvested biomass is below 70% with a corresponding ConcentRation Ratio of 231. The total flocculation time needed for this technique is 20 min. The optimum dosage Ratio for PAA to CPC ranges from 90 to 100 mg/mmol. Based on these results, an efficient harvesting method with a high ConcentRation Ratio is proposed to simplify the whole downstream harvesting and dewatering processes of microalgal biomass.
Lars Lind - One of the best experts on this subject based on the ideXlab platform.
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can the plasma ConcentRation Ratio of triglyceride high density lipoprotein cholesterol identify individuals at high risk of cardiovascular disease during 40 year follow up
Metabolic Syndrome and Related Disorders, 2018Co-Authors: Lars Lind, Erik Ingelsson, Johan Arnlov, Johan Sundstrom, Bjorn Zethelius, Gerald M ReavenAbstract:Abstract Background: The plasma ConcentRation Ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) is a simple way to estimate insulin resistance. We aimed to evaluate the TG/HDL...
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can the plasma ConcentRation Ratio of triglyceride high density lipoprotein cholesterol identify individuals at high risk of cardiovascular disease during 40 year follow up
Metabolic Syndrome and Related Disorders, 2018Co-Authors: Lars Lind, Erik Ingelsson, Johan Arnlov, Johan Sundstrom, Bjorn Zethelius, Gerald M ReavenAbstract:Abstract Background: The plasma ConcentRation Ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) is a simple way to estimate insulin resistance. We aimed to evaluate the TG/HDL-C Ratio as a simple clinical way to identify apparently healthy individuals with insulin resistance and enhanced risk of future cardiovascular disease (CVD). Methods: One thousand seven hundred twenty men, aged 50 years, free from diabetes and CVD when evaluated at baseline in 1970–1974 were followed for 40 years regarding incident CVD (myocardial infarction and/or ischemic stroke, n = 576). Results: Participants with a high TG/HDL-C Ratio (highest quartile >1.8) at baseline were more insulin resistant, with a significantly more adverse cardiometabolic risk profile (P < 0.001) at baseline, compared with those with a lower Ratio. This group also showed an increased risk of CVD [hazard Ratio, HR 1.47 (95% confidence interval 1.26–1.93) P < 0.001]. Fourteen percent of subjects with metabolic syndrome, in whom insu...
