The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Xinxin Pan - One of the best experts on this subject based on the ideXlab platform.
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effect of 5 aminolevulinic acid photodynamic therapy on keratinocyte proliferation and apoptosis in Condyloma acuminatum
Photodiagnosis and Photodynamic Therapy, 2017Co-Authors: Guangwen Yin, Ke Sha, Bingjie Cai, Xianxian Xia, Xinxin PanAbstract:Abstract Background The effect of 5-aminolevulinic acid photodynamic therapy on keratinocyte proliferation and apoptosis in Condyloma acuminatum tissues was evaluated. Methods An immunohistochemical method and TdT-mediated dUTP nick end labeling were performed to detect the positive expression of the keratinocyte proliferation-related gene Ki-67 and apoptosis, respectively, in Condyloma acuminatum tissues. Results Of 52 cases, 44 showed positive expression of Ki-67 in Condyloma acuminatum keratinocytes before the treatment, with a positive expression rate of 84.62% (44/52), an expression strength of mostly ++ − +++, and a Ki-67 proliferation index of 80.26 ± 5.07%. After treatment, 22 cases showed positive expression of Ki-67 in Condyloma acuminatum keratinocytes, with a positive expression rate of 42.31% (22/52), an expression strength of mostly − − ++, and a proliferation index of 42.67 ± 3.06%. The differences in the positive expression rate, expression strength, and proliferation index in the before- and after-treatment groups were statistically significant (χ2 = 20.070, P Conclusion 5-Aminolevulinic acid photodynamic therapy can inhibit the proliferation and promote the apoptosis of keratinocytes, and represents an effective mechanism for treating Condyloma acuminatum.
Yona Tadir - One of the best experts on this subject based on the ideXlab platform.
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selective photosensitizer distribution in vulvar Condyloma acuminatum after topical application of 5 aminolevulinic acid
American Journal of Obstetrics and Gynecology, 1996Co-Authors: Mathias K Fehr, Curtis F Chapman, Tatiana B Krasieva, Bruce J Tromberg, Jerry L Mccullough, Michael W Berns, Yona TadirAbstract:Abstract OBJECTIVE: Our purpose was to determine the feasibility of selective photosensitization of vulvar Condylomas by use of topical application of 5-aminolevulinic acid. STUDY DESIGN: In vivo fluorescence was assessed and biopsy specimens of Condylomas were taken for fluorescence microscopy in 24 patients at different times after application of 2.5% 5-aminolevulinic acid ointment or 20% 5-aminolevulinic acid cream. RESULTS: Both in vivo fluorescence imaging and fluorescence microscopy showed selective fluorescence of Condylomas of the labia minora and vestibule only within short time intervals, because fluorescence of poorly keratinized normal epithelium was induced by both 5-aminolevulinic acid formulations. In non-hair-bearing skin, lesional fluorescence remained highly selective. Fluorescence microscopy showed that 90 minutes after drug application peak selectivity in epithelial lesional fluorescence was significantly higher with 2.5% 5-aminolevulinic acid ointment (4.5 ± 0.9) than it was with 20% cream (2.1 ± 0.2). CONCLUSIONS: Selective fluorescence of vulvar Condyloma acuminatum can be induced by nonselective topical 5-aminolevulinic acid application. Studies evaluating selective photodynamic destruction of Condylomas are justified. (AM J OBSTET GYNECOL 1996;174:951-7.)
Yi Zhan - One of the best experts on this subject based on the ideXlab platform.
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Successful management of giant Condyloma acuminatum of vulva with the combination of surgery and photodynamic therapy: Report of two cases.
Photodiagnosis and photodynamic therapy, 2020Co-Authors: Xiufang Chen, Ying Zhou, Yixin Tan, Guozhen Duan, Puyu Zou, Rong Xiao, Yi ZhanAbstract:Patients with Condylomata acuminata of the vulva usually have increased difficulty to achieve complete response to treatment and also have a higher risk for disease recurrence. Treatment for this disease varies, including surgical excision, cryotherapy, electrocautery, CO2 laser therapy, topical therapy, and photodynamic therapy (PDT), but none of these alone provides a satisfactory outcome, especially for giant Condyloma acuminatum (GCA). We reported two cases of GCA successfully cured with surgical removal, electrocautery and photodynamic therapy.
Guangwen Yin - One of the best experts on this subject based on the ideXlab platform.
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effect of 5 aminolevulinic acid photodynamic therapy on keratinocyte proliferation and apoptosis in Condyloma acuminatum
Photodiagnosis and Photodynamic Therapy, 2017Co-Authors: Guangwen Yin, Ke Sha, Bingjie Cai, Xianxian Xia, Xinxin PanAbstract:Abstract Background The effect of 5-aminolevulinic acid photodynamic therapy on keratinocyte proliferation and apoptosis in Condyloma acuminatum tissues was evaluated. Methods An immunohistochemical method and TdT-mediated dUTP nick end labeling were performed to detect the positive expression of the keratinocyte proliferation-related gene Ki-67 and apoptosis, respectively, in Condyloma acuminatum tissues. Results Of 52 cases, 44 showed positive expression of Ki-67 in Condyloma acuminatum keratinocytes before the treatment, with a positive expression rate of 84.62% (44/52), an expression strength of mostly ++ − +++, and a Ki-67 proliferation index of 80.26 ± 5.07%. After treatment, 22 cases showed positive expression of Ki-67 in Condyloma acuminatum keratinocytes, with a positive expression rate of 42.31% (22/52), an expression strength of mostly − − ++, and a proliferation index of 42.67 ± 3.06%. The differences in the positive expression rate, expression strength, and proliferation index in the before- and after-treatment groups were statistically significant (χ2 = 20.070, P Conclusion 5-Aminolevulinic acid photodynamic therapy can inhibit the proliferation and promote the apoptosis of keratinocytes, and represents an effective mechanism for treating Condyloma acuminatum.
John A. Griswold - One of the best experts on this subject based on the ideXlab platform.
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Giant anorectal Condyloma acuminatum of Buschke-Löwenstein presents difficult management decisions.
Journal of surgical case reports, 2018Co-Authors: Hyunyoung G. Kim, Jennifer Kesey, John A. GriswoldAbstract:Condyloma acuminata, or anogenital warts, caused by human papillomavirus are the most common sexually transmitted disease. In rare cases, the disease could progress to an extensive neoplasm called Buschke-Lowenstein tumor (BLT), also known as giant Condyloma acuminatum. BLT differs from normal Condyloma acuminata by presenting with locally invasive growth, lack of spontaneous resolution, tendency for recurrence after treatment and potential for malignant transformation. We examine a BLT case reaching large dimensions in the anorectal region treated with neoadjuvant chemoradiation therapy and surgical excision of residual lesions. Furthermore, continuous follow-up care can help identify and prevent recurrence or malignant transformation of the tumor.