The Experts below are selected from a list of 14802 Experts worldwide ranked by ideXlab platform
Renjie Song - One of the best experts on this subject based on the ideXlab platform.
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general zinc catalyzed conia ene Reactions of 1 3 dicarbonyl compounds with alkynes including the classically challenging substrates under neat conditions
Advanced Synthesis & Catalysis, 2009Co-Authors: Chenliang Deng, Renjie Song, Yilin LiuAbstract:A simple, versatile new approach to four-membered ring to six-membered ring products has been developed by zinc-catalyzed intramolecular Conia-Ene Reactions of 1,3-dicarbonyl compounds with alkynes. This new route allows a wide range of dicarbonyl compounds, including the classically challenging 1,3-diesters and N,N'-disubstituted 1,3-keto amides, to be used for the Conia-Ene Reaction with inexpensive zinc chloride (ZnCl 2 ) under neat conditions.
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copper silver cocatalyzed conia ene Reactions of 2 alkynic 1 3 dicarbonyl compounds
Journal of Organic Chemistry, 2009Co-Authors: Chenliang Deng, Tao Zou, Zhiqiang Wang, Renjie SongAbstract:A copper/silver-catalyzed Conia−ene Reaction has been developed for selectively constructing five-membered and six-membered rings. In the presence of (CuOTf)2·C6H6 and AgBF4, a variety of 2-alkynic 1,3-dicarbonyl compounds underwent the Conia−ene intramolecular Reaction smoothly in moderate to good yields. It is noteworthy that both 2-phenylacetylhept-6-ynenitrile and diethyl 2-(pent-4-ynyl)malonate are also suitable substrates under the standard conditions, and the selectivity toward endo- or exo-products depends on the substitutents at the terminal of alkynes.
Chenliang Deng - One of the best experts on this subject based on the ideXlab platform.
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general zinc catalyzed conia ene Reactions of 1 3 dicarbonyl compounds with alkynes including the classically challenging substrates under neat conditions
Advanced Synthesis & Catalysis, 2009Co-Authors: Chenliang Deng, Renjie Song, Yilin LiuAbstract:A simple, versatile new approach to four-membered ring to six-membered ring products has been developed by zinc-catalyzed intramolecular Conia-Ene Reactions of 1,3-dicarbonyl compounds with alkynes. This new route allows a wide range of dicarbonyl compounds, including the classically challenging 1,3-diesters and N,N'-disubstituted 1,3-keto amides, to be used for the Conia-Ene Reaction with inexpensive zinc chloride (ZnCl 2 ) under neat conditions.
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copper silver cocatalyzed conia ene Reactions of 2 alkynic 1 3 dicarbonyl compounds
Journal of Organic Chemistry, 2009Co-Authors: Chenliang Deng, Tao Zou, Zhiqiang Wang, Renjie SongAbstract:A copper/silver-catalyzed Conia−ene Reaction has been developed for selectively constructing five-membered and six-membered rings. In the presence of (CuOTf)2·C6H6 and AgBF4, a variety of 2-alkynic 1,3-dicarbonyl compounds underwent the Conia−ene intramolecular Reaction smoothly in moderate to good yields. It is noteworthy that both 2-phenylacetylhept-6-ynenitrile and diethyl 2-(pent-4-ynyl)malonate are also suitable substrates under the standard conditions, and the selectivity toward endo- or exo-products depends on the substitutents at the terminal of alkynes.
Jonathan W Burton - One of the best experts on this subject based on the ideXlab platform.
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a zinc ii catalyst system for the conia ene Reaction of alkynyl aminomalonates applicable to 5 endo dig Reactions
ChemInform, 2012Co-Authors: Wilfried Hess, Jonathan W BurtonAbstract:Various nitrogen heterocycles are obtained by zinc(II)-catalyzed 5-exo-dig and 5-endo-dig cyclizations of alkynyl-α-aminomalonates.
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a zinc ii catalyst system for the conia ene Reaction of alkynyl aminomalonates applicable to 5 endo dig Reactions
Advanced Synthesis & Catalysis, 2011Co-Authors: Wilfried Hess, Jonathan W BurtonAbstract:The zinc(II)-catalyzed 5-exo-dig (Conia-Ene) and 5-endo-dig cyclizations of a range of alkynyl-α-aminomalonates give rise to nitrogen heterocycles with good efficiency. The Reaction allows the synthesis of a broad range of synthetically useful building blocks.
Yilin Liu - One of the best experts on this subject based on the ideXlab platform.
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general zinc catalyzed conia ene Reactions of 1 3 dicarbonyl compounds with alkynes including the classically challenging substrates under neat conditions
Advanced Synthesis & Catalysis, 2009Co-Authors: Chenliang Deng, Renjie Song, Yilin LiuAbstract:A simple, versatile new approach to four-membered ring to six-membered ring products has been developed by zinc-catalyzed intramolecular Conia-Ene Reactions of 1,3-dicarbonyl compounds with alkynes. This new route allows a wide range of dicarbonyl compounds, including the classically challenging 1,3-diesters and N,N'-disubstituted 1,3-keto amides, to be used for the Conia-Ene Reaction with inexpensive zinc chloride (ZnCl 2 ) under neat conditions.
Darren J Dixon - One of the best experts on this subject based on the ideXlab platform.
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bronsted base lewis acid cooperative catalysis in the enantioselective conia ene Reaction
Journal of the American Chemical Society, 2009Co-Authors: Ting Yang, Filippo Sladojevich, Alessandro Ferrali, Leonie Campbell, Darren J DixonAbstract:A mutually compatible and cooperative combination of copper(I) triflate and bifunctional 9-amino-9-deoxyepicinchona-derived urea compounds for the enantioselective Conia-Ene cyclization of alkyne-tethered β-ketoester substrates is reported. The Reaction is efficient, broad in scope, and easy to perform and allows access to chiral methylenecyclopentane products with high enantiocontrol. The transformation illustrates the concept of combining inactive precatalysts with inactive transition-metal-ion complexes in situ to reversibly create a catalytically active combination of the two.
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bronsted base lewis acid cooperative catalysis in the enantioselective conia ene Reaction
Journal of the American Chemical Society, 2009Co-Authors: Ting Yang, Filippo Sladojevich, Alessandro Ferrali, Leonie Campbell, Darren J DixonAbstract:A mutually compatible and cooperative combination of copper(I) triflate and bifunctional 9-amino-9-deoxyepicinchona-derived urea compounds for the enantioselective Conia-Ene cyclization of alkyne-tethered beta-ketoester substrates is reported. The Reaction is efficient, broad in scope, and easy to perform and allows access to chiral methylenecyclopentane products with high enantiocontrol. The transformation illustrates the concept of combining inactive precatalysts with inactive transition-metal-ion complexes in situ to reversibly create a catalytically active combination of the two.