The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Slobodan Nikolić - One of the best experts on this subject based on the ideXlab platform.
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Head injuries in falls from a standing height: Do fractures of the orbital roof matter? A prospective autopsy study
Forensic Science Medicine and Pathology, 2014Co-Authors: Vladimir Živković, Slobodan NikolićAbstract:Purpose The aim of this study was to analyze the occurrence and characteristics of orbital roof fractures, periorbital hematoma, Conjunctival Hemorrhage, orbital roof discoloration, and concomitant head injuries in falls from a standing height. Methods A prospective autopsy study was performed over a 4-year period (from 2010 to 2013). Subjects who had died due to traumatic brain injury caused by falls from a standing height were included in the study. Results Fifty cases of ground level falls were recorded. This group consisted of 39 men and 11 women, with an average age of 67.3 ± 13.6 years, and median age of 70 years. Skull fractures originating in the proximity of impact site were found in 47 of 50 individuals, and 22 had isolated orbital roof fractures not connected to the fracture line. Bluish discoloration of the orbital roof was noted in 19 subjects, 14 had periorbital hematomas, and 12 had blotchy or purpura-like Conjunctival Hemorrhages. Conclusions Isolated orbital roof fractures in falls from a standing height are easily detected using a standard autopsy technique, with special regard to careful removal of the dura in the anterior cranial fossa. Our study shows that orbital roof fractures can occur in accidental falls from a standing height and may not be associated with concomitant skull fractures and brain injuries.
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Head injuries in falls from a standing height: do fractures of the orbital roof matter? A prospective autopsy study.
Forensic science medicine and pathology, 2014Co-Authors: Vladimir Živković, Slobodan NikolićAbstract:Purpose The aim of this study was to analyze the occurrence and characteristics of orbital roof fractures, periorbital hematoma, Conjunctival Hemorrhage, orbital roof discoloration, and concomitant head injuries in falls from a standing height.
Vladimir Živković - One of the best experts on this subject based on the ideXlab platform.
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Head injuries in falls from a standing height: Do fractures of the orbital roof matter? A prospective autopsy study
Forensic Science Medicine and Pathology, 2014Co-Authors: Vladimir Živković, Slobodan NikolićAbstract:Purpose The aim of this study was to analyze the occurrence and characteristics of orbital roof fractures, periorbital hematoma, Conjunctival Hemorrhage, orbital roof discoloration, and concomitant head injuries in falls from a standing height. Methods A prospective autopsy study was performed over a 4-year period (from 2010 to 2013). Subjects who had died due to traumatic brain injury caused by falls from a standing height were included in the study. Results Fifty cases of ground level falls were recorded. This group consisted of 39 men and 11 women, with an average age of 67.3 ± 13.6 years, and median age of 70 years. Skull fractures originating in the proximity of impact site were found in 47 of 50 individuals, and 22 had isolated orbital roof fractures not connected to the fracture line. Bluish discoloration of the orbital roof was noted in 19 subjects, 14 had periorbital hematomas, and 12 had blotchy or purpura-like Conjunctival Hemorrhages. Conclusions Isolated orbital roof fractures in falls from a standing height are easily detected using a standard autopsy technique, with special regard to careful removal of the dura in the anterior cranial fossa. Our study shows that orbital roof fractures can occur in accidental falls from a standing height and may not be associated with concomitant skull fractures and brain injuries.
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Head injuries in falls from a standing height: do fractures of the orbital roof matter? A prospective autopsy study.
Forensic science medicine and pathology, 2014Co-Authors: Vladimir Živković, Slobodan NikolićAbstract:Purpose The aim of this study was to analyze the occurrence and characteristics of orbital roof fractures, periorbital hematoma, Conjunctival Hemorrhage, orbital roof discoloration, and concomitant head injuries in falls from a standing height.
Gary D. Novack - One of the best experts on this subject based on the ideXlab platform.
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Long-term Safety and Ocular Hypotensive Efficacy Evaluation of Netarsudil Ophthalmic Solution: Rho Kinase Elevated IOP Treatment Trial (ROCKET-2)
American Journal of Ophthalmology, 2019Co-Authors: Malik Y Kahook, Theresa Heah, Nancy Ramirez-davis, Janet B Serle, Casey Kopczynski, Dale W. Usner, Michael B Raizman, Gary D. NovackAbstract:Purpose To evaluate netarsudil 0.02% ophthalmic solution in patients with open-angle glaucoma (OAG) and ocular hypertension (OHT). Design Double-masked, randomized, multicenter, parallel-group, noninferiority clinical study. Methods After a washout of all prestudy ocular hypotensive medications, 756 eligible patients with elevated IOP were randomized to receive netarsudil 0.02% once a day (q.d.) (251); netarsudil 0.02% twice a day (b.i.d.) (254); or timolol 0.5% b.i.d. (251) for 12 months, as well as a noninterventional Corneal Observation Study (COS) for patients manifesting cornea verticillata. Results On treatment, mean IOP at 8:00 AM decreased from a baseline IOP of 22.5-22.6 mm Hg to 17.9-18.8 mm Hg, 17.2-18.0 mm Hg, and 17.5-17.9 mm Hg for netarsudil q.d., netarsudil b.i.d., and timolol, respectively, over 12 months. The most frequently reported adverse events (AEs) were ocular, with the most frequent ocular AE being Conjunctival hyperemia, with an incidence of 61%, 66%, and 14%, respectively. The next most frequent AEs were corneal deposits (corneal verticillata), with an incidence of 26%, 25%, and 1%, respectively, and Conjunctival Hemorrhage (typically petechial), with an incidence of 20%, 19%, and 1%, respectively. All 3 AEs were generally scored as mild, with Conjunctival hyperemia and/or Hemorrhage appearing sporadically during the study. In the observational follow-up component of this study, there was no clinically meaningful impact of corneal verticillata on visual function in affected patients. Conclusions In this randomized, double-masked trial, once-daily dosing of netarsudil 0.02% was effective, consistently lowering IOP through 12 months, and was tolerated by the majority of patients.
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Double-masked, randomized, dose-response study of AR-13324 Ophthalmic Solution compared to latanoprost in patients with elevated intraocular pressure
Investigative Ophthalmology & Visual Science, 2014Co-Authors: Harvey Dubiner, Casey Kopczynski, Brian Levy, Gary D. NovackAbstract:Adverse Events (most common) AR-13324 0.01% q.d. PM n=75 AR-13324 0.02% q.d PM n=72 Latanoprost q.d. PM n=77 Eye Disorders 41 (54.7%) 45 (62.5%) 20 (26.0%) Conjunctival Hyperemia 29 (38.7) 34 (47.2) 12 (15.6) Ocular Hyperemia 10 (13.3) 7 ( 9.7) 0 Lacrimation Increased 4 ( 5.3) 5 ( 6.9) 0 Conjunctival Hemorrhage 4 ( 5.3) 4 ( 5.6) 0 Foreign Body Sensation 0 5 ( 6.9) 3 ( 3.9) Vision Blurred 2 ( 2.7) 3 ( 4.2) 2 ( 2.6) Eye Pruritus 2 ( 2.7) 1 ( 1.4) 2 ( 2.6) Eye Discharge 1 ( 1.3) 0 1 ( 1.3) Photophobia 0 2 ( 2.8) 0 Visual Acuity Reduced 0 1 ( 1.4) 1 ( 1.3) Administration Site Conditions Instillation site pain 5 ( 6.7) 9 (12.5) 4 ( 5.2) Number of Subjects with Treatment-Emergent Adverse Events
Chloe Gottlieb - One of the best experts on this subject based on the ideXlab platform.
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Ozurdex (dexamethasone intravitreal implant) for the treatment of intermediate, posterior, and panuveitis: a systematic review of the current evidence
Journal of Ophthalmic Inflammation and Infection, 2020Co-Authors: Saanwalshah Samir Saincher, Chloe GottliebAbstract:Background This study aims to determine if the intravitreal dexamethasone implant (DEX implant, Ozurdex; Allergan, Inc., Irvine, California) is effective for treating intermediate, posterior, and panuveitis as a monotherapy or adjunctive treatment to systemic immunomodulatory therapies. Methods A systematic review using MEDLINE, EMBASE, and PubMed database searches was conducted with the Oxford Centre for Evidence-based Medicine Levels of Evidence criteria to select publications. Available background information and patient data from each study was tabulated. Outcomes studied were central retinal thickness (CRT), best corrected visual acuity, intraocular inflammation (anterior chamber cells, vitreous haze), number of patients with prior and concomitant immunomodulatory treatments, intraocular pressure (IOP) elevation (≥ 25 mmHg), and other adverse effects associated with the implant. Results One hundred ninety-five (61.51%) patients had previous immunomodulatory treatment while 232 (64.8%) were treated with concomitant immunomodulatory therapy with the DEX implant. CRT decreased by an average of 198.65 μm (42.74%). Visual acuity improved to an average of 0.451 (logMAR) or 20/57 (Snellen) which is a 43.11% improvement from baseline. One hundred seventy-three (59%) of eyes were quiescent at the end of the trials, of which 40 (13.7%) previously inflamed eyes became quiescent. Elevated IOP occurred in 91 (20.6%). The most common adverse events were cataract/posterior subcapsular opacities in 47 (11.03%) patients and Conjunctival Hemorrhage in 24 (5.44%) patients. Conclusions The DEX implant is an effective medication for the treatment of posterior segment uveitis, uveitic macular edema, and results in improved visual acuity. Development of elevated IOP and cataract should be closely monitored as they are tangible risks associated with the DEX implant. This study was not able to determine whether the DEX implant was more effective as a monotherapy or as an adjunctive therapy to systemic immunomodulatory treatment.
Jyoti Barwa - One of the best experts on this subject based on the ideXlab platform.
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Traumatic Asphyxial Deaths Due to an Uncontrolled Crowd at Railway station: Two case reports
Journal of Indian Academy of Forensic Medicine, 2010Co-Authors: Amit Sharma, Anju Rani, Jyoti BarwaAbstract:Deaths in stampede accidents are not new in India. Majority of causalities occurred as a result of traumatic asphyxia in such cases. Traumatic asphyxia is a rare syndrome first described over 150 years ago by Olivier. It is caused by sudden compressive chest trauma and is associated with craniocervical cyanosis, facial edema and petechiae, sub-Conjunctival Hemorrhage, and neurological symptoms. Although minor incidents of jostling are common at railway stations, but deaths occurring consequent to stampede by an uncontrollable crowd is not very common. A stampede occurred at New Delhi railway station which results in death of two persons and injuring many. The autopsy findings along with circumstantial evidence, results in arriving of conclusion that these deaths occurs as a consequence of traumatic asphyxia. Various clinical features of this condition are described in the literature, a brief review of which is given in this article. In the conclusion few preventive measures are also suggested so that in future such tragedies can be averted.