The Experts below are selected from a list of 19236 Experts worldwide ranked by ideXlab platform
Jiaxu Hong - One of the best experts on this subject based on the ideXlab platform.
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ambient air pollution weather changes and outpatient visits for allergic Conjunctivitis a retrospective registry study
Scientific Reports, 2016Co-Authors: Taoling Zhong, Zhe Mu, Xiaofang Ye, Jianming Xu, Huili Li, Jiaxu Hong, Yi Lu, Alireza MashaghiAbstract:With the rapid industrialization and urbanization, air quality problems and other environmental health troubles are particularly becoming major sources of morbidity and mortality in human1. Allergic Conjunctivitis is one of the most common ocular surface diseases; it damages the ocular surface and causes debilitating symptoms of redness and itching, resulting in impaired quality of life for patients and limited physical activity2. More importantly, allergic Conjunctivitis affects up to 40 percent of the population of the United States3. Pollen, animal dander, and other environmental antigens are the main causes of allergic Conjunctivitis, yet a recent (2014) hospital-based study showed that exposure to ambient air pollution—especially particulate air pollution—possibly increases the risk of allergic Conjunctivitis4. The effects of exposure to other well-defined pollutants such as ozone (O3), sulfur dioxide (SO2), and nitrogen dioxide (NO2) on this disease remain inconclusive. Although several studies have evaluated this issue, with limited success4,5, we still lack a long-term study with a large sample size to make statistically significant statements. Furthermore, human health is being adversely affected by climate change6. This change in weather patterns has been proven to affect the timing, distribution, quantity, and quality of aeroallergens, and has changed the distribution and severity of asthma and allergic disease7; its role in the development of allergic Conjunctivitis, however, remains unknown. The effect of ambient air pollution and weather pattern changes on allergic Conjunctivitis may differ from asthma and other allergic diseases due to anatomical differences between the eyes and lungs. For example, unlike the lungs, where air pollutants tend to penetrate deeply and stay, the cleansing system of the ocular surface (i.e. tears) may be capable of alleviating the cellular damage induced by air pollutants. On the other hand, the ocular surface is directly exposed to the environment, which means that it may be more susceptible to weather changes. Taken together, we hypothesize that ambient air pollution as well as weather changes, are both associated with risk for allergic Conjunctivitis. To address this issue, population-wide data is crucial. The current study exemplifies a unique situation whereby population-wide outpatient attendance for allergic Conjunctivitis in Shanghai was recorded systemically from 2008 to 2012, as well as the information on ambient air pollutants and weather conditions. The availability of such a large dataset allowed us to assess the effects of ambient air pollutants and weather conditions on the prevalence of allergic Conjunctivitis with statistical rigor.
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ambient air pollution weather changes and outpatient visits for allergic Conjunctivitis a retrospective registry study
Scientific Reports, 2016Co-Authors: Taoling Zhong, Alireza Mashaghi, Jiaxu Hong, Xinghuai Sun, Ying Zhou, Mengxi Tan, Zuguo LiuAbstract:Allergic Conjunctivitis is a common problem that significantly impairs patients' quality of life. Whether air pollution serves as a risk factor for the development of allergic Conjunctivitis remains elusive. In this paper, we assess the relationship between air pollutants and weather conditions with outpatient visits for allergic Conjunctivitis. By using a time-series analysis based on the largest dataset ever assembled to date, we found that the number of outpatient visits for allergic Conjunctivitis was significantly correlated with the levels of NO2, O3, and temperature, while its association with humidity was statistically marginal. No associations between PM10, PM2.5, SO2, or wind velocity and outpatient visits were seen. Subgroup analyses showed that sex seemed to modify the effects of humidity on outpatient visits for allergic Conjunctivitis, but not for NO2, O3, or temperature. People younger than 40 were found to be susceptible to changes of all four parameters, while those older than 40 were only consistently affected by NO2 levels. Our findings revealed that higher levels of ambient NO2, O3, and temperature increase the chances of outpatient visits for allergic Conjunctivitis. Ambient air pollution and weather changes may contribute to the worsening of allergic Conjunctivitis.
Alireza Mashaghi - One of the best experts on this subject based on the ideXlab platform.
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ambient air pollution weather changes and outpatient visits for allergic Conjunctivitis a retrospective registry study
Scientific Reports, 2016Co-Authors: Taoling Zhong, Zhe Mu, Xiaofang Ye, Jianming Xu, Huili Li, Jiaxu Hong, Yi Lu, Alireza MashaghiAbstract:With the rapid industrialization and urbanization, air quality problems and other environmental health troubles are particularly becoming major sources of morbidity and mortality in human1. Allergic Conjunctivitis is one of the most common ocular surface diseases; it damages the ocular surface and causes debilitating symptoms of redness and itching, resulting in impaired quality of life for patients and limited physical activity2. More importantly, allergic Conjunctivitis affects up to 40 percent of the population of the United States3. Pollen, animal dander, and other environmental antigens are the main causes of allergic Conjunctivitis, yet a recent (2014) hospital-based study showed that exposure to ambient air pollution—especially particulate air pollution—possibly increases the risk of allergic Conjunctivitis4. The effects of exposure to other well-defined pollutants such as ozone (O3), sulfur dioxide (SO2), and nitrogen dioxide (NO2) on this disease remain inconclusive. Although several studies have evaluated this issue, with limited success4,5, we still lack a long-term study with a large sample size to make statistically significant statements. Furthermore, human health is being adversely affected by climate change6. This change in weather patterns has been proven to affect the timing, distribution, quantity, and quality of aeroallergens, and has changed the distribution and severity of asthma and allergic disease7; its role in the development of allergic Conjunctivitis, however, remains unknown. The effect of ambient air pollution and weather pattern changes on allergic Conjunctivitis may differ from asthma and other allergic diseases due to anatomical differences between the eyes and lungs. For example, unlike the lungs, where air pollutants tend to penetrate deeply and stay, the cleansing system of the ocular surface (i.e. tears) may be capable of alleviating the cellular damage induced by air pollutants. On the other hand, the ocular surface is directly exposed to the environment, which means that it may be more susceptible to weather changes. Taken together, we hypothesize that ambient air pollution as well as weather changes, are both associated with risk for allergic Conjunctivitis. To address this issue, population-wide data is crucial. The current study exemplifies a unique situation whereby population-wide outpatient attendance for allergic Conjunctivitis in Shanghai was recorded systemically from 2008 to 2012, as well as the information on ambient air pollutants and weather conditions. The availability of such a large dataset allowed us to assess the effects of ambient air pollutants and weather conditions on the prevalence of allergic Conjunctivitis with statistical rigor.
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ambient air pollution weather changes and outpatient visits for allergic Conjunctivitis a retrospective registry study
Scientific Reports, 2016Co-Authors: Taoling Zhong, Alireza Mashaghi, Jiaxu Hong, Xinghuai Sun, Ying Zhou, Mengxi Tan, Zuguo LiuAbstract:Allergic Conjunctivitis is a common problem that significantly impairs patients' quality of life. Whether air pollution serves as a risk factor for the development of allergic Conjunctivitis remains elusive. In this paper, we assess the relationship between air pollutants and weather conditions with outpatient visits for allergic Conjunctivitis. By using a time-series analysis based on the largest dataset ever assembled to date, we found that the number of outpatient visits for allergic Conjunctivitis was significantly correlated with the levels of NO2, O3, and temperature, while its association with humidity was statistically marginal. No associations between PM10, PM2.5, SO2, or wind velocity and outpatient visits were seen. Subgroup analyses showed that sex seemed to modify the effects of humidity on outpatient visits for allergic Conjunctivitis, but not for NO2, O3, or temperature. People younger than 40 were found to be susceptible to changes of all four parameters, while those older than 40 were only consistently affected by NO2 levels. Our findings revealed that higher levels of ambient NO2, O3, and temperature increase the chances of outpatient visits for allergic Conjunctivitis. Ambient air pollution and weather changes may contribute to the worsening of allergic Conjunctivitis.
Taoling Zhong - One of the best experts on this subject based on the ideXlab platform.
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ambient air pollution weather changes and outpatient visits for allergic Conjunctivitis a retrospective registry study
Scientific Reports, 2016Co-Authors: Taoling Zhong, Zhe Mu, Xiaofang Ye, Jianming Xu, Huili Li, Jiaxu Hong, Yi Lu, Alireza MashaghiAbstract:With the rapid industrialization and urbanization, air quality problems and other environmental health troubles are particularly becoming major sources of morbidity and mortality in human1. Allergic Conjunctivitis is one of the most common ocular surface diseases; it damages the ocular surface and causes debilitating symptoms of redness and itching, resulting in impaired quality of life for patients and limited physical activity2. More importantly, allergic Conjunctivitis affects up to 40 percent of the population of the United States3. Pollen, animal dander, and other environmental antigens are the main causes of allergic Conjunctivitis, yet a recent (2014) hospital-based study showed that exposure to ambient air pollution—especially particulate air pollution—possibly increases the risk of allergic Conjunctivitis4. The effects of exposure to other well-defined pollutants such as ozone (O3), sulfur dioxide (SO2), and nitrogen dioxide (NO2) on this disease remain inconclusive. Although several studies have evaluated this issue, with limited success4,5, we still lack a long-term study with a large sample size to make statistically significant statements. Furthermore, human health is being adversely affected by climate change6. This change in weather patterns has been proven to affect the timing, distribution, quantity, and quality of aeroallergens, and has changed the distribution and severity of asthma and allergic disease7; its role in the development of allergic Conjunctivitis, however, remains unknown. The effect of ambient air pollution and weather pattern changes on allergic Conjunctivitis may differ from asthma and other allergic diseases due to anatomical differences between the eyes and lungs. For example, unlike the lungs, where air pollutants tend to penetrate deeply and stay, the cleansing system of the ocular surface (i.e. tears) may be capable of alleviating the cellular damage induced by air pollutants. On the other hand, the ocular surface is directly exposed to the environment, which means that it may be more susceptible to weather changes. Taken together, we hypothesize that ambient air pollution as well as weather changes, are both associated with risk for allergic Conjunctivitis. To address this issue, population-wide data is crucial. The current study exemplifies a unique situation whereby population-wide outpatient attendance for allergic Conjunctivitis in Shanghai was recorded systemically from 2008 to 2012, as well as the information on ambient air pollutants and weather conditions. The availability of such a large dataset allowed us to assess the effects of ambient air pollutants and weather conditions on the prevalence of allergic Conjunctivitis with statistical rigor.
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ambient air pollution weather changes and outpatient visits for allergic Conjunctivitis a retrospective registry study
Scientific Reports, 2016Co-Authors: Taoling Zhong, Alireza Mashaghi, Jiaxu Hong, Xinghuai Sun, Ying Zhou, Mengxi Tan, Zuguo LiuAbstract:Allergic Conjunctivitis is a common problem that significantly impairs patients' quality of life. Whether air pollution serves as a risk factor for the development of allergic Conjunctivitis remains elusive. In this paper, we assess the relationship between air pollutants and weather conditions with outpatient visits for allergic Conjunctivitis. By using a time-series analysis based on the largest dataset ever assembled to date, we found that the number of outpatient visits for allergic Conjunctivitis was significantly correlated with the levels of NO2, O3, and temperature, while its association with humidity was statistically marginal. No associations between PM10, PM2.5, SO2, or wind velocity and outpatient visits were seen. Subgroup analyses showed that sex seemed to modify the effects of humidity on outpatient visits for allergic Conjunctivitis, but not for NO2, O3, or temperature. People younger than 40 were found to be susceptible to changes of all four parameters, while those older than 40 were only consistently affected by NO2 levels. Our findings revealed that higher levels of ambient NO2, O3, and temperature increase the chances of outpatient visits for allergic Conjunctivitis. Ambient air pollution and weather changes may contribute to the worsening of allergic Conjunctivitis.
Bradley A. Perkins - One of the best experts on this subject based on the ideXlab platform.
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isolation of haemophilus aegyptius associated with brazilian purpuric fever of chloropidae diptera of the genera hippelates and liohippelates
Revista Do Instituto De Medicina Tropical De Sao Paulo, 1994Co-Authors: M. L. C. Tondella, M. C. C. Brandileone, V. S. D. Vieira, Kinue Irino, C H Paganelli, I M Bortolotto, O A Takano, Mezzacapa B Neto, Bradley A. PerkinsAbstract:The recognition of the Brazilian purpuric fever (BPF) in 1984 led to a number of studies which showed a relation between this disease and Conjunctivitis caused by Haemophilus aegyptius. The increase in cases of Conjunctivitis in children associated with higher population density of eye gnats (Chloropidae: Hippelates) has been reported since last century. This phenomenon is related to the attraction that those flies show for the eyes, secretions and wounds, from where they feed on. Although there are evidences on the role of these flies in the mechanical transmission of seasonal bacterial Conjunctivitis, the isolation of Haemophilus aegyptius from them in their natural habitat had not been demonstrated yet. In this study Haemophilus aegyptius associated to BPF was isolated from two pools of chloropids collected around the eyes of children with conjuntivitis which were identified as Liohippelates peruanus (Becker) and a new species Hippelates neoproboscideus.
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Isolamento de Haemophiliis aegyptius associado à Febre Purpúrica Brasileira, de cloropídeos (Diptera) dos gêneros Hippelates e Liohippelates Isolation of Haemophilus aegyptius associated to Brazilian purpuric fever from Hippelates and Liohippelates f
Universidade de São Paulo, 1994Co-Authors: M. L. C. Tondella, M. C. C. Brandileone, V. S. D. Vieira, Kinue Irino, C H Paganelli, I M Bortolotto, O A Takano, Mezzacapa B Neto, Bradley A. PerkinsAbstract:O reconhecimento da Febre Purpúrica Brasileira (FPB), em 1984, originou uma série de estudos que revelaram uma correlação desta doença com conjuntivites causadas por Haemophiliis aegyptius. A associação do aumento de conjuntivites em crianças e a maior densidade populacional de cloropídeos do gênero Hippelates já havia sido verificada desde o século passado. Este fenômeno está relacionado ao tropismo que estes insetos apresentam pelos olhos, secreções e feridas de onde se alimentam. Embora haja evidências do papel destes cloropídeos na transmissão mecânica de conjuntivites bacterianas, o isolamento de Haemophilus aegyptius a partir dos mesmos, no seu habitat natural, ainda não havia sido verificado. No presente trabalho obtivemos o isolamento de cepas invasivas de Haemophilus aegyptius, associadas à FPB, de duas coleções de cloropídeos, classificados como Liohippelates peruanus e uma espécie nova, Hippelates neoproboscideus, coletados ao redor dos olhos de crianças com conjuntivite.The recognition of the Brazilian purpuric fever (BPF) in 1984 led to a number of studies which showed a relation between this disease and Conjunctivitis caused by Haemophilus aegyptius. The increase in cases of Conjunctivitis in children associated with higher population density of eye gnats (Chloropidae: Hippelates) has been reported since last century. This phenomenon is related to the attraction that those flies show for the eyes, secretions and wounds, from where they feed on. Although there are evidences on the role of these flies in the mechanical transmission of seasonal bacterial Conjunctivitis, the isolation of Haemophilus aegyptius from them in their natural habitat had not been demonstrated yet. In this study Haemophilus aegyptius associated to BPF was isolated from two pools of chloropids collected around the eyes of children with conjuntivitis which were identified as Liohippelates peruanus (Becker) and a new species Hippelates neoproboscideus
Zuguo Liu - One of the best experts on this subject based on the ideXlab platform.
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ambient air pollution weather changes and outpatient visits for allergic Conjunctivitis a retrospective registry study
Scientific Reports, 2016Co-Authors: Taoling Zhong, Alireza Mashaghi, Jiaxu Hong, Xinghuai Sun, Ying Zhou, Mengxi Tan, Zuguo LiuAbstract:Allergic Conjunctivitis is a common problem that significantly impairs patients' quality of life. Whether air pollution serves as a risk factor for the development of allergic Conjunctivitis remains elusive. In this paper, we assess the relationship between air pollutants and weather conditions with outpatient visits for allergic Conjunctivitis. By using a time-series analysis based on the largest dataset ever assembled to date, we found that the number of outpatient visits for allergic Conjunctivitis was significantly correlated with the levels of NO2, O3, and temperature, while its association with humidity was statistically marginal. No associations between PM10, PM2.5, SO2, or wind velocity and outpatient visits were seen. Subgroup analyses showed that sex seemed to modify the effects of humidity on outpatient visits for allergic Conjunctivitis, but not for NO2, O3, or temperature. People younger than 40 were found to be susceptible to changes of all four parameters, while those older than 40 were only consistently affected by NO2 levels. Our findings revealed that higher levels of ambient NO2, O3, and temperature increase the chances of outpatient visits for allergic Conjunctivitis. Ambient air pollution and weather changes may contribute to the worsening of allergic Conjunctivitis.