The Experts below are selected from a list of 171 Experts worldwide ranked by ideXlab platform
Constantine Dumas - One of the best experts on this subject based on the ideXlab platform.
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Epidemiology of organic solvents and Connective Tissue disease
Arthritis Research & Therapy, 1999Co-Authors: David H Garabrant, Constantine DumasAbstract:Case reports suggest that solvents are associated with various Connective Tissue diseases (systemic sclerosis, scleroderma, undifferentiated Connective Tissue disease, systemic lupus erythematosis, and rheumatoid arthritis), particularly systemic sclerosis. A small number of epidemiological studies have shown statistically significant but weak associations between solvent exposure, systemic sclerosis, and undifferentiated Connective Tissue disease. However, the interpretation of these positive findings is tempered by a lack of replication, an inability to specify which solvents convey risk, and an absence of increasing risk with increasing exposure. Existing studies, on aggregate, do not show conclusively that solvents (either as a group of chemicals or individual chemicals) are causally associated with any Connective Tissue disease. Further investigations should be carried out to replicate the positive existing findings and to specify the solvents and circumstances of exposure that carry risk.
David H Garabrant - One of the best experts on this subject based on the ideXlab platform.
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Epidemiology of organic solvents and Connective Tissue disease
Arthritis Research & Therapy, 1999Co-Authors: David H Garabrant, Constantine DumasAbstract:Case reports suggest that solvents are associated with various Connective Tissue diseases (systemic sclerosis, scleroderma, undifferentiated Connective Tissue disease, systemic lupus erythematosis, and rheumatoid arthritis), particularly systemic sclerosis. A small number of epidemiological studies have shown statistically significant but weak associations between solvent exposure, systemic sclerosis, and undifferentiated Connective Tissue disease. However, the interpretation of these positive findings is tempered by a lack of replication, an inability to specify which solvents convey risk, and an absence of increasing risk with increasing exposure. Existing studies, on aggregate, do not show conclusively that solvents (either as a group of chemicals or individual chemicals) are causally associated with any Connective Tissue disease. Further investigations should be carried out to replicate the positive existing findings and to specify the solvents and circumstances of exposure that carry risk.
Xi-ping Cheng - One of the best experts on this subject based on the ideXlab platform.
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Update on undifferentiated Connective Tissue diseases
International Journal of Dermatology and Venereology, 2011Co-Authors: Xi-ping ChengAbstract:Undifferentiated Connective Tissue diseases are an actually existing clinical disease state of unknown origin. They clinically resemble autoimmune diseases with the presence of a kind of autoantibody, which does not meet the diagnostic criteria for any defined Connective Tissue disease. Evolution is the most prominent feature of undifferentiated Connective Tissue diseases, of which, 30％ could evolve into Connective Tissue diseases, 70％ remain in the initial state. The severity of Connective Tissue diseases evolving from undifferentiated Connective Tissue diseases tends to be mild with low-grade major organ injury. Clinical manifestations and evolution process reveal that undifferentiated Connective Tissue diseases are an important member in the spectrum of autoimmune diseases. Key words: Undifferentiated Connective Tissue diseases; Connective Tissue diseases
Eric L. Greidinger - One of the best experts on this subject based on the ideXlab platform.
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Mixed Connective Tissue Disease
Current Opinion in Rheumatology, 2000Co-Authors: Robert W. Hoffman, Eric L. GreidingerAbstract:Mixed Connective Tissue disease (MCTD) is often viewed as a “cousin” of systemic lupus erythematosus (SLE), with which it shares many disease features. Some experts regard MCTD as a variant of SLE because of the considerable overlap in clinical and serological manifestations. Others consider it to be a unique disorder because of the frequency with which certain phenotypic features occur in patients classified as MCTD. Patients with MCTD by definition have antibodies directed against ribonuceoprotein, i.e., anti-RNP antibodies. Common clinical manifestations of MCTD are arthritis, Raynaud's phenomenon, digital ischemia progressing to fingertip ulceration, pulmonary hypertension, interstitial lung disease, and gastrointestinal hypomotility. Some patients with MCTD evolve with time to a clinical phenotype that is more easily classified as SLE. Others, perhaps a majority, evolve over time to clinical syndromes most compatible with systemic sclerosis. MCTD must be distinguished from “undifferentiated” Connective Tissue diseases (in which a clear-cut rheumatological process may or may not emerge with time) and also from “overlap” Connective Tissue diseases, in which the disease features of two or more well-defined Connective Tissues diseases are present in the same patient. As example of an overlap Connective Tissue disease is the occurrence of SLE and polymyositis in the same patient. Such a patient would not be regarded as a “mixed” Connective Tissue disease (MCTD), but rather as the cooccurrence of two diseases in the same patient.
Sung-hee Pi - One of the best experts on this subject based on the ideXlab platform.
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Connective Tissue graft for root coverage
The Journal of The Korean Academy of Periodontology, 2008Co-Authors: Jae Young Park, Hyung-shik Shin, Sung-hee PiAbstract:Purpose: The treatment of gingival recessions is needed to reduce root sensitivity and improve esthetical satisfaction. Several surgical techniques have been proposed to achieve these goals. The use of Connective Tissue grafts has made esthetic root coverage a predictable procedure. Numerous clinical studies have represented that using Connective Tissue grafts to cover exposed root surface showed high success rates. This is a case report which demonstrates the technique to obtain root coverage of a buccal recession defect. Materials and Methods: A 35-year-old patient with a high level of oral hygiene was selected for the study. This patient had one Class Miller recession defect in the mandible. A coronally advanced flap in combination with the Connective Tissue Ⅰ graft was chosen for the treatment. After surgery, the patient was told to visit the hospital once a week for his oral management and professional prophylaxis. The depth of initial recession was 4.0 mm. Result: After three months, it reduced to 0.0 ㅤ mm, and the average recession reduction was 4.0 mm. The average root coverage was 100%. Conclusion: The Connective Tissue graft is both effective and predictable way to produce root coverage in increasing the width of CAL and KT of various adjacent gingival recessions. (J Korean Acad Periodontol 2008;38:231-236)
