The Experts below are selected from a list of 285 Experts worldwide ranked by ideXlab platform

Constantin E Orfanos - One of the best experts on this subject based on the ideXlab platform.

  • Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle.
    Archives of dermatological research, 1999
    Co-Authors: Katharina Kruger, Ulrike Blume-peytavi, Constantin E Orfanos
    Abstract:

    In the present study, the immunophenotype of basal cell carcinoma was analysed in comparison with human vellus hair follicular keratinocytes. We also established the lectin binding profile of basal cell carcinoma and human vellus hair follicles (VHF), using several lectins with different sugar specificities. Our findings showed an almost identical immunohistochemical profile for basal cell carcinoma and the suprabulbar region of the outer root sheath of VHF, whereas other follicular compartments such as the bulbar, the isthmus or the supraseboglandular regions did not correlate. In particular, homogeneous and Constant Expression of the basal differentiation markers CK 5 and CK 14 were found in both specimen, with no Expression of the simple epithelium type keratin CK 8 and the suprabasal differentiation markers CK 1 and CK 10. CK 19 showed variable Expression in basal cell carcinoma, with Constant Expression in the outer root sheath and the follicular bulge regions, but was always absent in interfollicular epidermal keratinocytes. In addition, the lectin binding profiles of basal cell carcinoma and the outer root sheath in the suprabulbar region of human VHF were comparable, with the presence of binding sites for PNA, Con A and WGA. These findings provide evidence for a histochemical relationship between basal cell carcinoma and the follicular epithelium of VHF which is closer than that with the epidermis, and suggest its possible origin from or possibly its differentiation pattern towards the cells of the outer root sheath and/or the follicular bulge region of the VHF.

  • basal cell carcinoma possibly originates from the outer root sheath and or the bulge region of the vellus hair follicle
    Archives of Dermatological Research, 1999
    Co-Authors: Katharina Kruger, Ulrike Blumepeytavi, Constantin E Orfanos
    Abstract:

    In the present study, the immunophenotype of basal cell carcinoma was analysed in comparison with human vellus hair follicular keratinocytes. We also established the lectin binding profile of basal cell carcinoma and human vellus hair follicles (VHF), using several lectins with different sugar specificities. Our findings showed an almost identical immunohistochemical profile for basal cell carcinoma and the suprabulbar region of the outer root sheath of VHF, whereas other follicular compartments such as the bulbar, the isthmus or the supraseboglandular regions did not correlate. In particular, homogeneous and Constant Expression of the basal differentiation markers CK 5 and CK 14 were found in both specimen, with no Expression of the simple epithelium type keratin CK 8 and the suprabasal differentiation markers CK 1 and CK 10. CK 19 showed variable Expression in basal cell carcinoma, with Constant Expression in the outer root sheath and the follicular bulge regions, but was always absent in interfollicular epidermal keratinocytes. In addition, the lectin binding profiles of basal cell carcinoma and the outer root sheath in the suprabulbar region of human VHF were comparable, with the presence of binding sites for PNA, Con A and WGA. These findings provide evidence for a histochemical relationship between basal cell carcinoma and the follicular epithelium of VHF which is closer than that with the epidermis, and suggest its possible origin from or possibly its differentiation pattern towards the cells of the outer root sheath and/or the follicular bulge region of the VHF.

Katharina Kruger - One of the best experts on this subject based on the ideXlab platform.

  • Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle.
    Archives of dermatological research, 1999
    Co-Authors: Katharina Kruger, Ulrike Blume-peytavi, Constantin E Orfanos
    Abstract:

    In the present study, the immunophenotype of basal cell carcinoma was analysed in comparison with human vellus hair follicular keratinocytes. We also established the lectin binding profile of basal cell carcinoma and human vellus hair follicles (VHF), using several lectins with different sugar specificities. Our findings showed an almost identical immunohistochemical profile for basal cell carcinoma and the suprabulbar region of the outer root sheath of VHF, whereas other follicular compartments such as the bulbar, the isthmus or the supraseboglandular regions did not correlate. In particular, homogeneous and Constant Expression of the basal differentiation markers CK 5 and CK 14 were found in both specimen, with no Expression of the simple epithelium type keratin CK 8 and the suprabasal differentiation markers CK 1 and CK 10. CK 19 showed variable Expression in basal cell carcinoma, with Constant Expression in the outer root sheath and the follicular bulge regions, but was always absent in interfollicular epidermal keratinocytes. In addition, the lectin binding profiles of basal cell carcinoma and the outer root sheath in the suprabulbar region of human VHF were comparable, with the presence of binding sites for PNA, Con A and WGA. These findings provide evidence for a histochemical relationship between basal cell carcinoma and the follicular epithelium of VHF which is closer than that with the epidermis, and suggest its possible origin from or possibly its differentiation pattern towards the cells of the outer root sheath and/or the follicular bulge region of the VHF.

  • basal cell carcinoma possibly originates from the outer root sheath and or the bulge region of the vellus hair follicle
    Archives of Dermatological Research, 1999
    Co-Authors: Katharina Kruger, Ulrike Blumepeytavi, Constantin E Orfanos
    Abstract:

    In the present study, the immunophenotype of basal cell carcinoma was analysed in comparison with human vellus hair follicular keratinocytes. We also established the lectin binding profile of basal cell carcinoma and human vellus hair follicles (VHF), using several lectins with different sugar specificities. Our findings showed an almost identical immunohistochemical profile for basal cell carcinoma and the suprabulbar region of the outer root sheath of VHF, whereas other follicular compartments such as the bulbar, the isthmus or the supraseboglandular regions did not correlate. In particular, homogeneous and Constant Expression of the basal differentiation markers CK 5 and CK 14 were found in both specimen, with no Expression of the simple epithelium type keratin CK 8 and the suprabasal differentiation markers CK 1 and CK 10. CK 19 showed variable Expression in basal cell carcinoma, with Constant Expression in the outer root sheath and the follicular bulge regions, but was always absent in interfollicular epidermal keratinocytes. In addition, the lectin binding profiles of basal cell carcinoma and the outer root sheath in the suprabulbar region of human VHF were comparable, with the presence of binding sites for PNA, Con A and WGA. These findings provide evidence for a histochemical relationship between basal cell carcinoma and the follicular epithelium of VHF which is closer than that with the epidermis, and suggest its possible origin from or possibly its differentiation pattern towards the cells of the outer root sheath and/or the follicular bulge region of the VHF.

Eric E Turner - One of the best experts on this subject based on the ideXlab platform.

  • direct autoregulation and gene dosage compensation by pou domain transcription factor brn3a
    Development, 2003
    Co-Authors: May Trieu, Natalia Fedtsova, Eric E Turner
    Abstract:

    Brn3a is a POU-domain transcription factor expressed in peripheral sensory neurons and in specific interneurons of the caudal CNS. Sensory Expression of Brn3a is regulated by a specific upstream enhancer, the activity of which is greatly increased in Brn3a knockout mice, implying that Brn3a negatively regulates its own Expression. Brn3a binds to highly conserved sites within this enhancer, and alteration of these sites abolishes Brn3a regulation of reporter transgenes. Furthermore, endogenous Brn3a Expression levels in the sensory ganglia of Brn3a +/+ and Brn3a +/- mice are similar, demonstrating that autoregulation can compensate for the loss of one allele by increasing transcription of the remaining gene copy. Conversely, transgenic overExpression of Brn3a in the trigeminal ganglion suppresses the Expression of the endogenous gene. These findings demonstrate that the Brn3a locus functions as a self-regulating unit to maintain a Constant Expression level of this key regulator of neural development.

M. V. Sangaranarayanan - One of the best experts on this subject based on the ideXlab platform.

  • Nonequilibrium thermodynamics formalism for Marcus theory of heterogeneous and self-exchange electron-transfer rate Constants.
    The journal of physical chemistry. A, 2008
    Co-Authors: Richa Sethi, M. V. Sangaranarayanan
    Abstract:

    The cross-exchange electron-transfer rate Constant Expression of Marcus is derived from the Flux-force formalism of non-equilibrium thermodynamics. The relationship governing the Onsager's phenomenological coefficients for cross-exchange and self-exchange electron-transfer processes is deduced. Onsager's phenomenological coefficient pertaining to the Butler-Volmer equation is derived and estimated from the experimental exchange current densities. The correlation between the heterogeneous and the homogeneous electron-transfer rate Constants derived by Marcus is analyzed in terms of the corresponding phenomenological coefficients.

Masahiko Higuchi - One of the best experts on this subject based on the ideXlab platform.

  • Coupling-Constant Expression and exact relations for the kinetic-energy functional in pair-density-functional theory
    Physical Review A, 2012
    Co-Authors: Katsuhiko Higuchi, Masahiko Higuchi
    Abstract:

    We derive the coupling-Constant Expression for the kinetic energy (KE) functional of the pair-density-functional theory. Such the Expression can be effectively used in developing the approximate KE functional. Indeed, on the basis of this Expression, we present an approximate form of the KE functional by means of the perturbation theory. Furthermore, as the first step of an alternative way of obtaining the approximate KE functional, we derive several relations and bounds for the KE functional by investigating how the KE functional changes with the nonuniform scaling, rotation, and translation of electron coordinates. Such relations and bounds can be utilized as restrictive conditions on the approximate form. Thus, the coupling-Constant Expression, relations and bounds obtained here provide useful tools for devising various types of the approximate KE functional that is indispensable for advancing the pair-density-functional theory.

  • exchange correlation energy functional and virial theorem in the extended constrained search theory
    Physical Review B, 2005
    Co-Authors: Katsuhiko Higuchi, Masahiko Higuchi
    Abstract:

    The coupling-Constant Expression and virial relation for the exchange-correlation energy functional of the extended-constrained search theory [M. Higuchi and K. Higuchi, Phys. Rev. B 69, 035113 (2004)] are derived. These provide the guideline for developing and testing the approximate form of the exchange-correlation energy functional.

  • Scheme for the energy-band calculation under the external magnetic field
    Physica B-condensed Matter, 2003
    Co-Authors: Katsuhiko Higuchi, Masahiko Higuchi
    Abstract:

    Abstract In the framework of the current-density functional theory (CDFT), we propose three kinds of approximation schemes for the exchange-correlation energy functional on the basis of the coupling-Constant Expression. These should be called the CDFT version of the local-density approximation, average-density approximation and weighted-density approximation. The validity of these approximations is estimated by using the sum rules which have recently been derived.