The Experts below are selected from a list of 138 Experts worldwide ranked by ideXlab platform
Vadim A Soloshonok - One of the best experts on this subject based on the ideXlab platform.
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biomimetic reductive amination under the Continuous Flow Reaction conditions
Journal of Fluorine Chemistry, 2010Co-Authors: Vadim A Soloshonok, Hector T Catt, Taizo OnoAbstract:This study present a full account of Continuous-Flow Reaction conditions for biomimetic reductive amination of fluorinated carbonyl compounds to corresponding amines and amino acids of biomedical importance. We demonstrate that simple silica-adsorbed DBU can be used as efficient catalysts for on-column 1,3-proton shift Reaction, a key transformation in the biomimetic reductive amination process. This new on-column process features operationally convenient conditions, higher chemical yields, enantioselectivity and purity of the corresponding products as compared with traditional in-flask Reactions. Moreover the removal of base-catalyst, the most delicate problem of the in-flask Reactions, is not an issue in the on-column process, as the silica-adsorbed DBU or polymer-bound guanidine remains on the column and can be reused. This feature renders the overall process substantially more economical and synthetically efficient, in particular, for large-scale synthesis of the corresponding fluorinated amines and amino acids target.
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Continuous Flow asymmetric biomimetic transamination
Journal of Fluorine Chemistry, 2009Co-Authors: Vadim A Soloshonok, Hector T Catt, Taizo OnoAbstract:This study has demonstrated that conceptually new Continuous-Flow Reaction procedure for biomimetic transamination of perfluoroalkyl-containing ketones is substantially more efficient as compared with conventional in-flask approach, allowing preparation of the target fluorinated amines with generally improved chemical yields and enantioselectivity.
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first example of Continuous Flow Reaction conditions for biomimetic reductive amination of fluorine containing carbonyl compounds
Journal of Fluorine Chemistry, 2008Co-Authors: Vadim A SoloshonokAbstract:Abstract This study presents the first example of Continuous-Flow Reaction conditions for biomimetic reductive amination of fluorinated carbonyl compounds using silica-adsorbed DBU as catalyst for on-column process. This new on-column process features operationally convenient conditions, higher chemical yields and purity of products as compared with traditional in-flask Reactions. Furthermore the removal of base-catalyst is not an issue in this process at all, as the catalyst (DBU) remains on the column in the “Reaction zone”, the feature which makes the overall process substantially more efficient and inexpensive, in particular, for large-scale synthesis of the target α-perfluoroalkyl amines.
Taizo Ono - One of the best experts on this subject based on the ideXlab platform.
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biomimetic reductive amination under the Continuous Flow Reaction conditions
Journal of Fluorine Chemistry, 2010Co-Authors: Vadim A Soloshonok, Hector T Catt, Taizo OnoAbstract:This study present a full account of Continuous-Flow Reaction conditions for biomimetic reductive amination of fluorinated carbonyl compounds to corresponding amines and amino acids of biomedical importance. We demonstrate that simple silica-adsorbed DBU can be used as efficient catalysts for on-column 1,3-proton shift Reaction, a key transformation in the biomimetic reductive amination process. This new on-column process features operationally convenient conditions, higher chemical yields, enantioselectivity and purity of the corresponding products as compared with traditional in-flask Reactions. Moreover the removal of base-catalyst, the most delicate problem of the in-flask Reactions, is not an issue in the on-column process, as the silica-adsorbed DBU or polymer-bound guanidine remains on the column and can be reused. This feature renders the overall process substantially more economical and synthetically efficient, in particular, for large-scale synthesis of the corresponding fluorinated amines and amino acids target.
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Continuous Flow asymmetric biomimetic transamination
Journal of Fluorine Chemistry, 2009Co-Authors: Vadim A Soloshonok, Hector T Catt, Taizo OnoAbstract:This study has demonstrated that conceptually new Continuous-Flow Reaction procedure for biomimetic transamination of perfluoroalkyl-containing ketones is substantially more efficient as compared with conventional in-flask approach, allowing preparation of the target fluorinated amines with generally improved chemical yields and enantioselectivity.
Sunwoo Lee - One of the best experts on this subject based on the ideXlab platform.
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Continuous Flow Reactions in water for the synthesis of propargylamines via a metal free decarboxylative coupling Reaction
ChemInform, 2015Co-Authors: Bongkyun Jung, Kyung Ho Park, Kwang Ho Song, Sunwoo LeeAbstract:Alkynyl carboxylic acids undergo decarboxylative coupling with amines and paraformaldehyde, using a Continuous Flow Reaction system to give propargylamines in excellent yields.
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Continuous Flow Reactions in water for the synthesis of propargylamines via a metal free decarboxylative coupling Reaction
Tetrahedron Letters, 2015Co-Authors: Bongkyun Jung, Kyung Ho Park, Kwang Ho Song, Sunwoo LeeAbstract:Abstract A range of propargylamines was synthesized via the metal-free decarboxylative coupling of alkynyl carboxylic acids with amines and paraformaldehyde in water, using a Continuous Flow Reaction system. Aryl- and alkyl-substituted propiolic acids were found to react with secondary amines in the presence of paraformaldehyde, at 140 °C in water to give the desired propargylamines in good yield.
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efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a Continuous Flow Reaction system
ChemInform, 2012Co-Authors: Hee Joon Lee, Kyung Ho Park, Goun Bae, Jaehoon Choe, Kwang Ho Song, Sunwoo LeeAbstract:Only trace amounts of symmetrical diarylalkynes are obtained in some cases as by- products.
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efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a Continuous Flow Reaction system
Tetrahedron Letters, 2011Co-Authors: Hee Joon Lee, Kyung Ho Park, Goun Bae, Jaehoon Choe, Kwang Ho Song, Sunwoo LeeAbstract:Abstract Unsymmetric diaryl alkynes were synthesized from the palladium-catalyzed decarboxylative coupling of aryl halides and propiolic acid using a Continuous Flow Reaction system. This Flow chemistry system Continuously gave the desired products in moderate to good yields, and produced less byproduct than was formed in the batch Reaction.
Hector T Catt - One of the best experts on this subject based on the ideXlab platform.
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biomimetic reductive amination under the Continuous Flow Reaction conditions
Journal of Fluorine Chemistry, 2010Co-Authors: Vadim A Soloshonok, Hector T Catt, Taizo OnoAbstract:This study present a full account of Continuous-Flow Reaction conditions for biomimetic reductive amination of fluorinated carbonyl compounds to corresponding amines and amino acids of biomedical importance. We demonstrate that simple silica-adsorbed DBU can be used as efficient catalysts for on-column 1,3-proton shift Reaction, a key transformation in the biomimetic reductive amination process. This new on-column process features operationally convenient conditions, higher chemical yields, enantioselectivity and purity of the corresponding products as compared with traditional in-flask Reactions. Moreover the removal of base-catalyst, the most delicate problem of the in-flask Reactions, is not an issue in the on-column process, as the silica-adsorbed DBU or polymer-bound guanidine remains on the column and can be reused. This feature renders the overall process substantially more economical and synthetically efficient, in particular, for large-scale synthesis of the corresponding fluorinated amines and amino acids target.
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Continuous Flow asymmetric biomimetic transamination
Journal of Fluorine Chemistry, 2009Co-Authors: Vadim A Soloshonok, Hector T Catt, Taizo OnoAbstract:This study has demonstrated that conceptually new Continuous-Flow Reaction procedure for biomimetic transamination of perfluoroalkyl-containing ketones is substantially more efficient as compared with conventional in-flask approach, allowing preparation of the target fluorinated amines with generally improved chemical yields and enantioselectivity.
Kwang Ho Song - One of the best experts on this subject based on the ideXlab platform.
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Continuous Flow Reactions in water for the synthesis of propargylamines via a metal free decarboxylative coupling Reaction
ChemInform, 2015Co-Authors: Bongkyun Jung, Kyung Ho Park, Kwang Ho Song, Sunwoo LeeAbstract:Alkynyl carboxylic acids undergo decarboxylative coupling with amines and paraformaldehyde, using a Continuous Flow Reaction system to give propargylamines in excellent yields.
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Continuous Flow Reactions in water for the synthesis of propargylamines via a metal free decarboxylative coupling Reaction
Tetrahedron Letters, 2015Co-Authors: Bongkyun Jung, Kyung Ho Park, Kwang Ho Song, Sunwoo LeeAbstract:Abstract A range of propargylamines was synthesized via the metal-free decarboxylative coupling of alkynyl carboxylic acids with amines and paraformaldehyde in water, using a Continuous Flow Reaction system. Aryl- and alkyl-substituted propiolic acids were found to react with secondary amines in the presence of paraformaldehyde, at 140 °C in water to give the desired propargylamines in good yield.
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efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a Continuous Flow Reaction system
ChemInform, 2012Co-Authors: Hee Joon Lee, Kyung Ho Park, Goun Bae, Jaehoon Choe, Kwang Ho Song, Sunwoo LeeAbstract:Only trace amounts of symmetrical diarylalkynes are obtained in some cases as by- products.
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efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a Continuous Flow Reaction system
Tetrahedron Letters, 2011Co-Authors: Hee Joon Lee, Kyung Ho Park, Goun Bae, Jaehoon Choe, Kwang Ho Song, Sunwoo LeeAbstract:Abstract Unsymmetric diaryl alkynes were synthesized from the palladium-catalyzed decarboxylative coupling of aryl halides and propiolic acid using a Continuous Flow Reaction system. This Flow chemistry system Continuously gave the desired products in moderate to good yields, and produced less byproduct than was formed in the batch Reaction.